• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6101-6104
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• 2012

Background: Breast cancer accounts about one million from total annual ten million new diagnosed cases of neoplasia worldwide and is the main cause of death due to cancer in women. Tamoxifen is the most popular selective estrogen receptor modulator used in anti estrogen treatments. Tamoxifen must be converted into its metabolite endoxifen for biologic effects; this conversion process is catalysed by highly polymorphic cytochrome P450 2D6 (CYP2D6). This study surveyed copy number variation of the CYP2D6 gene and its possible correlation with Tamoxifen resistance in breast cancer patients. Methods: This case control study was performed on samples taken from 79 patients with breast cancer who used tamoxifen in Yazd and Tehran Cities, Iran. Real time reactions were conducted for 10 healthy samples using the comparative $C_t$ (Cycles threshold) method, each pair of genes being compared and samples with ratios around 1 were taken as control samples. Proliferation reactions were done by Real-Time PCR ABI Prism 7500. All registered data were transformed into SPSS 15 program and analyzed. Results: Efficiency of PCR for both CYP2D6 and ALB genes was 100%. From all 23 drug resistant patients 21.7% had one copy, 47.8% two copies and 30.4% had three copies. Also from all 56 drug sensitive patients, 26.8% had one copy, 51.8% two copies and 21.4% had three copies. The percentage of patients with one and two copies was similar between two groups but patients with three copies were more likely to belong to the drug resistant group more. Odd ratios for one and two copies were 0.759 and 0.853 respectively, indicating possible protective effects while that for three copies was 1.604. Conclusions: Based on our study there is no significant link between CYP2D6 gene copy numbers and tamoxifen resistance in women with breast cancer. But more studies considering other influencing factors appear warranted.

• Korean Journal of Digital Imaging in Medicine
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• v.13 no.4
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• pp.171-175
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• 2011

Server and Pi view management, external image and internal image Copy Import business in PACS room is through the medical assistance. Import and Copy, and in particular the number of cases is increasing the number of import is a fast growing trend. Although the increase in workload With limited human resources to increase business efficiency so Remote system is using PACS room. This remote system will want to evaluate the effectiveness of using the service. Amount of data each 437.5 MB, Copy and Import time is to compare and evaluate sees by use 1 PC. 4 PC, 4 PC+ remote system. The use of the remote system before the January 2010 to June daily average waiting time and the use of the remote system after the January 2011 to June compared to a daily average patient waiting time, evaluate. Using the remote system in January 2011 to June Find out the average remote utilization. The biggest difference on the four copy and eight continued, Were performed two times faster by use 4 PC+ remote system than use 4 PC and four times faster than use 1 PC. Before using the remote system, the daily average wait time is 14.5 minutes after using the daily average 10.2 minutes, waiting time 30% of the existing waiting time was 4.3 minutes, to reduce. Using the remote system in January 2011 to June the average daily number of cases is 107 number and The number of remote and on average 35 cases with 32% in a day remote usage. The use of the remote system to Import, CD Copy and greatly increase the efficiency of their time could be. Hours due to efficiency could also reduce customer waiting time. As a result, the manpower and the use of a remote system over time to maximize efficiency in business hours, work was evaluated by.

• Journal of information and communication convergence engineering
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• v.12 no.3
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• pp.181-185
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• 2014

The lifetime of a solid-state drive (SSD) is limited because of the number of program and erase cycles allowed on its NAND flash blocks. Data cannot be overwritten in an SSD, leading to an out-of-place update every time the data are modified. This result in two copies of the data: the original copy and a modified copy. This phenomenon is known as write amplification and adversely affects the endurance of the memory. In this study, we address the issue of reducing wear leveling through efficient handling of write requests. This results in even wearing of all the blocks, thereby increasing the endurance period. The focus of our work is to logically divert the write requests, which are concentrated to limited blocks, to the less-worn blocks and then measure the maximum number of write requests that the memory can handle. A memory without the proposed algorithm wears out prematurely as compared to that with the algorithm. The main feature of the proposed algorithm is to delay out-of-place updates till the threshold is reached, which results in a low overhead. Further, the algorithm increases endurance by a factor of the threshold level multiplied by the number of blocks in the memory.

• Journal of Crop Science and Biotechnology
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• v.10 no.4
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• pp.237-242
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• 2007

Genome duplication(i.e. polyploidy) is a common phenomenon in the evolution of plants. The objective of this study was to achieve a comprehensive understanding of genome duplication for SNP discovery by Thymine/Adenine(TA) cloning for confirmation. Primer pairs were designed from 793 EST contigs expressed in the roots of a supernodulating soybean mutant and screened between 'Pureunkong' and 'Jinpumkong 2' by direct sequencing. Almost 27% of the primer sets were failed to obtain sequence data due to multiple bands on agarose gel or poor quality sequence data from a single band. TA cloning was able to identify duplicate genes and the paralogous sequences were coincident with the nonspecific peaks in direct sequencing. Our study confirmed that heterogeneous products by the co-amplification of a gene family member were the main cause of obtaining multiple bands or poor quality sequence data in direct sequencing. Counts of amplified bands on agarose gel and peaks of sequencing trace suggested that almost 27% of nonrepetitive soybean sequences were present in as many as four copies with an average of 2.33 duplications per segment. Copy numbers would be underestimated because of the presence of long intron between primer binding sites or mutation on priming site. Also, the copy numbers were not accurately estimated due to deletion or tandem duplication in the entire soybean genome.

