• Journal of Information Technology Applications and Management
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• 제19권1호
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• pp.37-46
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• 2012

The scheduling problem of large products like ships, airplanes, space shuttles, assembled constructions, and automobiles is very complex in nature. To reduce inherent computational complexity, we often design scheduling systems that the original problem is decomposed into small sub-problems, which are scheduled independently and integrated into the original one. Moreover, the steep growth of communication technology and logistics makes it possible to produce a lot of multi-nation corporation by which products are produced across more than one plant. Therefore vertical and lateral coordination among decomposed scheduling systems is necessary. In this research, we suggest an agent-based coordinating mechanism for multi-level scheduling systems in supply chain. For design of a general coordination mechanism, at first, we propose a grammar to define individual scheduling agents which are responsible to their own plants, and a meta-level coordination agent which is engaged to supervise individual scheduling agents. Second, we suggest scheduling agent communication protocols for each scheduling agent topology which is classified according to the system architecture, existence of coordinator, and direction of coordination. We also suggest a scheduling agent communication language which consists of three layers : Agent Communication Layer, Scheduling Coordination Layer, Industry-specific Layer. Finally, in order to improve the efficiency of communication among scheduling agents we suggest a rough capacity coordination model which supports to monitor participating agents and analyze the status of them. With this coordination mechanism, we can easily model coordination processes of multiple scheduling systems. In the future, we will apply this mechanism to shipbuilding domain and develop a prototype system which consists of a dock-scheduling agent, four assembly-plant-scheduling agents, and a meta-level coordination agent. A series of experiment using the real-world data will be performed to examine this mechanism.

• Parasites, Hosts and Diseases
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• 제52권2호
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• pp.169-175
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• 2014

There are 60 species of blood-feeding land leeches, 50 species belonging to the family Haemadipsidae and 10 species belonging to the family Xerobdellidae. Despite recent papers on the land leeches, their taxonomic identification is not fully understood, especially at a species level. In Korea, there have been no historical records of the terrestrial leeches, but recently an unrecorded blood-feeding land leech was discovered at Gageo-do (Island), Korea. Molecular analysis was used to identify the species of 29 leeches collected from Mt. Dock-Sil in Gageo-do. Conventional PCR was conducted using nuclear 18S rRNA and mitochondrial cytochrome c oxidase subunit 1 (CO1) genetic marker. The 18S rRNA sequences revealed that the leeches share 99.9% identity with Haemadipsa rjukjuana (inhabiting Taiwan), and the CO1 sequences revealed that the leeches are very close to H. rjukjuana (inhabiting Taiwan). The CO1 sequences were separated into 2 categories, 1 with 94.6% and the other with 94.3% similarity to the H. rjukjuana L00115A (inhabiting Taiwan). This new finding of the land leech is the first record in Korea. In addition, the north range of the distribution of the blood-feeding leech (Hirudiniformes: Haemadipisidae) should be reconsidered including Korea.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5605-5611
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• 2012

Background: In the last two decades, pioneering research on anti-tumour activity of saffron has shed light on the role of crocetin, picrocrocin and safranal, as broad spectrum anti-neoplastic agents. However, the exact mechanisms have yet to be elucidated. Identification and characterization of the targets of bioactive constituents will play an imperative role in demystifying the complex anti-neoplastic machinery. Methods: In the quest of potential target identification, a dual virtual screening approach utilizing two inverse screening systems, one predicated on idTarget and the other on PharmMapper was here employed. A set of target proteins associated with multiple forms of cancer and ranked by Fit Score and Binding energy were obtained from the two independent inverse screening platforms. The validity of the results was checked by meticulously analyzing the post-docking binding pose of the picrocrocin with Hsp90 alpha in AutoDock. Results: The docking pose reveals that electrostatic and hydrogen bonds play the key role in inter-molecular interactions in ligand binding. Picrocrocin binds to the Hsp90 alpha with a definite orientation appropriate for nucleophilic attacks by several electrical residues inside the Hsp90-alpha ATPase catalytic site. Conclusion: This study reveals functional information about the anti-tumor mechanism of saffron bioactive constituents. Also, a tractable set of anti-neoplastic targets for saffron has been generated in this study which can be further authenticated by in vivo and in vitro experiments.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3735-3742
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• 2013

