• 디지털융복합연구
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• 제11권3호
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• pp.115-126
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• 2013

이 연구의 목적은 정보시스템, PC 및 클라우드 컴퓨팅에 장착된 상용소프트웨어대비 공개소프트웨어 총소유비용 절감 정도가 어느 정도 되는지를 확인해 보는 것이었다. 이에 실제로 정부기관, 교육기관 및 민간업체의 정보시스템 분야 51개 업체, PC분야 18개 업체 그리고 클라우드 컴퓨팅 분야 6개 업체를 대상으로 정보시스템, PC 및 클라우드 컴퓨팅에 장착된 공개소프트웨어를 5년간 운영했을 때 소요되는 총소유비용 절감 비율을 전문가 서베이한 결과, (1)정보시스템 분야에서 DBMS, WAS, Web, OS 4개영역 평균 63.3%, (2)PC분야에서 OS, 문서프로그램, 백업 및 복구용, 스크린 캡쳐, 백신, 기타 6개 영역 평균 59.4%, (3)클라우드 컴퓨팅 분야에서 Virtualization, OS, WEM/WAS, DBMS, DFS, Cloud Management 6개 영역 평균 61.2%로 나타났다. 따라서 이 연구의 가장 큰 성과는 공개소프트웨어의 활용이 상용소프트웨어의 활용대비 총소유비용이 절감될 수 있음을 입증했다는 점이다. 그러나 이 연구의 결과는 공개소프트웨어의 활용이 회사 내부 인적 자산, 내부 프로세스의 효율성 향상, 경쟁력 강화 등 장점뿐만 아니라 진작 도움이 필요하거나 장애가 발생 시 기술지원을 받을 수 없다는 공개소프트웨어 이용에 대한 기술지원의 어려움 등 리스크도 동시에 내포하고 있음을 고려하여 해석해야 함을 잊어서는 안 될 것이다.

• 치위생과학회지
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• 제12권5호
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• pp.459-468
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• 2012

본 연구는 2011년 6월 10일~11일까지 유아기의 비만과 구강건강과의 관계에 대하여 조사 분석하였다. 연구대상은 강원도에 위치한 K어린이집의 유아 90명을 대상으로 설문조사와 구강검사를 실시하였다. 수집된 자료는 SPSS WIN 15.0프로그램을 이용하여 분석한 결과 다음과 같은 결론을 얻었다. 1. 유치우식경험자율은 56.7%이었으며, 유치우식유병자율은 42.2%로 나타났다. 2. 일반적 특성에 따른 유치우식경험율을 조사한 결과 연령이 증가할수록 유치우식경험율이 높게 나타났다. 3. 성장과 비만 정도에 따른 유치우식경험율을 조사한 결과, 신장이 100~110 cm, 체중이 25 kg 이상인 유아가 다른 유아보다 유치우식경험율이 높게 나타났으며, 110~115cm인 유아가 다른 유아보다 유치우식유병율이 높게 나타났다. 4. 일반적 특성에 따른 우식경험유치(면)수를 조사한 결과, 연령이 많은 유아일수록 우식경험유치수와 우식경험유치면수가 높게 나타났다. 5. 성장과 비만 정도에 따른 우식경험유치(면)수를 조사한 결과, 체중이 높은 유아일수록 우식경험유치수와 우식경험유치면수가 높게 나타났으며, 과체중인 유아일수록 우식유치수, 충전유치수, 우식경험유치수와 우식유치면수, 우식경험유치면수가 높게 나타났다. 비만과 치아우식증이 관련성이 있는 것으로 나타났으므로, 보육기관에서는 유아들이 올바른 식습관을 익히도록 유아, 부모(보호자), 보육교사를 대상으로 지속적인 구강보건교육을 통하여 효율적인 구강건강관리에 도움을 주어야 할 것이다. 또한 간식 선택에 있어서도 신중을 기해야 할 것으로 사료된다. 학령전기인 유아를 대상으로 체계적으로 구강보건사업을 실시하여 유치뿐만 아니라 영구치도 효율적으로 관리할 수 있도록 구강보건사업의 연계성을 높여야 할 것이다.

