• Molecules and Cells
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• 제19권1호
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• pp.23-30
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• 2005

Spinocerebellar ataxia type 1 (SCA1) is an autosomal-dominant neurodegenerative disorder caused by expansion of the polyglutamine tract in the SCA1 gene product, ataxin-1. Using d2EGFP, a short-lived enhanced green fluorescent protein, we investigated whether polyglutamine-expanded ataxin-1 affects the function of the proteasome, a cellular multicatalytic protease that degrades most misfolded proteins and regulatory proteins. In Western blot analysis and immunofluorescence experiments, d2EGFP was less degraded in HEK 293T cells transfected with ataxin-1(82Q) than in cells transfected with lacZ or empty vector controls. To test whether the stability of the d2EGFP protein was due to aggregation of ataxin-1, we constructed a plasmid carrying $ataxin-1-{\Delta}114$, lacking the self-association region (SAR), and examined degradation of the d2EGFP. Both the level of $ataxin-1-{\Delta}114$ aggregates and the amount of d2EGFP were drastically reduced in cells containing $ataxin-1-{\Delta}114$. Furthermore, d2EGFP localization experiments showed that polyglutamine-expanded ataxin-1 inhibited the general function of the proteasome activity. Taken together, these results demonstrate that polyglutamine-expanded ataxin-1 decreases the activity of the proteasome, implying that a disturbance in the ubiquitin-proteasome pathway is directly involved in the development of spinocerebellar ataxia type1.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.2389-2392
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• 2005

We present fast stereo matching algorithm using edge projection. Traditional stereo matching algorithm uses 2D template for the search of corresponding point thus it requires huge the computational cost. In this paper, we reduce the 2D search problem into 1D using edge projection along vertical and horizontal direction inside the region of interest. Also, by accumulation of edge projection along vertical and horizontal direction, the edge projection within the region of interest could simply be obtained by just subtracting two values. Experimental results show that matching algorithm using edge projection also gives comparable discriminating power compared to that of using intensity.

• 한국분무공학회지
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• 제18권2호
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• pp.94-99
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• 2013

The spherically-symmetric burning of an isolated droplet is a dynamic problem that involves the coupling of chemical reactions and multi-phase flow with phase change. For the improved understanding of these phenomena, this paper presents the numerical results on the n-heptane droplet combustion conducted at a 1 atm ambient pressure in three different initial droplet diameter ($d_0$). The main purpose of this study is to provide basic information of droplet burning, extinction and flame behavior of n-heptane and improve the ability of theoretical prediction of these phenomena. To achieve these, the numerical analysis was conducted in terms of normalized droplet diameter ($d/d_0$), flame diameter ($d_f$) and flame standoff ratio (FSR) under the assumptions that the droplet combustion can be described by both the quasi-steady behavior for the region between the droplet surface and the flame interface and the transient behavior for the region between the flame interface and ambient surrounding.

• 방송공학회논문지
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• 제4권1호
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• pp.44-58
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• 1999

본 논문에서는 영역 인접성 그래프를 사용한 반복적 병합법으로 율왜곡 기반 영상 분할을 수행하는 알고리듬을 제안하였다. 제안한 기법에서는, 인접한 두 영역간의 이질성을 율왜곡적 관접에서 고려한 Lagrange 비용함수로 표현하였다. 이 때 각 병합 단계에 맞는 Lagrange 상수를 추정하고 율왜곡 기반 비용이 최소가 되는 인접 영역 쌍을 탐색하여 이들을 새로운 영역으로 병합하였다. 이러한 병합과정은 어떤 정지조건에 이를때까지 반복한다. 제안된 분할법은 영역기반 부호화 혹은 분할기반 부호화 기법에 적합한 분할법이다. 실험 결과, 256x256 L둠 에 대해서 영역기반 부호화를 수행하였을 때, 제안한 기법은 평균밝기 차이, 왜곡의 변화량 및 JPEG에 비하여 각각 2.5~3.5dB, 0.8~1.0 dB, 0.3~0.6 dB 정도의 PSNR 성능 개선이 있는 것으로 나타났다.

