• Environmental Analysis Health and Toxicology
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• v.19 no.4
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• pp.359-366
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• 2004

Iron (Fe) is an essential metal in biological processes, which maintains a homeostasis in the human body. Divalent metal transporter 1 (DMT1) has been known as an iron transporting membrane protein, which is involved in the uptake Fe at the apical portion of intestinal epithelium, and may transport Fe across the membrane of acidified endosome in peripheral tissues. In this study, we studied the tissue distribution of DMT1 in the Fe supplemented (FeS) diet fed rats, and the regulation of DMT1 expression by depleting body Fe. Sprague-Dawley rats were divided into two groups, and fed FeS (120 mg Fe/kg) diet or Fe deficient (FeD, 2∼6 mg Fe/kg) diet for 4 weeks. The evaluation of body Fe status was monitored by measuring sFe, UIBC and tissue Fe concentration. Additionally, DMT1 mRNA levels were analyzed in the peripheral tissues by using the quantitative real time RT-PCR method. In the FeS diet fed rats, the tissue Fe was maintained at a relatively high level, and DMT1 was eventually expressed in all tissues studied. DMT1 was highly expressed in the testis, kidney and spleen, while a moderate levels of DMT1 expression was detected in the brain, liver and heart. In the digestive system, the highest level of DMT1 was found in the duodenum. Feeding the FeD diet caused a reduced body weight gain and depletion of body Fe with finding of decreased sFe, increased UIBC and decreased tissue Fe concentration. The depletion of body Fe upregulated DMT1 expression in the peripheral tissue. The expression of DMT1 was very sensitive to the body Fe depletion in the small intestine, especially in the duodenum, showing dramatically higher levels in the FeD rats than those of the FeS group. In the FeD diet fed animals, the expression of DMT1 was low significantly in other tissues compared with the duodenum. The expression of DMT1, however, was 60∼120% higher in the testis, kidney and spleen, and 30∼50% higher in the lung, liver and heart, compared to the FeS diet fed rats. In summary, DMT1 expression was ubiquitous in mammalian tissue, and the level of expression was the organ-dependent. The expression of DMT1 in peripheral tissues was upregulated by depletion of body Fe. Duodenum was the most sensitive tissue among organs studied during Fe depletion, and expressed the greatest level of DMT1, while other tissues were less higher than in duodenum. This study supports that DMT1 plays a role in maintaining the body Fe level through intestinal uptake as well as homeostasis of Fe in the peripheral tissue.

• Journal of the Korean Geotechnical Society
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• v.20 no.5
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• pp.17-25
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• 2004

The flat dilatometer test (DMT) is a geotechnical tool to estimate in-situ properties of various types of ground materials. The undrained shear strength is known to be the most reliable and useful parameter obtained by DMT. However, the existing relationships which were established for other local deposits depend on the regional geotechnical characteristics. In addition, the flat dilatometer test results have been interpreted using three intermediate indices - material index $(I_D)$, horizontal stress index $(K_D)$, and dilatometer modulus (E$_{D}$) and the undrained shear strength has been estimated merely using the horizontal stress index $(K_D)$. In this paper, the applicability of the flat dilatometer to Korean soft clay deposit has been investigated. Then an artificial neural network was developed to evaluate the undrained shear strength by DMT and the ANN, based on the $p_0, p_1, p_2, {\sigma '}_v$ and porewater pressure. The ANN which adopts the back-propagation algorithm was trained based on the DMT data obtained from Korean soft clay. To investigate the feasibility of ANN model, the prediction results obtained from data which were not used to train the ANN and those obtained from existing relationships were compared.

• Journal of the Korean Geotechnical Society
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• v.23 no.1
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• pp.67-76
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• 2007

Flat DMT penetration was analyzed using a finite element model based on a large strain formulation. The ABAQUS/Explicit, a commercial finite element method, was used to study the flat DMT penetration in soils. Then, because the very large mesh distortion occurred due to the penetration of flat DMT, the adaptive meshing technique was utilized to maintain a high quality mesh configuration. The undrained shear strength obtained from the flat DMT is estimated using only the horizontal stress index ($K_{D}$) and so it became necessary to examine using the analysis results obtained from the penetration of the flat DMT. Analysis results show that in normally consolidated region of $K_{D}=2$, the results obtained from the correlations proposed by Marchetti show good agreement with those estimated from the finite element method. The present analysis also shows that in overconsolidated region of $K_{D}>2$, the results obtained from the relationships proposed by Kamei and Iwasaki show good agreement with those provided by the penetration analysis.

• Biomolecules & Therapeutics
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• v.13 no.1
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• pp.1-6
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• 2005

Lead and cadmium are potent environmental toxicants that affect populations living in Europe. Americas, and Asia. Identifying transporters for lead and cadmium could potentially 1 help us better understand possible risk factors. The iron transporter, divalent metal transporter 1 (DMT1), mediates intestinal transport of cadmium, and lead in yeast and fobroblasts overexpressing DMT1. In human intestinal cells knocking down expression of DMT1 attenuated uptake of cadmium and iron but not lead. A possible explanation is the expression of a second transporter for lead in intestine. In astrocytes, however, DMT1 appears to transport lead in an extracellular buffer at pH value. At neutral pH, transport was not mediated by DMT1 but rather by a transporter that is stimulated by bicarbonate and inhibited by 4,4'-diisothiocyanatodihydrostilbene-2,2'-disulfonic acid. The identity of this lead transporter will beverified by future study.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2004.11a
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• pp.50-61
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• 2004

Lead and cadmium are potent environmental toxicants that affect populations living in Europe, Americas, and Asia. Identifying transporters for lead and cadmium could potentially 1 help us better understand possible risk factors. The iron transporter divalent metal transporter 1(DMT1) mediates intestinal transport of cadmium, and lead in yeast and fibroblasts overexpressing DMT1. In human intestinal cells knocking down expression of DMT1 attenuated uptake of cadmium and iron but not lead. A possible explanation is the expression of a second transporter for lead in intestine. In astrocytes, however, DMT1 appears to transport lead in an extracellular buffer at pH value. At neutral pH, transport was not mediated by DMT1 but rather by a transporter that is stimulated by bicarbonate and inhibited by 4,4'-diisothiocyanatodihydrostilbene-2,2'-disulfonic acid. The identity of this lead transporter is under study.

