• Journal of Broadcast Engineering
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• v.15 no.1
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• pp.14-28
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• 2010

This paper considers technological requirements to broadcast digital television signals using distributed frequency network (DFN) in the advanced television systems committee (ATSC) transmission system and proposes distributed translator (DTxR) to meet such requirements. In the DFN, DTxR uses different frequency from main transmitter, but same among DTxRs. In addition, this paper introduces digital signal processing (DSP) techniques, which consist of demodulation, equalization, transmitter identification (TxID) generation and insertion, and modulation, to implement DTxR.

• Archives of Obesity and Metabolism
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• v.1 no.2
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• pp.47-52
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• 2022

Digital therapeutics (DTx) are emerging as a novel solution to improve lifestyle and prevent non-communicable diseases. Obesity is a complex, multi-factorial, chronic condition that requires patient-centered lifestyle modification. DTx, such as mobile applications and wearables, may offer easily accessible, efficient, and personalized care in the field of obesity and metabolic diseases. Yet, there is controversy over its clinical usefulness. This review will provide a comprehensive overview of DTx, including its potential role and current limitation in obesity care, based on recent literature.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.9 no.1
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• pp.49-54
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• 2010

3GPP(Third Generation Partnership Project) LTE system that is the next step forward in cellular 3G services address the issues related to power saving at LTE base station. This is because that most of the energy in a typical telecommunication network is consumed by the wireless network's base station site. Power saving at LTE base station fall in with low-carbon green technology. This thesis proposes a power saving MAC protocol for LTE base station which utilizes different graded DRX/DTX(Discontinuous. Reception/Transmission). Considering traffic type in UE, proposed MAC protocol controls adaptive DRX/DTX cycle. The proposed method is more improve power saving performance than another method which is unchanged DRX/DTX by conditions. In this thesis, I propose an power saving MAC protocol in an environment where LTE base station are communicated with UE and prove improvement in performance through simulations.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.23
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• pp.10413-10420
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• 2015

Side effects are an unavoidable consequence of chemotherapy drugs, during which liver injury often takes place. The current study was designed to investigate the protective effect of Astragalus polysaccharides (APS) against the hepatotoxicity induced by frequently-used chemical therapy agents, cyclophosphamide (CTX), docetaxel (DTX) and epirubicin (EPI)) in mice. Mice were divided into five groups, controls, low or high dose groups ($DTX_L$, $CTX_L$, $EPI_L$ or $DTX_H$, $CTX_H$, $EPI_H$), and low or high dose chemotherapeutics+APS groups ($DTX_L$+APS, $CTX_L$+APS, $EPI_L$+APS or $DTX_H$+APS, $CTX_H$+APS, $EPI_H$+APS). Controls were treated with equivalent normal saline for 28 days every other day; low or high dose group were intraperitoneal (i.p) injected with low or high doses of CTX, DTX and EPI for 28 days every other day; low or high dose chemotherapeutics+APS group were separately intraperitoneal (i.p) injected with chemotherapeutics for 28 days every other day and i.p with APS (100 mg/kg) for 7 days continually from the 22th to the 28th days. The body weight, serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), histopathological features, and ultrastructure morphological change of liver tissues, protein expression level of caspase-3 were estimated at different time points. With high dose treatment of DTX, CTX and EPI, weight gain was inhibited and serum levels of ALT and AST were significantly increased. Sections of liver tissue showed massive hepatotoxicity in $CTX_H$ group compared to the control group, including hepatic lobule disorder, granular and vacuolar degeneration and necrosis in hepatic cells. These changes were confirmed at ultrastructural level, including obvious pyknosis, heterochromatin aggregation, nuclear membrane resolution, and chondrosome crystal decrease. Western blotting revealed that the protein levels of caspase-3 increased in $CTX_H$ group. The low dose groups exhibited trivial hepatotoxicity. More interestingly, after 100 mg/kg APS, liver injury was redecued not only regarding serum transaminase activities (low or high dose chemotherapeutics+APS group), but also from pathological and ultrastructural changes and the protein levels of caspase-3 ($CTX_H$+APS group). In conclusion, DTX, CTX and EPI induce liver damage in a dose dependent manner, whereas APS exerted protective effects.

• Journal of Broadcast Engineering
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• v.14 no.4
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• pp.518-536
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• 2009

To verify the performance of a Distributed Translator Network(DTxR) system in the real world conditions, 5 legacy DTV broadcasting repeater sites were implemented with 5 DTxR systems and field-tested by the DTV field test truck. The 4 DTV broadcasting repeater sites are selected in congested areas where their service areas are overlapped and the 5th site is deviated from the other sites to examine the effect of long-delayed multipath signals. First of all, we checked the receiving signal of the main station that used as a transmitting signal in 5 DTxR systems on the pre-selected 60 test points and tested every case of a DTxR system's on & off except 1 repeater site due to the already built-in DTV repeater system. The test items are received signal electric field strength, noise margin, ease of reception and subjective evaluation of the picture quality for received signals. We used 3rd, 5th, and 6th generation DTV receivers to examine the differences of the receivability by each generation of DTV receivers. Reviewing the test results, we conclude that the DTxR system can be adopted in the current DTV Repeater sites and it could improve the quality and receivability of the main signals by extending the service areas and enhancing the signal levels in the shadow areas without using the extra broadcasting channels.

