• Title/Summary/Keyword: Defense Research Center

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Evaluation of prooxidant-antioxidant balance in in vitro fertilization-conceived mice

  • Ahmadi, Hamid;Fathi, Fardin;Moeini, Ashraf;Amidi, Fardin;Sobhani, Aligholi
    • Clinical and Experimental Reproductive Medicine
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    • v.45 no.2
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    • pp.82-87
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    • 2018
  • Objective: Concerns about the safety of assisted reproductive technology (ART) have been raised, as some studies have shown elevated incidence rates of childhood cancer, asthma, allergies, and other diseases in ART-conceived babies. Findings regarding the health of ART-conceived babies are controversial. The present study was conducted to evaluate the prooxidant-antioxidant balance (PAB) in in vitro fertilization (IVF)-conceived mice in comparison to naturally conceived offspring. Methods: Mice (6-8 weeks) were divided into two groups (IVF-conceived and naturally conceived) matched by sex, age, weight, and litter size. A 1-mL blood sample was taken and the sera were separated. The oxidant-antioxidant balance was evaluated using a fast and reliable PAB assay. The results were expressed as $mean{\pm}standard$ deviation. Results: The mean PAB values (HK units) in the IVF-conceived and naturally conceived groups were $59.70{\pm}22.30$ and $54.70{\pm}18.22$, respectively (p= 0.82). Conclusion: Since free radicals contribute to several pathological conditions and antioxidants play an important protective role against oxidative stress, evaluating the oxidant-antioxidant balance is very important. Although the results of this study showed that the quality of the defense mechanism against free radicals was not significantly different between the IVF-conceived and naturally conceived mice, other parameters of metabolic dysfunction need to be measured.

Low Conversion Loss and High Isolation W-band MMIC Mixer Module (낮은 변환 손실 및 높은 격리 특성의 W-band MMIC 믹서 모듈)

  • An, Dan;Rhee, Jin-Koo
    • Journal of the Institute of Electronics and Information Engineers
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    • v.52 no.2
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    • pp.50-54
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    • 2015
  • In this paper, we report on a high performance 94 GHz MMIC mixer module using 0.1-um metamorphic high electron mobility transistors (MHEMTs). A modified resistive mixer with a RF amplifier was proposed in this work for low conversion loss and high LO-RF isolation. The MMIC mixer module was fabricated using a MMIC chip and CPW-waveguide transitions. The fabricated mixer chip and module showed a low conversion loss of 6.3 dB and 9.5 dB, and LO-RF isolations of 24.8 and 30.4 dB at 94 GHz, respectively. This results are superior to those of previously W-band (75-110 GHz) MMIC mixers.

High-performance 94 GHz MMIC Low Noise Amplifier using Metamorphic HEMTs (Metamorphic HEMT를 이용한 우수한 성능의 94 GHz MMIC 저잡음 증폭기)

  • Kim, Sung-Chan;An, Dan;Rhee, Jin-Koo
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.45 no.8
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    • pp.48-53
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    • 2008
  • In this paper, we developed the MMIC low noise amplifier using 100 nm metamorphic HEMTs technology in combination with coplanar circuit topology for 94 GHz applications. The $100nm\times60{\mu}m$ MHEMT devices for the MMIC LNA exhibited DC characteristics with a drain current density of 655 mA/mm, an extrinsic transconductance of 720 mS/mm. The current gain cutoff frequency $(f_T)$ and maximum oscillation frequency $(f_{max})$ were 195 GHz and 305 GHz, respectively. The realized MMIC LNA represented $S_{21}$ gain of 14.8 dB and noise figure of 4.6 dB at 94 GHz with an over-all chip size of $1.8mm\times1.48mm$.

A Study on the Spatial Structure of ChungChong-Do Province Eupchi in the Late Chosun Dynasty (조선후기(朝鮮後期) 충청도(忠淸道) 지방(地方) 읍치(邑治)의 공간구조(空間構造)에 관한 연구(硏究))