• Journal of Communications and Networks
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• v.12 no.1
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• pp.11-18
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• 2010

Diversity-multiplexing tradeoff (DMT) is an efficient tool to measure the performance of multiple-input and multiple-output (MIMO) systems and cooperative systems. Recently, cooperative multicast system with wireless network coding stretched tremendous interesting due to that it can drastically enhance the throughput of the wireless networks. It is desirable to apply DMT to the performance analysis on the multicast system with wireless network coding. In this paper, DMT is performed at the three proposed wireless network coding protocols, i.e., non-regenerative network coding (NRNC), regenerative complex field network coding (RCNC) and regenerative Galois field network coding (RGNC). The DMT analysis shows that under the same system performance, i.e., the same diversity gain, all the three network coding protocols outperform the traditional transmission scheme without network coding in terms of multiplexing gain. Our DMT analysis also exhibits the trends of the three network coding protocols' performance when multiplexing gain is changing from the lower region to the higher region. Monte-Carlo simulations verify the prediction of DMT.

• 전자공학회논문지 IE
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• v.45 no.1
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• pp.24-30
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• 2008

In this paper, Digital MultiTone(DMT) is an emerging multi-carrier modulation scheme, which has been adopted for VDSL(Very high speed Digital Subscribe Line). A problem of DMT is its sensitivity to frequency offset between the transmitted and received carrier frequencies. This frequency offset introduces inter-carrier interference(ICI) in the DMT symbol. This paper is proposed an ICI cancelation scheme using Kalman Filtering. The performance of the proposed method is compared with conventional methods in terms of bit error rate performance, bandwidth efficiency, and computational complexity. Through simulations, it is shown that for high values of the frequency offset and for higher order modulation schemes, the EKF(Enhanced Kalman Filtering) method perform better than the others.

• Journal of the Korean Applied Science and Technology
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• v.26 no.3
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• pp.317-327
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• 2009

In this study DMT(Dimethylterephthalate), NDC(Dimethyl-2, 6-Naphthalene Dicarboxylate) were used to synthesize polyester polyol which shows enhanced storage stability, improved flame retardancy, and good compressive strength. If DMT and NDC react respectively with DEG(Diethylene Glycol) which is kind of linear diol, the obtained polyester polyols tend to crystallize easily after the reaction. In case of DMT, PA(Phthalic Anhydride) which has asymmetric structure was introduced to retard the crystallization. In case of NDC, DPG(Dipropylene Glycol) which has an methyl side chain was introduced to prevent the crystallization. It was found that to introduce DPG was much more effective method to prevent the crystallization than PA. NDC and DMT were reacted together with DPG for various compositions of NDC:DMT(8:2, 6:4, 4:6 mol ratio). The obtained NDC-DMT-DPG based polyester polyol showed improved flame retardancy, and good compressive strength with increasing the content of NDC.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2001.11a
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• pp.91-91
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• 2001

Nramp2, also known as DMT1 and DCT1, is a 12-transmembrane domain protein responsible for dietary iron uptake as well as metal ions such as lead, manganese, zinc, copper, nickel, cadmium, and cobalt. High expression of DMT1 increase lead uptake, and DMT1-dependent lead transport was H -dependent and inhibited by iron ions. The molecular mechanism of lead transport in CNS is as yet unknown. although interactions between iron and lead at the level of absorption have been known for some time. The process of lead uptake into astrocytes was not known yet. Nramp2 may mediate transport of heavy metal into astrocytes. We investigated whether Nramp2 mediate transport of lead into astrocytes. And we do whether Nramp2 was expressed highly by deprivation of iron in Astrocytes, and lead uptake into astrocytes was influenced by expression of Nramp2. Immortalized human fetal astrocyte(SV-FHA) cells were cultured in medium containing Dulbecco's modified Eagle's medium and treated with Deferoxamine. Northern blot analysis was done for determining mRNA level of DMT1 and lead uptake assay was done in incubation condition of pH 5.5 and 7.4.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.2A
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• pp.1-11
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• 2005

S-CDMA is the advanced physical layer modulation techniques of DOCSIS 2.0 specification. S-DMT is another challenging modulation technique for cable modem upstream channel due to the intrinsic robustness for fading and impulse noise. The BER performance of S-DMT and S-CDMA over the mixed channel model of AWGN and impulse noise were evaluated in comparison with TDMA. The mathematical BER derivation and the comparison of those three types of technique were performed based on the ${\varepsilon}-mixture$ non-Gaussian impulse noise model. The results of simulation show good compliance with those of analytic BER derivation. By the results of comparisons, it was verified that the performance of S-CDMA and S-DMT is almost the same, but the performance of S-DMT is far superior to that of TDMA at typical BER range of the practical data communications.