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Comparison of Results between Cytogenetic Technique and Molecular Genetic Technique in Colorectal Carcinoma Patients (대장암환자의 염색체 결실에서 세포유전학적 기법과 분자유전학적 기법의 결과 비교)

  • Park, Cheolin;Lee, Jae Sik
    • Korean Journal of Clinical Laboratory Science
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    • v.49 no.3
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    • pp.285-293
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    • 2017
  • Globally, 1.3 million people develop colon cancer every year, and 600,000 people die each year it. In Korea, colorectal carcinoma was associated with the highest death rate, accounting for 8,380 people, among solid cancers in 2015. Among the various methods for the diagnosis and study of colorectal carcinoma, the results obtained by cytogenetic and molecular genetic methods were compared. Detection rate was 47% in 18q, 40% in 17p, 27% in 22q, and 17% in 10q via CGH; detection rate was 57% in D18S59, 50% in D18S68, 50% in TP53CA, 47% in D18S6940% in D22S274, 37% in D22S283, 27% in D10S187, and 23% in D10S541 with LOH. Microsatellite marker matching rates were 100% in D22S274, 100% in D22S283, 100% in D10S186, 100% in D10S187, 100% in D10S541, 93% in D18S69, 93% in D18S68, 92% in TP53CA, and 89% in D18S59. The agreement rate between the two methods was 94.4% based on positive results using CGH. Based on the advantages of CGH, which was the ability to obtain information regarding the entire tumor genome at once, this experiment could identify the region with significant deletion using CGH and the more limited region LOH, with a completely different approach. LOH in the recurrent high-risk group, 18q21, was helpful in the selection of treatment modalities and in prognostic estimation as well as making the most appropriate decision for treatment. Therefore, it is suggested that LOH with surgical site tissues could be one of the treatment methods for recurrent high-risk group among patients with colorectal carcinoma.

Mutation Cases in the Korean Population using 23 Autosomal STR Loci Analysis

  • Kim, Jeongyong;Kim, Hyojeong;Lee, Ja Hyun;Kim, Hyo Sook;Kim, Eungsoo
    • Biomedical Science Letters
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    • v.27 no.2
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    • pp.105-110
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    • 2021
  • Short Tandem Repeats (STR) analysis which characterized by genetic polymorphism has been widely used in the forensic genetic fields. Unfortunately, mutation occurred in various STR loci could make it difficult to interpret STR data. Thus, the mutation rate of STR loci plays an important role for the data interpretation in human identification and paternity test. To verify the mutation of the STR loci in the Korean population, 545 trio sets (father, mother, and child) were analyzed with two commercial STR kits that include the 23 autosomal STR loci (D1S1656, TPOX, D2S441, D2S1338, D3S1358, FGA, D5S818, CSF1PO, D7S820, D8S1179, D10S1248, TH01, D12S391, VWA D13S317, D16S539, D18S51, D19S433, D21S11, D22S1045, SE33, Penta E and Penta D). As a result, 36 mutations were observed in 14 STR loci. The types of mutation were also classified by the increase or decrease of the alleles. The overall mutation rate was 1.4×10-3, and the paternal mutation rate was four times higher than that of the maternal. This study will provide more detailed criterion for human identification by the mutation rate of STR loci in the Korean population.

A Study on the Performance Characteristics of a Chirp RTLS over Wireless Channel with Gaussian Noise (가우시안 잡음이 존재하는 무선채널에서 Chirp RTLS 시스템의 성능 특성에 관한 연구)

  • Kang, Byeong-Gwon
    • Journal of Digital Convergence
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    • v.11 no.7
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    • pp.201-207
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    • 2013
  • The chirp signaling has been mainly used in radar systems due to its good correlation characteristics, and nowadays it is applied to real time locating system(RTLS). The RTLS with chirp signaling was chosen as a standard such as ISO/IEC 24730-5 and IEEE 802.15.4a. In this paper, the performance of a real time locating system with chirp signaling was evaluated and simulated with relative distance error rates. We considered three cases of S/I = -30[dB], -20[dB], and -10[dB] with Rician factor K=10 and K=20. The performance was enhanced with K factor improvement by 25%, 27% and 50% for respective three cases of S/I. As results, in case of S/I < -20[dB], the minimum signal power is required for performance improvement even though the line of sight component is helpful. And also, in case of S/I ${\geq}$ -20[dB], as the line of sight component is stronger the better performance is obtained.

