• BMB Reports
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• v.31 no.2
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• pp.183-188
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• 1998

2-chloroethylethyl sulfide (CEES) is an alkylating agent that readily reacts with a wide variety of biological molecules causing metabolic abnormality. The mechanism of cell death during CEES injury is poorly understood. We have examined the effect of exposure of thymocytes with various concentrations of CEES to determine the pattern of cell death in thymocytes injury induced by CEES. In the present study, we show that two patterns of cell death occurred by either one of two mechanisms: apoptosis and necrosis. Exposure to low level of CEES (100 ${\mu}M$) for 5 h caused an induction of apoptosis on thymocytes, as identified by the following criteria: DNA fragmentation visualized by the characteristic "ladder" pattern was observed upon agarose gel electrophoresis and morphological features were revealed by microscopical observations. In contrast, exposure to high levels of CEES (500 ${\mu}M$) induce necrotic features such as cell lysis. Thus, depending on the concentrations, CEES can result in either apoptotic or necrotic cell damage. Our findings suggest that thymocytes which are not killed directly, but merely injured by low levels of CEES, are able to activate an internally-programmed cell death mechanism, whereas thymocytes receiving severe damages apparently can not.

• Journal of Powder Materials
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• v.26 no.4
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• pp.311-318
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• 2019

The objective of this study is to investigate the influence of powder shape and densification mechanism on the microstructure and mechanical properties of Ti-6Al-4V components. BE powders are uniaxially and isostatically pressed, and PA ones are injection molded because of their high strengths. The isostatically compacted samples exhibit a density of 80%, which is higher than those of other samples, because hydrostatic compression can lead to higher strain hardening. Owing to the higher green density, the density of BE-CS (97%) is found to be as high as that of other samples (BE-DS (95%) and P-S (94%)). Furthermore, we have found that BE powders can be consolidated by sintering densification and chemical homogenization, whereas PA ones can be consolidated only by simple densification. After sintering, BE-CS and P-S are hot isostatically pressed and BE-DS is hot forged to remove residual pores in the sintered samples. Apparent microstructural evolution is not observed in BE-CSH and P-SH. Moreover, BE-DSF exhibits significantly fine grains and high density of low-angle grain boundaries. Thus, these microstructures provide Ti-6Al-4V components with enhanced mechanical properties (tensile strength of 1179 MPa).

• Journal of the Korea Institute of Military Science and Technology
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• v.22 no.3
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• pp.392-400
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• 2019

This paper provides a fin actuation system of missile based on electromagnetic-spring mechanism to miniaturize the system and lower the cost. Compared with proportional electro-mechanical actuators, the output of Electromagnetic-Spring Actuators(EMSA) has two or three discrete states, but the mechanical configuration of EMSA is simple since it does not need power trains like gears. The simple mechanism of EMSA makes it easy to build small size, low cost, and relatively high torque actuators. However, fast response time is required to improve the dynamic performance and accuracy of missiles since bang-off-bang operation of EMSA affects the flight performance of missile. In this paper the development of EMSA including parameter optimization and mathematical modeling is described. The simulation results using Simulink and experimental test results of prototype EMSAs are presented.

• Journal of the Korea Institute of Military Science and Technology
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• v.22 no.2
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• pp.179-188
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• 2019

Laser beam is directional and small in divergence angle so that it is well qualified to deliver high intensity infrared energy into a coming MANPADS threat for aircraft survivability. The threat will be deceived and loose tracking of a target when it is exposed to the laser beam modulated relevant to the track mechanism of the threat. The laser beam goes through scattering inside the seeker of the threat and reach the detector in a stray light form, which is a critical phenomenon enabling jamming of the seeker. The mechanism of the laser beam based jamming against a pulse modulated infrared seeker is shown. Simulations are carried out to support the understanding of how the jam technique works.

