• BMB Reports
• /
• 제50권12호
• /
• pp.597-598
• /
• 2017

Mitochondria have evolutionarily, functionally and structurally distinct outer- (OMM) and inner-membranes (IMM). Thus, mitochondrial morphology is controlled by independent but coordinated activity of fission and fusion of the OMM and IMM. Constriction and division of the OMM are mediated by endocytosis-like machineries, which include dynamin-related protein 1 with additional cytosolic vesicle scissoring machineries such as actin filament and Dynamin 2. However, structural alteration of the IMM during mitochondrial division has been poorly understood. Recently, we found that the IMM and the inner compartments undergo transient and reversible constriction prior to the OMM division, which we termed CoMIC, ${\underline{C}}onstriction$ ${\underline{o}}f$ ${\underline{M}}itochondrial$ ${\underline{I}}nner$ ${\underline{C}}ompartment$. In this short review, we further discuss the evolutionary perspective and the regulatory mechanism of CoMIC during mitochondrial division.

• Journal of information and communication convergence engineering
• /
• 제14권1호
• /
• pp.21-25
• /
• 2016

N-screen is a promising technology to improve support for multimedia multicasting, content sharing, content mobility, media scalability, and seamless mobility. In this paper, the WiMedia distributed-MAC (D-MAC) protocol is adopted for development of a seamless N-screen wireless service. Furthermore, to provide a multi-hop, one source multi-use N-screen service through point to point streaming in a seamless D-MAC protocol, a dynamic multi-frame transmission technology is proposed. In this technology, a dynamic time slot allocation scheme and a multi-hop resource reservation scheme are combined. In the proposed dynamic time slot allocation scheme, two thresholds, a hard threshold and a soft threshold, are included to satisfy the power consumption and delay requirements. A multi-frame DRP reservation scheme is proposed to minimize end-to-end delay during the multi-hop transmissions between N-screen devices. The proposed dynamic multi-frame transmission scheme enhances N-screen performance in terms of the multi-hop link establishment success rate and link establishment time compared to the conventional WiMedia D-MAC system.

• International Journal of Internet, Broadcasting and Communication
• /
• 제8권1호
• /
• pp.53-63
• /
• 2016

This paper applies WiMedia UWB network into a wireless ship area network (WSAN) so as to support high-quality multimedia services on board and reliable instrument control information as well, since the need for mixed high-quality video traffic and shipboard control data traffic is essential for a high-cost valued digital ship. Thus, in this paper, prioritized contention access (PCA) and distributed reservation protocol (DRP) based on WiMedia UWB (ECMA-368) MAC protocols are combined and proposed to such mixed traffic environment, by varying the portions of superframe according to traffic type. It is shown that the proposed WiMedia UWB MAC protocol can provide reliable mixed video and shipboard control data traffic as well.

