• 동의생리병리학회지
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• 제26권6호
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• pp.803-811
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• 2012

Oriental Medicine always attach great importance to the damp diseases. Dampness is related with many organs and many clinical diseases. The cause and the location of the damp disease, nature of the symptoms, combination with other pathogenic factors are very diverse. This article analyzed the concept, cause of disease, pathogenesis, characteristic of symptoms, treatment method and prescriptions of Epidemic Warm Diseases of dampness syndrome and cases of dampness-heat diseases based on the theories of Epidemic Warm Diseases and found that theories of Epidemic Warm Diseases have very wide area of application. Dampness is classified into cold-dampness and dampness-heat by combination of heat or cold. The dampness syndrome is related with organs such as lung, spleen, kidney, triple energizers and bladder, and affects liver and heart. The basic treatment methods are dispelling dampness turbidity and diffusing qi movement. The detail treatment methods are spreading lung qi with lightness and resolving dampness and excreting turbidity in upper energizer, opening and dipping down with pungent-bitter and diffusing qi movement and strengthening the spleen and stomach in the middle energizer, draining dampness with bland in the lower energizer. Warming Yang is the main method of treatment for cold-dampness and clearing heat is for dampness-heat with the assistant methods such as resolving dampness and promoting the flow of qi. 5. Acute fever, virus diseases, epidemic diseases among modern diseases are much related with the dampness-heat syndrome.

• 대한한의진단학회지
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• 제17권2호
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• pp.90-111
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• 2013

Objectives Migratory pathogenic factor(六淫) occupies an important position in the etiology of Korean Medicine. This paper shows how Dampness, one of Migratory pathogenic factor(六淫), is explained in Donguibogam(東醫寶鑑). And, based on this, we will figure out how to make a judgement of Dampness through diagnosis. Method 1. Collect parts of Dampness mentioned in Donguibogam(東醫寶鑑). 2. From the collection, extract contents about mechanism and symptom of Dampness, which is considered necessary for diagnosis. 3. Put all the extraction together, suggest the diagnosis element which can be criteria of judgement of Dampness through diagnosis. Result & Conclusions The occurrence of Dampness come from a wet climate and environment externally, and overeating of greasy food and digestive disorder internally. There are many different kinds of symptoms throughout the body cause of poor circulation. Dampness is classed as Cold-dampness, Damp-heat, and Dampness-phlegm depending on characteristic symptoms, and mainly shows musculoskeletal disease and digestive troubles. Typical symptoms are pitting edema, distention and fullness, moderate and thready pulse, volume of perspiration increase, loose feces, urine volume decrease, pain of joint and muscle, restriction of movement, etc.

• 대한한방내과학회지
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• 제31권4호
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• pp.752-762
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• 2010

Objective : In the present study, we investigated genetic distribution of eight single nucleotide polymorphisms of PON1 between Dampness and Phlegm and non Dampness and Phlegm pattern identification(PI) among Korean stroke patients. Materials and Methods : One hundred forty stroke subject without Dampness and Phlegm and fifty eight stroke subjects with Dampness and Phlegm were participated in this study. After informed consents, eight single nucleotide polymorphisms(SNPs) in PON1 of each subjects were identified by DNA sequencing and primer extension method and statistical analysis was performed to determine the significant difference between Dampness and Phlegm and non Dampness and Phlegm groups. Results : Among anthropometric characteristics and blood parameters, waist circumference and total cholesterol were significantly higher in Dampness and Phlegm. Among 8 SNPs of PON1, frequency of M allele and subjects with M allele in L55M SNP were significantly higher in Dampness and Phlegm group (p=0.0032 and p=0.0053, respectively) but subjects with T allele in C-2033T SNP were lower in Dampness and Phlegm group(p=0.0302). Effect of L55M and C-2033T on Dampness and Phlegm were 3.07% and 1.75%, respectively. Conclusion : Our results suggest that L55M SNP in exon and C-2033T in promoter region of PON1 maybe affect to Dampness and Phlegm pattern identification. However, further study should be carried out to find out the detailed mechanism how L55M and C-2033T can affect Dampness and Phlegm stroke patients.

