• BMB Reports
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• v.44 no.5
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• pp.335-340
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• 2011

In this study, we attempted to isolate novel mast cell-stimulating molecules from Staphylococcus aureus. Water-soluble extract of S. aureus cell lysate strongly induced human interleukin-8 in human mast cell line-1 and mouse interleukin-6 in mouse bone marrow-derived mast cells. The active molecule was purified to homogeneity through a $C_{18}$ reverse phase HPLC column. By determination of its structure by MALDITOF and $^1H$- and $^{13}C$-NMR, adenosine was revealed to be responsible for the observed cytokine induction activities. Further studies using 8-sulfophenyl theophylline, a selective adenosine receptor blocker, verified that purified adenosine can induce interleukin-8 production via adenosine receptors on mast cells. Moreover, adenosine was purified from S. aureus-engulfed RAW264.7 cells, a murine macrophage cell line, used to induce phagocytosis of S. aureus. These results show a novel view of the source of exogenous adenosine in vivo and provide a mechanistic link between inflammatory disease and bacterial infection.

• Journal of Applied Reliability
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• v.8 no.1
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• pp.39-59
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• 2008

The performance of weapon system, based on the acceleration of advanced scientific technology, has been reinforced to the state of precision, complexion and multi-function. People have given great interest for a long time on its development, acquisition cost and enormous expense of operation/support. Under this environmental situation, this research paper proposes two kinds of implementation that can improve the RAM(Reliability, Availability, Maintainability) on weapon system. The first section is to understand all of the actual states on its reliability, in the acquisition process and to make the improvement for RAM at the milestones on the acquisition steps. The next section is to establish a defense RAM center, which will be closely cooperated with acquisition organization such as Ministry of Defense, DAPA(Defense Acquisition Program Administration), DTaQ(Defense agency for Technology and Quality) and ADD(Agency for Defense Development), etc. and to conclusively improve the RAM of weapon system in South Korea.

• Journal of Microbiology and Biotechnology
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• v.18 no.2
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• pp.270-282
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• 2008

The yeast Saccharomyces cerevisiae has defense mechanisms identical to higher eukaryotes. It offers the potential for genome-wide experimental approaches owing to its smaller genome size and the availability of the complete sequence. It therefore represents an ideal eukaryotic model for studying cellular redox control and oxidative stress responses. S. cerevisiae Yap1 is a well-known transcription factor that is required for $H_2O_2$-dependent stress responses. Yap1 is involved in various signaling pathways in an oxidative stress response. The Gpx3 (Orp1/PHGpx3) protein is one of the factors related to these signaling pathways. It plays the role of a transducer that transfers the hydroperoxide signal to Yap1. In this study, using extensive proteomic and bioinformatics analyses, the function of the Gpx3 protein in an adaptive response against oxidative stress was investigated in wild-type, gpx3-deletion mutant, and gpx3-deletion mutant overexpressing Gpx3 protein strains. We identified 30 proteins that are related to the Gpx3-dependent oxidative stress responses and 17 proteins that are changed in a Gpx3-dependent manner regardless of oxidative stress. As expected, $H_2O_2$-responsive Gpx3-dependent proteins include a number of antioxidants related with cell rescue and defense. In addition, they contain a variety of proteins related to energy and carbohydrate metabolism, transcription, and protein fate. Based upon the experimental results, it is suggested that Gpx3-dependent stress adaptive response includes the regulation of genes related to the capacity to detoxify oxidants and repair oxidative stress-induced damages affected by Yap1 as well as metabolism and protein fate independent from Yap1.

• Journal of the Korea Institute of Military Science and Technology
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• v.23 no.6
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• pp.639-649
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• 2020

Air data systems measure airspeed, pressure altitude, angle of attack and angle of sideslip. These measurements are essential for operating flight control laws to ensure safe flights. Since the loss or corruption of air data measurements is considered as catastrophic, a high level of operational reliability needs to be achieved for air data systems. In the case of unmanned air vehicles, failure of any of air data sensors is more critical due to the absence of onboard pilot decision aid. This paper presents design of a dual redundancy air data system and the integration process for an unmanned air vehicle. The proposed dual-redundant architecture is based on two independent air data probes and redundancy management by central processing in two independent flight control computers. Starting from unit testing of single air data sensor, details are provided of system level tests used to meet overall requirements. Test results from system integration demonstrate the efficiency of the proposed process.

