• 대한화장품학회지
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• 제28권1호
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• pp.135-149
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• 2002

To date, research on the regulation of melanogenesis has focused on factors which affect tyrosinase, the rate-limiting enzyme in the melanogenic pathway, by searching for chemicals which competitively inhibit tyrosinase function. Many types of tyrosinase inhibitors have been developed, but no satisfactory results have been made clinically until now, To find a new whitening agent, which effectively inhibits melanogenesis, we synthesized several compounds and selected compounds by cell-based assay system. Finally, 3, 4, 5-trimethoxy cinnamaie thymol ester(TCTE, Melasolv) was selected and the effects of TCTE on melanogenesis were investigated. Treatment of mouse-derived melanocyte melan-a cells with TCTE results in a marked down-regulation of tyrosinase activity. 80% decrease of tyrosinase activity occurs with 30uM TCTE treatment for 72 hours without affecting cell growth. The inhibition of tyrosinase activity is dose-dependent and melanin content was also decreased to 40%. From the in vitro tyrosinase assay using cell extract, TCTE does not act as a direct inhibitor of the enzyme. Treatment of melan-a cultures with TCTE blocks the increase in tyrosinase activity by either forskolin, 3-isobutyl-1-methtyl-xanthine. TCTE decreased the expression of tyrosinase, TRP-1 without effects on TRP-2 protein expression through the down regulation of tyrosinase and TRP-1 mRNA. From the results of cAMP immunoassays, intracellular levels of the cyclin nucleotide are unaffected in cells treated with TCTE. The inhibitory effects of melanin synthesis were also shown in reconstitute human epidermis model by topical application. These findings suggest that TCTE can be used for studying the regulation of melanogenesis and depigmenting agent.

• 대한의용생체공학회:의공학회지
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• 제40권3호
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• pp.116-124
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• 2019

The rehabilitation training robots for treating the upper limbs of stroke patients were mainly focused on the upper proximal treatment of it, but recently studies of the distal parts of the upper limbs for rehabilitation of the hand is making some progress even though it is still a small number so far. In this paper, we present the hand robot for the rehabilitation training of stroke patients that is the fingertip contact-typed mechanism, and it has also equipped with the wrist rehabilitation unit to be worked like human hand that enables any movements through mutual cooperation by fingers while picking up or grasping objects. The robot that is presented for this purpose supports the movement of fingers with 5-DoF and the wrist with 3-DoF that moves independently, and operates with a structure that allows the joints of the wrist and fingers to be collaborated organically together to each other. Also, hereby the simulation and evaluation test on its robot mechanism are performed to ensure that fingers with 5-DoF and the wrist with 3-DoF of the serial kinematical mechanism are designed to comply with or exceed ROM for ADL.

• Plant Resources
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• 제3권3호
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• pp.219-222
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• 2000

For the purpose of establishing an efficient propagation through airlift bioreactor system of Zingiber of officinale Rosc. Korean native Seosanjong, the effect of different factors and bioreactor on cultured plantlets were investigated. The highest number of plantlets, fresh weight per plant was obtained from explants when cultured in MS liquid medium including 0.3 mg/L NAA and 2.0 mg/L kinetin for 40 days. A 10 L bottle type bubble bioreactor, compared with 250 mL Erlenmeyer flask, was more efficient, producing 4.7 plantlets or from 1.5 to 1.6 times more than did the Erlenmeyer flask. The results demonstrate the rapid mass propagation of airlift bioreactor to produce normal ginger.

• Parasites, Hosts and Diseases
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• 제42권1호
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• pp.1-6
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• 2004