• 미생물학회지
• /
• 제46권3호
• /
• pp.278-285
• /
• 2010

국내에 자생하는 당귀, 삽주, 쇠무릎, 지모, 황기의 근권토양내 EPS 생성균주의 분포율을 조사한 결과 당귀로부터 분리된 균주의 56%가 EPS 생성 균주로 가장 높은 분포율을 나타내었다. 또한, 당귀 근계 (근권, 근면, 근 내부) 내 EPS 생성 세균의 밀도를 측정한 결과, 근권 토양 내에는 $9.0{\times}10^6$ CFU/$g{\cdot}soil$, 근면에는 $7.0{\times}10^6$ CFU/$g{\cdot}soil$, 그리고, 근 내부에는 $1.4{\times}10^3$ CFU/$g{\cdot}soil$로 확인되어, 다수의 EPS 생성 세균이 분포하고 있음이 확인되었다. 당귀 근권으로부터 분리된 EPS 생성세균은 Alphaproteobacteria (4 strains), Betaproteobacteria (6 strains), Firmicutes (2 strains), Actinobacteria (3 strains), 그리고 Bacteroidetes (1 strain) 계통군에 속하는 균주였다. 근면으로 부터 분리된 EPS 생성세균은 Alphaproteobacteria (7 strains), Betaproteobacteria (3 strains), Actinobacteria (2 strains), Bacteroidetes (3 strains), 그리고 Acidobacteria (1 strain) 계통군으로 나타났으며, 근 내부에서 분리된 EPS 생성세균은 모두 Bacteroidetes 계통군 Chitinophaga에 속하는 특징을 나타내었다. 약초 근권토양으로부터 분리된 EPS 생성세균 112균주중에서 Burkholderia caribiensis DR14 (1,547 mpa.s), Terriglobus sp. DRP35균주(2,136 mpa.s), Rhizobium hainanense SAP110균주(1,680 mpa.s)를 최우수 EPS 생성 균주로 선발하였다. 분리 정제된 EPS를 Bio-LC로 분석한 결과 glucose, galactose, mannose의 중성당과, galactosamine, glucosamine의 아미노당이 나타났다. 특히 Rhizobium hainanense SAP110 균주는 주요 중성당으로 glucose (60-89%)를 그리고 주요 아미노당으로 glucosamine (8.5%)을 생성하는 특징을 나타내었다.

• BMB Reports
• /
• 제44권8호
• /
• pp.517-522
• /
• 2011

Mitochondrial dynamics not only involves mitochondrial morphology but also mitochondrial biogenesis, mitochondrial distribution, and cell death. To identify specific regulators to mitochondria dynamics, we screened a chemical library and identified niclosamide as a potent inducer of mitochondria fission. Niclosamide promoted mitochondrial fragmentation but this was blocked by down-regulation of Drp1. Niclosamide treatment resulted in the disruption of mitochondria membrane potential and reduction of ATP levels. Moreover, niclosamide led to apoptotic cell death by caspase-3 activation. Interestingly, niclosamide also increased autophagic activity. Inhibition of autophagy suppressed niclosamide-induced cell death. Therefore, our findings suggest that niclosamide induces mitochondria fragmentation and may contribute to apoptotic and autophagic cell death.

• 한국전기전자재료학회:학술대회논문집
• /
• 한국전기전자재료학회 1988년도 추계학술대회 논문집
• /
• pp.36-40
• /
• 1988

High TC Y-Ba-Cu-O Superconductors were fabricated by sintering, sinter+HIP encapsulation. Specimens were sintered at 920$^{\circ}C$∼960$^{\circ}C$. A part of sintered specimens were treated by HIP, and HIP conditions were 150 MPa, 880$^{\circ}C$, 30min under the Ar atmosphere. The relative density of HIP specimens was increased 5∼8% in comparison with sintered one(90∼93% relative density). X-ray analysis represented the orthorhobic-tetragonal phase transition with annealing condition. Tc measurements showed a sharp drp within 3$^{\circ}C$, 91K onset and 89K offset. Transport current density(Jc) of sintered specimens showed typically∼159A/㎤ but that of sinter+HIP encapsulation was decreased to∼89A/㎤ because of insufficient oxygen diffusion, Hardness(H) and Toughness(Kc) were increased to 38GPa; and 2.9 MPam$\^$$\frac{1}{2}$/, respectively.

• 한국IT서비스학회지
• /
• 제6권1호
• /
• pp.31-45
• /
• 2007

With the announcement of Basel II Accord in 2004, worldwidebanks have been strengthening their risk management system. Under the circumstances, S became the first bank among other financial institutions in Korea to establish bank-wide BCP process that goes beyond the past Disaster Recovery Planning or DRP. Considering that the purpose of the process is to guarantee stability of work under the real disastrous situation, other banks are anticipated to introduce the process sooner or later to cope with any possible disaster and adhere Basel II Accord. The purpose of this thesis is to see how much impact does the work process or its improvement would have on employees' satisfaction level by considering Recovery Time Objectives (RTO) via Business Impact Analysis (BIA) and influence of BCP process implementation on parties involved.

