• 유통과학연구
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• 제3권2호
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• pp.77-99
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• 2005

In the business environment which enclosed the domestic small and d medium distribution industry, and a business sign of recovery, reduction of income, job insecurity, and a national pension an aging society - positive exhibition of the large-sized store in comparison with the low personal consumption depended uneasy and deregulation, and consumer needs progress of individualization diversification it is ultimately faced with a difficult situation. Therefore the seen research examine the various range of a circulation policy through precedence research. It is going to consider and see the influence which the circulation regulation means of the purpose of large-sized store regulation and a major power is compared, and regulation.

• 한국자동차공학회논문집
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• 제19권2호
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• pp.98-104
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• 2011

The introduction of a diesel engine into the passenger car and light duty applications in the United States involves significant technical challenges for the automotive makers. This paper describes the SCR System optimization procedure for such a diesel engine application to meet Tier2 Bin5 emission regulation. A urea SCR system, a representative $NO_x$ reduction after-treatment technique, is applied to a 3.0 liter diesel engine. To achieve the maximum $NO_x$ reduction performance, the exhaust system layout was optimized using series of the computational fluid dynamics and the urea distribution uniformity test. Furthermore a comprehensive simulation model for the key factors influencing $NO_x$ reduction performance was developed and embedded in the Simulink/Matlab environment. This model was then applied to the urea SCR system and played a key role to shorten the time needed for SCR control parameter calibration. The potential of a urea SCR system for reducing diesel $NO_x$ emission is shown for FTP75 and US06 emission standard test cycle.

• 한국측량학회:학술대회논문집
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• 한국측량학회 2003년도 추계학술발표회 논문집
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• pp.251-256
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• 2003

Conventional 2D GIS has many difficulties to visualize and analyze three dimensional real world. To improve those problems and implement realistic spatial analysis, Interest in 3D GIS is increasing remarkably. Currently, Some local governments are carrying out pilot projects for 3D GIS, Government also is setting up the master plan and the road map for national information construction. In this study, introducing 3D GIS to urban planning, we evaluated limits of conventional regulation and proposed effective and reasonable means lot restricting location of merrymaking place in local government.

• Journal of Microbiology
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• 제43권spc1호
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• pp.110-117
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• 2005

Salmonella enterica serovar Typhimurium causes human gastroenteritis and a systemic typhoid-like infection in mice. A critical virulence determinant of Salmonella is the ability to invade mammalian cells. The expression of genes required for invasion is tightly regulated by environmental conditions and a variety of regulatory genes. The hilA regulator encodes an OmpR/ToxR family transcriptional regulator that activates the expression of invasion genes in response to both environmental and genetic regulatory factors. Work from several laboratories has highlighted that regulation of hilA expression is a key point for controlling expression of the invasive phenotype. A number of positive regulators of hilA expression have been identified including csrAB, sirA/barA, pstS, hilC/sirC/sprA, fis, and hilD. HilD, an AraC/XylS type transcriptional regulator, is of particular importance as a mutation in hilD results in a 14-fold decrease in chromosomal hilA::Tn5lacZY-080 expression and a 53-fold decrease in invasion of HEp-2 cells. It is believed that HilD directly regulates hilA expression as it has been shown to bind to hilA promoter sequences. In addition, our research group, and others, have identified genes (hilE, hha, pag, and lon) that negatively affect hilA transcription. HilE appears to be an important Salmonella-specific regulator that plays a critical role in inactivating hilA expression. Recent work in our lab has been directed at understanding how environmental signals that affect hilA expression may be processed through a hilE pathway to modulate expression of hilA and the invasive phenotype. The current understanding of this complex regulatory system is reviewed.

• Human Ecology Research
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• 제59권1호
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• pp.71-82
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• 2021

This study examined the structural relationships among parent's play participation, children's playfulness, self-regulation and happiness. In this Study, subjects were 274 children who were 4 through 5 years old. The participants included 274 preschoolers' parents and their teachers in D city. The parents completed questionnaires regarding parent's play participation with their children and children's self-regulation. The teachers completed questionnaires regarding preschoolers' happiness and playfulness. Data was analyzed using descriptive statistics, pearson correlation analysis and mediation analysis based on structural equation modeling with SPSS 25.0 and AMOS 23.0 program. Also, specific indirect effects were analyzed using AMOS user-defined estimand function. The primary results of this study were as follows. 1) The parent's play participation had an influence upon children's playfulness and self-regulation. 2) The children's playfulness had an influence upon children's self-regulation and happiness. 3) The children's self-regulation had an influence upon children's happiness. 4) Between the parent's play participation and children's happiness were mediated by the children's playfulness and self-regulation. This study revealed that parent's play participation, children's playfulness and self-regulation need to be considered simultaneously to explain the level of the children's happiness. The results highlight the structural relationships among parent's play participation, children's playfulness, self-regulation and happiness.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2005년도 춘계학술대회논문집
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• pp.109-112
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• 2005

Since 1989, when the first European noise regulation against construction equipments came into force, much investigation had been devoted to reduce the noise and had produced the remarkable improvement in noise reduction technology. EU Directive 2000/14/EC Stage 2, more stringent noise regulation, is going to be implemented from Jan. 2006. The technology trends and examples for noise reduction in typical construction equipment R&D is described briefly.

