• The Korean Journal of Pharmacology
• /
• v.31 no.3
• /
• pp.313-321
• /
• 1995

Conflicting data have been reported on the effect of nicotine on gastric mucosal damage. To elucidate the effect of chronic intermittent nicotine on gastric mucosal damage, intragastric nicotine (5 mg/kg, 10 mg/kg) was administered twice per day for 9 days. Gastric mucosal damage was created by s.c. injection of a large dose (1.2 mg/kg) of pentagastrin followed by pylorus ligation for 6 hours. Nicotine treated rats showed reduced gastric mucosal damage about 50% of the control. To examine the mechanism of the protective effect of nicotine, gastric perfusion experiments were done. Basal acid secretion was not affected by intragastric or intravenous nicotine. However, pentagastrin-stimulated acid secretion markedly inhibited by a bolus injection of nicotine, and this response was dose-related. These data indicates that chronic intermittent administration of nicotine protects gastric mucosa against gastrin-induced gastric mucosal damage, and nicotine-induced inhibition of gastrin-stimulated acid secretion has an important role for the protective effect of nicotine. Considering reports concerning nicotine's aggravating effect on the gastric mucosal damage, it is suggested that the methods of administration of nicotine may be an important decisive factor of the divergent action of nicotine on the gastric mucosa.

• Journal of the Korea institute for structural maintenance and inspection
• /
• v.9 no.1
• /
• pp.189-196
• /
• 2005

The effects of the impulse and the magnitude of the impulsive loads to the responses of the structure are analyzed with the safety criteria established with the peak load and impulse ratio. It is shown for the loadings with short duration that the impulse is dominant factor for the damage of the structures due to the inertial effect. On the other hand the magnitude of the load is dominant factor for the load with long duration due to the duration time long enough for the loads to overcome the inertia force. It is also shown that the peak particle velocity and the peak particle acceleration of the foundation have the same influences as the impulse and the magnitude of the loads do to the structures.

• Korean Journal of Environment and Ecology
• /
• v.22 no.2
• /
• pp.113-118
• /
• 2008

This study was carried out with the aim to provide basic data for efficient park management by analyzing satisfaction factors and estimated regression model through questionnaire survey method for the visitors to Bukhansan National Park in Korea. As a result of analysis, it was found that visitors are satisfied with such variables as 'illegal camping', 'cooking act' and 'padded bills' but extremely unsatisfied with 'waste problem', 'congestion', 'damage of visiting trails' and 'lack of cultural facilities'. In the result of satisfaction factors, it was revealed that 'facility management factor' was found to have the greatest effect on satisfaction degree. In the estimated model by Multiple Regression Analysis, 'damage of natural resources' and 'damage of cultural and historic resources', and 'lack of traffic facilities' were found to affect visitors' satisfaction.

• Journal of Applied Biological Chemistry
• /
• v.66
• /
• pp.106-113
• /
• 2023

Plant extracts have been studied due to their potential as photoprotective agents against UV and blue light exposure. Previous studies have revealed that several plant extracts have photoprotection capacities and synergistic effects with synthetic products. However, such results for pu'er tea and Curcuma longa L. have not been reported yet for a cosmetic formulation. Thus, the objective of this study was to evaluate photoprotection capacities of pu'er tea and C. longa L. extracts for a sunscreen compound. The pu'er tea extract improved sun protection factor value of 2-ethyl-hexyl methoxycinnamate (a synthetic sunscreen compound) by 46% and showed a high antioxidant capability that could help skin recover from photo-induced damage. C. longa L. extract also showed a potential to protect skin from blue light-induced damage because it not only had a maximum absorption peak at the blue light range, but also protected human fibroblasts from blue light-induced damage. The addition of both extracts shifted the critical wavelength of 2-ethyl-hexyl methoxycinnamate from 350 nm to 386 nm, giving it a broad-spectrum feature. Thus, pu'er tea and C. longa L. extracts may enhance the photoprotection ability of synthetic sunscreen products.