• 한국사회복지학
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• 제63권1호
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• pp.267-289
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• 2011

본 연구의 목적은 Antonak(1982)이 개발한 SADP and ATDP-O(Scale of Attitudes for Disabled Persons and Attitudes towards Disabled Persons Scale-Original)척도의 타당도를 검증하고 국내에서의 활용방안을 모색하는 것이다. 이를 위해 공무원, 의료인, 교사, 언론인, 장애인복지시설 종사자로 구성된 표적집단과 일반집단으로 구분한 비장애인 500명을 표집하여 척도의 타당도 및 신뢰도를 검증하고, 표적집단과 일반집단 간의 장애인에 대한 태도 차이를 비교하였다. 탐색적 요인분석 결과, 원 척도는 '염세주의-고정관념', '낙관주의-인권', '손상된 성격' 세 가지 차원의 15개 문항으로 정리되었고, 확인적 요인분석 결과, 재구성한 척도의 적합성은 수용할만한 수준(good/reasonable fit)인 것으로 나타났다. 전체척도의 Cronbach's ${\alpha}$ 값은 .8이 넘어 안정적인 신뢰도를 보였으며, DFS(Disability Factor Scale)와는 전반적으로 높은 수준에서 통계적으로 유의미한 상관관계를 나타내 수렴타당도가 확보되었다. 또한 표적집단이 일반집단보다 장애인에 대해 긍정적인 태도를 지닌 것으로 나타났다. 본 연구에서 타당도가 검증된 도구는 다양한 장애유형에 활용할 수 있도록 장애유형별 검증이 필요하며, 척도의 활용으로 장애인에 대한 태도를 개선하기 위한 임상적, 실천적 방안이 모색되어야 할 것이다.

• Journal of Breast Cancer
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• 제21권4호
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• pp.433-4341
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• 2018

Purpose: This study aimed to evaluate the effects of sentinel lymph node biopsy (SLNB) on recurrence and survival after neoadjuvant chemotherapy (NAC) in breast cancer patients with cytology-proven axillary node metastasis. Methods: We selected patients who were diagnosed with invasive breast cancer and axillary lymph node metastasis and were treated with NAC followed by curative surgery between January 2007 and December 2014. We classified patients into three groups: group A, negative sentinel lymph node (SLN) status and no further dissection; group B, negative SLN status with backup axillary lymph node dissection (ALND); and group C, no residual axillary metastasis on pathology with standard ALND. Results: The median follow-up time was 51 months (range, 3-122 months) and the median number of retrieved SLNs was 5 (range, 2-9). The SLN identification rate was 98.3% (234/238 patients), and the false negative rate of SLNB after NAC was 7.5%. There was no significant difference in axillary recurrence-free survival (p=0.118), disease-free survival (DFS; p=0.578) or overall survival (OS; p=0.149) among groups A, B, and C. In the subgroup analysis of breast pathologic complete response (pCR) status, there was no significant difference in DFS (p=0.271, p=0.892) or OS (p=0.207, p=0.300) in the breast pCR and non-pCR patients. Conclusion: These results suggest that SLNB can be feasible and oncologically safe after NAC for cytology-determined axillary node metastasis patients and could help reduce arm morbidity and lymphedema by avoiding ALND in SLN-negative patients.

• Journal of Breast Cancer
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• 제21권4호
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• pp.406-414
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• 2018