  • Kim, Ki-Deok;Lee, Jae-Heon
    • Journal of architectural history
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    • v.12 no.1 s.33
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    • pp.43-58
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    • 2003
  • This study is to analyze spatial structure of Eupchi(邑治) on Chungchong province with Chungchong-do regional maps(忠淸道地方地圖) and Eupjis(邑誌, topography) being compiled in the late Chosun dynasty. According to the analysis of it in this study, we make conclusions as follows; 1. Gunhyeon(郡縣) which had been Eupseong(邑城) on Chungchong-do in Chosun dynasty was 13 provinces, and the construction of Eupseong was the coast Eupseong built for the purpose of defense and military Eupseong built at Byeongyeong(兵營) and Geojin(巨鎭). And a measure used In the construction of a castle was Pobaekcheok(布帛尺) used to survey a frontier defence in Chosun dynasty, also Jucheok(周尺) or Yeongjocheok(營造尺) could be assumed to be wide use at that time. 2. Eupchi of Chungchong-do Gunhyeon was almost disposed to the south direction, also had been Jinsan(鎭山) safeguarding it. With relation to Jwahyang(坐向) and Jinsan, its Jinsan and Myeongdang-cheon(明堂川) match each other in location of Eupchi, as it get Jinsan sat, and take main river in front of it. And provincial government office to be the center of a Eupchi is organized into Gaeksa(客舍), Dongheon(東軒), Naea(內衙), Hyangcheong(鄕廳), and practical business facilities, Jakcheong(作廳) or Jangcheong etc., the others is composed for the use of support of those. 3. In most Eupchi in Chungchong province, the layout Sajikdan(社稷壇) and Yeodan(礪壇) was gone with a principle as they were disposed in the west and the north with Eupchi. Seonghwangdan(城隍壇) and Munmyo(文廟) was built in defiance of a principle, as a condition of province. Jangsi(場市) of Eupchi was opened in front of government office or Gaeksa, and the Gunhyeon which had Eupseong was established in the inside and outside of Eupseong.

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Inverse Synthetic Aperture Radar Imaging Using Stepped Chirp Waveform (계단 첩 파형(Stepped Chirp Waveform)을 이용한 ISAR 영상 형성)

  • Lee, Seong-Hyeon;Kang, Min-Suk;Park, Sang-Hong;Shin, Seung-Yong;Yang, Eunjung;Kim, Kyung-Tae
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.25 no.9
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    • pp.930-937
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    • 2014
  • Inverse synthetic aperture radar (ISAR) images can be generated by radar which radiates the electromagnetic wave to a target and receives signal reflected from the target. ISAR images can be widely used to target detection and recognition. This paper proposed a method of generation of high resolution ISAR images by synthesizing frequency spectrums of each stepped chirp waveform in one burst and sub-sampling in frequency domain. This process is performed over entire bursts during coherent processing interval. Conventional ISAR image generation method using stepped frequency waveform has a severe problem of short unambiguous range, loading to ghost phenomenon. However, this problem can be resolved by the proposed method. In simulations, we generate high resolution ISAR image of the moving target which is Boeing-737 aircraft model composed of several ideal point scatterers.

A Study on the Kinetic Energy and Dispersion Behavior of High-velocity Impact-induced Debris Using SPH Technique (SPH 기법을 이용한 고속충돌 파편의 운동에너지와 분산거동 연구)

  • Sakong, Jae;Woo, Sung-Choong;Kim, Tae-Won
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.40 no.5
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    • pp.457-467
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    • 2016
  • In this study, we investigate the dispersion behavior of debris and debris cloud generated by high-velocity impacts using the smoothed particle hydrodynamics (SPH) technique. The projectile and target plate were made of aluminum, and we confirm the validity of the SPH technique by comparing the measured major and minor axis lengths of the debris cloud in the reference with the predicted values obtained through the SPH analysis. We perform high-velocity impact and fracture analysis based on the verified SPH technique within the velocity ranges of 1.5~4 km/s, and we evaluate the dispersion behavior of debris induced by the impact in terms of its kinetic energy. The maximum dispersion radius of the debris on the witness plates located behind the target plate was increased with increasing impact velocity. We derive an empirical equation that is capable of predicting the dispersion radius, and we found that 95% of the total kinetic energy of the debris was concentrated within 50% of the maximum dispersion radius.

Marker Production by PCR Amplification with Primer Pairs from Conserved Sequences of WRKY Genes in Chili Pepper

  • Kim, Hyoun-Joung;Lee, Heung-Ryul;Han, Jung-Heon;Yeom, Seon-In;Harn, Chee-Hark;Kim, Byung-Dong
    • Molecules and Cells
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    • v.25 no.2
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    • pp.196-204
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    • 2008
  • Despite increasing awareness of the importance of WRKY genes in plant defense signaling, the locations of these genes in the Capsicum genome have not been established. To develop WRKY-based markers, primer sequences were deduced from the conserved sequences of the DNA binding motif within the WRKY domains of tomato and pepper genes. These primers were derived from upstream and downstream parts of the conserved sequences of the three WRKY groups. Six primer combinations of each WRKY group were tested for polymorphisms between the mapping parents, C. annuum 'CM334' and C. annuum 'Chilsung-cho'. DNA fragments amplified by primer pairs deduced from WRKY Group II genes revealed high levels of polymorphism. Using 32 primer pairs to amplify upstream and downstream parts of the WRKY domain of WRKY group II genes, 60 polymorphic bands were detected. Polymorphisms were not detected with primer pairs from downstream parts of WRKY group II genes. Half of these primers were subjected to $F_2$ genotyping to construct a linkage map. Thirty of 41 markers were located evenly spaced on 20 of the 28 linkage groups, without clustering. This linkage map also consisted of 199 AFLP and 26 SSR markers. This WRKY-based marker system is a rapid and simple method for generating sequence-specific markers for plant gene families.

