• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6513-6518
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• 2013

Background: To evaluate the treatment outcome and major late complications of all patients with recurrent nasopharyngeal carcinoma (NPC) treated with intracavitary brachytherapy (ICBT) in Hospital Kuala Lumpur. Materials and Methods: This retrospective study was conducted at the Department of Radiotherapy and Oncology, Hospital Kuala Lumpur, Malaysia. All patients with histologically confirmed recurrent NPC in the absence of distant metastasis treated in the period 1997-2010 were included in this study. These patients were treated with ICBT alone or in combination with external beam radiotherapy (EBRT). Treatment outcomes measured were local recurrence free survival (LRFS), disease free survival (DFS) and overall survival (OS). Results: Thirty three patients were eligible for this study. The median age at recurrence was 56 years with a median time to initial local recurrence of 27 months. Majority of patients were staged as rT1-2 (94%) or rN0 (82%). The proportion of patients categorised as stage III-IV at first local recurrence was only 9%. Twenty one patients received a combination of ICBT and external beam radiotherapy while 12 patients were treated with ICBT alone. Median interval of recurrence post re-irradiation was 32 months (range: 4-110 months). The median LRFS, DFS and OS were 30 months, 29 months and 36 months respectively. The 5 year LRFS, DFS and OS were 44.7%, 38.8% and 28.1% respectively. The N stage at recurrence was found to be a significant prognostic factor for LRFS and DFS after multivariate analysis. Major late complications occurred in 34.9% of our patients. Conclusions: Our study shows ICBT was associated with a reasonable long term outcome in salvaging recurrent NPC although major complications remained a significant problem. The N stage at recurrence was a significant prognostic factor for both LRFS and DFS.

• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1455-1461
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• 2015

Background: Young onset breast cancer (BC) has a worse outcome as compared to in the elderly. However, some studies have shown that BC in the elderly, despite indolent features, does also cause increase in mortality. In an attempt to compare clinic-pathological characteristics, BC subtypes and survival in patients with BC presenting at extremes of age, we performed a retrospective study. Materials and Methods: Patients were either ${\leq}40$ or ${\geq}70$ years old. Subtypes were defined using immunohistochemistry and histological grade. Chi-Square test was used for evaluation of categorical variables, and Kaplan-meier and log-rank for disease-specific survival (DSS) and disease free survival (DFS). Results: We analyzed 256 patients ${\leq}40$ and 366 patients ${\geq}70$. Younger patients presented with more aggressive disease, with less luminal A but more luminal B and triple negative (TN) subtype. With a median follow-up of 57.5 months, DFS at 5 years in younger patients was 72.3% vs 84.6% in the elderly (p=0.007). Luminal A and B disease presented with worse DFS in younger patients. The opposite was seen in the TN subgroup. Although we found no significant differences in DSS, older patients with TN tumors died of BC more frequently. This group also received less chemotherapy. Conclusions: Young patients present with more aggressive disease, this translating into worse DFS. However, elderly patients with TN disease represent a particular subpopulation with worse DFS and DSS, suggesting that chemotherapy should not be withheld only because of age.

• 한국가정과학회지
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• 제3권1호
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• pp.15-24
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• 2000

This study was performed to assess the extent of dietary diversity and nutrient intakes of Korean child-bearing women and to investigate the relationships between dietary diversity indices and nutrient intakes. A total of 91 women aged 18 to 48 years old participated. They were divided into four groups by age 15 subjects in teens, 20 in twenties. 32 in thirties and 24 in forties. Mean energy intake was 1638${\pm}$471㎉/day and it was low as 81.4% of the Korean RDA for energy. Mean intakes of folate, calcium and iron were also low as 81.7%. 72.6% and 57.2% of the RDAs. On the other hand, protein, vitamin A, thiamin, riboflavin and vitamin C were consumed close to or above the RDAs. It was obvious that the subjects in teens and twenties took less all of the nutrients as well as energy than those In thirties and forties. Mean nutrient adequacy ratio( MNAR) was 0.77 and showed a trend to raise with increasing age. Thus MNAR of the teens was the lowest and that of the forties was the highest among the age groups. The results in this study support the previous findings that nutrient intakes of women in teens and twenties were poorer compared to those in thirties and forties. Mean dietary diversity score( DDS) . dietary variety score(DVS) and dietary frequency score( DFS) were 4.1. 11.6 and 14.7. respectively. DVS and DFS of the teens and twenties were lower than those in thirties and forties. DDS significantly correlated to the intakes of energy and calcium only, however, DVS and DFS had significant relationships to the intakes of all nutrients. The MNAR significantly related to DVS and DFS. but not DDS. In conclusion, the intakes of energy, folate. calcium and iron of child-bearing women were not sufficient and their nutrient adequacy highly correlated with dietary diversity. It indicates that to consume various foods helps to enhance the nutritional status.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2006년도 춘계종합학술대회
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• pp.607-610
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• 2006