• 한국항공우주학회지
• /
• 제38권8호
• /
• pp.790-797
• /
• 2010

마하수 1.0~1.2 범위의 초음속 제트에서 발생되는 축대칭 스크리치 톤 소음의 모드 전이 현상이 수치적으로 분석되었다. 이를 위해 k-e 난류모델을 가진 축대칭 Navier-Stokes 방정식이 사용되었으며 수치기법으로서 공간에 대해 소산관계보존기법과 시간에 대해 최적화된 4단계 시간 적분법이 사용되었다. 특히 낮은 마하수에서 발생하는 축대칭 A1 모드의 경우, 비선형성에 기인한 부가적인 음향파 발생을 확인하였으며, 강한 와류의 발생으로 인해 스크리치 소음 주파수는 와류 통과 주파수와 일치함을 알게 되었다.

• 한국임상약학회지
• /
• 제32권3호
• /
• pp.215-225
• /
• 2022

Background: Patients with hematologic cancers have a risk of drug-related problems (DRPs) from medications associated with chemotherapy and supportive care. Although the role of oncology pharmacists has been widely documented in the literature, few studies have reported its impact on cost reduction. This study aimed to describe the activities of oncology pharmacists with respect to hematologic diseases and evaluate the associated cost avoidance. Methods: From January to July 2021, patients admitted to the department of hemato-oncology at Seoul National University, Bundang Hospital were studied. The activities of oncology pharmacists were reported by DRP type following the Pharmaceutical Care Network version 9.1 guidelines, and the acceptance rate was calculated. The avoided cost was estimated based on the cost of the pharmacy intervention, pharmacist manpower, and prescriptions associated with the intervention. Results: Pharmacists intervened in 584 prescriptions from 208 patients during the study period. The most prevalent DRP was "adverse drug event (possibly) occurring" (32.4%), followed by "effect of drug treatment not optimal" (28.6%). "Drug selection" (42.5%) and "dose selection" (30.3%) were the most common causes of DRPs. The acceptance rate of the interventions was 97.1%. The total avoidance cost was KRW 149,468,321; the net profit of the avoidance cost, excluding labor costs, was KRW 121,051,690; and the estimated cost saving was KRW 37,223,748. Conclusion: Oncology pharmacists identified and resolved various types of DRPs from prescriptions for patients with hematologic disease, by reviewing the prescriptions. Their clinical service contributed to enhanced patient safety and the avoidance of associated costs.

• 대한방사성의약품학회지
• /
• 제3권2호
• /
• pp.65-71
• /
• 2017

To assess the effects of filter and reconstruction of Cu-64 PET data on Siemens scanner, the various reconstruction algorithm with various filters were assessed in terms of spatial resolution, non-uniformity (NU), recovery coefficient (RC), and spillover ratio (SOR). Image reconstruction was performed using filtered backprojection (FBP), 2D ordered subset expectation maximization (OSEM), 3D reprojection algorithm (3DRP), and maximum a posteriori algorithms (MAP). For the FBP reconstruction, ramp, butterworth, hamming, hanning, or parzen filters were used. Attenuation or scatter correction were performed to assess the effect of attenuation and scatter correction. Regarding spatial resolution, highest achievable volumetric resolution was $3.08mm^3$ at the center of FOV when MAP (${\beta}=0.1$) reconstruction method was used. SOR was below 4% for FBP when ramp, Hamming, Hanning, or Shepp-logan filter were used. The lowest NU (highest uniform) after attenuation & scatter correction was 5.39% when FBP (parzen filter) was used. Regarding RC, 0.9 < RC < 1.1 was obtained when OSEM (iteration: 10) was used when attenuation and scatter correction were applied. In this study, image quality of Cu-64 on Siemens Inveon PET was investigated. This data will helpful for the quantification of Cu-64 PET data.