• 대한한의학회지
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• 제38권4호
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• pp.104-109
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• 2017

Objectives: Epicardial fat is true visceral fat that is known to be associated with metabolic syndrome, high abdominal fat, insulin resistance, coronary artery diseases, low coronary flow reserve and subclinical atherosclerosis. Dampness-Phlegm pattern is one of the pattern diagnosis of traditional Korean medicine. Previous studies showed that Dampness-Phlegm pattern is associated with hypertension, dyslipidemia, metabolic syndrome. This study is intended to find association between Dampness-Phlegm pattern and epicardial fat thickness. Methods: This study was a community-based single center trial. Ischemic stroke patients within 30 days after their ictus were enrolled. Epicardial fat thickness was measured using transthoracic echocardiography. Other measured and obtained variables are medical history, weight, height, body mass index, fasting blood glucose, cholesterol, triglycerol, high density lipoprotein, lipid and low density lipoprotein. Results: Three hundred sixty six were enlisted, and one hundred forty were diagnosed with the Dampness-Phlegm pattern. Dampness-Phlegm pattern group had significantly thicker epicardial fat. Binary logistic regression also showed statistically significant result. Conclusions: This study showed close association between epicardial fat and Dampness-Phlegm pattern. This result suggests a clue to standardization of pattern identification.

• 동의생리병리학회지
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• 제25권2호
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• pp.185-188
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• 2011

Dampness is usually caused by the disorder of gi(氣) function, splenic dysfunction. It can be divided into exogenous and endogenous according to the route of invasion. The symptoms of dampness include heaviness of body and four limbs, heaviness of head like being bound, heaviness and lassitude of the whole body. Prescriptions for eliminating dampness are mostly composed of drugs that are aromatic, warm, dry, sweet and bland and can promote diuresis. This group of prescriptions tends to consume and impair body fluid. For this reason, they should be carefully used for patients with deficiency of eum(陰) and body fluid, or those who have weak constitution after illness. In order to select the right therapy for dampness, we must carefully analyze the state of dampness and the condition of healthy gi(氣), and distinguish the relationship between dampness and the healthy state of internal organs.

• 대한한방내과학회지
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• 제27권1호
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• pp.237-252
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• 2006

Objectives : This study was done to investigate clinical frequency and correlation among the indicators of dampness-phlegm pattern identification settled by tentative Korean Standard Differentiation of the Symptoms and Signs for Stroke. Methods : The subjects were 147 hospitalized patients with stroke, and a list of registry was made for each of them. Among the five types of pattern identification, fire-heat, dampness-phlegm, blood-stasis and deficiency of Qi and of Yin, those that have shown a high frequency in dampness-phlegm type were categorized as the dampness-phlegm pattern group. Frequency of dampness-phlegm indicators was compared with those from the non-dampness-phlegm pattern group. Correlations among dampness-phlegm indicators were also studied. Results : 1. Dampness-phlegm pattern group included 26 patients out of 147. 2. Among the indicators of dampness-phlegm pattern. those, in order of highest frequency, were 'tiredness or sluggishness', 'white Coated tongue' and 'sputum'. 3. In comparing dampness-phlegm pattern group with non-dampness-phlegml group, the indicators such as 'lightheadedness', 'nigrescence', 'sputum', 'dermatic dysaesthesia' showed significantly high frequency. 4. Among the indicators, 'sputum' and 'tiredness or sluggishness', 'sputum' and 'yellow coated tongue', and 'white coated tongue' and 'yellow coated tongue' showed significant correlation. 5. In investigation of the correlation of scale in symptoms, various results such as positive correlation and negative correlation were obtained. Conclusion : In this study, more sensitive indicators of dampness-phlegm pattern identification were found. Based on these results, it is suggested that a more practical Korean Standard Differentiation of the Symptoms and Signs of Stroke would be established through continuous clinical studies by giving weight on each specific type of pattern identification.

• 대한한의학원전학회지
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• 제29권1호
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• pp.77-97
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• 2016

Objectives : Yiyuan(醫原) written by Shi Shoutang(石壽棠) is well known for its focusing on the concept of dryness and dampness in medical theory. This study was done to analyze the formation process of main academic thought in Yiyuan, which included tracing its original sources that had made it possible to construct the main idea in this book. Methods : Firstly, Yiyuan was analyzed in comparison with Yili(醫理) by Yu Guopei(余國佩), which is regarded as the main origin of Yiyuan. And secondly, many diverse medical theories before Yu Guopei and Shi Shoutang was scrutinized to understand the process of the construction of dryness/dampness-centered medical theory. Results & Conclusions : Shi Shoutang took over the main idea of Yu Guopei and expanded it both in theoretical and clinical aspects. Especially, the most remarkable contribution by Shi Shoutang can be said that he used the astronomical theory which had the concept of multi-layered heaven and intensified the theoretical basis of medical theory emphasizing the significance of dryness and dampness. Besides, Shi Shoutang's medical theory was a thing which was also based on many cumulative assertions about dryness and dampness before him. Yu Jiayan's assertion on dryness and dampness could be acknowledged as the most influential one, and it also could be said that the arguments surrounding the property of dryness had formed the main question in the development of medical theory centered on dryness and dampness.