본 논문에서는 고속 주파수 도약과 높은 주파수 분해도 신호를 발생하는 디지털 주파수 합성기를 구현한다. 고속 주파수 도약과 미세한 도플러 주파수 보정을 위한 높은 주파수 분해도를 갖는 DDS 기술과 직접주파수 변환을 위한 광대역 PLL 기술을 적용하여 DVB-RCS 전송을 위한 전송 중간 주파수 신호를 직접 발생하는 주파수 합성기를 구현한다. $2.5\sim3.0GHz$ 대역의 500 MHz 사용 주파수 대역내에서 -50 dBc 이하의 스퓨리어스 신호 억압을 제공하고, 0.233 Hz의 세밀한 주파수 분해도와 125 ns 이하의 고속 주파수 도약 특성을 갖는 DFS구조를 갖는다. 또한 제작된 DFS는 광대역 사용주파수 영역에서 3 dB 이내의 이득 평탄도를 나타내었으며, 위상잡음은 1 KHz ???낵쩔【??? -75 dBc/Hz의 양호한 특성을 나타내었다.

• 한국정보통신학회논문지
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• 제11권2호
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• pp.223-228
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• 2007

본 논문에서는 고속 주파수 도약과 높은 주파수 분해도 그리고 광역 주파수 신호를 발생하는 디지털 주파수 합성기를 설계하고 구현한다. 고속 주파수 도약과 미세한 도플러 주파수 보정을 위한 높은 주파수 분해도를 갖는 DDS 기술과 직접 주파수 변환을 위한 광대역 PLL 기술을 적용하여 DVB-RCS 전송을 위한 전송 중간 주파수 신호를 직접 발생하는 주파수 합성기를 구현한다. $2.5{\sim}3.0$ GHz 대역의 500 MHz 사용 주파수 대역내에서 -50 dBc 이하의 스퓨리어스 신호 억압을 제공하고, 0.233 Hz의 세밀한 주파수 분해도와 125 ns 이하의 고속 주파수 도약 특성을 갖는 DFS구조를 갖는다. 또한 제작된 DFS는 광대역 사용주파수 영역에서 3 dB 이내의 이득 평탄도를 나타내었으며, 위상잡음은 1 KHz ?낵쩔【? -75 dBc/Hz의 양호한 특성을 나타내었다.

• Korean Journal of Radiology
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• 제20권4호
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• pp.569-579
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• 2019

Objective: To investigate the usefulness of computed tomography (CT) texture analysis (CTTA) in estimating histologic tumor grade and in predicting disease-free survival (DFS) after surgical resection in patients with hepatocellular carcinoma (HCC). Materials and Methods: Eighty-one patients with a single HCC who had undergone quadriphasic liver CT followed by surgical resection were enrolled. Texture analysis of tumors on preoperative CT images was performed using commercially available software. The mean, mean of positive pixels (MPP), entropy, kurtosis, skewness, and standard deviation (SD) of the pixel distribution histogram were derived with and without filtration. The texture features were then compared between groups classified according to histologic grade. Kaplan-Meier and Cox proportional hazards analyses were performed to determine the relationship between texture features and DFS. Results: SD and MPP quantified from fine to coarse textures on arterial-phase CT images showed significant positive associations with the histologic grade of HCC (p < 0.05). Kaplan-Meier analysis identified most CT texture features across the different filters from fine to coarse texture scales as significant univariate markers of DFS. Cox proportional hazards analysis identified skewness on arterial-phase images (fine texture scale, spatial scaling factor [SSF] 2.0, p < 0.001; medium texture scale, SSF 3.0, p < 0.001), tumor size (p = 0.001), microscopic vascular invasion (p = 0.034), rim arterial enhancement (p = 0.024), and peritumoral parenchymal enhancement (p = 0.010) as independent predictors of DFS. Conclusion: CTTA was demonstrated to provide texture features significantly correlated with higher tumor grade as well as predictive markers of DFS after surgical resection of HCCs in addition to other valuable imaging and clinico-pathologic parameters.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2002년도 하계종합학술대회 논문집(3)
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• pp.149-152
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• 2002

