• 한국정보과학회논문지:소프트웨어및응용
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• 제32권2호
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• pp.99-107
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• 2005

본 논문에서는 단일염기변이(SNP: Single Nucleotide Polymorphism)와 같은 유전형(Rcnotype)자료에서 결측치가 발생하였을 경우 유전형 자료의 특이성을 고려해 자료 원래의 정보손실을 최소화하는 대치법인 연관불균형 기반의 대치법(linkage disequilibrium- based imputation)과 일배체형 기반의 대치법(haplotype-based imputation)을 제시한다. 이러한 결측치 대치는 실험상에서 발생하는 결측치에 의한 중요한 정보의 손실을 최소화 한다는 점에서 필요한 방법이다. 일반적으로 그동안 생물학 자료의 결측치 대치는 대부분 주형질 대치법(major allele imputation)이 활용되어왔는데 유전형 자료에서의 이 방법의 사용은 사료의 특이성으로 인하여 결측치에 대한 높은 오차율(error rate)을 보임으로서 자료의 신뢰성을 떨어뜨릴 수 있다. 본 논문에서는 유전형 자료인 단일염기변이 자료의 시뮬레이션을 통하여 기존의 주형질 대치법과 논문에서 제안된 연관불균형 기반의 대치법과 일배체형 기반의 대치법을 비교하고 그 결과를 보여 준다.

• 응용통계연구
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• 제21권1호
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• pp.1-17
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• 2008

형제 쌍(sibpair)의 연속형 형질(continuous traits) 자료를 이용한 유전연관성 검정 법(linkage test)으로서 Haseman과 Elston (1972)의 최소제곱(ordinary least square, OLS) 회귀분석법이 주로 사용된다. 비모수적 방법으로서 제시된 Kruglyak과 Lander (1995)의 검정통계량은 Haseman과 Elston (1972)의 방법에 대응되는 방법처럼 보이지만 실제로는 매우 다르다. 본 논문에서는 Kruglyak와 Lander (1995)의 검정통계량과 Haseman과 Elston (1972)의 검정통계량의 관계를 설명하고 모의실험으로 두 검정통계량의 검정력을 비교한다. 유전연관성에 사용되는 형제 자료의 특징은 한정된 설명변수의 값에 매우 많은 자료가 반복(replicated)되었다는 점이며, 이러한 반복 자료에 더욱 적절한 가중 회귀분석법을 제안한다. 가중 회귀분석법의 효율성을 정규분포 또는 정규분포가 아닌 연속형 형질 모의실험 자료로 알아본 결과 형제 쌍 자료의 유전연관성 검정에서 가중 회귀분석법이 다른 검정법들보다도 검정력이 높음을 확인하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제28권7호
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• pp.926-935
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• 2015

The efficiency of genome-wide association analysis (GWAS) depends on power of detection for quantitative trait loci (QTL) and precision for QTL mapping. In this study, three different strategies for GWAS were applied to detect QTL for carcass quality traits in the Korean cattle, Hanwoo; a linkage disequilibrium single locus regression method (LDRM), a combined linkage and linkage disequilibrium analysis (LDLA) and a $BayesC{\pi}$ approach. The phenotypes of 486 steers were collected for weaning weight (WWT), yearling weight (YWT), carcass weight (CWT), backfat thickness (BFT), longissimus dorsi muscle area, and marbling score (Marb). Also the genotype data for the steers and their sires were scored with the Illumina bovine 50K single nucleotide polymorphism (SNP) chips. For the two former GWAS methods, threshold values were set at false discovery rate <0.01 on a chromosome-wide level, while a cut-off threshold value was set in the latter model, such that the top five windows, each of which comprised 10 adjacent SNPs, were chosen with significant variation for the phenotype. Four major additive QTL from these three methods had high concordance found in 64.1 to 64.9Mb for Bos taurus autosome (BTA) 7 for WWT, 24.3 to 25.4Mb for BTA14 for CWT, 0.5 to 1.5Mb for BTA6 for BFT and 26.3 to 33.4Mb for BTA29 for BFT. Several candidate genes (i.e. glutamate receptor, ionotropic, ampa 1 [GRIA1], family with sequence similarity 110, member B [FAM110B], and thymocyte selection-associated high mobility group box [TOX]) may be identified close to these QTL. Our result suggests that the use of different linkage disequilibrium mapping approaches can provide more reliable chromosome regions to further pinpoint DNA makers or causative genes in these regions.