• 동의생리병리학회지
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• 제25권5호
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• pp.773-776
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• 2011

This study was focused on a certain clinical symptom, which could applicated by Pyeongwi-san, and the radical treatment. Pyeongwi-san is applicable to dampness retention in the spleen and stomach, accompanied by abdominal fullness, anorexia, nausea and regurgitation. Main action of Pyeongwi-san is to dry dampness, invigorate the spleen, promote the flow of gi, and regulate the stomach. The herbal remedy drying dampness like Pyeongwi-san however, is just indicatio symptomatica therefore radical treatment must be used together. Jeunginmaegchi, a medical book written by Gyeong-Myeong Jin, who was lived in Myeong dynasty. This book contains many clinical applicable symptoms and constituents derived from Pyeongwi-san. The herbal prescriptions composing Pyeongwi-san is composed of Changchul, Hubak, Jinpi, Gamcho. The major action of these herbs is drying dampness. Therefore, it shoud be seriously consider that curative therapy must eliminate the cause of endogenous dampness.

• 대한한방부인과학회지
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• 제19권4호
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• pp.33-46
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• 2006

Purpose : This study was conducted to investigate effects of 7 herbs among medicinals resolving dampness with aroma on vaginal microorganisms. Methods : Staphylococcus aureus, Methicillin- resistant Staphylococcus aureus, Candida albicans and Gardnerella vaginalis were used for vaginal pathogenic microorganisms. Lactobacillus gasseri, Streptococcus spp. and Escherichia coli HB101 were used for vaginal flora. Medicinals resolving dampness with aroma, Pogostemonis Herba, Amomi Cardamomi Fructus, Amomi Semen, Atractylodis Rhizoma, Ammomi Tsao-ko Fructus, Alpiniae Katsumadaii Semen and Magnoliae Cortex were used in this study. In vitro antimicrobial activities were observed by optical density and colony test. Results : The optical density showed that Alpiniae Katsumadaii Semen and Magnoliae Cortex among medicinals resolving dampness with aroma had antimicrobial effects on pathogenic vaginal microorganisms (Methicillin-resistant Staphylococcus aureus). Pogostemonis Herba, Ammomi Tsao-ko Fructus had antimicrobial effects on Gardnerella vaginalis. The colony test showed that Alpiniae Katsumadaii Semen, Magnoliae Cortex among medicinals resolving dampness with aroma had antimicrobial effects on Methicillin-resistant Staphylococcus aureus. Pogostemonis Herbs, Alpiniae Katsumadaii Semen had antimicrobial effects aganist Gardnerella vaginalis. The optical density showed that Magnoliae Cortex among medicinals resolving dampness with aroma had antimicrobial effect on normal vaginal microorganisms (Streptococcus spp.). The colony test showed that medicinals resolving dampness with aroma had no antimicrobial effect on normal vaginal microorganisms. Conclusion : From this study, we could suggest that Pogostemonis Herba, Ammomi Tsao-ko Fructus, Alpiniae Katsumadaii Semen, Magnoliae Cortex of medicinals resolving dampness with aroma are available to antimicrobial agent of pathogenic vaginal microorganisms in vitro.

• 대한한의진단학회지
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• 제13권2호
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• pp.24-33
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• 2009

Objectives : This study was aimed to clarify the relationship between the tongue diagnosis of dampness-phlegm and hyperlipidemia in acute stroke patients. Methods : We analyzed the data of 1405 patients with acute stroke in 10 oriental medical hospitals from November 2006 to December 2008. We classified patients into two groups, dampness-phlegm and non dampness-phlegm by tongue diagnosis such as the white coating of the tongue, thick coating of the tongue, swollen tongue and teeth printed tongue which is oriental medical diagnosis. And We analyzed their characteristics with type of stroke and lipid blood level. Results : 1. There was no significant difference of stroke type between the dampness-phlegm tongue diagnosis group and the non dampness-phlegm tongue diagnosis group. 2. The ratio of SVO was higher in dampness-phlegm tongue diagnosis group (76.06%) than the non dampness-phlegm tongue diagnosis group (61.26%). 3. According to the blood test, the dampness-phlegm tongue diagnosis group showed higher in total cholesterol, HDL cholesterol, LDL cholesterol and triglyceride than the control group. 4. Total cholesterol and HDL cholesterol were significant higher in dampness-phlegm tongue diagnosis than the control group. Conclusion : According to the analysis, the relationship between the tongue diagnosis of dampness-phlegm and hyperlipidemia in acute stroke patients were more clarified. Based on these results, more prospective studies are to be done with more clinical data.