• 한국임상약학회지
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• 제25권4호
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• pp.246-253
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• 2015

Background & Object: Ankylosing spondylitis (AS) is a chronic inflammatory disease that causes ankylosis and deformation of axial joints. Since current medicine cannot cure the disease yet, alleviating pain and preventing deformation with medications are the main therapy for patients with AS. The key medications for these purposes include nonsteroidal anti-inflammatory drugs (NSAIDs), and tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) inhibitors. This study aims to analyze prescribing patterns of AS patients in South Korea. Method: National Patients Sample data compiled by the Health Insurance Review and Assessment Service from 2013 was analyzed. Patients with AS were identified with Korean Standard Classification of Diseases code-6, which was M45. The rates of prescription, discontinuation, and switching ingredients were calculated for each medication during 2013. Results: Total number of patients was 655, and most of them were male (n = 514, 78.5%). Of all age groups, the proportion of 30-40 year old patients was the greatest (35.1%). The most utilized drug class was NSAIDs (82.4%). Less than half of patients were prescribed $TNF-{\alpha}$ inhibitors (n = 212, 32.4%). Meloxicam, aceclofenac, and celecoxib were the most frequently prescribed NSAIDs. In case of $TNF-{\alpha}$ inhibitors, adalimumab, etanercept and infliximab were the top three most prescribed drugs. Although not recommended by the current practice guideline, significant proportions of patients were identified using disease modifying anti-rheumatic drugs (DMARDs). Conclusion: Considering the current practice guideline and previous studies about the efficacy, the use of DMARDs should be reduced and medical insurance term in South Korea should be re-examined.

• 한국안전학회지
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• 제27권4호
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• pp.7-12
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• 2012

In this study, the solidification characteristics inside the AC7A casting material was analyzed using the numerical analysis method and was verified using the experimental method by the pre-heated temperature conditions of metal casting device. For the numerical analysis, "COMSOL Multiphysics", the commercial code based on the finite element analysis(FEA), was used in order to predict the thermal deformation of the AC7A casting material including temperature, displacement and stress distribution. Also, in order to verify the results calculated by the numerical analysis, the experiment for temperature measurement inside the AC7A casting material was performed using the K-type thermocouple under the same condition of numerical analysis method. In the numerical results, thermal deformation inside AC7A casting material was well-suited for manufacturing products when the pre-heated temperatures of the metal casting device was $250^{\circ}C$. When the results of the temperature distribution were experimentally measured and were compared with those of the numerical result, it appeared that there was some temperature difference because of the latent heat by phase change heat transfer. However, the result of cooling temperature and patterns were almost similar except for the latent heat interval. The solidification characteristics was closely related to the temperature difference between the surface and inside of the casting.

• 전산구조공학
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• 제9권1호
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• pp.151-159
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• 1996

구조용 콘크리트의 비선형 거동을 예측하기 위하여, 압축강도 연화현상, 거시적 및 회전균열모델등의 내용을 포함하고 있는 압축장 응력장 이론(CFT)에 근거한 유한요소법이 개발/제시되었다. 또한, 이와 관련하여 CFT가 암시하는 탄젠트 및 세칸트 재료강성이 반복계산해법의 관점에서 정의/논의되었다. 최종적으로 계산상의 효율성 증대 및 최대하중 이후의 거동 포착에 주안점을 두어 초기재료 강성을 채택한 변위증분법 논리 및 빠른 수렴을 위한 Over-Relaxtion방법이 Isoparametric계의 8-Node요소에 포함/유도되었다. 이와 같이하여 제시된 비선형 해석 프로그램 NASCOM은 응력 혼돈지역에 위치하는 콘크리트 평면요소의 하중 지지능력, 탄성범위 이후의 변형 특성, 균열양상 및 보강근의 항복범위등의 예측을 가능하게 하였다. NASCOM의 제한된 검증을 위하여, Cervenka의 판넬 시험결과에 대한 하중지지능력 및 변형이력등을 예측한 결과가 전체적인 의미에서 실험결과와 상응하는 일치를 나타내었다.