The present study was undertaken to investigate the infection status of Cryptosporidium parvum in the villagers and the reservoir hosts in several rural areas in Korea. A total 5,262 fecal samples were collected from the inhabitants residing at Gangwon-do, Chungcheongbuk-do, Jeollanam-do, and Gyeongsangnam-do between the dates of September, 2001 to June, 2002. In addition, 1,453 fecal samples were collected from livestock reared in Gokseong-gun, Jeollanam-do and Chungju-si, Chungcheongbuk-do. All the fecal smears were prepared by formalin-ether sedimentation, and examined by light microscopy after modified acid-fast staining. The overall positive rate of human cryptosporidiosis was 3.3%. Gokseong-gun, Jeollanam-do showed a 8.2% positive rate and appeared as the highest endemic area among the surveyed areas. Haman-gun, Gyeongsangnam-do showed a 0.4% positive rate and was the lowest endemic area. The positive rate of livestock infection in Gokseong-gun, Jeollanam-do was 94%, which was more than ten times higher than that of Chungju-si, Chungcheongbuk-do (9.3%). From these results, it was revealed that cryptosporidiosis was an endemic disease in some rural areas of Korea, and the livestock could be an important source of human infection.

• 한국분말야금학회:학술대회논문집
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• 한국분말야금학회 2006년도 Extended Abstracts of 2006 POWDER METALLURGY World Congress Part2
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• pp.1112-1113
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• 2006

The perovskite- type oxide $(ABO_3)$ containing transition metals on the B-site show mixed (electronic/ionic) conductivity. These mixed-conductivity oxides are promising materials for oxygen permeating membranes. The main objective of this research work is to synthesize and characterization ceramic powders of the Sr-Co-Fe-O system for methane conversion using membrane reactor. SCFO powders were synthesized from the route was based on the complex method of combination of acid EDTA and citrate and shown be available by control efficient of synthesis to performed $SrCo_{0.8}Fe_{0.2}O_{3-\delta$, moreover, it presented easy implementation, reproducibility and operation. Powder ceramic was characterized by XRD, microscopic optic, SEM and TG-DTA.

• 한국균학회지
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• 제41권2호
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• pp.91-96
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• 2013

기존 큰느타리버섯 품종의 단점을 개선하고자 단교배를 통하여 여러 가지 형질을 복합적으로 지니는 품종을 육성하고자 애린이와 나 계통을 모본으로 선택하고, 이들 계통으로부터 유래한 단핵균사간의 단교잡을 실시하였다. 애린이10${\times}$나5계통이 수확량, 생육소요일수, 전체적인 모양에서 다른 계통보다 우수하였고 이 계통을 애린이 3으로 명명하였다. 애린이 3은 큰느타리2호보다 수확일이 2~3일 빠르고, 수확량도 110.5 g으로 기존품종의 108%수준이었다. 갓직경과 대두께의 비율은 1.8로 기존품종의 2.1보다 우수하여 수확이나 유통시 버섯의 손상이 적을 것으로 사료된다. 소비자에 대한 맛과 구매의향 조사에서 육성계통은 31.4%가 매우우수, 53.3%가 우수로 평가한 반면 기존 품종은 20.7%가 매우우수, 34.8%가 우수로 판정하였다. 구매의향도 총 86.9%가 높음 이상이어서 기존 품종의 46.8%보다 높아 시장성이 높을 것으로 사료된다.

• 공업화학
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• 제20권4호
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• pp.370-374
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• 2009

용존산소농도(DO)와 pH를 동시에 검출하기 위하여 이중층 광학 센서 막을 제조하였다. DO 민감성 염료인 Rudpp를 MTMS 졸-겔에 혼합하고 24-웰 마이크로타이터 플레이트에 코팅하였다. DO-검출층 위에 HPTS와 혼합된 GA 졸-겔용액을 코팅하고 pH 측정을 위해 사용하였다. 이중층 광학 센서 막은 온도와 이온 강도에 영향을 받았다. 또한 DO와 pH 이중층 광학 센서 막은 미생물발효공정에 온라인 모니터링 하는데 응용하였으며 좋은 성능을 보였다.

