• Title/Summary/Keyword: Degradation

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Dissolution Profile Analysis of Hydroxypropyl Methylcellulose-based Vitamin C Tablets (Hydroxypropyl methylcellulose를 활용한 비타민 C 지속성 정제의 용출 특성 분석)

  • Cha, Ja-Hyun;Hong, Jun-Kee;Lee, Sung-Wan;Cha, Jae-Uk;Ko, Won-Hwa;Baek, Hyon-Ho;Park, Hyun-Jin
    • Korean Journal of Food Science and Technology
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    • v.44 no.3
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    • pp.274-279
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    • 2012
  • The objective of this study was to develop oral matrix tablets for the sustained release of vitamin C. In this study hydroxypropyl methylcellulose (HPMC) has been utilized as an excipient, as it is one of the most widely used polymers, for use during long periods of time in formations. The vitamin C tablet formulation depends on the molecular weight and concentration of sustained-delivery in HPMC. Anti-oxidants have been added as a dissolution medium in order to prevent vitamin C degradation in water. The dissolution test was carried out in a distilled water medium, and the release model equation was applied to analyze the vitamin C release pattern. The results demonstrated that the release and lasting power of vitamin C tablets, containing HPMC, lasted for more than 12 h.

LxBSM: Loadable Kernel Module for the Creation of C2 Level Audit Data based on Linux (LxBSM: C2 수준의 감사 자료 생성을 위한 리눅스 기반 동적 커널 모듈)

  • 전상훈;최재영;김세환;심원태
    • Journal of KIISE:Computing Practices and Letters
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    • v.10 no.2
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    • pp.146-155
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    • 2004
  • Currently most of commercial operating systems contain a high-level audit feature to increase their own security level. Linux does not fall behind the other commercial operating systems in performance and stability, but Linux does not have a good audit feature. Linux is required to support a higher security feature than C2 level of the TCSEC in order to be used as a server operating system, which requires the kernel-level audit feature that provides the system call auditing feature and audit event. In this paper, we present LxBSM, which is a kernel module to provide the kernel-level audit features. The audit record format of LxBSM is compatible with that of Sunshield BSM. The LxBSM is implemented as a loadable kernel module, so it has the enhanced usability. It provides the rich audit records including the user-level audit events such as login/logout. It supports both the pipe and file interface for increasing the connectivity between LxBSM and intrusion detection systems (IDS). The performance of LxBSM is compared and evaluated with that of Linux kernel without the audit features. The response time was increased when the system calls were called to create the audit data, such as fork, execve, open, and close. However any other performance degradation was not observed.

Short -term changes of microbial communities after control of Cochlodinium polykrikoides by yellow clay and chemical compound dosing in microcosm experiments (황토와 화학물질 살포에 의한 적조생물Cochlodinium polykrikoides 제어에 따른 미소생물그룹의 단주기변화)

  • Baek, Seung Ho
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.4
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    • pp.2971-2977
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    • 2015
  • This study aimed to understand the changes in microbial community after algicide dosing to control the fish-killing dinoflagellate Cochlodinium polykrikoides in 10L microcosm. Based on our microcosm experiments, the algicidal activity for C. polykrikoides of yellow clay at the concentrations of 4g and 10g per 10 L was < 20%. At $0.8{\mu}M$ concentration of thiazolidinedione(TD49), the population of C. polykrikoides was controlled to be > 85%. In microbial community, a significant increase in heterotrophic bacterial (HB) abundance was observed at day 1 in the TD49 and yellow clay treatments including control. The HB remained high for 2 days and then gradually decreased. In contrast, the abundance of heterotrophic nanoflagellates (HNFs) increased significantly on days 3 and 5 in the TD49 treatments, indicating that the decline in HB was probably a result of predation by the high density of HNFs. In addition, fluctuations in the aloricate ciliate Uronema sp., which feed on bacteria, was clearly correlated with fluctuations in HB abundance, with a lag period of 1-3 days. Therefore, the short-term responses of the HNF and Uronema sp. may have been a result of the rapidly increasing of HB abundance, which is related to degradation of the dense C. polykrikoides bloom, particularly in the TD49 treatment. In addition, large aloricate ciliate Euplotes sp. was significantly increased after reproduction of HNFs and Uronema sp. Consequently, the algicide TD49 had positive effect on the microbial communities, which indicates that the microbial loop was temporarily enhanced in the microcosm by energy flow from HB through HNFs to ciliate.

Shadow Recovery for Column-based Databases (컬럼-기반 데이터베이스를 위한 그림자 복구)

  • Byun, Si-Woo
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.4
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    • pp.2784-2790
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    • 2015
  • The column-oriented database storage is a very advanced model for large-volume data transactions because of its superior I/O performance. Traditional data storages exploit row-oriented storage where the attributes of a record are placed contiguously in hard disk for fast write operations. However, for search-mostly data warehouse systems, column-oriented storage has become a more proper model because of its superior read performance. Recently, solid state drive using flash memory is largely recognized as the preferred storage media for high-speed data analysis systems. In this research, we propose a new transaction recovery scheme for a column-oriented database environment which is based on a flash media file system. We improved traditional shadow paging schemes by reusing old data pages which are supposed to be invalidated in the course of writing a new data page in the flash file system environment. In order to reuse these data pages, we exploit reused shadow list structure in our column-oriented shadow recovery(CoSR) scheme. CoSR scheme minimizes the additional storage overhead for keeping shadow pages and minimizes the I/O performance degradation caused by column data compression of traditional recovery schemes. Based on the results of the performance evaluation, we conclude that CoSR outperforms the traditional schemes by 17%.

