• 한국환경농학회지
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• 제41권4호
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• pp.261-275
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• 2022

BACKGROUND: Prior to implementing a positive list system (PLS), there is a need to establish acceptable daily intake (ADI) and maximum residue limit (MRL) for veterinary drugs that have been approved a few decades ago in South Korea. On top of that, chronic dietary exposure assessment of veterinary drug residues should be performed to determine whether the use of these veterinary drugs would cause health concerns or not. METHODS AND RESULTS: To establish the ADI, the relevant toxicological data were collected from evaluation reports issued by international organizations. A slightly modified global estimate of chronic dietary exposure (GECDE) model was employed in the exposure assessment owing to the limited residual data. Therefore, only the ADI of ephedrine was established due to insufficient data for the other veterinary drugs. Thus, instead of ADI, the threshold of toxicological concern (TTC) value was used for the other drugs. Lastly, the hazard index (HI) was calculated, except for etizazole hydrochloride, due to the potential of mutagenicity. CONCLUSION(S): The HI values of ephedrine, menichlopholan, and anacolin were found to be as high as 6.4%, suggesting that chronic dietary exposure to the residues from these uses was unlikely to be a public health concern. Further research for exposure assessment of veterinary drug residues should be performed using up-todate Korean national health and nutrition examination survey (KNHANES) food consumption data. In addition, all relevant available data sources should be utilized for identifying the potentials of toxicity.

• 한국산업간호협회지
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• 제16권2호
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• pp.18-25
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• 2009

• 한국환경보건학회:학술대회논문집
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• 한국환경보건학회 2003년도 Challenges and Achievements in Environmental Health
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• pp.183-186
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• 2003

To evaluate the effect of air pollution on respiratory health in children, we conducted a longitudinal study in which children were asked to record their daily levels of peak expiratory flow rate using potable peak flow meter (mini-Wright) far 4 weeks. The relationship between daily PEFR and ambient air particle levels was analyzed using a mixed linear regression models including gender, age in you, weight, the presence of respiratory symptoms, and relative humidity as an extraneous variable. The daily mean concentrations of PM$\_$10/ and PM$\_$2.5/ over the study period were 64.9$\mu\textrm{g}$/㎥ and 46. l$\mu\textrm{g}$/㎥, respectively. The range of daily measured PEFR in this study was 170-481 l/min. Daily mean PEFR was regressed with the 24-hour. average PM$\_$10/ (or PM$\_$2.5/) levels, weather information such as air temperature and relative humidity, and individual characteristics including sex, weight, and respiratory symptoms. The analysis showed that the increase of air particle concentrations was negatively associated with the variability in PEFR. We estimated that the IQR increment of PM$\_$10/ or PM$\_$2.5/ were associated with 1.5 l/min (95% Confidence intervals -3.1, 0.1) and 0.8 l/min (95% Cl -1.8, 0.1) decline in PEFR. Even though this study shows negative findings on the relationship between respiratory function and air particles, it is worth noting that the findings must be interpreted cautiously because exposure measurement based on monitoring of ambient air likely results in misclassification of true exposure levels and this is the first Korean study that PM$\_$2.5/ measurement is applied as an index of air particle quality.

• Environmental Analysis Health and Toxicology
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• 제25권4호
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• pp.307-314
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• 2010

Objectives : Arsenic (As) is ubiquitously distributed in the environment and has been known as a human carcinogen. The main source of arsenic exposure in general population is an oral route through As-contaminated water and foods. This study was performed to estimate the daily intake of As from diet and associated factors in Korean adults. Methods : We investigated 590 adults, 249 males and 341 females, with age of 20 years and older, who had not been exposed to the As occupationally. Study subjects were interviewed for demographic characteristics, lifestyles and diets during the last 24 hours. The estimation of As intake daily was based on amount of food consumption and As concentration in each food by using database of As concentrations in 117 food species. Results : Daily As intake was estimated as $56.46\;{\mu}g$/day, $56.60\;{\mu}g$/day in male and $56.36\;{\mu}g$/day in female. As intake was not significant from sex, age group, smoking and alcoholic habits, while was by occupation with the most intake of As in fishery. The daily As intakes was positively correlated with the total food consumption, specifically related with fishes and shellfishes, seaweeds, oils, grains and flavors. About 75% of As intake from diet was contributed by seafoods, such as $32.07\;{\mu}g$/day from fishes & shellfishes and $10.05\;{\mu}g$/day from seaweeds. However, it is necessary to evaluate if the dietary As intake affects on the levels of As in the body. Conclusions : The amount of As intake daily in Korean adults was estimated as $56.46\;{\mu}g$/day, and is determined mainly by diet behavior. The seafoods, such as fishes & shellfishes and seaweeds, is major source of As exposure from diet in Korean.