Purpose: T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) is an emerging immune response molecule related to T-cell anergy. There has been tremendous interest in breast cancer targeting immune checkpoint molecules, especially in the triple-negative breast cancer (TNBC). This study was designed to investigate TIM-3 expression on tumor infiltrating lymphocytes (TILs), its relationships with clinicopathological parameters and expression of programmed death receptor 1 (PD-1)/programmed death receptor ligand 1 (PD-L1), and its prognostic role. Methods: Immunohistochemistry on tissue microarray blocks produced from 109 samples of invasive ductal carcinoma type TNBC was performed with antibodies toward TIM-3, PD-1, PD-L1 and breast cancer-related molecular markers. Associations between their expression and clinicopathological parameters as well as survival analyses were performed. Results: TIM-3 was expressed in TILs from all 109 TNBCs, consisting of 17 cases (<5%), 31 cases (6%-25%), 48 cases (26%-50%), and 13 cases (>51%). High TIM-3 was significantly correlated with younger patients (p=0.0101), high TILs (p=0.0029), high tumor stage (p=0.0018), high PD-1 (p=0.0001) and high PD-L1 (p=0.0019), and tended to be associated with higher histologic grade, absence of extensive in situ components and microcalcification. High TIM-3 expression was significantly associated with a combinational immunophenotype group of high PD-L1 and high PD-1 (p<0.0001). High TIM-3 demonstrated a significantly better disease-free survival (DFS) (p<0.0001) and longer overall survival (OS) (p=0.0001), together with high TILs and high PD-1. In univariate survival analysis, high TIM-3 showed reduced relapse risk (p<0.0001) and longer OS (p=0.0003), together with high PD-1 expression. In multivariate analysis, high TIM-3 was statistically significant in predicting prognosis, showing better DFS (hazard ratio [HR], 0.0994; 95% confidence interval [CI], 0.0296-0.3337; p=0.0002) and longer OS (HR, 0.1109; 95% CI, 0.0314-0.3912; p=0.0006). Conclusion: In this study, we demonstrate that TIM-3 expression is an independent positive prognostic factor in TNBC, despite its association with poor clinical and pathologic features.

• Journal of Chest Surgery
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• 제51권6호
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• pp.376-383
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• 2018

Background: The aim of this study was to evaluate the outcomes of surgical resection in patients with radiographically noninvasive lung adenocarcinoma according to the surgical strategy. Methods: A retrospective study was conducted of 128 patients who underwent pulmonary resection for ground-glass opacity (GGO)-dominant nodules measuring ${\leq}2cm$ with a consolidation/tumor ratio ${\leq}0.25$ based on computed tomography between 2008 and 2015. The 5-year disease-free survival (DFS) rate and 5-year overall survival (OS) rate were analyzed. Results: Among the 128 patients, wedge resection, segmentectomy, and lobectomy were performed in 40 (31.2%), 22 (17.2%), and 66 patients (51.6%), respectively. No significant differences were found among the groups in the mean size of tumors (p=0.119), the rate of pure-GGO nodules (p=0.814), the consolidation/tumor ratio (p=0.695), or the rate of invasive adenocarcinoma (p=0.378). Centrally located tumors were more common in the lobectomy group (21.2%) than in the wedge resection (0%) or segmentectomy (0%) groups (p=0.001). There were no significant differences in the 5-year DFS rate (100%, 100%, 92.7%, respectively; p=0.76) or 5-year OS rate (100%, 100%, 100%; p=0.223) among the wedge resection, segmentectomy, and lobectomy groups. Conclusion: For radiographically noninvasive lung adenocarcinoma measuring ${\leq}2cm$ with a consolidation/tumor ratio ${\leq}0.25$, wedge resection and segmentectomy could be comparable surgical options to lobectomy.

• Korean Journal of Radiology
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• 제21권9호
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• pp.1077-1086
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• 2020

Objective: To evaluate the effect of perfluorobutane microbubbles (Sonazoid^®, GE Healthcare) on steam popping during radiofrequency (RF) ablation for treating hepatocellular carcinoma (HCC), and to assess whether popping affects treatment outcomes. Materials and Methods: The institutional review board approved this retrospective study, which included 90 consecutive patients with single HCC, who received percutaneous RF ablation as the first-line treatment. The patients were divided into two groups, based on the presence or absence of the popping phenomenon, which was defined as an audible sound with a simultaneous sudden explosion within the ablation zone as detected via ultrasonography during the procedure. The factors contributing to the popping phenomenon were identified using multivariable logistic regression analysis. Local tumor progression (LTP) and disease-free survival (DFS) were assessed using the Kaplan-Meier method with the log-rank test for performing comparisons between the two groups. Results: The overall incidence of the popping phenomenon was 25.8% (24/93). Sonazoid^® was used in 1 patient (4.2%) in the popping group (n = 24), while it was used in 15 patients (21.7%) in the non-popping group (n = 69). Multivariable analysis revealed that the use of Sonazoid^® was the only significant factor for absence of the popping phenomenon (odds ratio = 0.10, p = 0.048). There were no significant differences in cumulative LTP and DFS between the two groups (p = 0.479 and p = 0.424, respectively). Conclusion: The use of Sonazoid^® has a suppressive effect on the popping phenomenon during RF ablation in patients with HCC. However, the presence of the popping phenomenon may not affect clinical outcomes.