• Journal of the Korean Society for Precision Engineering
• /
• v.10 no.4
• /
• pp.152-162
• /
• 1993

The purpose of this study is to investigate problems of residual bending strength and the impact damage experimentally when CFRP composite laminates are subjected to Foreign object damage. The specimens composed of four types of CR/EPOXY and a CF/PEEK composite laminates which involved difference of fiber stracking orientation and matrics. The result were summariged as follows : 1) It is found that both orthotropic and guasi-isotropic composite laminates are increasimg lineally between impact energy and damage delamination area. 2) Delamination devel- opment energy(mm$^{2}$J) OF cf/epoxy composite aminates is less than that of CF/PEEK. 3) When impact energy is applied to specimens within 3J, the residual strength of orthotropic is greater than guasi-isotropic composite laminates. On the other hand, it is predicted that residual bending strength of orthotropic composite laminates is less than that of quasi-isotropic when impact energy is more thaen 3J. 4) It is found in CF/PEEK that for the impact side compression, residual of bending strength versus impact energy is almost constant, while in case of impact side tension, residual bending strength is decreased rapidly near 1.2J. of impact energy due to the effect of delamination buckling.

• Journal of the Korean Geotechnical Society
• /
• v.28 no.7
• /
• pp.55-65
• /
• 2012

Total reduction factor that is used when calculating allowable tensile strength of geogrids is made by multiplying the installation damage reduction factor ($RF_{ID}$), chemical degradation reduction factor ($RF_D$), and creep reduction factor ($RF_{CR}$) etc. In case of a model estimating allowable tensile strength considering reduction factor over the short-term tensile strength of geogrids, it has a limit of not considering interaction force between reduction factors. Junction strength comes to be reduced by installation damages or chemical degradation in the same way as tensile strength. Single junction test method cannot properly test damaged samples and shows large deviations as it does not consider scale effect. Besides, regarding calculating shear strength, no reasonable study on reduction factors was conducted yet. Therefore, in this study, reduction factors that may affect the long-term performance of geogrids were revaluated considering various conditions and accurate long-term allowable tensile strength was calculated considering interrelation between reduction factors. Creep results after installation damage and chemical resistance test showed lower value than calculated value according to GRI GG-4. After the installation damage test and the chemical resistance test, the reduction factor of junction strength was less than that of tensile strength. Shear strength before and after installation damage showed no change or increase.

• Proceedings of the Korean Geotechical Society Conference
• /
• 2010.03a
• /
• pp.1409-1416
• /
• 2010

It is essential to predict a blasting-induced excavation damage zone (EDZ) beyond the proposed excavation line of a tunnel because the unwanted damage area requires extra support system for tunnel safety. Complicated blasting process which may hinder a proper characterization of the damage zone can be effectively represented by two loading mechanisms. The one is a dynamic impulsive load generating stress waves outwards immediately after detonation. The other is a gas pressure that remains for a relatively long time. Since the gas pressure reopens up the arrested cracks and continues to extend some cracks, it contributes to the final formation of EDZ induced by blasting. This paper presents the simple method to evaluate EDZ induced by gas pressure during blasting in rock. The EDZ is characterized by analyzing crack propagation from the blasthole. To do this, a model of the blasthole with a number of radial cracks of equal length in an infinite elastic plane is considered. In this model, the crack propagation is simulated by using three conditions, the crack propagation criterion, the mass conservation of the gas, and the adiabatic condition. As a result, the stress intensity factor of the crack generally decreases as crack propagates from the blasthole so that the length of the crack is determined. In addition, the effect of rock properties, initial number of cracks, and the adiabatic exponent are investigated.