• Nutrition Research and Practice
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• v.15 no.1
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• pp.12-25
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• 2021

BACKGROUND/OBJECTIVES: The study was conducted to investigate the efficacy of the combination treatment of phytochemical resveratrol and the anticancer drug docetaxel (DTX) on prostate carcinoma LNCaP cells, including factors related to detailed cell death mechanisms. MATERIALS/METHODS: Using 2-dimensional monolayer and 3-dimensional spheroid culture systems, we examined the effects of resveratrol and DTX on cell viability, reactive oxygen species (ROS) levels, mitochondrial membrane potential, apoptosis, and necroptosis by MTT, flow cytometry, and Western blotting. RESULTS: At concentrations not toxic to normal human prostate epithelial cells, resveratrol effectively decreased the viability of LNCaP cells depending on concentration and time. The combination treatment of resveratrol and DTX exhibited synergistic inhibitory effects on cell growth, demonstrated by an increase in the sub-G0/G1 peak, Annexin V-phycoerythrin positive cell fraction, ROS, mitochondrial dysfunction, and DNA damage response as well as concurrent activation of apoptosis and necroptosis. Apoptosis and necroptosis were rescued by pretreatment with ROS scavenger N-acetylcysteine. CONCLUSIONS: We report resveratrol as an adjuvant drug candidate for improving the outcome of treatment in DTX therapy. Although the underlying mechanisms of necroptosis should be investigated comprehensively, targeting apoptosis and necroptosis simultaneously in the treatment of cancer can be a useful strategy for the development of promising drug candidates.

• Journal of Internet Computing and Services
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• v.25 no.3
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• pp.9-18
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• 2024

Digital therapy has emerged as a novel treatment modality, propelled by advancements in information and communication technology. In the last five years, there has been a substantial surge in research publications addressing digital therapeutics (DTx) interventions, signaling a sustained upward trajectory in this field. The dynamic nature of computer science, marked by continuous innovation and development, underscores the need for agile adaptation to rapid changes. Consequently, computer science education is compelled to offer students insights into the latest trends. This research endeavors to contribute to the evolving landscape by developing textbooks that impart knowledge about DTx, an integration of information technology. The study focuses on the application of these textbooks to elementary and middle school students in South Korea. The instructional materials have been carefully organized to enable students to learn about the principle of Attention Deficit Hyperactivity Disorder (ADHD) DTx at the elementary level and the DTx that can prevent and address the digital drama at the middle school level. Based on the application of the textbook, students who received instruction using the textbook showed statistically significant improvements in all subcategories of creative problem-solving ability, including idea modification, visualization, task focus, analogy, idea generation, and elaboration (p<.01). Additionally, there were statistically significant changes in students' self-efficacy before and after using the textbook, with negative efficacy decreasing, and positive efficacy and social efficacy increasing (p<.001).

• Korean Journal of Fisheries and Aquatic Sciences
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• v.24 no.3
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• pp.193-202
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• 1991

Antimicrobial substances were screened by paper disk plate method in marine sponges, Halichondria okadai, Halichendria sp., H iaponica and Haliclona Pemollis, collected from the south coast of Korea. Antibacterial components were detected in two species, H okadai and Halichondria sp.. Three components such as benzoic acid, okadaic acid(OA) and dinophysistoxin-1(DTX1) were identified from these sponges as the antimicrobial compounds by MS and NMR spectral data. OA$(550{\~}600{\mu}g/kg)$ and $(400{\~}490{\mu}g/kg)$ were determined from the wet H okadai and Halichondria sp., respectively, by using fluorometric HPLC analysis with 9-anthryldiazomethane(ADAM) as fluorescent labelling reagent.

• Horticultural Science & Technology
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• v.18 no.3
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• pp.342-347
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• 2000

The objectives of this study were to investigate the genetic and phenotypic features of male sterile transformants by pollen-specific expression of diphtheria toxin gene and to find out inheritance patterns of transgene to the next generation. When backcrossed (BC) progenies were tested for expression of kanamycin resistance ($Km^R$), 9 lines out of 13 lines, except 4 lines ($BC_{1}5-13,\;BC_{1}5-23,\;BC_{1}5-28,\;BC_{1}5-32$), showed the ratio of $Km^R$ to kanamycin sensitive ($Km^S$), from 1:30 to all $Km^S$. As a result, they were much lower than Mendelian segregation of a dominant gene. To determine whether male sterility is a heritable and stable trait, 5 male sterile plants ($BC_{1}5-13,\;BC_{1}5-14,\;BC_{1}5-23,\;BC_{1}5-32,\;BC_{1}5-33$ lines) which had different transgene copy numbers were backcrossed as female parents with pollens from wild type. To confirm the existence of the DTx-A gene in the genome of the progenies, PCR was conducted using specific primers of the DTx-A coding region. A PCR band of 428 bp was obtained from each generation, which is the predicted size of the DTx-A gene fragment. Trangenes were inherited to the next $BC_4T_0$ progenies and showed male sterility, however, based on the copy numbers of DTx-A gene male sterile plants did not show predicted ratio. When male sterile plants were backcrossed with fertile plants, fruit capsule sizes and seed settings were relatively reduced from those of selfing wild type plants. The fruit sizes and seed settings were reduced in proportion to the increase in the copy number of DTx-A gene.

• Journal of Broadcast Engineering
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• v.13 no.4
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• pp.463-478
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• 2008

A Distributed Translator Network(DTxR) is a cost-effective and frequency-effective method which can use existing transmission utilities and can be constructed in a shorter time as compared with Multiple Frequency Network(MFN) or Single Frequency Network(SFN) using On Channel Repeater(OCR). In order to verify the feasibility of DTxR, this field test was done in 30 points of north-west area in Seoul using 3rd, 5th, and 6th generation DIV receivers. Electric field strength, noise margin and ease of reception were measured and subjective evaluation of video quality was done in these points during the field test. With the test result, an improvement of receiving quality was obtained and an ease of reception was increased in case of the 5th. and 6th. receiver. From the results, we conclude that DTxR is a feasible method in DIV networks.