Protective effect of Asystasia gangetica reduced oxidative damage in the small intestine of streptozotocin-induced diabetic rats

  • Kumar, K. Asok;Umamaheswari, M.;Sivashanmugam, A.T.;Subhadradevi, V.;Somanathan, S.S.;Ravi, T.K.
    • Advances in Traditional Medicine
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    • v.9 no.4
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    • pp.307-314
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    • 2009
  • Oxidative stress plays an important role in the pathogenesis of various diabetic complications and small intestine is vulnerable to damage resulting in morphological and functional changes. In this study, the effects of Asystasia gangetica leaf extract (AGLE) on oxidative stress status in small intestine of diabetic rats were examined. The leaves of Asystasia gangetica was extracted with 70% ethanol. Oral administration of AGLE once daily (100 mg/kg and 200 mg/kg b.w.) for 28 days to diabetic rats significantly (P < 0.05) increased antioxidant levels of catalase, superoxide dismutase, glutathione peroxidase, glutathione, GSSH, carbohydrate metabolizing enzyme, glucose-6-phosphate dehydrogenase. The increased levels of protein carbonyl content, lipid peroxidation and xanthine oxidase/xanthine dehydrogenase in diabetic rats were reverted back to near normal levels on treatment with AGLE. Both doses of AGLE offered significant activity (P < 0.01) against oxidative damage and were comparable with standard, glibenclamide. The results revealed the occurrence of oxidative stress in small intestine during diabetes and suggest the potential of AGLE as an antioxidant in protecting the tissue defense system against oxidative damage in streptozotocin-induced diabetes.

Study of Clinical Characterized of Acute Myocardiac Infarction Patients on Youth & Adults Age in Emergency Room (응급실로 내원한 청장년층 급성심근경색증 환자의 임상특성 연구)

  • Hong, Hae-Sook;Jang, Yu-Ryang
    • Journal of forensic and investigative science
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    • v.3 no.1
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    • pp.50-59
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    • 2008
  • The purpose of this study was to figure out clinical characteristics in young and adult acute myocardial infarction patients come to emergency room. One hundred fifty four acute myocardial infarction cases were collected and analized from January 2003 to April 2006, especially focused on below the age 50. The results of the study were summarized as follows. The results were proportion up disease occur to women disease rate as men after 50 age and acute myocardial infarction occur to spring and winter most of all. Research for this patients coronary artery condition in cardiac angiography room and coronary artery condition is left anterior descending portion was obstruction and stenosis most of all at that time in emergency room. HDL-cholesterol was not normal range of this patients. About 57.9% patients downward normal range but total cholesterol was very variant condition. Investigated chest X-ray of this patients and result in upward 75% patients was C-T ratio 50% upward condition. And it was shown result from this patients 94. 7% was obesity condition and family history showed mother or father got hypertension or diabete mellitus patients but 42. 7% patients not family history. This patients not going to direct emergency room after via local medical center result in badly condition up. Have got outcomes of youth and adults age patient of acute myocardial infarction come to emergency room. Government and administration have to support advertising this results about acute myocardial infarction condition of nation people. We need to preservation and preventing this disease but if this disease occurrence, to the utmost directly and speedly emergency room for fast therapy.

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Estimation of Rheological Properties of Highly Concentrated Polymer Bonded Explosive Simulant by Microstructure Analysis (미세구조 해석을 통한 고농축 복합화약 시뮬란트의 유변물성 예측)

  • Lee, Sangmook;Hong, In-Kwon;Lee, Jae Wook;Shim, Jung Seob
    • Polymer(Korea)
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    • v.38 no.2
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    • pp.225-231
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    • 2014
  • The rheological properties of highly concentrated polymer bonded explosive simulant were studied by using poly(ethylene-co-vinyl acetate) with 30 and 60% vinyl acetate (VA) content as a binder, respectively. Calcium carbonate and Dechlorane, whose physical properties are similar to resarch department explosive (RDX)'s, were used as fillers. The suspensions were mixed in a batch melt mixer and it was possible to fill 75 v% at maximum. From dynamic mechanical analysis, Dechlorane showed higher interaction with binder resins than that with calcium carbonate fillers. The effects of microstructural change on the rheological properties of the suspensions were investigated by a plate-plate rheometer with constant shear rate and constant shear stress modes, respectively. The theoretical maximum packing fraction of EVA31/Dechlorane suspension obtained from Krieger-Dougherty equation was 70 v% and it was thought that 2000 Pa was proper shear stress condition for this melt processing.