• Journal of the Korea Safety Management & Science
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• v.17 no.4
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• pp.161-169
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• 2015

A fire sprinkler system is very important to extinguish fire in the building. The sprinkler system initiates sprinkler discharge if the detection system identifies a developing fire and opens the pre-action valve. However, pre-action fire sprinkler systems mainly installed in the underground parking lot at the apartment complex do not properly operate at fire if the connection type of fire sprinkler systems does not properly installed and operated. This study identified the relationship between fire dispersion & damage and the connection type of water supply in the sprinkler system from many fire cases at the apartment complex in South Korea. In addition, this study also identified the water supply differences and characteristics between South Korea and foreign countries. The main purpose of this study is also to improve the water connection types in the sprinkler system that can reduce the potential failures of pre-action valve operation through electrical signal system. The study also suggests the improvement plan for water connection types in pre-action fire sprinkler system that can minimize potential failure of pre-action fire sprinkler system. The suggestions for revising the fire safe standard in South Korea includes letting the water supply pipe of sprinkler system water inlet connect to the second side of pre-action valve and the water flow device that can minimize potential failure of sprinkler system.

• Composites Research
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• v.16 no.6
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• pp.16-22
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• 2003

This paper studied the AE(acoustic emission) characteristics of the laminated composite structures. The composite stiffened panels under the compressive loading emitted various AE signals when they buckled or changed the buckling modes. In addition, the failure initiated and propagation generated a lot of complex signals. From the continuous signal generation. we identified when the failures initiated and whether they propagated or not. The single lap joint of laminated plates under tensional load also generated AE signals when bonding region failed. The first failure occurrence and its propagation are monitored by generated AE signals. The characteristics of AE signals used in this analysis are cumulative hits, hit distribution, peak frequency of generated AE waveform and amplitude of signals. The analysis of AE signals shows that continuous increment of cumulative hits can be regarded as damage propagation and three dominant peak frequencies can correspond to typical failure modes in the laminated composites.

• Journal of Korean Society of Archives and Records Management
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• v.20 no.1
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• pp.1-25
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• 2020

This study investigated Ulsan locality during Joseon by searching and analyzing various records related to the Ulsan port including old literature, documents, and maps, and oral records relating to traditional knowledge, as well as extracting keywords arranged by the time series and space to reenact Ulsan Port and Ulsan during Joseon. The study examined the characteristics of Yeompo, which served defense and trade functions through Waegwan in the former half of Joseon, Gaewoonpo, Seosaengpo, and Dosanseong, which underwent damage during Imjinwaeran and other wars in middle Joseon, and Bangeojin, which operated state-owned ranches and defense facilities including signal fires through to the latter half of Joseon, Jangsaengpo, which played the role of a whaling zone, and neahwang-naru, iron mine of Dalcheon, trying to reproduce the trajectory of the Ulsan during Joseon. Research on the locality transfiguration process of the port will help establish the locality of the entire Ulsan.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.04a
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• pp.173-176
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• 2008

Use of concrete has undoubtedly become widespread in construction. Sensors are used to add functional characteristics to concrete. Self-diagnosing, smart concrete is also being developed. Development of these functional materials and structures will play an important role in protecting buildings and structures against external factors brought about by unusual weather among others. In this study, the innovative measurement system is presented where material damages and internal stress can simply be detected against the compressive and bending force of the structure using light-emitting diode and the resistance property of electric fuse.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.05a
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• pp.661-663
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• 2016

Corruption occurs in the process of processing image signal and the corruption changes the pixel value within the image to damage the original information. AWGN(additive white Gaussian noise) is a representative example. For filters to remove AWGN, there are filters such as MF(mean filter), WF(wiener filter), and AWMF(adaptive weighted mean filter). However images processed through standard previous filters lock preservation characteristics in edge areas. Therefore, threshold value is applied for processing on the standard deviation of the local mask in this study and if the standard deviation is smaller than the threshold value, it is not filtered and if the value is bigger than the threshold value, the study suggested an algorithm that processes using weighted value utilizing standard deviation.