• Korean Journal of Radiology
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• 제22권4호
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• pp.652-662
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• 2021

Objective: To investigate the association between CT imaging features and survival outcomes in patients with primary invasive mucinous adenocarcinoma (IMA). Materials and Methods: Preoperative CT image findings were consecutively evaluated in 317 patients with resected IMA from January 2011 to December 2015. The association between CT features and long-term survival were assessed by univariate analysis. The independent prognostic factors were identified by the multivariate Cox regression analyses. The survival comparison of IMA patients was investigated using the Kaplan-Meier method and propensity scores. Furthermore, the prognostic impact of CT features was assessed based on different imaging subtypes, and the results were adjusted using the Bonferroni method. Results: The median follow-up time was 52.8 months; the 5-year disease-free survival (DFS) and overall survival rates of resected IMAs were 68.5% and 77.6%, respectively. The univariate analyses of all IMA patients demonstrated that 15 CT imaging features, in addition to the clinicopathologic characteristics, significantly correlated with the recurrence or death of IMA patients. The multivariable analysis revealed that five of them, including imaging subtype (p = 0.002), spiculation (p < 0.001), tumor density (p = 0.008), air bronchogram (p < 0.001), emphysema (p < 0.001), and location (p = 0.029) were independent prognostic factors. The subgroup analysis demonstrated that pneumonic-type IMA had a significantly worse prognosis than solitary-type IMA. Moreover, for solitary-type IMAs, the most independent CT imaging biomarkers were air bronchogram and emphysema with an adjusted p value less than 0.05; for pneumonic-type IMA, the tumors with mixed consolidation and ground-glass opacity were associated with a longer DFS (adjusted p = 0.012). Conclusion: CT imaging features characteristic of IMA may provide prognostic information and individual risk assessment in addition to the recognized clinical predictors.

• 품질경영학회지
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• 제39권1호
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• pp.131-140
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• 2011

Today, due to the global recession car sales have been decreased rapidly and auto makers are competing continuously to expand their market share. Automakers are struggling in order to secure competitive cost and quality through continuous cost reduction and quality innovation activities to win in the competition. In this situation, auto parts makers are trying to reinforce price competitiveness by reducing COPQ (Cost Of Poor Quality) in the mass production stages by securing the quality of components in advance from the design stage through DFSS (Design For Six Sigma) activities which is 6 sigma approach in the R&D field. However, auto parts makers have been undergone various confusion, feeling difficulties to get interrelationship among various activities. Thus, this study is going to suggest approach method for much more effective R&D activities by securing interrelationship between ISO/TS 16949 system established in the auto parts industry and DFSS activities.

• Architectural research
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• 제12권2호
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• pp.53-62
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• 2010

The purpose of this study is to examine design preferences for the sales spaces of duty-free shops (DFSs) by conducting image evaluations. The results will help improve quality by influencing designs for the construction, extension or remodeling of these shops. An image measurement method, the semantic differential method, was used to measure cognitive structure using photos of shops. Photos were collected of the DFS at Jeju Island, as well as photos of brand stores designed by architects. Two sets of 16 photos (32 different photos in all) were selected according to photo classification standards and design concepts, both decided by reviewing previous studies and related materials. The evaluation and survey were done by two sets of subjects: sales employees, who have experience and special knowledge of the evaluation of sales space; and students majoring in architecture. To strengthen the evaluation results, I conducted a preliminary survey and a main survey, verifying and complementing findings. 116 surveys were conducted, of which 14 were of poor quality and rejected, leaving and 102 to be analyzed. The collected surveys were statistically analyzed, using SPSS 12.0 for Windows. Reliability, image profile, factor and multi-dimensional scaling analyses were conducted. As a result, image evaluation structure and characteristics were obtained for sales spaces of DFSs, confirming the difference between them and other spaces.