• The Journal of Advanced Prosthodontics
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• 제9권1호
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• pp.22-30
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• 2017

PURPOSE. The aim of this study was to investigate the effect of reinforcing materials on the fracture resistances of glass fiber mesh- and Cr-Co metal mesh-reinforced maxillary complete dentures under fatigue loading. MATERIALS AND METHODS. Glass fiber mesh- and Cr-Co mesh-reinforced maxillary complete dentures were fabricated using silicone molds and acrylic resin. A control group was prepared with no reinforcement (n = 15 per group). After fatigue loading was applied using a chewing simulator, fracture resistance was measured by a universal testing machine. The fracture patterns were analyzed and the fractured surfaces were observed by scanning electron microscopy. RESULTS. After cyclic loading, none of the dentures showed cracks or fractures. During fracture resistance testing, all unreinforced dentures experienced complete fracture. The mesh-reinforced dentures primarily showed posterior framework fracture. Deformation of the all-metal framework caused the metal mesh-reinforced denture to exhibit the highest fracture resistance, followed by the glass fiber mesh-reinforced denture (P<.05) and the control group (P<.05). The glass fiber mesh-reinforced denture primarily maintained its original shape with unbroken fibers. River line pattern of the control group, dimples and interdendritic fractures of the metal mesh group, and radial fracture lines of the glass fiber group were observed on the fractured surfaces. CONCLUSION. The glass fiber mesh-reinforced denture exhibits a fracture resistance higher than that of the unreinforced denture, but lower than that of the metal mesh-reinforced denture because of the deformation of the metal mesh. The glass fiber mesh-reinforced denture maintains its shape even after fracture, indicating the possibility of easier repair.

• 복식
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• 제53권1호
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• pp.49-66
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• 2003

In the relationship between post-modern feminism and the body. the body of women, which has been taken as 'other' by dominant arguments, has escaped from the fixed idea at post-modern times and the post-modern feminists tried to escape from the taste of the times about body image that was prevalent in the former times.'The taste of the times' here means the fixed physical form of ideal women's body by the educational custom, and it includes the educational prescription which establishes the docile body of women. This kind of educational custom aims at the perfect and permanent restriction on size, shape, desire, attitude and movement as well as on the overall demeanor and each part of the body. And the custom produces 'dependent and trained'. that is, inferiorized women's body. Hence, this paper points out that the feminity as a fixed Physical form should be overcome in order to move forward, and as one part of the effort, it attempts to analyze the designs which deformed and distorted women's body in 1990s. This research indicates that the work, which tries to deviate the fantasized and casted women's mystery, has been closely connected with the expression of 'non-separate bodies' and 'irregular body shapes' in 1990s, which aims at escaping from the fixation of women's body Image. Therefore, it is concluded that the target design trend of this research, which expressed the deformation and perversion of the body, provides the anti-these against the ideal body image of women and the these of feminity. which have been reproduced in various methods and patterns throughout the public and the culture on the whole by expressing the refusal and deviation of the existing women's body image through the post-fixation of the body pattern.

• 한국정밀공학회지
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• 제28권8호
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• pp.975-983
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• 2011

A microfin on a heated surface and its effects of the heat transfer has been investigated. The thickness of the fin is about 8 micrometer to allow the flexible up-down motion of the fin. Two-way complete FSI (Fluid-Structure Interaction) method has been applied for the analysis. Firstly, the deformation of a microfin due to the pulsating flow is evaluated using structure analysis. The flow and temperature patterns are predicted by CFD (Computational Fluid Dynamics) method. At each time step, using the pressure force and temperature distribution from CFD, the deformation of the wing is evaluated by FEM. Also in order to estimate the resonance probability, the natural frequency of the wing structure is calculated by modal analysis. The proposed numerical procedure was validated through experiment using a single fin. Through this work, we show that the increase of 40% in heat transfer capacity using the microfin has been compared with that of flat plate case.

• 한국정밀공학회지
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• 제22권2호
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• pp.164-171
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• 2005

This study aims to examine an effect of stacking sequence and curvature on the penetration characteristic of a composite laminated shell. For the purpose, we manufactured specimens with different stacking sequences and curvatures, and conducted a penetration test using an air-gun. To examine an influence according to stacking sequence, as flat plate and curvature specimen had more plies, their critical penetration energy was higher, Critical penetration energies of specimen A and C with less interfaces somewhat higher than those of B and D with more interfaces. The reason that with less interfaces, critical penetration energy was higher is pre-impact bending stiffness of composite laminated shell with less interfaces was lower than that of laminated shell with more interfaces, but bending stiffness after impact was higher. And it is because interface, the weakest part of the composite laminated shell, was influenced by transverse impact. As curvature increases, critical penetration energy increases linearly. It is because as curvature increases, resistance to in-plane deformation as well as bending deformation increases, which need higher critical penetration energy. Patterns of cracks caused by penetration of composite laminated shells include interlaminar crack, intralaminar crack, and laminar fracture. A 0$^{\circ}$ply laminar had a matrix crack, a 90$^{\circ}$ply laminar had intralaminar crack and laminar fracture, and interface between 0$^{\circ}$and 90$^{\circ}$laminar had a interlaminar crack. We examined crack length and delamination area through a penetration test. For the specimen A and C with 2 interface, the longest circumferential direction crack length and largest delamination area were observed on the first interface from the impact point. For the specimen B and D with 4 interface, the longest crack length and largest delamination area were observed on the third interface from the impact point.