Background: Cardamom (Elettaria cardamom), also known as "Queen of Spices", has been traditionally used as a culinary ingredient due to its pleasant aroma and taste. In addition to this role, studies on cardamom have demonstrated cancer chemopreventive potential in in vitro and in vivo systems. Nevertheless, the precise poly-pharmacological nature of naturally occurring chemo-preventive compounds in cardamom has still not been fully demystified. Methods:In this study, an effort has been made to identify the proapoptopic, anti-inflammatory, anti-proliferative, anti-invasive and anti-angiogenic targets of Cardamom's bioactive principles (eucalyptol, alpha-pinene, beta-pinene, d-limonene and geraniol) by employing a dual reverse virtual screening protocol. Experimentally proven target information of the bioactive principles was annotated from bioassay databases and compared with the virtually screened set of targets to evaluate the reliability of the computational identification. To study the molecular interaction pattern of the anti-tumor action, molecular docking simulation was performed with Auto Dock Pyrx. Interaction studies of binding pose of eucalyptol with Caspase 3 were conducted to obtain an insight into the interacting amino acids and their inter-molecular bondings. Results:A prioritized list of target proteins associated with multiple forms of cancer and ranked by their Fit Score (Pharm Mapper) and descending 3D score (Reverse Screen 3D) were obtained from the two independent inverse screening platforms. Molecular docking studies exploring the bioactive principle targeted action revealed that H- bonds and electrostatic interactions forms the chief contributing factor in inter-molecular interactions associated with anti-tumor activity. Eucalyptol binds to the Caspase 3 with a specific framework that is well-suited for nucleophilic attacks by polar residues inside the Caspase 3 catalytic site. Conclusion:This study revealed vital information about the poly-pharmacological anti-tumor mode-of-action of essential oils in cardamom. In addition, a probabilistic set of anti-tumor targets for cardamom was generated, which can be further confirmed by in vivo and in vitro experiments.

• 한국직업건강간호학회지
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• 제25권1호
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• pp.9-18
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• 2016

Purpose: This study was conducted to identify the factors affecting container terminal worker's recovery experience from job stress. Methods: The subjects were 299 workers from one S dock in P city. Data were collected from April 5 to June 5, 2015 and analyzed by SPSS/WIN 18.0 program using descriptive statistics, t-test, ANOVA, $Sheff{\acute{e}}$ test, Pearson's correlation coefficients, and logistic regression. Results: The mean scores of job stress, ego-resilience, and recovery experience from job stress were 47.18, 46.90, and 49.17 respectively. Recovery experience according to the general characteristics showed significant correlation between daily exercise. There was a significant negative correlation between recovery experience and job stress, and a positive correlation between recovery experience and ego-resilience. Recovery experience was 2.54 times higher for a high ego-resilience group than for a low ego-resilience group, and the group that exercised was 2.25 times higher, than the non-exercising group. The group with a low level of interpersonal conflict was 1.97 times higher, than a group with a high level of interpersonal conflict. Conclusion: Based on this study, intervention programs to increase ego-resilience, decrease interpersonal conflict, and encourage over 30-minute-daily exercise for in container terminal workers should be developed to improve recovery experience of job stress.

• Journal of Welding and Joining
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• 제33권4호
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• pp.44-49
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• 2015

The structural epoxy adhesive used in car body assembly needs the highest level of joint mechanical strength under lap shear, T-peel and impact peel conditions. In this study, the effect of nano functionalized block copolymer addition on the impact peel strength of epoxy adhesive was investigated. DSC analysis showed that the addition of nano functionalized block copolymer did not affect the curing reaction of epoxy adhesive. From single lap shear test, it was found out that the addition of nano functionalized block copolymer slightly decreased the cohesive strength of cured adhesive layer. The addition of nano functionalized block copolymer showed beneficial effect on T-peel strength by changing the adhesive failure mode to the mixed mode. However, the addition of nano functionalized block copolymer just decreased the room temperature impact peel strength. It was considered that the addition of nano functionalized block copolymer could have effect on disturbing the crack propagation only for the case of slow strain rate.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2010년도 추계 학술발표회
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• pp.124-143
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• 2010

