• Applied Biological Chemistry
• /
• v.50 no.3
• /
• pp.192-197
• /
• 2007

3D-QSARs on the fungicidal activity of N-phenylbenzenesulfonamide and N-phenyl-2-thienylsulfonamide analogues (1-37) against Phytophthora blight (Phytophthora capsici) were studied quantitatively using CoMFA and CoMSIA methods. The statistical results of the optimized CoMFA (2) model ($r^2_{cv.}(q^2)$ = 0.692 & $r^2_{ncv.}$= 0.965) show better predictability and fitness than CoMSIA (2) model ($r^2_{cv.}(q^2)$ = 0.796 & $r^2_{ncv.}$= 0.958). The fungicidal activities according to the information of the optimized CoMFA (2) model were dependent upon the steric and electrostatic fields of the molecules. Therefore, from the contribution contour maps of CoMFA (2) model, it is expected that 63% contribution was caused by the steric bulk of meta-substituent ($R_1$) on the S-phenyl ring. Also, the other contribution level of 32.9% was represented by the positive charged $R_4-group$ ($R_1$) on the N-phenyl ring and para-substituent ($R_1$) on the S-phenyl ring. A series of higher active compounds, $R_1$= 3-decyl substituent ($pred.pI_50$= 5.88) etc. were predicted based on the findings.

• Proceedings of the IEEK Conference
• /
• 1999.11a
• /
• pp.833-836
• /
• 1999

In this paper, a wideband MMIC LNA was designed using low Q matching network. Gains of 9.8~12.2 ㏈, and noise figures of 1.7~2.1 ㏈ were obtained from the fabricated wideband MMIC LNA in the frequency ranges of 1.5~2.5㎓. And maximum output power of 10.83 ㏈m were obtained at the center frequency of 2 ㎓. The chip size of the fabricated wideband MMIC low noise amplifier is 1.4 mm$\times$1.4 mm.

• Proceedings of the KSAR Conference
• /
• 2001.03a
• /
• pp.48-48
• /
• 2001

A new neurological mutant has been found in the ICR outbred strain mouse. Affected mice display profound deafness and a head-tossing and bidirectional circling behavior, showing an autosomal recessive mode of inheritance. It was, therefore, named cir/Kr with the gene symbol cir. The auditory tests identified clearly the hearing loss of the cir mice when compared to wild type mice. Pathological studies confirmed the developmental defects in the middle ear, cochlea, cochlear nerve, and semicircular canal areas, which were correlated to the abnormal behavior observed in the cir mice. Thus, cir mice may be useful as a model for studying inner ear abnormalities and deafness. We have constructed a genetic linkage map by positioning 14 microsatellite markers across the (cir) region and intraspecific backcross between cir and C57BL/6J mice. The cir mouse harbors an autosomal recessive mutation on mouse chromosome 9. The cir gene was mapped to a region between D9Mit116 and D9Mit38 Estimated distances between cir and D9Mit116, and between cir and D9Mit38 are 0.7 and 0.2 cM, respectively. The gene in order was defines : centromere-D9Mit182-D9Mit51/D9Mit79/D9Mit310-D9Mit212/D9Mit184-D9Mit116-cir-D9Mit38-D9Mit20-D9Mit243-D9Mit16-D9Mit55/D9Mit125-D9Mit281. The mouse map location of the cir locus appears to be in a region homologous to human 3q21. Our present date suggest that the nearest flanking marker D9Mit38 provides a useful anchor for the isolation of the cir gene in a yeast artificial chromosome contig.

• Journal of Power System Engineering
• /
• v.11 no.1
• /
• pp.82-91
• /
• 2007

기존의 2차원 FDLB 모델(D2Q21)에서 비열비 ${\gamma}$는 공간의 차원수(D)에 의존한다. 즉, 2차원 공간의 계산에서는 ${\gamma}=(D+2)/D=2.0$밖에 취할 수 없으며, 공기와 같은 실체기체를 전산모사 하기에는 여러 어려움이 있다. 이러한 이유 때문에 문헌[1]의 LBM에서 제안된 조정 가능한 비열비 모델을 2차원 FDLB모델에 적용하여 자려발생 에지톤(edgetone)의 수치계산이 수행되었다. wedge의 선단각도가 ${\alpha}=23^{\circ}$(Case I) 및 $20^{\circ}$(Case II)를 갖는 2가지 모델이 설정되었으며, 노즐출구에서 wedge선단까지의 거리 w/d는 $3d{\sim}12d$사이에서 주어졌다. edgetone은 노즐로부터 나온 분류와 edge의 상호작용으로 이난 음압(sound pressure)의 차에 의해서 소음이 발생하며, 이 음압은 다시 상류의 분류에 영향을 미쳐 분류의 변동을 가져온다. w/d가 ??9d이하인 경우, 피드백(feedback) 메커니즘에 기인한 주기적인 운동이 발생하지만, w/d가 큰 ??9d이상인 경우에는 분류의 불안정성 때문에 규칙적인 분류의 운동은 보이질 않으며, 이는 기존의 연구결과들과 잘 일치함을 보였다. 본 연구에서 적용된 모델을 이용하여 공기와 같은 2원자 기체의 비열비 ??${\gamma}=1.4$를 갖는 유체에 있어서 공력 소음의 수치예측이 가능하다는 것을 확인하였다.

