• Molecules and Cells
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• v.41 no.1
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• pp.35-44
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• 2018

Mitochondria are responsible for supplying of most of the cell's energy via oxidative phosphorylation. However, mitochondria also can be deleterious for a cell because they are the primary source of reactive oxygen species, which are generated as a byproduct of respiration. Accumulation of mitochondrial and cellular oxidative damage leads to diverse pathologies. Thus, it is important to maintain a population of healthy and functional mitochondria for normal cellular metabolism. Eukaryotes have developed defense mechanisms to cope with aberrant mitochondria. Mitochondria autophagy (known as mitophagy) is thought to be one such process that selectively sequesters dysfunctional or excess mitochondria within double-membrane autophagosomes and carries them into lysosomes/vacuoles for degradation. The power of genetics and conservation of fundamental cellular processes among eukaryotes make yeast an excellent model for understanding the general mechanisms, regulation, and function of mitophagy. In budding yeast, a mitochondrial surface protein, Atg32, serves as a mitochondrial receptor for selective autophagy that interacts with Atg11, an adaptor protein for selective types of autophagy, and Atg8, a ubiquitin-like protein localized to the isolation membrane. Atg32 is regulated transcriptionally and post-translationally to control mitophagy. Moreover, because Atg32 is a mitophagy-specific protein, analysis of its deficient mutant enables investigation of the physiological roles of mitophagy. Here, we review recent progress in the understanding of the molecular mechanisms and functional importance of mitophagy in yeast at multiple levels.

• Journal of the Korean Society for Precision Engineering
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• v.22 no.8 s.173
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• pp.92-99
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• 2005

Tungsten heavy metal is characterized by a high density and novel combination of strength and ductility. Among them, 90W-7Ni-3Fe is used for applications, where the high specific weight of the material plays an important role. They are used as counterweights, rotating inertia members, as well as fur defense purposes(kinetic energy Penetrators, etc.). Because of these applications, it is essential to detemine the dynamic characteristics of tungsten alloy. In this paper, Explicit FEM(finite element method) is employed to investigate the dynamic characteristics of tungsten heavy metal under base of stress wave propagation theory for SHPB, and the model of specimen is divided into two parts to understand the phenomenon that stress wave penetrates through each tungsten base and matrix. This simulation results were compared to experimental one and through this program, the dynamic stress-strain curve of tungsten heavy metal can be obtained using quasi static stress-strain curve of pure tungsten and matrix.

• ALGAE
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• v.27 no.1
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• pp.21-32
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• 2012

We report an oxidative burst triggered by prostaglandin $A_2(PGA_2)$ in the brown algal kelp Laminaria digitata, constituting the first such discovery in an alga and the second finding of an oxidative burst triggered by a prostaglandin in a living organism. The response is more powerful than the oxidative burst triggered by most other chemical elicitors in Laminaria. Also, it is dose-dependent and cannot be inhibited by diphenylene iodonium, suggesting that another source than NAD(P)H oxidase is operational in the production of reactive oxygen species. Despite the very strong oxidative response, rather few effects at other levels of signal transduction pathways could be identified. $PGA_2$ does not increase lipolysis (free fatty acids) in Laminaria, and only one oxylipin (15-hydroxyeicosatetraenoic acid; 15-HETE) was found to be upregulated in Laminaria. In a subsequent set of experiments in the genome model Ectocarpus siliculosus, none of 5 selected candidate genes, all established participants in various stress responses, showed any significant differences in their expression profiles.

• International Journal of Naval Architecture and Ocean Engineering
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• v.8 no.3
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• pp.235-242
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• 2016

Among underwater noise sources around submerged bodies, turbulence-induced noise has not been well investigated because of the difficulty of predicting it. In computational aeroacoustics, a number of studies has been conducted using the Ffowcs Williamse-Hawkings (FW-H) acoustic analogy without consideration of quadrupole source term due to the unacceptable calculation cost. In this paper, turbulence-induced noise is predicted, including that due to quadrupole sources, using a large eddy simulation (LES) turbulence model and a developed formulation of permeable FW-H method with an open source computational fluid dynamics (CFD) tool-kit. Noise around a circular cylinder is examined and the results of using the acoustic analogy method with and without quadrupole noise are compared, i.e. the FW-H method without quadrupole noise versus the permeable FW-H method that includes quadrupole sources. The usability of the permeable FW-H method for the prediction of turbulence-noise around submerged bodies is shown.