• Journal of the Korea Institute of Military Science and Technology
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• v.21 no.1
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• pp.17-24
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• 2018

Polar fomat algorithm (PFA) was derived from medical imaging theory, known as back projection, to process synthetic aperture radar(SAR) data. The difference between the operating condition of SAR and back projection assumption makes two distortions. First, the focusing performance of PFA is degraded in proportion to distances from the scene center. Second, the geometric accuracy in SAR images is distorted. Several methods were introduced to mitigate the distortions, but some disadvantages, such as the geometric discontinuity, are arisen when sub-images are combined. This paper proposes the novel method to compensate the geometric distortion with chirp Z-transform (CZT). This method corrects precisely the geometric errors without any problems, because a whole image can be processed all at once.

• Journal of the Korea Institute of Military Science and Technology
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• v.24 no.5
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• pp.503-510
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• 2021

This paper presents a system that measures the acceleration of the shock caused by the explosion of the precursor warhead for the tandem projectile. The proposed system, which is implemented based on the MIL-STD-810G, Method 517.1, consists of a miniaturized shock measurement device, a cable, accelerometers, and a trigger circuit. The shock measurement device has a size of ¢102 × 171 mm and cable has a length of 3 m. The operational confirmation test is conducted by implementing the measurement system. The Analysis of shock data(accelerometer output data) is carried out using Shock Response Spectrum(SRS), pseudo velocity and plot of acceleration time transient. Through measurement analysis, one can predict the damage of electronics in projectile when precursor warhead is exploded.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.46 no.4
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• pp.160-172
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• 2023

In contemporary global warfare, the significance and imperative of air transportation have been steadily growing. The Republic of Korea Air Force currently operates only light and medium-sized military cargo planes, but does not have a heavy one. The current air transportation capability is limited to meet various present and future air transport needs due to lack of performance such as payload, range, cruise speed and altitude. The problem of population cliffs and lack of airplane parking space must also be addressed. These problems can be solved through the introduction of heavy cargo planes. Until now, most studies on the need of heavy cargo plane and increasing air transport capability have focused on the necessity. Some of them suggested specific quantity and model but have not provided scientific evidence. In this study, the appropriate ratio of heavy cargo plane suitable for the Korea's national power was calculated using principal component analysis and cluster analysis. In addition, an optimization model was established to maximize air transport capability considering realistic constraints. Finally we analyze the results of optimization model and compare two alternatives for force structure.

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.598-598
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• 2005

• Journal of the Korea Institute of Military Science and Technology
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• v.23 no.4
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• pp.346-354
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• 2020

Nowadays, it is required to apply low observable technology to weapon systems in operation or under development. Radar Cross Section(RCS) is a measure of the scattered power in an given direction when a target is illuminated by an incident wave and used as a parameter to estimate the low observable performance of weapon system. RCS of a target can be calculated by various numerical methods. However, measurement is also needed to estimate RCS of a complex target because it is difficult to estimate theoretically. To acquire reliable measurement results, an analysis of measurement uncertainty is essential. In this paper, error components and uncertainties of near-field RCS measurement system which was constructed in ASTEC(Aerospace System Test & Evaluation Center) were analyzed based on the IEEE recommended practice for radar cross-section test procedures(IEEE Std. 1502-2007) which describes the uncertainty of RCS measurement and unique error components of this near-field measurement system were also identified.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.29 no.5
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• pp.1133-1151
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• 2019

Insider threats in the field of information security are so important that the research is continuing centering on the institutes attached to the Carnegie Mellon University. On the other hand, we do not have any separate research institutes. In particular, insider threat research on the defense IT environment directly connected with the survival of the country is not proceeding in depth. In addition, due to the specificity of the military, defense IT security has limited research as an academic discipline, and even the establishment of concepts has not been achieved properly. In addition, because of differences in the environment, the US standard can not be borrowed as it is. This paper analyzes the defense IT environment and defines an insider (threat) suitable for the Korea military environment. I'd like to suggest the type of insider threat and how to mitigate it.