• 한국안전학회지
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• 제27권3호
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• pp.182-188
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• 2012

In this study we analyzed carbon emissions of leaves of a Pinus densiflora which is vulnerable to a forest fire using the cone calorimeter in order to analyze greenhouse gas emissions from forest fires depending on region and altitude. Fuels were collected from 9 regions[Hongcheon(Gangwon-do), Chungsong(Gyeongbuk-do), Yanhpyeong (Gyeonggi-do), Jecheon(Chungchongbuk-do), Gongju(Chungcheongnam-do), Wuju(Jeollabuk-do), Youngam(Jeollanam-do), Busan and Jeju-do)] and 9 altitudes(80 m, 450 m, 900 m, 1000 m, 1100 m, 1200 m, 1300 m, 1400 m and 1500 m) and then, carbon dioxide and carbon monoxide emissions contained in a weight of 50 g of fuel were analyzed. According to the results, there were differences in carbon emissions by regional groups, as the average carbon dioxide and carbon monoxide emissions in 9 regions were nearly 43.5929 g to 52.8868 g, and 0.8842 g to 3.6422 g, respectively. Busan and Jecheon had relatively higher carbon dioxide emissions and especially, Busan had 1.23 times higher carbon dioxide emissions than Jeju-do. Also, Gongju, Chungcheongnamo Province and Busan had relatively higher carbon monoxide emissions and especially, Gongju and Pusan had relatively higher carbon monoxide emissions and especially, Gongju had 4.12 higher carbon monoxide emissions than Hongcheon. In addition, there were differences in carbon emissions too depending on altitude, since carbon dioxide and carbon monoxide emissions in 9 altitudes were respectively, 40.7015 g to 68.9297 g and 1.3923 g to 12.2918 g. At the altitude of 80m, carbon dioxide and carbon monoxide emissions were respectively, 68.9297 g and 12.2918 g, and at the altitude of 450m, carbon dioxide and carbon monoxide emissions were respectively, 65.5115 g and 11.2497 g. These results show that pine trees at the lower altitude discharge relatively more carbon. It is considered that this analysis on carbon emissions depending on region and altitude can be effectively used for predicting greenhouse gas emissions and establishing statistical data from forest fires in each region and altitude.

• International Journal of Advanced Culture Technology
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• 제10권3호
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• pp.33-38
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• 2022

Gyeongsangnam-do needed an employment stability response policy to induce re-employment of job seekers who retired due to large-scale unemployment and job instability following the employment crisis, and stable settlement and long-term employment after new employment.This study is to confirm the effective corporate support policy as an employment promotion strategy through new recruitment of the employment crisis in Gyeongsangnam-do. A total of 380 companies in Gyeongsangnam-do were targeted for the survey through online surveys and in-person surveys. As a result of the study, as a measure to improve working conditions through financial support for long-term employment stability, first, support for youth-middle-age asset formation of SME workers is required, and second, support for old-age income guarantee for SME workers was proposed. Third, direct corporate subsidies are continuously needed for job promotion and job stability of Gyeongsangnam-do companies.

• 한국멀티미디어학회논문지
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• 제15권6호
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• pp.711-721
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• 2012

본 연구의 목적은 "로봇의 시각"과 "로봇의 촉각"을 대체할 수 있는 스테레오 비전 기반 햅틱스 시스템에서 가장 적합하고 효과적인 3D 재구성(3D reconstruction) 방법을 제안하는 것이다. 삼차원 영상에 대하여 정확하게 촉감을 전달하려면 스테레오 영상에서 사물의 깊이 정보와 사물의 경계면에 대한 정확한 정보가 필요하다. 본 연구에서는 스테레오 영상에서 사물의 깊이 정보를 정확하게 얻기 위하여 전통적인 스테레오 정합과정에 경계면 추출 방법인 LoG(Laplacian of Gaussian) 방법과 DoG(Difference of Gaussian) 방법을 혼합적용하여 3D 영상을 재구성한 결과를 제시한다. 또한 어떤 방법이 햅틱 렌더링을 적용하는데 유용한 지 검증하기 위하여 연산 시간 및 오차 분석 실험을 수행한 결과, 본 연구처럼 비주얼 렌더링에 햅틱 렌더링을 추가하여 사용하는 경우에는 잡음 감소와 경계면 추출 성능이 더 우수한 DoG 방법이 더 효율적인 것으로 판단되었다. 본 논문에서 제안하는 스테레오 비전 기반 햅틱스 시스템을 위한 3D 재구성 방법은 이동형 정찰 로봇의 성능을 높이는 연구 등 여러 산업 분야와 군사 분야에 응용이 가능할 것이다.