• 열병합발전
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• s.16
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• pp.5-9
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• 2000

• 열병합발전
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• s.74
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• pp.18-21
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• 2010

• IMMUNE NETWORK
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• v.5 no.1
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• pp.36-44
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• 2005

Background: The anti-tumor therapeutic effect of autologous tumor cell lysate pulseddendritic cells (DCs) was studied for non-immunogenic and immune suppressive lung cancer model. To test the possibility as an adjuvant therapy, minimal residual disease model was considered in mouse in vivo experiments. Methods: Syngeneic 3LL lung cancer cells were inoculated intravenously into the C57BL/6 mouse. Autologous tumor cell (3LL) or allogeneic leukemia cell (WEHI-3) lysate pulsed-DCs were injected twice in two weeks. Intraperitoneal DC injection was started one day (MRD model) after tumor cell inoculation. Two weeks after the final DC injection, tumor formation in the lung and the tumor-specific systemic immunity were observed. Tumor-specific lymphocyte proliferation and the IFN-${\gamma}$ secretion were analyzed for the immune monitoring. Therapeutic DCs were cultured from the bone marrow myeloid lineage cells with GM-CSF and IL-4 for 7 days and pulsed with tumor cell lysate for 18 hrs. Results: Compared to the saline treated group, tumor formation was suppressed in 3LL tumor cell lysate pulsed-DC treated group, while 3LL-specific immune stimulation was minimum. WEHI-3-specific immune stimulation occurred in WEHI-3 lysate-pulsed DC treated group, which had no correlation with tumor regression. Conclusion: The data suggest the possible anti-tumor effect of cultured DCs as an adjuvant therapy for minimal residual disease state of lung cancer. The significance of immune modulation in DC therapy including the possible involvement of NK cell as well as antigen-specific cytotoxic T cell activity induction was discussed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.11
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• pp.6767-6773
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• 2014

The study examined the effects of trunk pattern exercise in proprioceptive neuromuscular facilitation (PNF) integrated transcranial direct current stimulation (tDCS) on the muscle activity and balance, walking speed in stroke patient. Thirty-one patients with hemiplegia due to stroke were assigned to either the experimental group (n=15) or control group (n=16). Both groups performed trunk pattern training in PNF for 3 times per week over a 6 week period for 20 minutes per session. The experimental group performed additional tDCS for 20 minutes. A comparison of the two groups after the intervention showed that the exercise program in experimental group had a more significant on the gastrocnemius, tibialis anterior and balance than the control group (p<.05). This showed that trunk pattern exercise in PNF integrated tDCS had a positive effect on the functional recovery of the lower extremity in stroke patients.

• IMMUNE NETWORK
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• v.7 no.4
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• pp.197-202
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• 2007

Background: Immunomodulators enhancing MHC-restricted antigen presentation would affect many cellular immune reactions mediated by T cells or T cell products. However, modulation of MHC-restricted antigen presentation has received little attention as a target for therapeutic immunoregulation. Here, we report that lectins isolated from mushroom Fomitella fraxinea enhance MHC-restricted exogenous antigen presentation in professional antigen presenting cells (APCs). Methods: Lectins, termed FFrL, were isolated from the carpophores of Fomitella fraxinea, and its effects on the class I and class II MHC-restricted presentation of exogenous ovalbumin (OVA) were examined in mouse dendritic cells (DCs) and mouse peritoneal macrophages. The effects of FFrL on the expression of total MHC molecules and the phagocytic activity were also examined in mouse DCs. Results: DCs cultured in the presence of FFrL overnight exhibited enhanced capacity in presenting exogenous OVA in association with class I and class II MHC molecules. FFrL increased slightly the total expression levels of both class I (H-$2K^b$) and class II (I-$A^b$) MHC molecules and the phagocytic activity of DCs. Antigen presentation-enhancing activity of FFrL was also observed in macrophages isolated from mouse peritoneum. Conclusion: Lectins isolated from the carpophores of Fomitella fraxinea increase MHC-restricted exogenous antigen presentation by enhancing intracellular processing events of phagocytosed antigens.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.12 no.3
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• pp.78-86
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• 2013

A hybrid MIMO(Multi Input Multi Output) antenna which is operating both a monopole and a IFA(Inverted F Antenna) is designed. It's applied Vlade(Vertical lade) technique to reduce antenna space, and a diagonally fed MIMO antenna is designed on the bare board for the data communication. Return losses due to variables of antenna length are simulated for the design. Antenna for the hexa-frequency band of LTE700, CDMA, GSM, DCS, PCS and WCDMA is designed and implemented. This antenna is satisfied 3:1 VSWR over the whole design band by the measurement of return loss. And average gains and efficiencies were -3.67 ~ -2.53dBi and 42.06 ~ 55.84% for LTE700/CDMA/GSM frequency band, -3.27 ~ -1.21dBi and 47.08 ~ 75.6% for DCS/PCS/WCDMA frequency band. The isolation between 2 antenna that is one of important factors for the MIMO system was measured good performance as -8.14 ~ -25.77dB over the whole service band.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.22 no.7
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• pp.737-743
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• 2011