• Journal of Ginseng Research
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• v.39 no.4
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• pp.322-330
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• 2015

Background: UV-irradiated keratinocytes secrete various proinflammatory cytokines. UV-induced skin damage is mediated by growth factors and proinflammatory cytokines such as granulocyte macrophage colony stimulating factor (GM-CSF). In a previous study, we found that the saponin of Korean Red Ginseng (SKRG) decreased the expression of GM-CSF in UVB-irradiated SP-1 keratinocytes. In this study, we attempted to find the inhibitory mechanism of SKRG on UVB-induced GM-CSF expression in SP-1 keratinocytes. Methods: We investigated the inhibitory mechanism of SKRG and ginsenosides from Panax ginseng on UVB-induced GM-CSF expression in SP-1 keratinocytes. Results: Treatment with SKRG decreased the expression of GM-CSF mRNA and protein induced by irradiation of UVB in SP-1 keratinocytes. The phosphorylation of ERK was induced by UVB at 10 min, and decreased with SKRG treatment in SP-1 keratinocytes. In addition, treatment with SKRG inhibited the UVB-induced phosphorylation of epidermal growth factor receptor (EGFR), which is known to be an upstream signal of ERK. From these results, we found that the inhibition of GM-CSF expression by SKRG was derived from the decreased phosphorylation of EGFR. To identify the specific compound composing SKRG, we tested fifteen kinds of ginsenosides. Among these compounds, ginsenoside-Rh3 decreased the expression of GM-CSF protein and mRNA in SP-1 keratinocytes. Conclusion: Taken together, we found that treatment with SKRG decreased the phosphorylation of EGFR and ERK in UVB-irradiated SP-1 keratinocytes and subsequently inhibited the expression of GM-CSF. Furthermore, we identified ginsenoside-Rh3 as the active saponin in Korean Red Ginseng.

• YAKHAK HOEJI
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• v.55 no.4
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• pp.301-308
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• 2011

Diabetes has been one of major health risks in industrialized countries. AMP-activated protein kinase (AMPK) has been focused as a novel therapeutic target for the treatment of metabolic syndromes, because AMPK increases glucose uptake through independent insulin signal pathway. In this study, we investigated the anti-diabetic effect of Angelica gigas Nakai extract (AGNEX), a mixture of decursin and decursinol angelate (53 : 47), decursin and decursinol angelate on blood glucose, glucose transport (GLUT) and AMPK expression levels in streptozotocin (STZ)-induced diabetic rats. To induce diabetes, 50 mg/kg of STZ was injected via i.v. route and AGNEX 2 mg/kg (STZ+AG), decursin 2 mg/kg (STZ+D), decursinol angelate 2 mg/kg (STZ+DA), and metformin 100 mg/kg (STZ+M) were administered orally for 21 days. STZ+DA group showed a significant decrease in fasting blood glucose levels compared to the other groups. Decursinol angelate significantly upregulated expression of glucose transporter 4 (GLUT4) and phosphorylation of AMPK (p-AMPK) in skeletal muscle of rats. In pancreas of rats, decursinol angelate significantly increased expression of GLUT2 through down-regulation of p-AMPK. In addition to the result of pancreatic islets morphology, AGNEX, decursin, decursinol angelate, and metformin treated group recovered ${\beta}$-cell damage by hyperglycemia. These results indicate that decursinol angelate might be a potential anti-diabetic agent and AGNEX could be useful in the treatment of diabetes mellitus.