An Efficient Snapshot Technique for Shared Storage Systems supporting Large Capacity (대용량 공유 스토리지 시스템을 위한 효율적인 스냅샷 기법)

  • 김영호;강동재;박유현;김창수;김명준
    • Journal of KIISE:Databases
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    • v.31 no.2
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    • pp.108-121
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    • 2004
  • In this paper, we propose an enhanced snapshot technique that solves performance degradation when snapshot is initiated for the storage cluster system. However, traditional snapshot technique has some limits adapted to large amount storage shared by multi-hosts in the following aspects. As volume size grows, (1) it deteriorates crucially the performance of write operations due to additional disk access to verify COW is performed. (2) Also it increases excessively the blocking time of write operation performed during the snapshot creation time. (3)Finally, it deteriorates the performance of write operations due to additional disk I/O for mapping block caused by the verification of COW. In this paper, we propose an efficient snapshot technique for large amount storage shared by multi-hosts in SAN Environments. We eliminate the blocking time of write operation caused by freezing while a snapshot creation is performing. Also to improve the performance of write operation when snapshot is taken, we introduce First Allocation Bit(FAB) and Snapshot Status Bit(SSB). It improves performance of write operation by reducing an additional disk access to volume disk for getting snapshot mapping block. We design and implement an efficient snapshot technique, while the snapshot deletion time, improve performance by deallocation of COW data block using SSB of original mapping entry without snapshot mapping entry obtained mapping block read from the shared disk.

Effective Index and Backup Techniques for HLR System in Mobile Networks (이동통신 HLR 시스템에서의 효과적인 색인 및 백업 기법)

  • 김장환;이충세
    • Journal of KIISE:Computing Practices and Letters
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    • v.9 no.1
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    • pp.33-46
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    • 2003
  • A Home Location Register(HLR) database system manages each subscriber's location information, which continuously changes in a cellular network. For this purpose, the HLR database system provides table management, index management, and backup management facilities. In this thesis, we propose using a two-level index method for the mobile directory number(MDN) as a suitable method and a chained bucket hashing method for the electronic serial number(ESN). Both the MDN and the ESN are used as keys in the HLR database system. We also propose an efficient backup method that takes into account the characteristics of HLR database transactions. The retrieval speed and the memory usage of the two-level index method are better than those of the R-tree index method. The insertion and deletion overhead of the chained bucket hashing method is less than that of the modified linear hashing method. In the proposed backup method, we use two kinds of dirty flags in order to solve the performance degradation problem caused by frequent registration-location operations. For a million subscribers, proposed techniques support reduction of memory size(more than 62%), directory operations (2500,000 times), and backup operations(more than 80%) compared with current techniques.

A Study on the Cobalt Electrodeposition of High Aspect Ratio Through-Silicon-Via (TSV) with Single Additive (단일 첨가제를 이용한 고종횡비 TSV의 코발트 전해증착에 관한 연구)

  • Kim, Yu-Jeong;Lee, Jin-Hyeon;Park, Gi-Mun;Yu, Bong-Yeong
    • Proceedings of the Korean Institute of Surface Engineering Conference
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    • 2018.06a
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    • pp.140-140
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    • 2018
  • The 3D interconnect technologies have been appeared, as the density of Integrated Circuit (IC) devices increases. Through Silicon Via (TSV) process is an important technology in the 3D interconnect technologies. And the process is used to form a vertically electrical connection through silicon dies. This TSV process has some advantages that short length of interconnection, high interconnection density, low electrical resistance, and low power consumption. Because of these advantages, TSVs could improve the device performance higher. The fabrication process of TSV has several steps such as TSV etching, insulator deposition, seed layer deposition, metallization, planarization, and assembly. Among them, TSV metallization (i.e. TSV filling) was core process in the fabrication process of TSV because TSV metallization determines the performance and reliability of the TSV interconnect. TSVs were commonly filled with metals by using the simple electrochemical deposition method. However, since the aspect ratio of TSVs was become a higher, it was easy to occur voids and copper filling of TSVs became more difficult. Using some additives like an accelerator, suppressor and leveler for the void-free filling of TSVs, deposition rate of bottom could be fast whereas deposition of side walls could be inhibited. The suppressor was adsorbed surface of via easily because of its higher molecular weight than the accelerator. However, for high aspect ratio TSV fillers, the growth of the top of via can be accelerated because the suppressor is replaced by an accelerator. The substitution of the accelerator and the suppressor caused the side wall growth and defect generation. The suppressor was used as Single additive electrodeposition of TSV to overcome the constraints. At the electrochemical deposition of high aspect ratio of TSVs, the suppressor as single additive could effectively suppress the growth of the top surface and the void-free bottom-up filling became possible. Generally, copper was used to fill TSVs since its low resistivity could reduce the RC delay of the interconnection. However, because of the large Coefficients of Thermal Expansion (CTE) mismatch between silicon and copper, stress was induced to the silicon around the TSVs at the annealing process. The Keep Out Zone (KOZ), the stressed area in the silicon, could affect carrier mobility and could cause degradation of the device performance. Cobalt can be used as an alternative material because the CTE of cobalt was lower than that of copper. Therefore, using cobalt could reduce KOZ and improve device performance. In this study, high-aspect ratio TSVs were filled with cobalt using the electrochemical deposition. And the filling performance was enhanced by using the suppressor as single additive. Electrochemical analysis explains the effect of suppressor in the cobalt filling bath and the effect of filling behavior at condition such as current type was investigated.

