• Journal of Veterinary Science
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• 제23권4호
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• pp.56.1-56.17
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• 2022

Background: At the therapeutic doses, diclofenac sodium (DFS) has few toxic side effects on mammals. On the other hand, DFS exhibits potent toxicity against birds and the mechanisms remain ambiguous. Objectives: This paper was designed to probe the toxicity of DFS exposure on the hepatic proteome of broiler chickens. Methods: Twenty 30-day-old broiler chickens were randomized evenly into two groups (n = 10). DFS was administered orally at 10mg/kg body weight in group A, while the chickens in group B were perfused with saline as a control. Histopathological observations, serum biochemical examinations, and quantitative real-time polymerase chain reaction were performed to assess the liver injury induced by DFS. Proteomics analysis of the liver samples was conducted using isobaric tags for relative and absolute quantification (iTRAQ) technology. Results: Ultimately, 201 differentially expressed proteins (DEPs) were obtained, of which 47 were up regulated, and 154 were down regulated. The Gene Ontology classification and Kyoto Encyclopedia of Genes and Genomes pathway analysis were conducted to screen target DEPs associated with DFS hepatotoxicity. The regulatory relationships between DEPs and signaling pathways were embodied via a protein-protein interaction network. The results showed that the DEPs enriched in multiple pathways, which might be related to the hepatotoxicity of DFS, were "protein processing in endoplasmic reticulum," "retinol metabolism," and "glycine, serine, and threonine metabolism." Conclusions: The hepatotoxicity of DFS on broiler chickens might be achieved by inducing the apoptosis of hepatocytes and affecting the metabolism of retinol and purine. The present study could provide molecular insights into the hepatotoxicity of DFS on broiler chickens.

• 한국식품영양과학회지
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• 제28권6호
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• pp.1380-1390
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• 1999

To assess the food intake and diet quality of preschool children in Pusan, dietary survey was conducted with 176 subjects using 24hr recall method. Diet quality was assessed by food group pattern, dietary diversity score(DDS), dietary variety score(DVS), and dietary frequency score(DFS). The total number of food items consumed was 307. The foods consumed most frequently were rice, Korean cabbage kimchi, milk and green onion. When investigating the consumption pattern of major six food groups, 38.1% of subjects consumed all six groups. Food group was missed in order of fruit(41.5%), sweet(19.9%), dairy(16.5), vegetable(4.5%) and meat(1.7%). The mean values of DDS, DVS, and DFS were 5.16, 13.82, and 16.07 re spectively. Persons who had higher DDSs also had higher DVSs(p<0.001). DDS, DVS and DFS correlated positively with NAR(nutrient adequacy ratio) and MAR(mean adequacy ratio) significantly. Associations between the NAR of most nutrients and MAR with DVS and DFS were higher than those between the NAR of most nutrients and MAR with DDS. People with DDS of above 6 or DVS of above 16 or DFS of above 21 met two thirds of recommended dietary allowance for nutrients. Based on the result of the food group intake, the food intake of subjects was not adequate, especially the fruit and dairy groups. When assessing the dietary quality of subjects using DDS, DVS and DFS, many people appeared not to have a desirable food intake.

• 한국환경과학회지
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• 제14권7호
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• pp.629-637
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• 2005

Polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) were investigated in soil and pine needle samples taken from 16 sites of industrial and residential areas in Changwon, Korea to assess their distribution levels and to suggest the influence of industrial activities, PCDDs/DFs levels in the soil samples ranged from 0.57 to 20.79 pg I-TEQ/g dry weight with a mean value of 4.20 pg I-TEQ/g dry weight. PCDDs/DFs levels in the pine needle samples ranged from 0.39 to 8.75 pg I-TEQ/g dry weight with a mean value of 4.09 pg I-TEQ/g dry weight. In both soil and pine needle samples, the PCDDs/DFs concentrations in the industrial area sites were higher than those in the residential area sites. Homologue profiles in pine needle samples showed different patterns compared with soil samples. Based on the results of principal component analysis (PCA), it was confirmed that pine needles reflected a direct influence from local potential sources of PCDDs/DFs, showing a much higher degree of reflection than in soils. Pine needles are very useful as an indicator for monitoring or estimating the contamination of PCDDs/DFs in other areas which have been impacted by point pollution sources.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2002년도 추계종합학술대회
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• pp.614-618
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• 2002