• 한국육종학회지
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• 제40권2호
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• pp.97-100
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• 2008

Lectin protein and Kunitz trypsin inhibitor (KTI) protein of mature soybean seed are a main antinutritional factor in soybean seed. The Le gene controls a lectin protein and Ti gene controls the KTI protein in soybean. Ti locus has been located on linkage group 9 in the classical linkage map of soybean. Position of Le locus on linkage map was not identified. Genetic relationship between Ti locus and Le locus could be useful in soybean breeding program for the genetic elimination of these factors. The objective of this study was to determine the independent inheritance or linkage between Ti locus and Le locus in soybean seed. Two $F_2$ populations were developed from three parents (Gaechuck#1, T102, and PI548415). The $F_1$ seeds from Gaechuck#1 (titiLeLe) ${\times}$ T102 (TiTilele) and Gaechuck#1 (titiLeLe) ${\times}$ PI548415 (TiTilele) were obtained. The lectin and KTI protein were analysed from $F_2$ seeds harvested from the $F_1$ plants to find independent assortment or linkage between Ti locus and Le locus. The segregation ratios of 3 : 1 for Le locus (129 Le_ : 44 lele) and Ti locus (132 Ti_ : 41 titi) and were observed. The segregation ratios of 9 : 3 : 3 : 1 (95 Le_Li_ : 34 Le_titi: 37 leleTi_ : 7 leletiti) between Le gene and Ti gene in $F_2$ seeds were observed. This data showed that Ti gene was inherited independently with the Le gene in soybean. These results will be helpful in breeding program for selecting the line with lacking both KTI and lectin protein in soybean.

• 한국산학기술학회논문지
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• 제21권8호
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• pp.160-169
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• 2020

이 연구는 공공 행정에서 서비스 전달 조직과 절차를 관리하고 재정을 지원하는 공공부문 사례관리 사업 중 방문건강관리 사업 실무자를 대상으로 타 사례관리 사업과의 연계협력 업무에 대한 경험을 파악하기 위해 실시하였다. 광역시와 시군 소재 보건소 방문건강관리사업 담당자 3명을 대상으로 포커스 그룹 인터뷰를 실시하였고, 자료 수집을 위해 사용한 인터뷰 질문들은 사전에 연구진간 논의를 거쳐 도출한 반구조화 질문지를 활용하였다. 연구 참여자들은 방문건강관리 업무를 수행하면서 경험한 연계협력의 성공과 실패 요인들을 심층적으로 기술하였다. 인터뷰 내용은 질적으로 분석되어 3개의 주제, 9개의 하위주제가 도출되었다. 연구결과, 공공부문 사례관리 사업 간 연계협력 업무안내서는 연계협력을 수행하는 데 있어 긍정적 성과요인이었지만, 방문건강관리 전문 인력의 불안정한 고용문제와 통합시스템의 부재는 연계협력의 장애요인이었으며, 성공적인 연계협력을 위해서는 인적 인프라 강화, 기능적 시스템 개선, 조직적 차원의 방안 마련 등 다각적인 접근이 필요한 것으로 확인되었다. 이에 명확한 연계협력 표준 및 절차 수립, 방문간호 전문인력의 처우 개선, 사례관리 통합정보시스템 개발을 제안한다. 또한, 지역 간 편차가 큰 방문건강관리 사업의 특성을 고려하여 다양한 지역을 대상으로 한 추후 연구가 필요함을 제안한다.

