• Title/Summary/Keyword: Damage Signal

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Crack Detection of Concrete Using Fiber Optic Cables (Fiber Optic Cable을 이용한 콘크리트 균열탐사)

  • Cho, Nam-So;Kim, Nam-Sik
    • Journal of the Korean Society for Nondestructive Testing
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    • v.27 no.2
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    • pp.157-163
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    • 2007
  • Crack detection technique for concrete structures has been developed in this study. Experimental tests were carried out to detect a surface and internal crack, employing common fiber optic cables and OTDR(optical time domain reflectometry), an optical signal analyzer which is widely used to detect damages at fiber optic cables in the field of optical engineering. While initial concrete crack is ready to occur under cracking force, the occurrence and location of the crack are simultaneously detected to give the same damage to fiber optic cables which have been attached to and/or embedded into concrete in advance. It is obtained through successive tests that the principal factors for crack detection is the covering state of fiber optic cable, and total 4 tests including a preliminary test were conducted and the crack detection technique was verified. The practical usefulness would be expected at crack management and maintenance of concrete structures.

Expression of phospholipase C β1 in olive flounder (Paralichthys olivaceus) following external stress stimulation

  • Woo, Soo Ji;Jang, Hee Young;Lee, Hyung Ho;Chung, Joon Ki
    • Fisheries and Aquatic Sciences
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    • v.19 no.4
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    • pp.18.1-18.10
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    • 2016
  • In this study, to clarify the function of $PoPLC-{\beta}1$, in response to stress challenge, we examined the $PoPLC-{\beta}1$ expression pattern in response to external stress (pathogen-associated molecular pathogen challenge and environmental challenge including temperature and salinity). $PoPLC-{\beta}1$ expression analysis of tissue from olive flounder showed that the messenger RNA (mRNA) was predominantly expressed in the brain, heart, eye, liver, spleen, and stomach. We also tested the mRNA expression of the $PoPLC-{\beta}1$ in the spleen and kidney of olive flounder by RT-PCR and real-time PCR following stimulation with lipopolysaccharide (LPS), concanavalin A (ConA), or polyinosinic:polycytidylic acid (PolyI:C) and compared with the inflammatory cytokines IL-1b and IL-6 in the stimulated flounder tissues. Each of the spleen and kidney and mRNA transcripts of $PoPLC-{\beta}1$ were increased 30- and 10-fold than normal tissue at 1-6 h post injection (HPI) with PolyI:C when the expression of $PoPLC-{\beta}1$ transcript was similar to LPS and ConA. We also tested the expression of $PoPLC-{\beta}1$ in response to temperature and salinity stress. The expression of $PoPLC-{\beta}1$ also was affected by temperature and salinity stress. Our results provide clear evidence that the olive flounder $PLC-{\beta}1$ signal pathways may play a critical role in immune function at the cellular level and in inflammation reactions. In addition, $PLC-{\beta}1$ appears to act as an oxidative-stress suppressor to prevent cell damage in fish.

Significance of ATM Gene Polymorphisms in Chronic Myeloid Leukemia - a Case Control Study from India

  • Gorre, Manjula;Mohandas, Prajitha Edathara;Kagita, Sailaja;Cingeetham, Anuradha;Vuree, Sugunakar;Jarjapu, Sarika;Nanchari, Santhoshirani;Meka, Phanni Bhushann;Annamaneni, Sandhya;Dunna, Nageswara Rao;Digumarti, Raghunadharao;Satti, Vishnupriya
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.2
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    • pp.815-821
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    • 2016
  • Background: Development of chronic myeloid leukemia (CML) involves formation of double strand breaks (DSBs) which are initially sensed by the ataxia telangiectasia mutated (ATM) signal kinase to induce a DNA damage response (DDR). Mutations or single nucleotide polymorphisms in ATM gene are known to influence the signaling capacity resulting in susceptibility to certain genetic diseases such as cancers. Materials and Methods: In the present study, we have analyzed -5144A>T (rs228589) and C4138T (rs3092856) polymorphisms of theATM gene through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 925 subjects (476 CML cases and 449 controls). Results: The A allele of -5144A>T polymorphism and T allele of C4138T polymorphism which were known to be influencing ATM signaling capacity are significantly associated with enhanced risk for CML independently and also in combination (evident from the haplotype and diplotype analyses). Significant elevation in the frequencies of both the risk alleles among high risk groups under European Treatment and Outcome Study (EUTOS) score suggests the possible role of these polymorphisms in predicting the prognosis of CML patients. Conclusions: This study provides the first evidence of association of functional ATM gene polymorphisms with the increased risk of CML development as well as progression.