• Journal of Aerospace System Engineering
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• v.10 no.1
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• pp.51-58
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• 2016

In this paper, we present some results on No-failure accelerated life test of aerial vehicle for reliability demonstration. The design of general accelerated life test consists of the three phases: 1) Estimating normal life test time of a single product from Weibull distribution model; 2) Determining the acceleration factor (AF) by utilizing the relation between the life of mechanical components and the applied torque; 3) Calculating the accelerated life test time, which comes from dividing the estimated normal life test time into AF. Then, we applied the calculated life test time to the real reliability test of the flap actuating system, while considering the requirement specification for mechanical components and operating environment of the actuation system. Real experimental processes and results are presented to validate the theory.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.26 no.1
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• pp.39-48
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• 2016

The latest research has shown that the turbulence-induced noise is important in total characteristics of flow noise. Also, turbulence-induced noise have a significant influence for performance of sonar dome. In this paper, Flow analysis is performed on vicinity of the sonar dome model using Large Eddy Simulation method. Also, direct method that extracts perturbational sound pressure, FW-H method without turbulence-induced noise and permeable FW-H method that is able to calculate turbulence- induced noise were compared in order to show turbulence effect.

• International Journal of Control, Automation, and Systems
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• v.6 no.3
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• pp.424-433
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• 2008

An ownship with towed array sonar (TAS) has limited maneuvers due to its dynamic feature, bearing and frequency measurements of a target which are not detected continuously but are often lost in ocean environment. We propose a pre-processing algorithm for the faded bearing and frequency measurements to solve the BFTMA problem of TAS under limited detection conditions. The proposed pre-processing algorithm to restore the faded bearing and frequency measurements is implemented to perform a BFTMA filter even if the measurements of a target are not continuously detected. The Modified Gain Extended Kalman Filter (MGEKF) method based on the Interacting Multiple Model (IMM) structure is applied for a BFTMA filter algorithm to estimate the target. Simulations for the various conditions were carried out to verify the applicability of the proposed algorithms, and confirmed superior estimation performance compared with the existing Bearings-Only TMA (BOTMA).

• Journal of Korean Institute of Industrial Engineers
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• v.34 no.4
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• pp.433-444
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• 2008

With development of RFID technology, medicine and national defense as well as logistics and distribution industries have tried to adopt RFID system. Small projects as well as large national projects have planned to adopt the new technology. However, a lot of companies that have promoted a RFID-based project have confronted many problems due to a lack of information about demonstration projects and absence of systematic guideline. Therefore, it's urgent to develop a practical and useful guideline for companies that have considered to adopt the RFID system. In this paper, a practical framework to adopt RFID system is suggested by five phases : establishment of project plan, analysis of objectives, selection of equipments, development/installation, and operation/post management phases. Besides, a detail method by each stages is also given. A systematic RFID system adoption procedure has been defined through an analysis on demonstrated projects and interview with an expert and the adoption method by stage has been suggested. The purpose of this paper is to minimize the entry barriers by suggesting a practical RFID adoption procedure.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.4
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• pp.367-374
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• 2011

Friction springs have different characteristics while loading and un-loading. Because of these characteristics, they are utilized in impact systems. In this paper, the design of a recoil system with friction springs for use in a machine gun system has been presented. In order to determine the stiffness of a friction spring, equations of motion for a simple gun model with a recoil system have been derived. The impulse balance scheme has been adopted. On the basis of simulation results, the diameter of the friction spring has been determined.

• Journal of Navigation and Port Research
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• v.33 no.6
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• pp.451-456
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• 2009

In this paper, we presents an algorithm which generates its high-resolution DTM using a low-resolution DTM of the sea floor terrain and fractal theory. The fractal dimension of each patch region divided from the DTM is extracted and then with this information and original data, each cell region in the patch is interpolated using the midpoint displacement method and a median filter is incorporated to generate natural and smooth sea floor surface. The effectiveness of the proposed algorithm is tested on a fractal terrain map.