In this paper, we designed and implemented a Monopole+IFA(Inverted F Antenna) hybrid antenna using the coupled feeding structure for the all band mobile phone. Studied antenna has wide band characteristics by the simultaneous operation both monopole and IFA under the coupled feeding structure. An antenna has designed PCB embedded type without antenna carrier component for the low in cost. Implemented antenna has within 2.5:1 for VSWR under LTE/CDMA/GSM900/DCS/USPCS/WCDMA/WiBro/WiFi in all band for the mobile services Measured average gains and efficiencies were -3.98~-0.09 dBi and 40.03~97.99 % for the LTE, CDMA, GSM900 band, and -3.90~-1.01 dBi and 40.70~79.31 % for the DCS, USPCS, WCDMA, WiBro, WiFi band. It's shown that studied antenna can be applied to all band mobile phone antenna including LTE.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.20 no.11
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• pp.1194-1200
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• 2009

An internal antenna which has 1 cc volume was implemented on the FPCB(Flexible Printed Circuit Board) for the mobile phone. We increased antenna gain and efficiency by the applying of current direction concept on the antenna pattern for this small antenna. Short antenna length for the GSM band was compensated by the spiral inductor on the FPCB. For broadening bandwidth on GSM band, it's applied 2 spiral inductors. A conductor pattern for the DCS band was positioned perpendicular with the FPCB. Antenna was implemented on FPCB that is dielectric constant 4.4 and thickness 0.05 mm, and FPCB was attached on a carrier dimensioned $L{\times}W{\times}H=30{\times}7{\times}5\;mm$. Measurements showed that max. VSWR 2:1, efficiency 42.49~60.95 % and 47.95~73.21 %, average gain -3.72~-2.15 dBi and -3.19~-1.35 dBi on the GSM and DCS band, respectively. These results are good performances among the small antenna. And the radiation patterns are omnidirectional on the H-plane to both band.

• Asian-Australasian Journal of Animal Sciences
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• v.16 no.3
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• pp.380-383
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• 2003

The gas dilution technique was used to evaluate the possibility of estimating the volume of gaseous phase in the rumen from its composition in sheep given rice whole crop silage (RWS) or dent corn silage (DCS) at a level of maintenance (M) or 2 M, and in the course of fasting. The rumen gas composition was determined at 2 and 7.5 h after morning feeding. Nitrogen gas was injected by using an airtight syringe into the rumen immediately after collecting the rumen gas sample as a control. Then rumen gas samples were collected at 5, 10, 20, 40 and 60 min. after injection. Dry-matter intakes were $42g/kg^{0.75}$ and $57g/kg^{0.75}$ for DCS, and $36g/kg^{0.75}$ and $59g/kg^{0.75}$ for RWS, at 1 M and 2 M levels, respectively. Animals ingested both silages about 20% less than expected at 2 M level. The rumen gas composition did not differ significantly between 2 h and 7.5 h after feeding except for $N_2$. Content of $CO_2$ in gas composition was significantly higher at 2 M level than at 1 M (p<0.05) for both RWS and DCS, whereas $CH_4$ showed no significant difference between feeding levels. At both feeding levels, $CO_2$ showed a higher (p<0.05) percentage in DCS than RWS. A dilution technique by using $N_2$ injection is not appropriate for the determination of gas production in vivo, unless the rate of rumen gas turnover is considered. Changes in composition at fasting indicate that the rumen fermentation may reach the lowest level after 72 h fasting for sheep given silage as their sole diet.

• Journal of Biomedical Engineering Research
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• v.32 no.4
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• pp.305-311
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• 2011

For effective stimulation with tDCS, spatial focality of induced electrical field(EF) and current density(CD) is one of the important factors to be considered. Recently, there have been some studies to improve the spatial focality via different types of electrodes and their new configurations: some improvements using ring electrodes were reported over the conventional pad electrodes. However, most of these studies assumed isotropic conductivities in the head. In this work, we have investigated the effect of tissue anisotropy on the spatial focality of tDCS with the 4 + 1 ring electrode configuration via a 3-D high-resolution finite element(FE) head model with anisotropic conductivities in the skull and white matter. By examining the profiles of the induced EF from the head models with isotropic and anisotropic conductivities respectively, we found that the spatial focality of the induced EF significantly drops and get diffused due to tissue anisotropy. Our analysis suggests that it is critical to incorporate tissue anisotropy in the effective stimulation of the brain via tDCS.