• 대한수학회보
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• 제55권3호
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• pp.957-965
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• 2018

We study the class $C{\mathcal{V}} ({\Omega})$ of analytic functions f in the unit disk ${\mathbb{D}}=\{z{\in}{\mathbb{C}}$ : ${\mid}z{\mid}$ < 1} of the form $f(z)=z+{\sum}_{n=2}^{\infty}a_nz^n$ satisfying $$1+\frac{zf^{{\prime}{\prime}}(z)}{f^{\prime}(z)}{\in}{\Omega},\;z{\in}{\mathbb{D}}$$, where ${\Omega}$ is a convex and proper subdomain of $\mathbb{C}$ with $1{\in}{\Omega}$. Let ${\phi}_{\Omega}$ be the unique conformal mapping of $\mathbb{D}$ onto ${\Omega}$ with ${\phi}_{\Omega}(0)=1$ and ${\phi}^{\prime}_{\Omega}(0)$ > 0 and $$k_{\Omega}(z)={\displaystyle\smashmargin{2}{\int\nolimits_{0}}^z}{\exp}\({\displaystyle\smashmargin{2}{\int\nolimits_{0}}^t}{\zeta}^{-1}({\phi}_{\Omega}({\zeta})-1)d{\zeta}\)dt$$. Let $z_0,z_1{\in}{\mathbb{D}}$ with $z_0{\neq}z_1$. As the first result in this paper we show that the region of variability $\{{\log}\;f^{\prime}(z_1)-{\log}\;f^{\prime}(z_0)\;:\;f{\in}C{\mathcal{V}}({\Omega})\}$ coincides wth the set $\{{\log}\;k^{\prime}_{\Omega}(z_1z)-{\log}\;k^{\prime}_{\Omega}(z_0z)\;:\;{\mid}z{\mid}{\leq}1\}$. The second result deals with the case when ${\Omega}$ is the right half plane ${\mathbb{H}}=\{{\omega}{\in}{\mathbb{C}}$ : Re ${\omega}$ > 0}. In this case $CV({\Omega})$ is identical with the usual normalized class of convex univalent functions on $\mathbb{D}$. And we derive the sharp upper bound for ${\mid}{\log}\;f^{\prime}(z_1)-{\log}\;f^{\prime}(z_0){\mid}$, $f{\in}C{\mathcal{V}}(\mathbb{H})$. The third result concerns how far two functions in $C{\mathcal{V}}({\Omega})$ are from each other. Furthermore we determine all extremal functions explicitly.

• Mycobiology
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• 제38권3호
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• pp.166-170
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• 2010

Gummy stem blight is a major foliar disease of muskmelon (Cucumis melo L.). In this study, morphological characteristics and rDNA internal transcribed spacer (ITS) sequences were analyzed to identify the causal organism of this disease. Morphological examination of the Jeonbuk isolate revealed that the percentage of monoseptal conidia ranged from 0% to 10%, and the average length $\times$ width of the conidia was 70 ($\pm$ 0.96) $\times$ 32.0 ($\pm$ 0.15) ${\mu}m$ on potato dextrose agar. The BLAST analysis showed nucleotide gaps of 1/494, 2/492, and 1/478 with identities of 485/492 (98%), 492/494 (99%), 491/494 (99%), and 476/478 (99%). The similarity in sequence identity between the rDNA ITS region of the Jeonbuk isolate and other Didymella bryoniae from BLAST searches of GenBank was 100% and was 95.0% within the group. Nucleotide sequences of the rDNA ITS region from pure culture ranged from 98.2% to 99.8%. Phylogenetic analysis with related species of D. bryoniae revealed that D. bryoniae is a monophyletic group distinguishable from other Didymella spp., including Ascochyta pinodes, Mycosphaerella pinodes, M. zeae-maydis, D. pinodes, D. applanata, D. exigua, D. rabiei, D. lentis, D. fabae, and D. vitalbina. Phylogenetic analysis, based on rDNA ITS sequence, clearly distinguished D. bryoniae and Didymella spp. from the 10 other species studied. This study identified the Jeonbuk isolate to be D. bryoniae.