• Journal of Sasang Constitutional Medicine
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• v.14 no.3
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• pp.97-113
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• 2002

Objective To study the effectiveness of Yuldahansotang against Allergic Contact Dermatitis, the change of cutaneous shape, histochemistry, immunohistochemistry and distribution of apoptotic cells was researched. materials and methods 4-month-old rats were divided into three groups of 10. One is a contrastive group which has applied Acetone olive oil only. Another is ACD group which has intentionally activated Allergic Contact Dermatitis by DNCB. And the other is YST group which has given medication of Yangkyuksanhawtang extract. Each group of mice were observed after 24, 48 and 72 hours. results 1. With the result of Contact hypersensitivity assay, YST group shows appreciably less ear swelling than ACD group. 2. Comparing YST and ACD groups to each other regarding general change of skin, YST group shows less hyperplasia of epidermis, less migration of inflammatory cells and less damage of epidermis than ACD group. 3. Regarding the change of collagen fiber, ACD group has appeared to be low in number of collagen fiber while YST shows similarity with the contrastive group. 4. In dermis YST group has showed lower number of mastocyte than ACD group and is granulated type. 5. In dermis YST group has showed less MAC-1,IL-1, $IL-2R-{\alpha}$, ICAM-1 and VCAM-1 than ACD group. 6. The distribution of apoptotic cells has appeared littler in YST group than in ACD 7. Among signal molecule of apoptosis Bcl-2 has distributed more in YST group than ACD group and Bax and Fas has distributed less in YST group than ACD group.

• Genomics & Informatics
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• v.8 no.3
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• pp.131-137
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• 2010

Genome-wide association studies (GWASs) have greatly contributed to the identification of common variants responsible for numerous complex traits. There are, however, unavoidable limitations in detecting causal and/or rare variants for traits in this approach, which depends on an LD-based tagging SNP microarray chip. In an effort to detect potential casual and/or rare variants for complex traits, such as type 2 diabetes (T2D) and triglycerides (TGs), we conducted a targeted resequencing of loci identified by the Korea Association REsource (KARE) GWAS. The target regions for resequencing comprised whole exons, exon-intron boundaries, and regulatory regions of genes that appeared within 1 Mb of the GWA signal boundary. From 124 individuals selected in population-based cohorts, a total of 0.7 Mb target regions were captured by the NimbleGen sequence capture 385K array. Subsequent sequencing, carried out by the Roche 454 Genome Sequencer FLX, generated about 110,000 sequence reads per individual. Mapping of sequence reads to the human reference genome was performed using the SSAHA2 program. An average of 62.2% of total reads was mapped to targets with an average 22X-fold coverage. A total of 5,983 SNPs (average 846 SNPs per individual) were called and annotated by GATK software, with 96.5% accuracy that was estimated by comparison with Affymetrix 5.0 genotyped data in identical individuals. About 51% of total SNPs were singletons that can be considered possible rare variants in the population. Among SNPs that appeared in exons, which occupies about 20% of total SNPs, 304 nonsynonymous singletons were tested with Polyphen to predict the protein damage caused by mutation. In total, we were able to detect 9 and 6 potentially functional rare SNPs for T2D and triglycerides, respectively, evoking a further step of replication genotyping in independent populations to prove their bona fide relevance to traits.

• Journal of the Korean Society for Nondestructive Testing
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• v.26 no.4
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• pp.220-230
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• 2006

Fracture behavior of a monolithic PZT and a plate-type piezoelectric composite actuator (PCA) has been investigated under a bending load at three points by an acoustic emission (AE) monitoring. AE signal from a monolithic PZT at the maximum bending load shows the characteristics of high amplitude and long duration with a low frequency band of $100{\sim}230kHz$ which is confirmed by fast Fourier transform (FFT). For a PCA, it is concluded that AE signals with high amplitude over 80dB and low dominant frequency band of $170{\sim}223kHz$ emitted in the stage I are due to the brittle fracture in the PZT layer and the delamination between the PZT layer and the adjacent fiber composite layer. Based on the above analysis of AE behavior and damage observations with an optical microscopy and a scanning electron microscopy, AE characteristics related to fracture behavior of asymmetrically laminated PCA have been elucidated.