Transmission of 10 Gb/s optical signais over 320 km of a dispersion shifted fiber (10Gb/s 광신호의 320km 분산천이 광섬유 전송실험)

  • 이상수
    • Korean Journal of Optics and Photonics
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    • v.10 no.1
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    • pp.64-67
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    • 1999
  • We have been implemented 10 Gb/s-320 km of dispersion-shifted fiber (DSF) transmission. The optical link consists of a 10 Gb/s optical transceiver, an optical booster amplifier, 3 sets of optical in-line amplifiers, an optical preamplifier and transmission fibers. Firstly, we investigated the Q-factor characteristics in terms of optical signal to noise ratio (OSNR) of 320 km of DSF, measured receiver sensitivity is -27 dBm and power penalty is 2 dB, respectively. We concluded that optical SNR degradation and path penalty gives rise to 1 dB penalty, respectively.

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Transmission of 10Gb/s signal over 200km of non-dispersion shifted fiber by using mid-span spectral inversion (스펙트럼 반전법을 이용한 10 Gb/s 광신호의 200 km 비분산천이 광섬유 전송)

  • 이상수;이창희
    • Korean Journal of Optics and Photonics
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    • v.7 no.4
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    • pp.428-433
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    • 1996
  • We have demonstrated 200 km non-dispersion shifted fiber(NDSF) transmission of 10 Gb/s signal by using mid-span spectral inversion(MSSI) method as a dispersion compensation technique. We have used four-wave mixing process in dispersion shifted fiber(DSF) to generate a spectrum inverted signal. The spectral inversion efficiency of -26.7dB and signal to noise ratio of 23.0 dB have been achieved. The measured sensitivities at $10^{-9}$ bit error rates (BER) were -28.0 dBm in back to back configuration and -27.0 dBm after transmission of 200 km NDSF.

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EXTENSIONS OF NAGATA'S THEOREM

  • Hamed, Ahmed
    • Journal of the Korean Mathematical Society
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    • v.55 no.4
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    • pp.797-808
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    • 2018
  • In [1], the authors generalize the concept of the class group of an integral domain $D(Cl_t(D))$ by introducing the notion of the S-class group of an integral domain where S is a multiplicative subset of D. The S-class group of D, $S-Cl_t(D)$, is the group of fractional t-invertible t-ideals of D under the t-multiplication modulo its subgroup of S-principal t-invertible t-ideals of D. In this paper we study when $S-Cl_t(D){\simeq}S-Cl_t(D_T)$, where T is a multiplicative subset generated by prime elements of D. We show that if D is a Mori domain, T a multiplicative subset generated by prime elements of D and S a multiplicative subset of D, then the natural homomorphism $S-Cl_t(D){\rightarrow}S-Cl_t(D_T)$ is an isomorphism. In particular, we give an S-version of Nagata's Theorem [13]: Let D be a Krull domain, T a multiplicative subset generated by prime elements of D and S another multiplicative subset of D. If $D_T$ is an S-factorial domain, then D is an S-factorial domain.

Implementation of Dielectric Duplexers and Bandpass Filters for K-PCS and US-PCS Bands (K-PCS와 US-PCS 대역용 유전체 듀플렉서와 밴드패스 필터 구현)

  • Choi, U-Sung
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.15 no.7
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    • pp.1433-1438
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    • 2011
  • Relative attenuations of Tx and Rx in K-PCS and US-PCS duplexers were about -60dB and -65dB, -51dB and -53dB, respectively. In the case of Rx and Tx in K-PCS and US-PCS bandpass filters, relative attenuations were about -40dB and -14dB, -5dB and -10dB, respectively. From the aboved results, the relative affect between Tx and Rx in K-PCS bands was smaller than that of US-PCS bands. Also, the various capacitances of passband were important role to determine the characterics of bandpass filter.