• 한국수산과학회지
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• 제48권6호
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• pp.913-919
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• 2015

In vertebrates, the vitamin D receptor (VDR), a member of the nuclear receptor superfamily, binds the biologically active ligand $1{\alpha},25-(OH)_2$-vitamin $D_3$ (1,25 $D_3$). Nearly all vertebrates, including Agnatha, possess a VDR with high ligand selectivity for 1,25 $D_3$ and related metabolites. Although a putative ancestral VDR gene is present in the genome of the chordate invertebrate Ciona intestinalis, the functional characteristics of marine invertebrate VDR are still obscure. To elucidate the ascidian Halocynthia roretzi VDR (HrVDR), we cloned full-length HrVDR cDNA and investigated the transcriptional activity of HrVDR in HEK293 cells. HrVDR consists of 1,680 nucleotides (559 amino acids [aa]), including a short N-terminal region (A/B domain; 26 aa), DNA-binding domain (C domain; 72 aa), hinge region (D domain; 272 aa), and C-terminal ligand-binding domain (E domain; 161 aa). The amino acid sequence identity of HrVDR was greatest to that of C. intestinalis VDR (56%). In the luciferase reporter assays, the transcriptional activity of HrVDR was not significantly increased by 1,25 $D_3$, whereas the farnesoid X receptor agonist GW4064 increased the transactivation of HrVDR. These results suggest the presence of a novel ligand for and a distinct ligand-binding domain in ascidian VDR.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 춘계학술대회
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• pp.1199-1204
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• 2003

The 3D simulations of the shielding concrete and the Rotary Specimen Rack(RSR) in the Korea Research Reactor-1&2(KRR-1&2) were carried out in present work. Four main dismantling processes, which are the removal of the RSR, reactor core region, beam tube, and thermal column and activated concrete, were selected for the graphic simulation by the consideration of the activation, worker training, work difficulty and so on. On the basis of these, we constructed their 3D CAD models and then drawn and reviewed their dismantling processes. In this study, the 3D simulation results of the shielding concrete and the RSR among main components are also presented and discussed.

• 한국환경과학회지
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• 제15권5호
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• pp.387-396
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• 2006

The numerical modeling and comparison with observations are performed to find out the detailed structure of meteorology and the characteristic of related dispersion phenomena of the non-reactive air pollutant at Kyoungin region, South Korea, where several industrial complex including Siwha, Banwol and Namdong is located. MM5 (Fifth Generation NCAR/Penn State Mesoscale Model), 3-D Land/sea breeze model and 3-D diagnostic meteorological model have been utilized for the meteorological simulation for September, 2002 with each different spatial resolution, while 3-D Eulerian air dispersion model for the air quality study. We can see the simulated wind field shows the very local circulation quitely well compared with in-site observations in shoreline area with complex terrains, at which the circulation of Land/sea breeze has developed and merged with the mountain and valley breeze eventually. Also it is shown in the result of the dispersion model that the diurnal variation and absolute value of daily mean $SO_2$ concentrations have good agreement with observations, even though the instant concentration of $SO_2$ simulated overestimates around 1.5 times rather than that of observation due to neglecting the deposition process and roughly estimated emission rate. This results may indicate that it is important for the air quality study at shoreline region with the complex terrain to implement the high resolution meteorological model which is able to handle with the complicate local circulation.

• 한국전기전자재료학회논문지
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• 제28권2호
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• pp.99-103
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• 2015

One-dimensional photonic crystals (1D PCs) were fabricated by RF sputtering technique on p-Si (100), and fused quartz substrates. The 1D PCs structures consisted of $TeO_x$ (x=1.42), and $SiO_2$ with the difference refractive index. In order to estimate the effect on a defect level within 1D PCs structures, samples were prepared with both normal, and defect mode. The structural and optical properties were confirmed by Scanning electron microscope (SEM), and Ultraviolet visible near-infrared spectrophotometer (UV-VIS-NIR) respectively. In the case of a 1D PC normal mode without defect layer, it had a photonic band gap (PBG) in the near infrared (NIR) region. In the case of a 1D PC defect mode with defect layer, it had a sharp transmission band owing to a defect level, and moved towards the longer wavelength after exposing He-Cd laser with a wavelength of 325 nm.