• 한국자원식물학회지
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• 제28권6호
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• pp.682-689
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• 2015

Abeliophyllum distichum Nakai (A. distichum) has been reported to exert the inhibitory effect on angiotensin converting enzyme and aldose reductase. Recently, our group found that branch extracts of A. distichum (EAFAD-B) induce apoptosis through ATF3 activation in human colon cancer cells. However, anti-cancer reagents exert their activity through the regulation of various molecular targets. Therefore, the elucidation of potential mechanisms of EAFAD-B for anti-cancer activity may be necessary. To elucidate the potential mechanism of EAFAD-B for anti-cancer activity, we evaluated the regulation of cyclin D1 in human colon cancer cells. EAFAD-B decreased cellular accumulation of cyclin D1 protein. However, cyclin D1 mRNA was not changed by EAFAD-B. Inhibition of proteasomal degradation by MG132 attenuated EAFAD-B-mediated cyclin D1 downregulation and the half-life of cyclin D1 was decreased in the cells treated with EAFAD-B. In addition, EAFAD-B induced cyclin D1 phosphorylation at threonine-286 and the point mutation of threonine-286 to alanine attenuated EAFAD-B-mediated cyclin D1 proteasomal degradation. Inhibitions of both ERK1/2 by PD98059 and NF-κB by a selective inhibitor, BAY 11-7082 suppressed cyclin D1 downregulation by EAFAD-B. From these results, we suggest that EAFAD-B-mediated cyclin D1 downregulation may result from proteasomal degradation through its threonine-286 phosphorylation via ERK1/2-dependent NF-κB activation. The current study provides new mechanistic link between EAFAD-B and anti-cancer activity in human colon cancer cells.

• 한국초전도ㆍ저온공학회논문지
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• 제16권2호
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• pp.47-53
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• 2014

In this paper, the general electromagnetic design process of a 10-MW-class high-temperature superconducting (HTS) synchronous generator that is intended to be utilized for large scale offshore wind generator is discussed. This paper presents three-dimensional (3D) electromagnetic design proposal and electrical characteristic analysis results of a 10-MW-class HTS synchronous generator for wind power. For more detailed design by reducing the errors of a two-dimensional (2D) design owing to leakage flux in air-gap, we redesign and analyze the 2D conceptual electromagnetic design model of the HTS synchronous generator using 3D finite element analysis (FEA) software. Then electrical characteristics which include the no-load and full-load voltage of generator, harmonic contents of these two load conditions, voltage regulation and losses of generator are analyzed by commercial 3D FEA software.

• Tuberculosis and Respiratory Diseases
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• 제70권3호
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• pp.206-217
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• 2011

Background: Transcription factor FOXP3 characterizes the thymically derived regulatory T cells. FOXP3 is expressed by cancer cell itself and FOXP3 expression was induced by TGF-${\beta}$ treatment in pancreatic cancer cell line. However, the expression of FOXP3 expression is not well known in patients with lung cancer. This study was conducted to investigate the expression of FOXP3 in patients with lung cancer and to investigate the regulation of FOXP3 expression by the treatment of TGF-${\beta}$ and DNA methyltransferase inhibitor in lung cancer cell lines. Methods: FOXP3 expression in the tissue of patients with resected non-small cell lung cancer (NSCLC) was evaluated by immunohistochemistry. The regulation of FOXP3 expression was investigated by Western blot and RT-PCR after lung cancer cell lines were stimulated with TGF-${\beta}1$ and TGF-${\beta}2$. The regulation of FOXP3 expression was also investigated by RT-PCR and flow cytometry after lung cancer cell lines were treated with DNA methyltransferase inhibitor (5-AZA-dC). Results: FOXP3 expression was confirmed in 27% of patients with NSCLC. In NCI-H460 cell line, TGF-${\beta}2$ decreased FOXP3 mRNA and protein expressions. In A549 cell line, both TGF-${\beta}1$ and TGF-${\beta}2$ decreased FOXP3 mRNA and protein expressions. 5-AZA-dC increased FOXP3 mRNA expression in NCI-H460 and A549 cell lines. Moreover, 5-AZA-dC increased intracellular FOXP3 protein expression in A549 cell lines. Conclusion: It was shown that FOXP3 is expressed by cancer cell itself in patients with NSCLC. Treatment of TGF-${\beta}2$ and DNA methyltransferase inhibitor seems to be associated with the regulation of FOXP3 expression in lung cancer cell lines.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2006년도 학술발표회 논문집
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• pp.1611-1615
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• 2006

본 연구에서는 GSTAR-1D 모형을 적용하여 대청 조정지댐과 공주 수위표 구간에 대해 1988년부터 2001년까지의 하상변동을 모의하고, 국내 적용성을 평가하였으며, 2002년부터 2017년까지의 장기 하상변동을 예측하였다. GSTAR-1D에서 제공하는 14개 유사이송공식에 대한 모의결과, Acker's & White 공식이 상대적으로 가장 안정적으로 산정되었다. 안정 계산시간 간격은 만제유량$(1,000m^2/s)$은 7일, 일최대유량$(4,273m^2/s)$은 3일, 시간최대유량$(7,605m^2/s)$과 최소유량$(8.5m^2/s)$은 1일로 분석되었다. 1988년부터 2001년까지의 하상변동 모의결과와 실측자료를 비교 평가한 결과, 대청 조정지댐${\sim}$매표수위표구간의 하상저하 모의결과는 하상토의 원인으로, 매포수위표${\sim}$공주수위표 구간의 하상저하모의결과는 대규모 골재채취에 의해 발생한 것으로 분석되었다. 2002년부터 2017년까지의 하상변동 예측결과는, 대청 조정지댐${\sim}$금남교 구간은 대부분 현재의 하상이 유지될 것으로 분석되었으며, 매포수위표${\sim}$공주수위표구간은 일부 구간에서의 하상저하가 예상되었으나, 인위적인 하상변동이 아니면, 전반적으로 안정한 하상을 유지할 것으로 분석되었다.