• Journal of The Korean Society of Clinical Toxicology
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• 제17권2호
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• pp.58-65
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• 2019

Purpose: Alpha-amanitin induces potent oxidative stress and apoptosis, and may play a significant role in the pathogenesis of hepatotoxicity. This study examined the mechanisms of α-amanitin-induced apoptosis in vitro, and whether green tea extract (GTE) offers protection against hepatic damage caused by α-amanitin (AMA) induced apoptosis in vivo. Methods: The effects of GTE and SIL on the cell viability of cultured murine hepatocytes induced by AMA were evaluated using an MTT assay. Apoptosis was assessed by an analysis of DNA fragmentation and caspase-3. In the in vivo protocol, mice were divided into the following four groups: control group (0.9% saline injection), AMA group (α-amanitin 0.6 mg/kg), AMA+SIL group (α-amanitin and silibinin 50 mg/kg), and AMA+GTE group (α-amanitin and green tea extract 25 mg/kg). After 48 hours of treatment, the hepatic aminotransferase and the extent of hepatonecrosis of each subject was evaluated. Results: In the hepatocytes exposed to AMA and the tested antidotes, the cell viability was significantly lower than the AMA only group. An analysis of DNA fragmentation showed distinctive cleavage of hepatocyte nuclear DNA in the cells exposed to AMA. In addition, the AMA and GTE or SIL groups showed more relief of the cleavage of the nuclear DNA ladder. Similarly, values of caspase-3 in the AMA+GTE and AMA+SIL groups were significantly lower than in the AMA group. The serum AST and ALT levels were significantly higher in the AMA group than in the control and significantly lower in the AMA+GTE group. In addition, AMA+GTE induced a significant decrease in hepatonecrosis compared to the controls when a histologic grading scale was used. Conclusion: GTE is effective against AMA-induced hepatotoxicity with its apoptosis regulatory properties under in vitro and in vivo conditions.

• Current Optics and Photonics
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• 제1권1호
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• pp.51-59
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• 2017

In addition to its typical use for skin rejuvenation, fractional laser irradiation of early cancerous lesions may reduce the risk of tumor development as a byproduct of wound healing in the stroma after the controlled injury. While fractional ablative lasers are commonly used for cosmetic/aesthetic purposes (e.g., photorejuvenation, hair removal, and scar reduction), we propose a novel use of such laser treatments as a stromal treatment to delay tumorigenesis and suppress carcinogenesis. In this study, we found that non-ablative fractional laser (NAFL) irradiation may have a possible suppressive effect on early tumor growth in syngeneic mouse tumor models. We included two syngeneic mouse tumor models in irradiation groups and control groups. In the irradiation group, a thulium fiber based NAFL at 1927 nm was used to irradiate the skin area including the tumor injection region with 70 mJ/spot, while no laser irradiation was applied to the control group. Numerical simulation with the same experimental condition showed that thermal damage was confined only to the irradiation spots, sparing the adjacent tissue area. The irradiation groups of both tumor models showed smaller tumor volumes than the control group at an early tumor growth stage. We also detected elevated inflammatory cytokine levels a day after the NAFL irradiation. NAFL treatment of the stromal tissue could potentially be an alternative anticancer therapeutic modality for early tumorigenesis in a minimally invasive manner.

• Korean Journal of Soil Science and Fertilizer
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• 제20권2호
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• pp.123-129
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• 1987

In order to find out more effective countermeasures against growth damage of paddy rice due to the irrigation of livestock waste water, pot experiments were carried out in 1985 and 1986. Experiment I conducted in 1985 was to find out the effects of irrigation control and application of ameliorators to paddy soil with irrigation of animal waste water. Experiment II conducted in 1986 was to find out the amounts of wollastonite to be applied. The results obtained were as follows. Experiment I ; Rice yields were higher in the treatment of continuously submersion until harvest than in that of intermittent irrigation. The yield was also increased with the application of soil ameliorators and it showed higher increase in the treatment of zeolite and wollastonite. Nitrogen contents in plant were increased with the nitrogen application and more amounts of irrigation of waste water, but they were considerably decreased with the application of soil ameliorators. Experiment II ; Rice yields were increased with the application of wollastonite and the optimum level of wollastonite for maximum yield in condition of 3.0 g/pot of nitrogen application was belived to be 60g/pot. The increment of yield by the application of wollastinte was though to be due to increase of No. of grains per panicle and ripening ratio. Steriled neck occurred by rice disease such as rice blast was increased with increasing the amounts of nitrogen application and nitrogen contained in irrigated waste water but that was remarkably decreased with the application of wollastonite.