• Genomics & Informatics
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• v.10 no.2
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• pp.81-87
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• 2012

Large-scale copy number variants (CNVs) in the human provide the raw material for delineating population differences, as natural selection may have affected at least some of the CNVs thus far discovered. Although the examination of relatively large numbers of specific ethnic groups has recently started in regard to inter-ethnic group differences in CNVs, identifying and understanding particular instances of natural selection have not been performed. The traditional $F_{ST}$ measure, obtained from differences in allele frequencies between populations, has been used to identify CNVs loci subject to geographically varying selection. Here, we review advances and the application of multinomial-Dirichlet likelihood methods of inference for identifying genome regions that have been subject to natural selection with the $F_{ST}$ estimates. The contents of presentation are not new; however, this review clarifies how the application of the methods to CNV data, which remains largely unexplored, is possible. A hierarchical Bayesian method, which is implemented via Markov Chain Monte Carlo, estimates locus-specific $F_{ST}$ and can identify outlying CNVs loci with large values of FST. By applying this Bayesian method to the publicly available CNV data, we identified the CNV loci that show signals of natural selection, which may elucidate the genetic basis of human disease and diversity.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.9 no.1
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• pp.102-107
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• 2005

With the advancement which development and information communication of the computer is quick about lower with multimedia technical diffusion of network base the necessity the use of the digital image technique which is various regarding the protection of sharp increasing multimedia contents raised its head in the social whole. the copyright protection against a multimedia data hazard the authentication techniques it will be able to confirm the content authentication, ownership authentication, illegal copy of the image which stands is demanded. confronts to the water marking technique of existing and the researches the fact that against a picture is most. In this paper, It does not damage the video data which is a multimedia contents not to be, it inserts copyright information and it protects the right of ownership. It is with a copyright protection which leads the wavelet transform which is a watermark of frequency base from visual system viewpoint in the human being center with it proposes the watermarking technique against a forgery prevention.

• Journal of Korea Multimedia Society
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• v.13 no.7
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• pp.933-942
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• 2010

The convergence of the telecommunication industry through the combination of existing network technology and multimedia technology has brought along interactive data services in addition to the traditional broadcast services by providing direct connections between the users and the broadcasters. The interactive data service technology has developed a network which is able to fully support QoS and also a fast enough channel changing technology that is satisfactory to the user, are prerequisites for IPTV success, to provide satisfactory levels of service to exist users. However the current server-client system can't support all increasing needs of users. To overcome these limitations, P2P based IPTV service is currently under researched. Therefore, this thesis proposes a logical view based copy-ahead technique for P2P IPTV to improve the performance of IPTV system.

• Archives of design research
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• v.15 no.1
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• pp.153-161
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• 2002

There exist various conventional ideas, but few ideas may be used for actual production of advertisements. Moreover, because we tend to obtain ideas primarily from the pictures, we rely more and more on data collections, and eventually, we tend to copy them. If there is an idea which designers and copy writers can share, it will be a very effective idea. On the other hard, we need to depart from the individualistic mannerism or the reset-oriented approach depending on incidental manual works and instead, develop a lecture program which helps students e strike systematic ideas centering around processes. In order tn solve such problems, the researcher attempts to suggest "Spring Method" which has heed verified through the advertisement design practice courses at college for 7 semesters. This method focuses on ′visualization of concept′ through such stages as compression, inference and expansion, and therefore, emphasizes an organic linkage between language-oriented idea process and visualization process for advertisement ideas.

• Journal of Information Technology Applications and Management
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• v.24 no.1
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• pp.1-10
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• 2017

Recently, the problem of plagiarism has emerged as a big social issue because not only literature but also thesis become the target of plagiarism. Even the government requires conformation for plagiarism of high-ranking official's thesis as a standard of their ethical morality. Plagiarism is not just direct copy but also paraphrasing, rewording, adapting parts, missing references or wrong citations. This makes the problem more difficult to handle adequately. We propose a plagiarism detection scheme called a bit signature in which each unique word of document is represented by 0 or 1. The bit signature scheme can find the similar documents by comparing their absolute and relative bit signatures. Experiments show that a bit signature scheme produces better performance for document copy detection than existing similar schemes.

• Korean Journal of Plant Taxonomy
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• v.51 no.2
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• pp.171-175
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• 2021

Daphne genkwa (Thymelaeaceae) is a small deciduous shrub widely cultivated as an ornamental. The complete chloroplast genome of this species is presented here. The genome is 132,741 bp long and has four subregions: 85,668 bp of large single-copy and 28,365 bp of small single-copy regions are separated by 9,354 bp of inverted repeat regions with 107 genes (71 protein-coding genes, four rRNAs, and 31 tRNAs) and one pseudogene. The phylogenetic tree shows that D. genkwa is nested within Wikstroemia and is not closely related to other species of Daphne, suggesting that it should be recognized as a species of Wikstroemia.