파일 공유를 위한 방법으로 FTP, NFS나 최근 P2P기술 등이 많이 제안되었지만, 현재까진 아직 FTP를 많이 사용하고 있다. 본 논문에서는 거의 기존 파일 전송 서비스 환경의 변경을 하지 않으면서도 고용량의 데이터를 보다 효율적으로 공유할 수 있는 방법으로써 Distributed File Server(DFS)방식을 제안한다. DFS의 특징은 기존 서버 클라이언트 방식의 FTP 환경을 변경하지 않고, 단지 다수의 서버들과 클라이언트 사이에 DFS를 설치함으로써 클라이언트에게 고용량 파일 저장 장소를 가진 FTP서버를 제공할 수 있다는 것이다. RedHat7.2 상에서 DFS 기능의 검증을 위한 프로토타입 구현을 통해 최근 대두되고 있는 고용량 데이터들로 인한 파일 시스템의 부족등의 문제점을 해결할 수 있음을 보였다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3075-3079
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• 2014

Background: The relationship between body mass index(BMI) and outcomes after chemoradiotherapy(CRT) has not been systematically addressed. The purpose of this study was to evaluate the effect of BMI on survival in patients with esophageal squamous cell carcinoma (ESCC). Materials and Methods: Sixty ESCC cases were retrospectively reviewed in this study. Patient overall survival(OS) and disease-free survival (DFS) were compared between two groups (BMI< $24.00kg/m^2$ and $BMI{\geq}24.00kg/m^2$). Results: There were 41 patients in the low/normal BMI group (BMI< $24.00kg/m^2$) and 19 in the high BMI group ($BMI{\geq}24.00kg/m^2$). No significant differences were observed in patient characteristics between these. We found no difference in 2-year OS and DFS associated with BMI (p=0.763 for OS; p=0.818 for DFS) using the Kaplan-Meier method. Univariate analysis revealed that higher clinical stage was prognostic for worse 2-year OS and DFS, metastasis for 2-year OS, lymph node status for 2-year DFS, while age, gender, smoking, drinking, tumor location and BMI were not prognostic. There were no differences in the 2-year OS (hazard ratio=1.117; p=0.789) and DFS(hazard ratio=1.161; p=0.708) between BMI groups in multivariate analysis, whereas we found statistical differences in the 2-year OS and DFS associated with clinical stage, gender and tumor infiltration (p<0.04), independent of age, smoking, drinking, tumor location, the status of lymph node metastases and BMI. Conclusions: BMI was not associated with survival in patients with ESCC treated with CRT as primary therapy. BMI should not be considered a prognostic factor for patients undergoing CRT for ESCC.

• 한국지구과학회:학술대회논문집
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• 한국지구과학회 2004년도 춘계학술발표회 논문집
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• pp.38-38
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• 2004

• 대한안전경영과학회지
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• 제19권4호
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• pp.63-76
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• 2017

This thesis provides background information on DFS carried out by the government in an effort to reduce the accident rate, cases of DFS in other advanced countries to study their risk detection, risk assessment, risk control measures, and cases in which application of DFS during the designing phase succesfully led to reduction of the accident rate. Till now, the focus has been on incident responses after the occurance of accidents, it describes the importance of considering safety during the desining process through safety results and cases.