• 간호행정학회지
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• 제16권2호
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• pp.121-142
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• 2010

Purpose: The purpose of this study was to identify NANDA, NIC, and NOC frequently used and their linkages in major nursing departments for development of the nursing process and nursing management system. Methods: This study was a descriptive study. Data were collected from 123 nurses who worked in medical, surgical, pediatric, gynecologic, and psychiatric department. The questionnaire was based on the NANDA, NOC, NIC, and NANDA-NOC-NIC linkage system. This research was analyzed by an EXCEL program and SPSS $Pc^{+}15.0$. Results: Nursing diagnoses frequently used were 'anxiety', 'disturbed sleep pattern', 'activity intolerance', 'social isolation', 'nausea', 'ineffective airway clearance', 'chronic pain', nursing outcomes frequently used were 'thermoregulation', 'bowel elimination', 'pain control', 'vital sign status', 'pain level', and nursing interventions frequently used were 'nausea management', 'airway suctioning', 'bowel elimination management', 'diarrhea management', 'medication management'. NANDA-NOC-NIC linkages in major nursing departments were recognized, and these results were similar to the results of other researches. Conclusion: The results of this study will be provided as a guideline to apply to the nursing process and development of the nursing process system with the NANDA-NOC-NIC linkage in major nursing department.

• Asia pacific journal of information systems
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• 제15권2호
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• pp.171-193
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• 2005

Small firms are considered as the last mile in electronic networks of business enterprises. Since small firms lack in their resources and capabilities for IT deployment, it seems a challenging project to make them electronically linked to their trading partners. This study aims to investigate the factors that influence the intent of small firms to adopt electronic linkage to their trading partners. This study considers the context where small firms already have transaction relationships with partner firms and where their adoption of electronic linkage may influence the nature and performance of the transactional relationships. This study considers the expected value of electronic linkage and the joint actions of the trading firms as the major factors. Its research model also includes traditional factors such as influences from the industry and the trading partner, the support of CEO, and the readiness of the trading partner. Based on the survey data from more than 1000 small firms, the present study performs regression analysis and finds that all but one factor are significant in explaining the variations in the adoption intention of small firms. The exception is the joint action, which is shown to decrease the intention. Based on the results, this study offers business and policy implications that would be useful to business managers and policy makers.

• 응용통계연구
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• 제28권2호
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• pp.221-230
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• 2015

전통적으로 반복 측정된 형제 쌍 연관 분석에서는 선형 혼합 모형이 사용되어 왔다. 그러나 그 모형은 관심있는 표현형과 연관된 유전자좌를 찾는 것에 있어서 검정력이 문제가 되는 것으로 지적되어 왔다. 본 연구에서 우리는 이러한 검정력 문제를 개선하는 방법으로 감마 혼합 모형을 고려하였고, 검정력과 제 1종 오류의 관점에서 선형 혼합 모형과 성능을 서로 비교하여 보았다. Genetic Analysis Workshop 13에서 제공된 자료를 이용하여 살펴본 결과, 감마 혼합 모형이 검정력에 있어서 큰 이득을 볼 수 있는 것으로 나타났다.

• KDI Journal of Economic Policy
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• 제40권1호
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• pp.45-66
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• 2018

This paper measures the extent of comovements in stock returns between Korea and three major countries (China, Japan and the U.S.) using industry-level data for Korea from 2003 to 2016 in the spirit of the international capital asset pricing model. It also examines what drives the comovements between Korea and the three countries. We find that the comovements of Korean stock returns with those of the U.S. and Japan became smaller after the global financial crisis. In contrast, the comovement in stock returns between Korea and China became larger after the crisis. After an additional analysis, we conclude that trade linkage is the main driver of the comovements between Korea and the three countries.

• 대한기계학회논문집
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• 제18권6호
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• pp.1365-1373
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• 1994

Elasto-dynamic deformation of flexible linkage mechanism was analyzed using the finite element method. A computer program was constructed and applied to analyze a specific crank-level 4-bar mechanism, in which the elasto-dynamic deformation of the mechanism system was obtained using mode superposition method in the case of constant input speed and the effect of geometric stiffness on the mechanism is included. Experimental verification of numerical results was conducted by measuring the elasto-dynamic deformation of mid-points of coupler and lever for the 4-bar lingkage mechanism using high speed camera and image data processing systeem. For the elasto-dynamic deformation at the lever mid-point, the numerical results including geometric stiffness almost agree with the experimental ones. However, the numerical results excluding geometric stiffness good agree with the experimental ones at the couper mid-point.