• Digital Contents
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• no.8 s.3
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• pp.83-84
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• 1993

• Digital Contents
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• no.2 s.69
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• pp.25-25
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• 1999

• Digital Contents
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• no.9 s.28
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• pp.20-23
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• 1995

• Digital Contents
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• no.2 s.21
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• pp.80-88
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• 1995

• Korean Journal of Head & Neck Oncology
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• v.20 no.2
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• pp.147-155
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• 2004

Objectives: Head and neck squamous cell carcinoma (HNSCC) is the most common head and neck malignant tumor. The molecular genetic changes involving both oncogenes and tumor suppressor genes are known to be involved in head and neck squamous cell carcinogenesis, but the roles of the known tumor suppressor genes in carcinogenesis are not fully elucidated. The objectives of this study are to demonstrate the genetic alterations including the loss of heterozygosity (LOH) , amplification, and microsatellite instability of known tumor suppressor genes in HNSCC and to evaluate the relationship between genetic alterations of tumor suppressor genes and clinicopathologic features. Materials and Methods: Genetic alterations of 10 micro satellite markers of the 6 known tumor suppressor genes (APC, EXT1, DPC4, p16, FHIT, and PTEN) were analysed by DNA-PCR in paraffin-embedded histologically confirmed HNSCC specimens. Results: The genetic alterations of tumor suppressor genes were found frequently. Among the genetic alterations, LOH was most frequently found one. LOH was found frequently in APC (45.4%), EXT1 (36.4%), DPC4 (54.5%), and p16 (50%), but not found in FHIT. Also, the author found that abnormalities of APC gene was related to cervical lymph node metastasis and recurrence and that abnormalities of EXT1 gene were coexisted with those of APC gene or DPC4 gene. But these coexistences had no correlation with clinical features. Conclusion: These results suggested that APC, EXT1, p16, and DPC4 genes might play important roles and multiple tumor suppressor genes may participate dependently or independently in the carcinogenesis of HNSCC. These results also suggested that APC gene might relate to prognosis.

• Progress in Superconductivity
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• v.8 no.1
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• pp.113-118
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• 2006

The design of superconducting magnets for a 600 kJ SEMS was discussed. The basic constraint conditions in the design of a 600 kJ SMES magnet were V-I loss(<1 W), inductance of magnet(<24 H), the number of Double Pancake Coils(DPC about 10), the number of turns of DPC(<300), outer diameter of DPC(close to 800 mm) and total length of HTS wire in a DPC(<500 m). As a result of optimum design, we obtained design parameters of the 600 kJ SMES magnet with two operating currents, 360 A and 370 A, which are in the limited conditions without V-I loss. V-I loss of each operating current was calculated with design parameters and V-I characteristic of the HTS wire. As a result of calculations, V-I losses with operating currents of 360 A and 370 A were 0.6 W and 1.86 W, respectively. Even though all design parameters of the SMES magnet in case of operating current of 360 A were in the restricted conditions, V-I loss of SMES magnet showed a tendency to generate at local DPCs, which are located on the top and the bottom of the SMES magnet more than that of the other DPCs.

• Molecules and Cells
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• v.25 no.3
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• pp.358-367
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• 2008

The embryonic germ cell (EGCs) of mice is a kind of pluripotent stem cell that can be generated from pre- and post-migratory primordial germ cells (PGCs). Most previous studies on DNA methylation of EGCs were restricted to 12.5 days post coitum (dpc). This study was designed to establish and characterize murine EGC lines from migrated PGCs as late as 13.5 dpc and to estimate the degrees of methylation of their imprinted genes as well as of the non-imprinted locus, Oct4, using an accurate and quantitative method of measurement. We established five independent EGC lines from post migratory PGCs of 11.5-13.5 dpc from C57BL/6 ${\times}$ DBA/2 F1 hybrid mouse fetuses. All the EGCs exhibited the typical features of pluripotent cells including hypomethylation of the Oct4 regulatory region. We examined the methylation status of three imprinted genes; Igf2, Igf2r and H19 in the five EGC lines using bisulfite genomic sequencing analysis. Igf2r was almost unmethylated in all the EGC lines irrespective of the their sex and stage of isolation; Igf2 and H19 were more methylated than Igf2r, especially in male EGCs. Moreover, EGCs derived at 13.5 dpc exhibited higher levels of DNA methylation than those from earlier stages. These results suggest that in vitro derived EGCs acquire different epigenotypes from their parental in vivo migratory PGCs, and that sex-specific de novo methylation occurs in the Igf2 and H19 genes of EGCs.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.1C
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• pp.79-85
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• 2008

Dirty Paper Coding(DPC) can achieve the sum capacity of a multiuser multiple-input multiple-output(MU MIMO) broadcast channels. However, due to the high computational complexity of the successive encoding and decoding, deploying DPC in real systems is impractical. As one of practical alternatives to DPC, Block Diagonalization(BD) was researched. BD is an extension of the zero-forcing preceding technique that eliminates interuser interference(IUI) in downlink MIMO systems. Though BD has lower complexity than DPC, BD shows poor sum capacity performance. We show that sum capacity performance of BD is degraded due to no IUI constraint. Then, we modify BD to improve its sum capacity performance with relaxing the constraint and sub optimal channel set searching. With simulation results, it can be verified that our modification in BD induces some improvement in sum capacity performance.

• Journal of the Korean Association of Geographic Information Studies
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• v.23 no.4
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• pp.16-41
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• 2020

Geospatial input setting to represent the reality of spatial distribution or quantitative property within model has become a major interest in earth system simulation. Many studies showed the variation of grid resolution could lead to drastic changes of spatial model results because of insufficient surface property estimations. Hence, in this paper, the authors proposed Monte Carlo Integration (MCI) to apply spatial probability (SP) in a spatial-sampling framework using a three-dimensional point cloud (3DPC) to keep the optimized spatial distribution and area/volume property of buildings in urban area. Three different decision rule based building identification results were compared : SP threshold, cell size, and 3DPC density. Results shows the identified building area property tend to increase according to the spatial sampling grid area enlargement. Hence, areal building property manipulation in the sampling frameworks by using decision rules is strongly recommended to increase reliability of geospatial modeling and analysis results. Proposed method will support the modeling needs to keep quantitative building properties in both finer and coarser grids.

• Development and Reproduction
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• v.17 no.3
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• pp.215-220
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• 2013

Recently, the RNA/DNA-binding protein FUS, Fused in sarcoma, was shown to play a role in growth, differentiation, and morphogenesis in vertebrates. Because little is known about Fus, we investigated its expression pattern in murine tooth development. In situ hybridization of mouse mandibles at specific developmental stages was performed with a DIG-labeled RNA probe. During early tooth development, Fus was detected in the dental epithelium and dental mesenchyme at 11 days postcoitum (dpc) and 12 dpc. From 14 dpc, Fus was strongly expressed in the dental papilla and the cervical loop of the dental epithelium. At postnatal day 4 (PN4), Fus expression was observed in the odontoblasts, ameloblasts, the proliferation zone of the pulp, and the cervical loop. At PN14, the expression pattern of Fus was found to be maintained in the odontoblasts and the proliferation zone of the pulp. Furthermore, Fus expression was especially strong in the Hertwig's epithelial root sheath (HERS). Therefore, this study suggests that Fus may play a role in the HERS during root development.