• Journal of Environmental Science International
• /
• v.12 no.8
• /
• pp.853-860
• /
• 2003

Plants sequester atmospheric CO$_2$, a major agent of climate change, during the growing periods and mitigate its rising accumulation in the atmosphere. Pinus densiflora and Quercus mongolica are the native tree species dominant in the temperate forests of Korea. This study quantified the annual CO$_2$ uptake by the two species at forest sites in Chuncheon in the middle of the country. The quantification was based on seasonal measurements of CO$_2$ exchange rates under natural conditions by an infrared gas analyzer over the growing season (1999). The monthly CO$_2$ uptake per unit leaf area ranged from 1.6-6.7 mg/d㎡/h for P. densiflora and from 3.7-8.9 mg/d㎡/h for Q. mongolica, with a maximum in mid-summer. An equation for each species was generated to estimate easily the annual CO$_2$ uptake by total leaf area per tree, which subtracted the CO$_2$ release (i.e. respiration) by leaves and woody organs from the gross CO$_2$ uptake (diurnal uptake and release by leaves). Annual CO$_2$ release by leaves and woody organs accounted for 58-73％ of the gross CO$_2$ uptake across tree specimens. Annual CO$_2$ uptake per tree increased with increasing dbh (stem diameter at breast height) for the study diameter range, and was greater for Q. mongolica than for P. densiflora in the same dbh sizes. This was mainly associated with a greater total leaf area in the former. For example, the annual CO$_2$ uptake by one tree with dbh of 25 cm was 35.6 kg/yr for P. densiflora and 47.9 kg/yr for Q. mongolica. The results from this study can be applied to evaluate an atmospheric CO$_2$ reduction of woody plants by forest type and age class.

• Journal of Korean Society of Environmental Engineers
• /
• v.31 no.4
• /
• pp.256-262
• /
• 2009

The use of hydrodynamic separator is becoming increasingly popular for suspended solids reduction in urban storm runoff. This study is a laboratory investigation of the use of Vortex Screen to reduce the solids concentration of synthesized storm runoff. The synthesized storm runoff was made with water and addition of particles; manhole sediment, road sediment, fly ash, and ployvinyl chloride powder. Vortex Screen was made of acryl resin with 250 mm of diameter and height of 700 mm. To determine the removal efficiency for various influent concentrations of suspended solids (SS) and chemical oxygen demand (COD), tests were performed with different operational conditions. The samples were taken simultaneously at the influent storage tank and effluent tank, and measured SS and COD concentrations. The ranges of surface loading rate were 110 to 1,550 $m^3/m^2$/day, and influent SS concentrations were varied from 141 to 1,986 mg/L. This paper was intended to evaluate the effect of inlet baffle and the ratio of underflow to overflow ($Q_U/Q_O$) on particle separation efficiency for various particle size using Vortex Screen. It was found that when increase of $Q_U/Q_O$ from 10% to 20%, SS removal efficiency was increased about 6%. The range of SS and COD removal efficiencies of road sediment particle size 125<$d_p$<300 ${\mu}m$ were 68.0~81.0%, 53.1~71.9%, respectively. Results showed that SS removal efficiency with inlet baffle improved by about 10~20% compared without inlet baffle.

• Journal of Environmental Health Sciences
• /
• v.26 no.4
• /
• pp.97-104
• /
• 2000