Cofferdam is a temporary levee or dam structure built by using sheet pile or earth materials to prevent water infiltration during construction work of bridge, dam, harbour dock, or hydraulic structures in the river. In this regard, it is required to secure cutoff ability for dry work and workability for rapid installation and removal of the temporary dam or levee structures. In this paper, case studies for design and construction of cofferdam were performed, and water diversion method was briefed with some examples of cofferdam type as well. For the case study details of design and construction were reviewed based on cofferdams under construction related to 16 submerged weirs of "The 4-river restoration project" and dam type cofferdam respectively. From the review, it was known that the method for changing the water flow is selected based on the data from geological and geo-hydraulic site investigation in order to mitigate environmental effects by making sure if the design cross-sectional area of flow and maximum working days are sufficiently guaranteed. Finally, the primary findings and main conclusion derived are summarized that determination of applicable type of cofferdam should be checked by case study and meet design requirements such as water inflow control, constructability.

• 대한조선학회 특별논문집
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• 대한조선학회 2009년도 특별논문집
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• pp.97-106
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• 2009

Many production methods are tried to enhance the productivity efficiency. Parallel connected floating cranes are one of the examples to lift mega-blocks quickly and efficiently. However, a general operation manual to operate parallel connected floating cranes and a method to consider risks during lifting operation are not confirmed. And if each floating crane is operated by itself, it is very hard to cooperate. Therefore, Synchronized operation system is installed to control parallel connected floating cranes simultaneously and to be informed of each floating cranes data. And weighting factor is calculated by considering all hazards during the operation and the general operation manual is confirmed based on the factor. This paper introduces the procedure for lifting operations by parallel Connected Floating Cranes using synchronized operation system, and its applications to lifting operation of a heavy cargo such as barge lifting test, floating dock installation and 900 ton goliath crane replacement operation, etc.

• 한국실내디자인학회논문집
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• 제25권5호
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• pp.42-54
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• 2016

The purpose of this study is to provide a reference for stage planning by analyzing current state of major theaters' stage space and understanding feedback from directors belonged to theaters. Each room in total 18 theaters' stage facilities was measured and their usage and requirements were analyzed on the spot. In addition, each director provided their experiential knowledge about appropriate stage composition for musical performance. The findings are as follow: under stage machinery is not needed for musical. Tour teams prefer to use their own show-deck for set conversion. On the other hand, over stage flying system needs to be able to deal with dense, fast, and accurate scene change. The size and location of the motor room needs to be carefully considered. The number of set battens is directly linked up with the size of the motor room, which should be located lower than the gridiron. As stage sets get bigger and complicated, the number of works at the gridiron is also increasing. The grating floor has to have enough strength coping with machines lifting heavy sets. Most sound control for musical performance is being done at F.O.H. these days rather that in the sound control room. It should equip enough work area and related infra especially for tour teams. 1st gallery needs to have enough effective width, power infra for lighting fixture, and strong guardrail. Lastly, the whole process of parking-unloading-transporting equipments and sets from loading dock to stage and vice versa needs to be efficient, and this has to be carefully considered from early stage of planning.

• Structural Engineering and Mechanics
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• 제23권3호
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• pp.293-308
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• 2006

This paper presents a complete and consistent formulation to study the seismic response of a free-standing ship supported by an arrangement of n keel blocks which are all located in a dry dock. It is considered that the foundation of the system is subjected to both horizontal and vertical in plane excitation. The motion of the system is classified in eight different modes which are Rest (relative), Sliding of keel blocks, Rocking of keel blocks, Sliding of the ship, Sliding of both keel blocks and the ship, Sliding and rocking of keel blocks, Rocking of keel blocks with sliding of the ship, and finally Sliding and rocking of keel blocks accompanied with sliding of the ship. For each mode of motion the governing equations are derived, and transition conditions between different modes are also defined. This formulation is based on a number of fundamental assumptions which are 2D idealization for motion of the system, considering keel blocks as the rigid ones and the ship as a massive rigid block too, allowing the similar motion for all keel blocks, and supposing frictional nature for transmitted forces between contacted parts. Also, the rocking of the ship is not likely to take place, and the complete ship separation from keel blocks or separation of keel blocks from the base is considered as one of the failure mode in the system. The formulation presented in this paper can be used in its entirety or in part, and they are suitable for investigation of generalized response using suitable analytical, or conducting a time-history sensitivity analysis.