A Design of Wide-Bandwidth LDO Regulator with High Robustness ESD Protection Circuit

  • Cho, Han-Hee;Koo, Yong-Seo
    • Journal of Power Electronics
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    • v.15 no.6
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    • pp.1673-1681
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    • 2015
  • A low dropout (LDO) regulator with a wide-bandwidth is proposed in this paper. The regulator features a Human Body Model (HBM) 8kV-class high robustness ElectroStatic Discharge (ESD) protection circuit, and two error amplifiers (one with low gain and wide bandwidth, and the other with high gain and narrow bandwidth). The dual error amplifiers are located within the feedback loop of the LDO regulator, and they selectively amplify the signal according to its ripples. The proposed LDO regulator is more efficient in its regulation process because of its selective amplification according to frequency and bandwidth. Furthermore, the proposed regulator has the same gain as a conventional LDO at 62 dB with a 130 kHz-wide bandwidth, which is approximately 3.5 times that of a conventional LDO. The proposed device presents a fast response with improved load and line regulation characteristics. In addition, to prevent an increase in the area of the circuit, a body-driven fabrication technique was used for the error amplifier and the pass transistor. The proposed LDO regulator has an input voltage range of 2.5 V to 4.5 V, and it provides a load current of 100 mA in an output voltage range of 1.2 V to 4.1 V. In addition, to prevent damage in the Integrated Circuit (IC) as a result of static electricity, the reliability of IC was improved by embedding a self-produced 8 kV-class (Chip level) ESD protection circuit of a P-substrate-Triggered Silicon Controlled Rectifier (PTSCR) type with high robustness characteristics.

Effect on the Inhibition of DNA-PK in Breast Cancer Cell lines(MDA-465 and MDA-468) with DNA-PKcs Binding Domain Synthetic Peptide of Ku80 (Ku80의 DNA-PKcs 결합부위 합성 Peptide 투여에 의한 유방암세포의 DNA-dependent protein kinase 억제 효과)

  • 김충희;김태숙;문양수;정장용;강정부;김종수;강명곤;박희성
    • Journal of Veterinary Clinics
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    • v.21 no.3
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    • pp.253-258
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    • 2004
  • DNA double-strand break (DSB) is a serious treat for the cells including mutations, chromosome rearrangements, and even cell death if not repaired or misrepaired. Ku heterodimer regulatory DNA binding subunits (Ku70/Ku80) bound to double strand DNA breaks are able to interact with 470-kDa DNA-dependent protein kinase catalytic subunit (DNA-PKcs), and the interaction is essential for DNA-dependent protein kinase (DNA-PK) activity. The Ku80 mutants were designed to bind Ku70 but not DNA end binding activity and the peptides were treated in breast cancer cells for co-therapy strategy to see whether the targeted inhibition of DNA-dependent protein kinase (DNA-PK) activity sensitized breast cancer cells to ionizing irradiation or chemotherapy drug to develop a treatment of breast tumors by targeting proteins involved in damage-signaling pathway and/or DNA repair. We designed domains of Ku80 mutants, 26 residues of amino acids (HN-26) as a control peptide or 38 (HNI-38) residues of amino acids which contain domains of the membrane-translocation hydrophobic signal sequence and the nuclear localization sequence, but HNI-38 has additional twelve residues of peptide inhibitor region. We observed that the synthesized peptide (HNI-38) prevented DNA-PKcs from binding to Ku70/Ku80, resulting in inactivation of DNA-PK complex activity in breast cancer cells (MDA-465 and MDA-468). Consequently, the peptide treated cells exhibited poor to no DNA repair, and became highly sensitive to irradiation or chemotherapy drugs. The growth of breast cancer cells was also inhibited. These results demonstrate the possibility of synthetic peptide to apply breast cancer therapy to induce apoptosis of cancer cells.

Bicycle Accident Position Tracing and Alarm System (자전거 사고 위치 추적 및 알림 시스템)

  • Kim, Jang-Won
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.14 no.6
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    • pp.93-98
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    • 2014
  • Bicycle accidents increase as the number of people riding bicycles increases following the trend try to enhance health and looking for alternative energy sources in the era of high oil price. In bicycle accident cases, physical risk is higher because the impact of the accident has a direct effect on the body of the rider. Therefore, the bicycle rider in an accident might unable to report the accident by themselves, thus, unable to quickly respond to the accident situation. This study developed a system for informing bicycle accidents upon bicycle accident by reporting and texting the accident location using a smart phone application after identifying the accident location using a GPS equipment based on the signal that senses the accident through the system installed in the bicycle for the purpose to improve bicycle riders' safety. This study confirmed the effectiveness of the system developed to quickly respond to the accident to prevent secondary damage through an experiment.