최근 인터넷 사용자가 늘어나면서 클러스터링 기반의 대형 서버가 등장하게 되었고 또한 분산파일시스템(DFS)에 대한 관심이 커지게 되었다. 기존 분산파일 시스템들은 파일시스템 측면의 많은 기능들이 제공되고 뛰어난 성능을 발휘하지만 사용자 인터페이스 및 관리 측면에서 본다면 미흡한 점이 많다. 본 논문에서는 분산파일 시스템의 종류와 플랫폼에 상관없이, 사용하기 쉬운 DFS Management System을 설계하고 구축한다. 전체 시스템 구조를 파악 할 수 있도록 GUI 환경을 제공하며, 모듈화/계층화 구조로 설계하는데 기존 DFS와 연동하기 위한 하부 통신모듈이 포함된다. 본 논문에서는 Java기반으로 DFS Management System을 구축하였으며, Coda DFS가 설치된 클러스터링 서버와 연동하여 시험하였다.

• 디지털콘텐츠학회 논문지
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• 제10권2호
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• pp.217-223
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• 2009

XScale PXA255 기반 Embedded Linux 환경에서 전력 소비를 줄이기 위해 DFS(Dynamic Frequency Scaling) 기법의 디바이스 드라이버를 제작하고 이 디바이스 드라이버가 포팅되어 있는 임베디드 타겟보드의 전력을 관리하기 위한 미들웨어 DFM(Dynamic Frequency Management)를 설계하고 구현하여 임베디드 시스템의 전력 소비를 감소하는 방법을 제시한다.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2005년도 한국컴퓨터종합학술대회 논문집 Vol.32 No.1 (B)
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• pp.595-597
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• 2005

본 논문에서는 자율 에이전트에 의해 미지의 공간을 탐사하는 실시간 그래프 탐색 알고리즘 DFS-RTA*와 DFS-PHA*를 제안하고 그 효율성을 비교한다. 두 알고리즘들은 모두 깊이-우선 탐색(DFS)을 기초로 하고 있으며, 직전 노드로의 빠른 후진(backtrack) 을 위해 각각 실시간 최단 경로 탐색 방법인 RTA*와 PHA*를 적용하는 것이 특징이다. 본 논문에서는 대표적인 3차원 온라인 게임 환경인 Unreal Tournament 게임과 지능형 캐릭터 에이전트인 KGBot를 이용한 실험을 통해 두 탐색 알고리즘의 완전성과 효율성을 분석해본다.

• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 2005년도 춘계학술대회
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• pp.222-231
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• 2005

본 논문에서는 자율 에이전트에 의해 미지의 공간을 탐사하는 실시간 그래프 탐색 알고리즘 $DFS-RTA^{\ast}$와 $DFS-PHA^{\ast}$를 제안하고 그 효율성을 비교한다. 두 알고리즘들은 모두 깊이-우선 탐색(DFS)을 기초로 하고 있으며, 직전 노드로의 빠른 후진(backtrack) 을 위해 각각 실시간 최단 경로 탐색 방법인 $RTA^{\ast}$와 $PHA^{\ast}$를 적용하는 것이 특징이다. 본 논문에서는 대표적인 3차원 온라인 게임 환경인 Unreal Tournament 게임과 지능형 캐릭터 에이전트인 KGBot를 이용한 실험을 통해 두 탐색 알고리즘의 완전성과 효율성을 분석해본다.