• Title/Summary/Keyword: Dae Hee Lee

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Bioequivalence of $Ersteine^{TM}$ Capsule to $Erdos^{TM}$ Capsule(Erdosteine 300 mg)

  • Ha, Yong-Hwa;Cho, Sung-Hee;Hong, Sung-Je;Lee, Heon-Woo;Seo, Seong-Hoon;Rew, Jae-Hwan;Lee, Kyung-Tae
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.242.2-242.1
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    • 2003

  • The purpose of the present study was to evaluate the bioequivalence of two Erdosteine capsules, $Erdos^{TM}$(Dae Woong Pharmaceutical Co., Ltd.) and $Ersteine^{TM}$(Dae Won Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal male volunteers,23.88 ${\pm}$2.89 year in age and 68.50 ${\pm}$ 7.71 kg in body weight, were divided into two groups and radkomied 2${\times}$2 cross-over study was empolyed. Ater three capsules containing 300 mg of erdosteine per capsule were orally administered, blood was taken at predetermined time intervals and concentrations of erdostene I in plasma were determined using HPLC. (omitted)

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Isolation of Flavonoids from the Fruits of Cornus kousa Burg

  • Lee, Dae-Young;Lyu, Ha-Na;Kwak, Ho-Young;Jung, La-Koon;Lee, Youn-Hyung;Kim, Dae-Keun;Chung, In-Sik;Kim, Sung-Hoon;Baek, Nam-In
    • Journal of Applied Biological Chemistry
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    • v.50 no.3
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    • pp.144-147
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    • 2007

  • Dried, unripe fruits of Cornus kousa Burg. were extracted with 80% aqueous MeOH and the concentrated extracts were partitioned between EtOAc and $H_2O$. From the EtOAc fraction, four flavonoids were isolated through repeated silica gel, ODS and Sephadex LH-20 column chromatographies followed by a preparative HPLC. Based on the spectroscopic data including NMR, MS and IR, the chemical structures of the compounds were determined as kaempferol (1), astragalin (2), hyperin (3) and isoquercitrin (4). These compounds were isolated for the first time from the fruits of this plant.

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