The purpose of this is made an examination of phosphorus loading model for eutrophication response in the Yongsan lake. For the model, we measured the total amount of nutrients derived from the Yongsan river watershed, inflow rate to the Yongsan lake, water quality, and water budget from January to December in 1999. The total amount of precipitation in the Yongsan river watershed was 4,951.7$\times$10$^{6}$ ㎥/y and inflow amount was 2,569.7$\times$10$^{6}$ ㎥/y, therefore the outflow rate of the Yongsan river watershed was 51.9%. The develop loading of total nitrogen was 86,928.1kg/d and that of total phosphorus was 22,007.6kg/d at the Yongsan river watershed, But, as the inflow loading of total nitrogen was 33,962kg/d and the inflow loading of total phosphorus was 2,218kg/d to the Yongsan lake. so each infolw rate was 39.0% and 10.1%. The hydraulic residence time was 34days, total phosphorus loading [L(P)] on the surface area was 23.398g/㎥/y, the hydraulic load( $Q_{s}$) of inflow water was 74.269m/y, the reserve rate of phosphorus in the lake was 0.359, and the settinh velocity of phosphorus was 0.114m/d at the Yongsan lake. Mathematical model of phosphorus loading to estimate the responses of eutrophication at the Yongsan lake is [ $P_{j}$] = 0.838 [L(P)/Q.(1+√ $T_{w}$)$^{-1}$ ] . ] . .

• Natural Product Sciences
• /
• v.23 no.4
• /
• pp.253-257
• /
• 2017

The phytochemical study for the extract of Nelumbo nucifera (Nymphaceae) seeds has led to the isolation of ten compounds including five simple phenolic compounds, two indole derivatives, a flavonoid glycoside, two abscisic acid derivatives. The interpretation of 1D and 2D NMR and ESI-Q-TOF-MS spectroscopic data revealed the chemical structures of isolates to be p-hydroxybenzoic acid (1), protocatechuic acid (2), (E)-p-coumaric acid (3), (E)-ferulic acid (4), (E)-sinapate-4-O-${\beta}$-$\text\tiny{D}$-glucopyranoside (5), tryptophan (6), 3-indoleacetic acid (7), isoschaftoside (8), dihydrophaseic acid (9), dihydrophaseic acid 3'-O-${\beta}$-$\text\tiny{D}$-glucopyranoside (10). To the best of our knowledge, 1 - 5 and 7 were identified for the first time from N. nucifera seeds, and the presence of dihydrophaseic acid (9) and its glucoside (10) were demonstrated secondly in this plant.

• Transactions of the Korean Society of Mechanical Engineers
• /
• v.12 no.4
• /
• pp.825-832
• /
• 1988

An experiment was performed to study the heat pipe phenomenon of porous media heated above at one-dimensional steady state for the range of heat flux, 300 W/ $m^{2}$ ~ 2000w/ $m^{2}$. Glass beads, sand, and copper particles were used as porous media and distilled water was used as a working fluid. Result of experiment shows that the length of the two-phase zone increases with the decreasing particle size for the same heat flux. At relatively lower heat flux the length of the two-phase zone increases with the increasing heat flux, which contradicts the result of earlier work. However, its length remains nearly constant when the heat flux increases above a certain value. The length of the two-phase zone is proportional to the product of the heat flux by the hydrostatic capillary height under the limited value on heat flux, that is, $l_{t}$ = A(q. $l_{cap}$)+B, q.leg.1/A(C+B/ $l_{cap}$) where A is 1.7*10$^{-4}$ $m^{2}$/w, B is 1.9*10$^{-2}$ m, and C is 0.43 for copper particles and 0.31 for glass beads and sand.d.d.d.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.6
• /
• pp.2629-2633
• /
• 2012

Background: Raw betel nut (RBN) chewing is an important contributing factor for esophageal squamous cell carcinoma (ESCC), although associated genomic changes remain unclear. One difficulty in assessing the effects of exclusively RBN induced genetic alterations has been that earlier studies were performed with samples of patients commonly using tobacco and alcohol, in addition to betel-quid. Both CDKN2A (at 9p21) and Rb1 gene (at 13q14.2) are regarded as tumor suppressors involved in the development of ESCC. Therefore, the present study aimed to verify the RBN's ability to induce ESCC and assess the involvement of CDKN2A and Rb1 genes. Methods: A panel of dinucelotide polymorphic markers were chosen for loss of heterozygosity studies in 93 samples of which 34 were collected from patients with only RBN-chewing habit. Promoter hypermethylation was also investigated. Results: Loss in microsatellite markers D9S1748 and D9S1749, located close to exon $1{\beta}$ of CDKN2A/ARF gene at 9p21, was noted in 40% ESCC samples with the habit of RBN-chewing alone. Involvement of a novel site in the 9p23 region was also observed. Promoter hypermethylation of CDKN2A gene in the samples with the habit of only RBN-chewing alone was significantly higher (p=0.01) than Rb1 gene, also from the samples having the habit of use both RBN and tobacco (p=0.047). Conclusions: The data indicate that the disruption of 9p21 where CDKN2A gene resides, is the most frequent critical genetic event in RBN-associated carcinogenesis. The involvement of 9p23 as well as 13q14.2 could be required in later stages in RBN-mediated carcinogenesis.