• BMB Reports
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• v.41 no.2
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• pp.93-101
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• 2008

The major cell wall components of bacteria are lipopolysaccharide, peptidoglycan, and teichoic acid. These molecules are known to trigger strong innate immune responses in the host. The molecular mechanisms by which the host recognizes the peptidoglycan of Gram-positive bacteria and amplifies this peptidoglycan recognition signals to mount an immune response remain largely unclear. Recent, elegant genetic and biochemical studies are revealing details of the molecular recognition mechanism and the signalling pathways triggered by bacterial peptidoglycan. Here we review recent progress in elucidating the molecular details of peptidoglycan recognition and its signalling pathways in insects. We also attempt to evaluate the importance of this issue for understanding innate immunity.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.46 no.1
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• pp.22-28
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• 2001

The induction of enzymes and the accumulation of their end products associated with self-defense mechanism in rice were investigated. When rice leaves were irradiated with UV light, activities of diterpene cyclase, phenylalanine ammonia-lyase (PAL), and cinnamic acid 4-hydroxylase (CA4H) were induced and rice phytoalexin, momilactone A was accumulated. The content of p-coumaric acid in rice leaves was closely correlated with self-defense or allelopathic potential against barnyardgrass. UV-challenged rice leaves gave rise to the inhibition of barnyardgrass growth.

• Convergence Security Journal
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• v.22 no.5
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• pp.115-126
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• 2022

This study studied the working relationship between national crisis management and national defense elements from a comprehensive security perspective. The elements of national defense are presented in the Integrated Defense Act. Therefore, by presenting the principles, problems, and alternatives of integrated defense, the study was conducted with the aim of protecting the lives and property of the people in the event of a national crisis and strengthen national security. As a theoretical background, an analysis frame was envisioned based on the four stages of crisis management in the 'Comprehensive Crisis Management Model' and the 'Basic Guidelines for National Crisis Management'. Through this, four domestic and foreign case studies were conducted. As a result of the study, it can be confirmed that related laws, organizations, and public awareness must be provided in order for the national defense elements at each stage of national crisis management to work well. For the completeness of national crisis management, it was suggested that the enactment of the Framework Act on National Crisis Management, the establishment of an integrated defense plan, linked training, C4I for communication, strengthening the capabilities of local government heads, and national defense elements of firefighters.

• Journal of the Korea Institute of Military Science and Technology
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• v.18 no.3
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• pp.293-299
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• 2015

We analyzed the damage effect on Glass Fibre Reinforced Plastics(GFRP) under air flow by irradiation of continuous wave near-IR laser. Damage process and temporal temperature distribution were demonstrated and material characteristics were observed with laser intensity, surface flow speed and angle. Surface temperature on GFRP rapidly increased with laser intensity, and the damaged pattern was different with flow characteristics. In case of no flow, penetration on GFRP by burning and flame generation after laser irradiation was appeared at once. GFRP was penetrated by the heat generated from resin ignition. In case of laser irradiation under flow, a flame generated after burning extinguished at once by flow and penetration pattern on GFRP were differently shown with flow angle. From the results, we presented the damage process and its mechanism.

• Journal of Korea Society of Digital Industry and Information Management
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• v.6 no.4
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• pp.117-130
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• 2010

Paper is on defense for so-called internet crisis, the attack of DDoS (Distributed Denial of Service) which was targeted to the central government ministries, financial sector, and portal sites of chief counties including Korea on June 7th, 2009 as its start. By conducting attack with various DDoS attacking methods in the lab environment and dividing networks targeted by the attack by layers, this paper records and analyzes the chief information for attack, destination information of packets, defense policy setting, and the flow of packet attack with the subjects of the networks separated. This study suggests CFC system using multiple firewalls applying defense policy corresponding to the target layer for ultimate attack and tests it according to the result of analyzing the attack packet information and its amount, log analysis, access recording port, and MAC and IT information, etc. by layers. This article is meaningful in that it analyzes the attack by layers, establishes firewall policy for protecting each layer, and secures accurate mechanism for detect and defense.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.6 no.9
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• pp.2231-2252
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• 2012

With the prevalence of diverse services-oriented applications, such as IPTV systems and on-line games, the current underlying communication networks face more and more challenges on the aspects of flexibility and adaptability. Therefore, an effective and efficient multicast routing mechanism, which can fulfill different requirements of different personalized services, is critical and significant. In this paper, we first define the neighbor gradient, which is calculated based on the weighted sum of attributes such as residual link capacity, normalized hop count, etc. Then two distributed multicast routing algorithms which are neighbor Gradient-based Multicast Routing for Static multicast membership (GMR-S) and neighbor Gradient-based Multicast Routing for Dynamic multicast membership (GMR-D), are proposed. GMR-S is suitable for static membership situation, while GMR-D can be used for the dynamic membership network environment. Experimental results demonstrate the effectiveness and efficiency of our proposed methods.