• 한국강구조학회 논문집
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• 제14권5호통권60호
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• pp.613-625
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• 2002

본 연구는 강한 반복하중하에서 강부재가 파괴에 이르는 손상과정을 규명하고, 손상과 관련된 인자들을 이용하여 손상지수를 제시하며, 이와 관련된 해석 기법을 개발하는 것을 목적으로 한다. 제안된 손상평가 방법은 변형이 가장 심하게 집중된 단면에 있어서 국소 변형율의 이력에 초점을 맞추어 유도되었다. 해석모델은 좌굴변형의 발생 방향을 가정한 켄틸레버형 강상자형 부재이다. 파괴에 이르는 중심 압축하중과 일정 압축하중이 가해진 상태에서 반복 제어변위가 작용하는 강부재에 대해 비선형해석을 실시하였다. 본 해석에 적용된 주요 변수는 하중 재하패턴, 강종이다. 각 변수가 파괴모드, 변형능력, 그리고 손상과정에 미치는 영향을 기술하였고, 각각 강종에 따른 파괴 과정을 비교하였다. 그 결과 강한 반복하중하에서의 강부재의 파괴는 국부좌굴에 의해서 결정되고 특히 파괴와 직접적으로 연관성이 있는 국소 소성변형율과 관련되어 있음을 알 수 있었다.

• 마이크로전자및패키징학회지
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• 제13권4호
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• pp.17-25
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• 2006

본 논문에서는 FC-PBGA 패키지를 대상으로 하여 온도변화에 따른 열변형에 대한 실험과 해석을 수행하였다. 모아레 간섭계를 이용하여 각 온도단계에서 변위분포를 나타내는 간섭무늬를 얻고, 그로부터 굽힘변형 거동 및 솔더볼의 변형률에 대한 해석을 수행하였다. 한 개의 패키지가 PCB에 연결되어 있는 단면 패키지 결합체와 두 개의 패키지가 PCB의 양쪽에 연결되어 있는 양면 패키지 결합체의 변형 거동을 비교하였다. FC-PBGA의 단면 패키지 결합체 패키지의 최대 굽힘변위는 결합되지 않은 패키지보다 20%정도 작게 발생된 것으로 나타났으며 앙면 패키지의 경우는 대칭성으로 인하여 칩 윗면의 최대 굽힘변위가 단면패키지보다 반 정도 작게 발생되었다. 솔더볼의 파손에 큰 영향을 미치는 유효변형률은 단면 패키지 결합체의 경우 칩 가장자리의 바로 바깥쪽 솔더볼에서, 양면 패키지 결합체의 경우는 칩 가장자리의 바로 안쪽 솔더볼에서 가장 큰 값을 가졌으며, 그 최대값은 양면패키지 결합체의 경우가 50%정도 더 큰 것으로 나타났다.

• 한국지진공학회논문집
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• 제6권2호
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• pp.51-61
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• 2002

본 연구에서는 액상화-종방향 영구지반변형에 대한 지중매설관로의 거동특성을 해석하기 위하여 수치해석 알고리즘을 개발하였다. 기존의 연구결과가 간략한 해석식의 제안을 중심으로 진행되어 왔으며 영구지반변형의 형상과 폭에 따라 해석방법이 달라지는 단점을 가지고 있었던 것을 고려한다면, 개발된 수치해석 기법은 다양한 영구지반변형의 형상과 폭을 단일한 알고리즘 내에서 처리할 수 있다는 특징을 가지고 있다. 이를 위해 본 연구에서는 연속관 형태의 지중매설관로와 주변지반을 보요소와 등가지반강성으로 표현되는 탄-소성 지반 스프링을 이용하여 모형화하였으며, 지진발생시 실측된 지반변형에 기초하여 영구지반변형의 형상을 5가지의 대표적인 형태로 이상화하여 고려하였다. 국내 계기지진피해사례의 부족으로 인하여 영구지반변형의 크기와 지반변형의 폭은 기존의 연구결과를 참조하여 설정하였으며, 국내에서 사용되는 일반적인 강관을 대상으로 지반변형의 형상과 크기 및 폭, 매설관로의 관경, 관두께 등을 변화시켜 가면서 다양한 수치해석을 수행하였다. 수치해석 결과, 종방향 영구지반변형에 대한 매설관로의 거동에 미치는 주요 인자들의 영향정도를 평가할 수 있었다.