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Structural Integrity Evaluation of Mechanically Fastened FRP Beams Under the Effects of Sustained Loads and Environments (지속하중과 환경영향을 받은 MF-FRP 보강보의 구조건전성 평가)

  • Lee, Jae-Ha;Kim, Woo-Seok
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.18 no.1
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    • pp.10-18
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    • 2014
  • Mechanically fastening FRP (MF-FRP) strips using nails and anchors, has been shown to provide a more ductile behavior to the strengthened structural element than using bonded FRP. To further advance the state of the knowledge on this strengthening method, the current study examined environmental effects for six months on MF-FRP beams. Reinforced concrete beams strengthened with mechanically fastened FRP strips and subjected to sustained loads for six months were exposed to outdoor weather and constant high temperatures ($40^{\circ}C$). For comparison, the behavior of RC beam with and without sustained loads was evaluated. Results from flexural tests did not show any significant degradation or change of failure mode as a result of sustained load and of environmental effects such as high temperatures and outdoor weather over a period of six months. Failure of the beams was governed by FRP delamination followed by concrete crushing as not much load applied to the nail and anchors because of slip effects.

The Strain of Transverse Steel and Concrete Shear Resistance Degradation after Yielding of Reinforced Concrete Circular Pier (철근콘크리트 원형 교각의 횡방향철근 변형률과 항복이후 콘크리트 전단저항 저감)

  • Ko, Seong Hyun
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.22 no.1
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    • pp.147-157
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    • 2018
  • The basis of capacity design has been explicitly or implicitly regulated in most bridge design specifications. It is to guarantee ductile failure of entire bridge system by preventing brittle failure of pier members and any other structural members until the columns provides fully enough plastic rotation capacity. Brittle shear is regarded as a mode of failure that should be avoided in reinforced concrete bridge pier design. To provide ductility behavior of column, the one of important factors is that flexural hinge of column must be detailed to ensure adequate and dependable shear strength and deformation capacity. Eight small scale circular reinforced concrete columns were tested under cyclic lateral load with 4.5 aspect ratio. The test variables are longitudinal steel ratio, transverse steel ratio, and axial load ratio. Eight flexurally dominated columns were tested. In all specimens, initial flexural-shear cracks occurred at 1.5% drift ratio. The multiple flexural-shear crack width and length gradually increased until the final stage. The angles of the major inclined cracks measured from the vertical column axis ranged between 42 and 48 degrees. In particular, this study focused on assessing transverse reinforcement contribution to the column shear strength. Transverse reinforcement contribution measured during test. Each three components of transverse reinforcement contribution, axial force contribution and concrete contribution were investigated and compared. It was assessed that the concrete stresses of all specimen were larger than stress limit of Korea Bridge Design Specifications.

Attenuant Effects of Hovenia dulcis Extract on Inflammatory Orifacial Pain in Rats (헛개나무 추출물이 안면염증통증의 경감효과)

  • Lee, Jun-Seon;Lee, Min-Kyung;Kim, Yun-Kyung;Kim, Ki-Eun;Hyun, Kyung-Yae
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.8
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    • pp.5088-5094
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    • 2014
  • Hovenia dulcis extract (HDE) has positive effects on alcohol degradation, recovery of liver damage and antioxidant activities. This study examined whether HDE exerts an ameliorative effect on inflammatory orifacial pain in an animal algesic model with formalin. The animals (rats) were divided into four groups: group I (control), group II (right facial subcutaneous injection of 5% formalin, inflammatory orifacial pain group), group III (5% formalin + distilled water administration), and group IV injection (5% formalin + 4.5 ml/kg of HDE), respectively. The scores from the scratch and effleurage tests were applied to evaluate the differences between three groups. The expression of p38 MAPK, iNOS and Nrf2 in the brain and medulla oblongata, which are involved in pain regulation, inflammation, antioxidation and nitric oxide production, were analyzed by western blot. The degree of orifacial pain was significantly lower in group IV than in groups I, II and, III. The expression of p38MAPK, iNOS and Nrf2 in the brain and medulla were also lower in group IV than in the other groups. These findings suggested that a Hovenia dulcis extract can attenuate inflammatory orifacial pain by suppressing the expression of p38 MAPK, iNOS and Nrf2.