• Korean Journal of Soil Science and Fertilizer
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• 제34권1호
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• pp.55-63
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• 2001

N fertilizer recommendations to optimize with consideration to maximum crop yields, maximum profits, and minimum N losses to ground or runoff water, an advisory system. Nitrogen Expert System (NES), was developed. The system was to estimate the optimal rate of N fertilizer application cornfields in Illinois. NES was constructed using Smart Elements, a knowledge-based system that manages the expertise of human experts. NES was reinforced by addition of the effect of a productivity index (PI), soil organic matter content (SOM), and pre-sidedressing of nitrate concentration (PSNT) to the optimal N fertilizer recommendation. NES contains 49 rules, 1 class, 14 objects, and 2 properties. NES was successfully operated, showing N recommendations with inputs of three soil properties including PI, SOM, and PSNT. NES can reduce N loss to the environment, but adherence to the recommendations may also reduce farmers income. Therefore, NES will be more effective by evaluating both environmental damage assessment and other economic agricultural management parameters and other soil physico-chemical parameters.

• Korean Journal of Soil Science and Fertilizer
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• 제42권5호
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• pp.355-363
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• 2009

Double cropping system of oilseed crops introduced rape and castor bean was studied in the newly reclaimed tidal land of Korea. Surface soil EC to reach at 50% of growth reduction to the tallest height of crops was estimated $4dS\;m^{-1}$ for castor bean and $6dS\;m^{-1}$ for rape by logarithmic function. The castor bean cultivated during rainy summer much more suffered serious growth and yield reduction by flooding damage in the Hwaong and Yeonsangang reclaimed lands having low soil conductivity and finer textured soil than in the Iweon reclaimed land having higher soil conductivity and coarse sandy textured soil. Rape cultivated during dry winter-spring much more suffered serious growth and yield reduction by high soil salinity come from re-salting process. 50% yield reduction was estimated at $2.0\;2.5dS\;m^{-1}$ of surface soil EC by logarithmic function. Consequentially, it was concluded that oilseed production for energy by double cropping system of rape and castor bean might be possible under good controling soil salinity below $4dS\;m^{-1}$ for castor and $3dS\;m^{-1}$ for rape in the newly reclaimed land of Korea.

• Korean journal of applied entomology
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• 제60권4호
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• pp.339-355
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• 2021

Aphids can damage plants directly by absorbing their phloem sap and indirectly by transferring plant viruses and causing sooty mold. We compared the thermal effect on the development, survivorship, and reproduction of four cereal crop-damaging aphid species, Rhopalosiphum padi, Aulacorthum solani, Aphis craccivora, and Acyrthosiphon pisum using a life table analysis method. We investigated the stage-specific development period, survivorship, adult longevity, and fecundity of the above mentioned four aphids at 10, 15, 20, 25, and 30℃, respectively, and analyzed their life table parameters using the age-stage, two-sex life table analysis. A. solani nymphs could not complete their development to adulthood at 30℃. The intrinsic increase rate of R. padi was the highest at all tested temperatures except for that at 15℃ (0.12, 0.34, 0.47, and 0.32 at 10, 20, 25, and 30℃, respectively), and that of A. pisum displayed negative values at 30℃ (-0.04). It is speculated that R. padi would be a dominant species under high temperature conditions and A. solani is a highly adaptive species at low temperatures through the comparative analysis of the life table parameters of four aphid species damaging to cereal crops.

