• Bulletin of the Korean Mathematical Society
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• v.47 no.1
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• pp.89-102
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• 2010

This paper concerns the problem of global robust stability of a time-delay discontinuous system with a positive-defined connection matrix under polytopic-type uncertainty. In order to give the stability condition, we firstly address the existence of solution and equilibrium point based on the properties of M-matrix, Lyapunov-like approach and the theories of differential equations with discontinuous right-hand side as introduced by Filippov. Second, we give the delay-independent and delay-dependent stability condition in terms of linear matrix inequalities (LMIs), and based on Lyapunov function and the properties of the convex sets. One numerical example demonstrate the validity of the proposed criteria.

• JSTS:Journal of Semiconductor Technology and Science
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• v.15 no.5
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• pp.455-462
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• 2015

H-field EMI measurements have been performed for the single-ended, the differential, and the pseudo-differential signaling on a 11" FR4 microstrip line. The pseudo-differential signaling reduces EMI by more than 10 dB compared to the single-ended signaling if the delay mismatch is lower than 5% of a period for a 3 GHz clock signal. Empirical H-field equations for both differential and single-ended signaling showed fair agreements with measurements.

• Communications of the Korean Mathematical Society
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• v.34 no.2
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• pp.685-699
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• 2019

This research is focused on a continuous epidemic model of transmission of Plasmodium vivax malaria with a time delay. The model is represented as a system of ordinary differential equations with delay. There are two equilibria, which are the disease-free state and the endemic equilibrium, depending on the basic reproduction number, $R_0$, which is calculated and decreases with the time delay. Moreover, the disease-free equilibrium is locally asymptotically stable if $R_0<1$. If $R_0>1$, a unique endemic steady state exists and is locally stable. Furthermore, Hopf bifurcation is applied to determine the conditions for periodic solutions.

• Kyungpook Mathematical Journal
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• v.62 no.1
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• pp.119-132
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• 2022

Virotherapy is an effective method for the treatment of cancer. The oncolytic virus specifically infects the lyse cancer cell without harming normal cells. There is a time delay between the time of interaction of the virus with the tumor cells and the time when the tumor cells become infectious and produce new virus particles. Several types of viruses are used in virotherapy and the delay varies with the type of virus. This delay can play an important role in the success of virotherapy. Our present study is to explore the impact of this delay in cancer virotherapy through a mathematical model based on delay differential equations. The partial success of virotherapy is guarenteed when one gets a stable non-trivial equilibrium with a low level of tumor cells. There exits Hopf-bifurcation by considering the delay as bifurcation parameter. We have estimated the length of delay which preserves the stability of the non-trivial equilibrium point. So when the delay is less than a threshold value, we can predict partial success of virotherapy for suitable sets of parameters. Here numerical simulations are also performed to support the analytical findings.

• Bulletin of the Korean Mathematical Society
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• v.49 no.6
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• pp.1193-1198
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• 2012

By constructing suitable Lyapunov functionals and combining with matrix inequality technique, a new simple sufficient condition is presented for the global asymptotic stability of the Cohen-Grossberg neural network models. The condition contains and improves some of the previous results in the earlier references.

• East Asian mathematical journal
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• v.36 no.1
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• pp.81-90
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• 2020

Many compartment models assume a kinetically homogeneous amount of materials that have well-stirred compartments. However, based on observations from such processes, they have been heuristically fitted by exponential or gamma distributions even though biological media are inhomogeneous in real environments. Fractional differential equations using a specific kernel in Pharmacokinetic/Pharmacodynamic (PKPD) model are recently introduced to account for abnormal drug disposition. We discuss a tumor growth inhibition (TGI) model using fractional-order derivative from it. This represents a tumor growth delay by cytotoxic agents and additionally show variations in the equilibrium points by the change of fractional order. The result indicates that the equilibrium depends on the tumor size as well as a change of the fractional order. We find that the smaller the fractional order, the smaller the equilibrium value. However, a difference of them is the number of concavities and this indicates that TGI over time profile for fitting or prediction should be determined properly either fractional order or tumor sizes according to the number of concavities shown in experimental data.

• Journal for History of Mathematics
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• v.24 no.2
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• pp.47-59
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• 2011

Various mathematical models have been widely studied recently in both fields of mathematics and ecology since they help us understand the dynamical process of population changes in biological species living in a certain habitat and give useful predictions. The world population model proposed by Malthus, a British economist, in his work 'An Essay on the Principle of Population' published in the period of 1789~1826 is one of the early mathematical models on population changes. Malthus' models and the carrying capacity models of Verhulst in 1845 were based on exponential type functions. The independent research field of mathematical ecology has been started from Lotka's works in 1920's. Since then various different mathematical models has been proposed and examined. This article mainly deals with single species population change models expressed in terms of ordinary differential equations.

• International Journal of Control, Automation, and Systems
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• v.5 no.4
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• pp.355-363
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• 2007

The paper deals with the Kalman stochastic filtering problem for linear continuous-time systems with both instantaneous and time-delayed measurements. Different from the standard linear system, the system state is corrupted by multiplicative white noise, and the instantaneous measurement and the delayed measurement are also corrupted by multiplicative white noise. A new approach to the problem is presented by using projection formulation and reorganized innovation analysis. More importantly, the proposed approach in the paper can be applied to solve many complicated problems such as stochastic $H_{\infty}$ estimation, $H_{\infty}$ control stochastic system with preview and so on.

• Journal of the Korean Society of Propulsion Engineers
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• v.22 no.3
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• pp.46-52
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• 2018

A simple Crocco's $n-{\tau}$ time delay model and linear analysis of fluid flow coupled with acoustics are combined to investigate the high frequency combustion instability in the combustion chamber of LOX/hydrocarbon engines. The partial differential equation of the velocity potential is separated into ordinary differential equations, and eigenvalues that correspond to tangential resonance modes in the cylindrical chamber are determined. A general solution is obtained by solving the differential equation in the axial direction, and boundary conditions at the injector face and nozzle entrance are applied in order to calculate the chamber admittance. Frequency analysis of the transfer function is used to evaluate the stability of system. Stability margin is determined from the system gain and phase angle for the desired frequency range of 1T mode. The chamber model with variable baffle length and configurations are also considered in order to enhance the 1T mode stability of the combustion chamber.

• Advances in nano research
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• v.10 no.4
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• pp.359-371
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• 2021

A tumor immune interaction is a main topic of interest in the last couple of decades because majority of human population suffered by tumor, formed by the abnormal growth of cells and is continuously interacted with the immune system. Because of its wide range of applications, many researchers have modeled this tumor immune interaction in the form of ordinary, delay and fractional order differential equations as the majority of biological models have a long range temporal memory. So in the present work, tumor immune interaction in fractional form provides an excellent tool for the description of memory and hereditary properties of inter and intra cells. So the interaction between effector-cells, tumor cells and interleukin-2 (IL-2) are modeled by using the definition of Caputo fractional order derivative that provides the system with long-time memory and gives extra degree of freedom. Moreover, in order to achieve more efficient computational results of fractional-order system, a discretization process is performed to obtain its discrete counterpart. Furthermore, existence and local stability of fixed points are investigated for discrete model. Moreover, it is proved that two types of bifurcations such as Neimark-Sacker and flip bifurcations are studied. Finally, numerical examples are presented to support our analytical results.