• Safety and Health at Work
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• 제10권4호
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• pp.437-444
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• 2019

Background: Headache/eyestrain symptoms are common health problems that people experience in daily life. Various studies have examined risk factors contributing to headache/eyestrains, and physicochemical exposure was found to be a leading risk factor in causing such symptoms. The purpose of this study was to examine the relationship of headache/eyestrain symptoms with physicochemical exposure among Korean construction workers depended on worksite. Methods: This study used data from the 4th Korean Workers Conditions Survey and selected 1,945 Korean construction workers as participants. Multivariable logistic regression analysis was used to determine the relationship. Results: Exposure to vibrations among all construction workers affected the moderate exposure group [odds ratio (OR) 1.53, 95% confidence interval (CI) 1.01-2.32], the high exposure group (OR 1.77 95%CI 1.17-2.67), and the indoor high exposure group (OR 1.61, 95%CI 1.02-2.55) and among outdoor construction workers, the moderate group (OR 6.61, 95%CI 15.4-28.48) and the high group (OR 6.61, 95%CI 1.56-27.98). When exposed to mist, dust, and fumes, the indoor high exposure group was significantly affected (OR 1.63, 95%CI 1.07-2.47). All construction workers exposed to organic solvents were affected, high exposure group (OR 1.69, 95%CI 1.15-2.49) and indoor high exposure group (OR 1.77, 95%CI 1.08-2.89). The high exposure group in all construction worker (OR 1.70, 95%CI 1.20-2.42) and the indoor high exposure group (OR 1.83, 95%CI 1.17-2.89) also were affected by secondhand smoking exposure. Conclusion: Many physicochemical exposure factors affect headache/eyestrain symptoms among construction workers, especially indoor construction workers, suggesting a deficiency in occupational hygiene and health environments at indoor construction worksites.

• 한국대기환경학회지
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• 제18권5호
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• pp.373-381
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• 2002

Benzene, Ethyl-benzene, Toluene and Xylene (BTEX) can be released to a groundwater in case of the oil leakage from underground storage tank of a gas station. These chemicals are found to contribute to the total inhalation risk from contaminated indoor air. This study presents the assessment of a human exposure to such chemicals released from the groundwater into indoor air. At first, a 2-compartment model is developed to describe the transfer and distribution of the chemicals released from groundwater in a house through showering, washing clothes, and flushing toilets. The model is used to estimate a daily human exposure through inhalation of such BTEX for adults based on two sets of exposure scenarios. Finally, a sensitivity analysis is used to identify important parameters. The results obtained from the study would help to increase the understanding of risk assessment issues associated with the indoor pollution by BTEX released from contaminated groundwater.

• 한국대기환경학회지
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• 제17권3호
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• pp.241-249
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• 2001

A report by the National Research Council in the United States suggested that many lung cancer deaths each year are associated with breathing radon in indoor air. Most of the indoor radon comes directly from soil beneath the basement of foundation. Recently, radon released from groundwater is found to contribute to the total inhalation risk from indoor air. This study presents the assessment of a exposure to radon released from the groundwater into indoor air. At first, a 3-compartment model is describe the transfer and distribution if radon released from groundwater in a house through showering, washing clothes, and flushing toilets. The model is used to estimate a daily human exposure through inhalation of such radon for adults based on two sets of exposure scenarios, Finally, a sensitivity analysis is used to identify important parameters. The results obtained from the study would help to increase the understanding of risk assessment issues associated with the indoor radon released from groundwater.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2001년도 추계학술대회논문집 I
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• pp.455-458
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• 2001

In this paper, ISO2631-1(1997) was used to assess the vibration and shock transmitted by train seat with respect to possible effects on human health. Evaluations have been performed on the seat acceleration measured in two type of train, Saemaulho and Mugunghwaho. For each train, limiting daily exposure durations were estimated by comparing the frequency weighted root mean square(i.e., r.m.s) acceleration and the vibration dose values(i.e., VDV), calculated according to ISO2631-1(1997) with exposure limits, health guidance caution zones.

• 한국환경보건학회:학술대회논문집
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• 한국환경보건학회 2006년도 Perspectives of Evironmental Health Issues in Asia-Pacific Region
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• pp.90-110
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• 2006

In the natural course of events, most human exposure to MeHg is through fish/shellfish consumption. The methylmercury exposure levels depends on the amount and species of fish/shellfish consumed daily. The developing brain in the late gestation period is known to be most vulnerable. Further, more methylmercury accumulates in the fetuses than in mothers. Therefore, efforts must be made to protect the fetuses from the risk of methylmercury, especially in populations which consume a lot of fish/shellfish.

• 한국대기환경학회:학술대회논문집
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• 한국대기환경학회 2000년도 춘계학술대회 논문집
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• pp.317-318
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• 2000

오늘날 우리는 문명이 발달하고 고도로 산업화된 사회의 구성원으로써 살아나가고 있다. 그러나 우리의 삶을 영위하는 과정에서 생긴 각종 환경오염에 노출되고 있어서 이로 인하여 우리의 삶의 질이 저하되기도 한다. 여러 가지 오염물질이 대기중에 가득한 가운데서 순간순간 숨을 쉬며 살아가는 우리 인간은 호흡기나 피부를 통하여 각종 대기오염물질에 직·간접적으로 노출되고 있는 실정이다. 이중 특히, 벤젠이나 톨루엔과 같은 휘발성유기화합물(Volatile Organic Compounds : VOCs)은 실내 생활이나 작업, 야외활동, 또 여러 삶의 과정에서도 노출되고 있는 듯 하다. (중략)