• Korean Journal of Remote Sensing
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• 제37권5_2호
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• pp.1307-1315
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• 2021

The Changjiang Diluted Water (CDW) spreads over the East China Sea every summer and significantly affects the sea surface salinity changes in the seas around Jeju Island and the southern coast of Korea peninsula. Sometimes its effect extends to the eastern coast of Korea peninsula through the Korea Strait. Specifically, the CDW has a significant impact on marine physics and ecology and causes damage to fisheries and aquaculture. However, due to the limited field surveys, continuous observation of the CDW in the East China Sea is practically difficult. Many studies have been conducted using satellite measurements to monitor CDW distribution in near-real time. In this study, an algorithm for estimating Sea Surface Salinity (SSS) in the East China Sea was developed using the Geostationary Ocean Color Imager (GOCI). The Multilayer Perceptron Neural Network (MPNN) method was employed for developing an algorithm, and Soil Moisture Active Passive (SMAP) SSS data was selected for the output. In the previous study, an algorithm for estimating SSS using GOCI was trained by 2016 observation data. By comparison, the train data period was extended from 2015 to 2020 to improve the algorithm performance. The validation results with the National Institute of Fisheries Science (NIFS) serial oceanographic observation data from 2011 to 2019 show 0.61 of coefficient of determination (R²) and 1.08 psu of Root Mean Square Errors (RMSE). This study was carried out to develop an algorithm for monitoring the surface salinity of the East China Sea using GOCI and is expected to contribute to the development of the algorithm for estimating SSS by using GOCI-II.

• Korean Journal of Remote Sensing
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• 제37권6_3호
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• pp.1975-1984
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• 2021

Urban expansion results in raising the temperature in the city, which can cause social, economic and physical damage. In order to prevent the urban heat island and reduce the urban land surface temperature, it is important to quantify the cooling effect of the features of the urban space. Therefore, in order to understand the relationship between each object of land cover and the land surface temperature in Seoul, the land cover map was classified into 6 classes. And the correlation and multiple regression analysis between land surface temperature and the area of objects, perimeter/area, and normalized difference vegetation index was analyzed. As a result of the analysis, the normalized difference vegetation index showed a high correlation with the land surface temperature. Also, in multiple regression analysis, the normalized difference vegetation index exerted a higher influence on the land surface temperature prediction than other coefficients. However, the explanatory power of the derived models as a result of multiple regression analysis was low. In the future, if continuous monitoring is performed using high-resolution MIR Image from KOMPSAT-3A, it will be possible to improve the explanatory power of the model. By utilizing the relationship between such various land cover types considering vegetation vitality of green areas with that of land surface temperature within urban spaces for urban planning, it is expected to contribute in reducing the land surface temperature in urban spaces.

• Journal of the Korea institute for structural maintenance and inspection
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• 제25권4호
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• pp.28-36
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• 2021

It is known that buried rebars inside concrete structures are protected from corrosion due to passive layer. It is very important to delay the timing of corrosion or evaluate a detection of corrosion initiation for the purpose of cost-beneficiary service life of a structure. In this study, corrosion monitoring was performed on concrete specimens considering 3 levels of cover depth(60 mm, 45 mm, and 30 mm), W/C(water to cement) ratio(40.0%, 50.0%, and 60.0%) and chloride concentration(0.0%, 3.5%, and 7.0%). OCP(Open Circuit Potential) was measured using agar-based socket type sensors. The OCP measurement showed the consistent behavior where the potential was reduced in wet conditions and it was partially recovered in dry conditions. In the case of 30 mm of cover depth for most W/C ratio cases, the lowest OCP value was measured and rapid OCP recovery was evaluated in increasing cover depth from 30 mm to 45 mm, since cover depth was an effective protection against chloride ion ingress. As the chloride concentration increased, the effect on the cover depth tended to be more dominant than the that of W/C ratio. After additional monitoring and physical evaluation of chloride concentration after specimen dismantling, the proposed system can be improved with increasing reliability of the corrosion monitoring.

• Journal of the Korea Academia-Industrial cooperation Society
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• 제20권8호
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• pp.23-28
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• 2019

The structural integrity of a surface metal coating was evaluated through numerical results to improve the efficiency and reduce the damage caused by cavitation in ships and marine plants. The goal was to ensure structural strength and performance, even if the thickness of the wing is reduced to reduce the weight of the material and surface coating. Analytical methods were used for four models: a non-coating model, one with the same thickness after coating, one with a thickness reduction of 3% after coating, and one with thickness reduction of 5% after coating. With a thickness reduction of 5% after coating, the stress was increased to 12%, and the safety factor was 0.99%, so the structural integrity was insufficient. However, a better material or a thicker coating could allow a sufficient safety factor to be secured. The structural integrity was improved by the coating, and even when the weight was reduced up to 5%, the structural integrity could be sufficiently secured due to the coating effect.