Quality and Fruit Productivity of the Second Truss Blooming Seedlings Depending on Concentration of Nutrient Solution in Cherry Tomato (양액 농도에 따른 방울토마토 2화방 개화묘의 소질 및 과실 생산성)

  • Lee, Mun Haeng
    • Journal of Bio-Environment Control
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    • v.31 no.3
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    • pp.230-236
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    • 2022
  • This study was carried out to produce two-flowered seedlings, harvest them early in a greenhouse, and extend the harvest period. This study was carried out to effectively produce the second truss blooming seedlings to harvest tomatoes early and extend the harvest period. For production of the second truss blooming seedlings (one stem), the nutrient solution EC was supplied at 1.5, 2.0, 2.5 dS·m-1, and dynamic management (3.0 → 3.5 → 4.5 dS·m-1). The seedling period was 60 days, which was 20-40 days longer than conventional seedlings, and 10 days longer than the first truss blooming seedlings (cube seedlings). The plant height was 78 and 77 cm in EC 2.5 dS·m-1 and dynamic management respectively, which was shorter than EC 1.5 dS·m-1 with 88 cm. As for the EC in the cube before formulation, dynamic management had the highest EC 5.5 dS·m-1, and the cube supplied with EC 1.5 dS·m-1 had the lowest. The production yield by treatment did not a difference among in the second truss blooming seedlings, but the first truss blooming seedlings showed lower productivity than second truss blooming seedlings. The second truss blooming seedling were harvested 35 days after planting on June 4, the first harvest date, and the first truss blooming were harvested in 42 days on June 11th. There was no difference in plant height and root growth due to bending at frequency planting. In the study on the production of the second truss blooming seedlings (two stem), the nutrient solution EC was supplied under 2.0, 2.5, 3.0 dS·m-1, and dynamic management (3.0 → 3.5 → 4.5 dS·m-1). The seedling period was 90 days, which was 40-50 days longer than conventional seedlings and 10 days longer than the first truss blooming seedlings (cube seedlings). Plant height was 80 and 81 cm in EC 2.0 dS·m-1 and 2.5 dS·m-1 respectively, but was the shortest at 73 cm in dynamic management. EC in the medium increased as the seeding period increased in all treatments. The dynamic management was the highest with EC 5.1 dS·m-1. There was no difference in yield among EC treatments in the second truss blooming seedlings, which had a longer seeding period of about 10 days, produced 15% more than the first truss blooming seedlings. In order to shorten the plant height of the second truss blooming seedlings, it is judged that the most efficient method is increasing the concentration of nutrient solution.

Phylogeny of Subgenus Drosophila (Drosophilidae: Drosophila) in Korea by Allozyme and Soluble Protein Analysis (동위효소와 수용성단백질 분석에 의한 한국 초파리아속 10종의 계통)

  • Eun Young Joo;Nam Woo Kim
    • Animal Systematics, Evolution and Diversity
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    • v.19 no.2
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    • pp.217-225
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    • 2003
  • This study was conducted to ascertain interspecific relationships by analyzing allozyme and soluble proteins of ten species in the Drosophila (Drosophila) to form a part of systematic studies of Korean drosophilids. The results of allozyme and TDE analysis showed that D. (D.) curvispina and D (D.) tsigana had the furthest genetic distance. On the other hand, the genetic distance between D (D.) angularis and D (D.) brachynephros was extremely close. And, ten species of the subgenus Drosophila can be divided into the first group of D. (D.) virilis, D. (D.) tsigana and D. (D.) lacertosa , and the second group consisted of four subgroups; the first subgroup clustered D. (D.) angularis and D (D.) brachynephros, the second subgroup clustered D. (D.) unispina and D. (D.) curvispina, the third subgroup of D (D.) takadai and D. (D.) kuntzei and the fourth subgroup of D. (D.) nigromaculata alone.

A Note on S-Noetherian Domains

  • LIM, JUNG WOOK
    • Kyungpook Mathematical Journal
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    • v.55 no.3
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    • pp.507-514
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    • 2015
  • Let D be an integral domain, t be the so-called t-operation on D, and S be a (not necessarily saturated) multiplicative subset of D. In this paper, we study the Nagata ring of S-Noetherian domains and locally S-Noetherian domains. We also investigate the t-Nagata ring of t-locally S-Noetherian domains. In fact, we show that if S is an anti-archimedean subset of D, then D is an S-Noetherian domain (respectively, locally S-Noetherian domain) if and only if the Nagata ring $D[X]_N$ is an S-Noetherian domain (respectively, locally S-Noetherian domain). We also prove that if S is an anti-archimedean subset of D, then D is a t-locally S-Noetherian domain if and only if the polynomial ring D[X] is a t-locally S-Noetherian domain, if and only if the t-Nagata ring $D[X]_{N_v}$ is a t-locally S-Noetherian domain.