Rapid Effect of Low Temperature on the Freezing Resistance of Dehardening Trees (단기(短期) 저온처리(低溫處理)가 수목휴면지(樹木休眠枝) 내한성도(耐寒性度)에 미치는 효과(効果))

  • Hong, Sung Gak;Cho, Tae Hwan
    • Journal of Korean Society of Forest Science
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    • v.28 no.1
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    • pp.31-35
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    • 1975
  • The present study explored the rapid effect of low temperature on the freezing resistance of dehardening twigs of three apple cultivars and sweet cherry. The effect of low temperature was depending upon the thawing treatment following to the low temperature treatment. When the freezing temperature to $-9^{\circ}C$ for three hours followed by thawing treatment ($5^{\circ}C$) was given repeatedly twice, the low temperature increased apparently the cold hardiness of apple and cherry by 3 to $9^{\circ}C$. On the other hand, when the freezing temperature ($-9^{\circ}C$) for ten hours was pretreated without thawing, the low temperature appeared not affecting the cold resistance of the twigs. The role of freezing-thawing temperature cycle in nature was discussed as a signal of environmental stimulus to which dehardening plant may be responding to increase their cold hardiness so as to adapt against the damage of late frost in early spring.

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Development of Diagnosis System for LNG Pump (LNG 펌프 고장 진단 시스템 개발)

  • Hong S. H.;Lee Y. W.;Hwang W G.;Ki Ch. D.;Kim Y. B.
    • Journal of the Korean Institute of Gas
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    • v.2 no.3
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    • pp.88-95
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    • 1998
  • Vibration analysis of rotating machinery can give an indication of possible faults thus allowing maintenance before further damage occurs. Current predictive maintenance system installed in Pyung-tak has the ability to diagnose the mechanical problems within the LNG Pump when the vibration exceeds preset overall alarm levels. In this study, LNG pump auto-diagnosis system based upon Windows NT and DSP Board is developed. This system analysis velocity signal acquired from dual accelerometer input monitor system to diagnose pump condition. Many plots which display machine condition are shown and features of vibration are stored in every time. If the fault is found, the system diagnoses automatically using expert system and trend monitoring. Operator checks pump condition intuitively using personal computer monitor.

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Kawasaki disease presenting as retropharyngeal abscess (후인두부 농양으로 오인된 가와사끼병)

  • Cho, Sung Yoon;Cho, Hye Kyung;Cho, Ky Young;Kim, Hae Soon;Sohn, Sejung
    • Clinical and Experimental Pediatrics
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    • v.51 no.9
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    • pp.1023-1027
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    • 2008
  • A group of patients with Kawasaki disease (KD) initially present with cervical lymphadenitis or deep neck infection. These unusual KD presentations lead to unnecessary antibiotic therapy or surgical intervention, thereby delaying intravenous immunoglobulin treatment and increasing the risk of coronary artery damage. We present four KD patients whose initial presentations mimicked a retropharyngeal abscess. Nonsuppurative cervical lymphadenitis or suspected neck abscess unresponsive to intravenous antibiotics could signal the possibility of KD.

Long-Term Measurement of Static Strains of Jacket Type Offshore Structure under Severe Tidal Current Environments (빠른 조류 환경에서의 재킷식 해양구조물 시공 중 및 운영 중 장기 변형률 계측 및 분석)

  • Yi, Jin-Hak;Park, Jin-Soon;Park, Jun-Seok;Lee, Kwang-Soo
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.32 no.6A
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    • pp.389-398
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    • 2012
  • In this study, structural strain responses of the jacket-type Uldolmok tidal current power plant structure under severe tidal environments were measured and analyzed using long-term measurement system during construction and also operation. It was observed that there were significant changes in strain responses at the steps of jacket lifting, block loading, pile ejection and insertion. Strains due to dead loads and tidal loads were analyzed before and after removal of a jacket leg, and it was also found that the strains due to dead load were much significantly changed after jacket leg removal. From the measurement data during operation, it was found that strain responses were fluctuated with M2 and M4 tidal periods and also relatively short period of about 10 min due to the peculiar tidal characteristics in the Uldolmok strait. Finally, the neural network-based non-parametric estimation models were investigated to build up the signal-based structural damage monitoring system.