• Journal of Ginseng Research
• /
• v.47 no.2
• /
• pp.311-318
• /
• 2023

Background: The beneficial effects of compound K (CK) on different chronic diseases have been shown to be at least related to antioxidant action. Nevertheless, since its antioxidant activity in human retinal pigment epithelial (RPE) cells is still unknown, here we investigated whether CK alleviates oxidative stress-stimulated damage in RPE ARPE-19 cells. Methods: The cytoprotective consequence of CK in hydrogen peroxide (H₂O₂)-treated cells was evaluated by cell viability, DNA damage, and apoptosis assays. Fluorescence analysis and immunoblotting were performed to investigate the inhibitory action of CK on reactive oxygen species (ROS) production and mitochondrial dysfunction. Results: H₂O₂-promoted cytotoxicity, oxidative stress, DNA damage, mitochondrial impairment, and apoptosis were significantly attenuated by CK in ARPE-19 cells. Furthermore, nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation level and its shuttling to the nucleus were increased, which was correlated with upregulated activation of heme oxygenase-1 (HO-1). However, zinc protoporphyrin, a blocker of HO-1, significantly abrogated the preventive action of CK in H₂O₂-treated ARPE-19 cells. Conclusion: This study indicates that activation of Nrf2/HO-1 signaling by CK plays an important role in rescuing ARPE-19 cells from oxidative cellular damage.

• Preventive Nutrition and Food Science
• /
• v.18 no.1
• /
• pp.38-44
• /
• 2013

The protective effect of Polyopes lancifolia extract on high glucose-induced oxidative stress was investigated using human umbilical vein endothelial cells (HUVECs). High concentration of glucose (30 mM) treatment induced HUVECs cell death, but Polyopes lancifolia extract, at concentrations of 25, 50, and $100{\mu}g/mL$, protected cells from high glucose-induced damage. Furthermore, thiobarbituric acid reactive substances, intracellular reactive oxygen species, and nitric oxide levels increased by high glucose treatment were effectively decreased by treatment with Polyopes lancifolia extract in a dose-dependent manner. Also, Polyopes lancifolia extract treatment reduced the overexpressions of inducible nitric oxide synthase, cyclooxygenase-2, and nuclear factor-kappa B proteins activation that was induced by high glucose in HUVECs. These results indicate that Polyopes lancifolia extract is a potential therapeutic material that will reduce the damage caused by high glucose-induced-oxidative stress associated with diabetes.

• PNF and Movement
• /
• v.17 no.3
• /
• pp.487-497
• /
• 2019

Purpose: This tutorial review investigated the effect of prior fatigue and passive stretches on eccentric contraction-induced muscle injuries, as well as the underlying mechanisms of eccentric contraction-related injuries. Methods: Contraction-induced muscle damage is the most common disabling problem in sports and routines. The mechanisms underlying the pathology and prevention of muscle damage lessened by prior fatigue or stretches are critical in assessing musculoskeletal injuries. Even though there are treatments to reduce eccentric contraction-induced muscle injuries, fatigue negatively influences them. Therefore, we reviewed previous studies on eccentric contraction-induced muscle injuries with prior treatments using the MEDLINE and PubMed databases. Results: Prior passive stretching had a preventative and therapeutic effect, but prior lengthening contractions did not. On the other hand, prior isometric contractions involving relatively small forces may not provide a sufficient stimulus to induce protection. As a result, high force isometric contractions may be necessary. The studies supported the positive effects of prior fatigue, concluding that it was a factor in determining the amount of damage caused by eccentric exercise. This was due to a reduction in force and increased temperature. Studies that did not support the positive effects of prior fatigue concluded that a shift in optimal length to a longer length and reduced energy absorption during lengthening are evidence that fatigue is not related to muscle injuries induced by lengthening. Conclusion: The variability of the experiment models, conditions, muscles, and treatment methods make it necessary to interpret the conditions of previous studies carefully and draw conclusions without making direct comparisons. Thus, additional studies should be carefully conducted to investigate the positive effect of fatigue on lengthening.