• 지능정보연구
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• 제11권1호
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• pp.153-167
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• 2005

본 논문에서는 이동 로봇이나 자율 캐릭터 에이전트로 미지의 환경을 탐사하는 문제를 다룬다 전통적으로 공간탐사 문제를 해결하기 위한 연구노력들은 주로 그래프기반의 공간 표현법들과 그래프 탐색법들에 초점을 맞추어 왔다. 최근 들어, 공간탐사를 위한 가장 효율적인 그래프 탐색법들 중 최대 $min(mn, d^2+m)$에지들만을 탐색하는 EXPLORE알고리즘이 발견되었다. 이때 d는 그래프의 부족도(deficiency)를 나타내고, m은 그래프 에지들의 수를, n은 그래프 노드들의 수를 나타낸다. 본 논문에서는 자율 에이전트에 의해 미지의 공간을 탐사하는 실시간 그래프 탐색 알고리즘 DFS-RTA*와 DFS-PHA*를 제안한다. 두 알고리즘들은 모두 EXPLORE 알고리즘과 같이 깊이-우선 탐색(DFS)을 기초로 하고 있으며, 직전 노드로의 빠른 후진을 위해 각각 실시간 최단 경로 탐색 방법인 RTA*와 PHA*를 적용하는 것이 특징이다. 본 논문에서는 대표적인 3차원 온라인 게임 환경인 Unreal Tournament게임과 지능형 캐릭터 에이전트인 KGBot를 이용한 실험을 통해 두 탐색 알고리즘의 완전성과 효율성을 분석해본다.

• 분석과학
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• 제27권6호
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• pp.347-351
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• 2014

산업폐기물 소각장의 비산재와 바닥재에서 PCDDs와 DFs를 측정한 결과, 비산재에서 PCDDs와 DFs의 농도는 각각 4.5063과 13.004 ng-TEQ/g이었고 바닥재에서는 0.2367과 0.0993 ng-TEQ/g의 함유량을 보였다. 비산재 속에는 1,2,3,4,6,7,8-HpCDD, OCDD, 2,3,4,6,7,8-HxCDF, 2,3,4,7,8-PeCDF 동종체가 다량 함유되었고 바닥재에는 1,2,3,7,8-PeCDD와 2,3,4,7,8-PeCDF가 많았다.

• Radiation Oncology Journal
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• 제35권4호
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• pp.332-339
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• 2017

Purpose: This study aimed to evaluate the prognostic effects of lymphovascular invasion (LVI) in triple-negative breast cancer (TNBC) patients who underwent surgical resection. Materials and Methods: A total of 63 non-metastatic TNBC patients who underwent surgical resection were retrospectively investigated from 2007 to 2016 in Inje University Busan Paik Hospital. Pathological tests revealed that 12 patients (19.0%) had LVI. Approximately 61.9% (n = 39) of the patients' samples stained positive for p53. Additional chemotherapy and radiotherapy (RT) were performed in 53 (84.1%) and 47 (74.6%) patients, respectively. Results: The median follow-up period was 39.5 months (range, 5.9 to 123.0 months). The pathological T stage (p = 0.008), N stage (p = 0.014), and p53 positivity (p = 0.044) were associated with LVI. Overall, the 3-year disease-free survival (DFS) rate and overall survival (OS) rate were 85.4% and 90.2%, respectively. Ten patients (15.9%) experienced relapse. LVI (n = 12) was associated with relapses (p = 0.016). p53 positivity was correlated with poor DFS (p = 0.048). Furthermore, LVI was related to poor DFS (p = 0.011) and OS (p = 0.001) and considered as an independent prognostic factor for DFS (p = 0.039). The 3-year DFS of patients with LVI (n = 12) was only 58.3%. Adjuvant RT minimized the negative prognostic effect of LVI on DFS (p = 0.068 [with RT] vs. p = 0.011 [without RT]). Conclusion: LVI was related to the detrimental effects of disease progression and survival of TNBC patients. Thus, a more effective treatment strategy is needed for TNBC patients with LVI.