• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1993년도 제2회 신약개발 연구발표회 초록집
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• pp.155-155
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• 1993

항우울약인 rolipran(RP)등 phosphodiesterase-억제 약(PDE-1)들이 thrombin(TB: 0.25 U/ml)에 의한 혈소판 응집에 미치는 작용을 가토-혈소판에서 일차 검토하였다. 신 PDE-1인 KR-30075(KR)의 $IC_{50}$/은 sodim nitroprusside의 것보다 낮았고 PDE-1들은 혈소판내 cAMP와 cGMP를 증가시켰으며 특히 KR은 타 PDE-1와 달리 I $P_3$를 감소시켰다. 아울러 rolipram은 cGMP와 I $P_3$를 증가시켰으나, amitriptyline(AT), sertraline(57), chlorpromazine(CP) 및 spermine은 I $P_3$를 증가시켰다. 그러나 이들과 PDE-1들은 강도의 차이는 있으나 모두 TB에 의한 혈소판응집을 모두 억제하였다. 따라서, PDE-1 중 IBMX(2$\times$$10^{-5}$M), KR(5$\times$10$_－7/M), 및 rolipram(10$_{-3}$M) 그 외에 항우울약인 AT(1.5 $\times$10$_－4/M) 와 ST(10$_－4/M) 및 항정신병약인 CP(10$_－4/M)둥이 혈소판내 I $P_3$, [C $a^{＋＋}$], Tx $B_2$, 및 PG $I_2$ 함량과 단백-인산화의 TB에 의한 변동에 미치는 영향을 검토하였다. 그 결과 TB에 의한 혈소판내 I $P_3$, [C $a^{＋＋}$], Tx $B_2$, 및 PG $I_2$ 함량의 증가가 PDE-1들과 항우울약들에 의하여 억제되었다 단, 항우울성약들과 CP는 정상 혈소판 I $P_3$를 증가시켰다. 아울러 혈소판-단백인산학에서 TB는 41-43 kD와 20 kD의 인산화를 현저히 증가시키며 19 kD의 인산화는 감소시켰고, PKC의 기질인 41-43 kD와 20 kD의 단백인산화가 PDE-1들과 항우울약들 뿐 아니라 CP에 의하여 현저히 억제되었다. 단, 20 kD 인산화에 대한 AT의 억제작용은 미약하였고, cAMP와 PDE-1들은 22kD 인산화를 증가시켰다. AT, ST, 및 CP는 A23187에 의한 41-43 kD 인산화는 현저히 억제하나 20 kD 인산화에는 영향을 미치지 않았고, PMA(3.2$\times$$10^{－7}$ M)에 의한 단백인산화에 대하여는 더 미약한 억제-효과를 나타내었다. 이상의 결과는 PDE-1과 항우울약들의 항혈소판작용은 PKC-기질인 41-43 kD와 20 kD의 인산화를 억제함에 기인되는 것으로 사료된다.다. 것으로 사료된다.다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2010년도 춘계학술대회 논문집
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• pp.573-574
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• 2010

• 한국자기학회:학술대회 개요집
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• 한국자기학회 1999년도 춘계연구발표회 논문개요집
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• pp.56-57
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• 1999

• Journal of Nutrition and Health
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• 제29권7호
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• pp.758-771
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• 1996

This study attempted to define reference data for the distribution of vitamin d status and to explore the relationship between vitamin D status and related biochemical indices in Korean women. The vitamin D status of 179 Korean women aged from 20 to 75 years was analyzed by using HPLC(High Pressure Liquid Chromatography). Related biochemical indices such as iPTH, alkaline phosphatase, creatinine, albumin, Ca, Mg and P were also measured. The mean serum level of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were s25.8ng/ml and 89.8pg/ml, respectively. Low 25-hydroxyvitamin D (<25nmol/L) was found in 29 subjects(16.5%). There was a significantly progressive decrease in serum 25-hydroxyvitamin D with increasing age(p<0.05). After in their, there was a dramatical reduction in 25-hydroxyvitamin D(p<0.05). It was also significant in post-menopasusal women compared with pre-menopausal women(p<0.000). Serum alkaline phosphatase levels increased significantly with age(p<0.001). Whereas serum calcium and phosphorus levels remained constant with age. Serum 250-hydroxyvitamin D was invesely related to iPTH (p<0.05) and alkaline phophatase (p<0.001).

• Journal of the Korean Statistical Society
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• 제11권2호
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• pp.88-93
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• 1982

A local limit theorem for large deviations for the i.i.d. random variables was given by Richter (1957), who used the saddle point method of complex variables to prove it. In this paper we give an alternative form of local limit theorem for large deviations for the i.i.d. random variables which is essentially equivalent to that of Richter. We prove the theorem by more direct and heuristic method under a rather simple condition on the moment generating function (m.g.f.). The theorem is proved without assuming that $E(X_i)=0$.

• 대한수학회지
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• 제35권2호
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• pp.399-422
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• 1998

A useful method of proving the finite decidability of an equationally definable class V of algebras (i.e., variety) is to prove the decidability of the class of finite directly indecomposable members of V. The validity of this method relies on the well-known result of Feferman-Vaught: if a class K of first-order structures is decidable, then so is the class {$\prod$$_{i}$＜n/ $A_{i}$│ $A_{i}$ $\in$ X (i < n), n $\in$ $\omega$}. In this paper we show that the converse of this does not necessarily hold.d.d.

• Communications for Statistical Applications and Methods
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• 제2권1호
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• pp.55-63
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• 1995

The characteristics of $I{\lambda}$-optimality are investigated with repsect to other experimental design's criteria, D-and G-optimality. The comparisons are based on D- and G-, and $I{\lambda}$-efficiencies using the Beta(p, q) distribution as a weighting function for $I{\lambda}$-optimality. Results indicate that serious consideration should be given to the $I{\lambda}$-optimality criterion especially when the error variance function is not homogeneous.

• 대한수학회지
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• 제45권4호
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• pp.993-1005
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• 2008

Let {$X,\;X_n;n{\geq}1$} be a sequence of i.i.d. random variables. Set $S_n=X_1+X_2+{\cdots}+X_n,\;M_n=\max_{k{\leq}n}|S_k|,\;n{\geq}1$. Then we obtain that for any -1$\lim\limits_{{\varepsilon}{\searrow}0}\;{\varepsilon}^{2b+2}\sum\limits_{n=1}^\infty\;{\frac {(log\;n)^b}{n^{3/2}}\;E\{M_n-{\varepsilon}{\sigma}\sqrt{n\;log\;n\}+=\frac{2\sigma}{(b+1)(2b+3)}\;E|N|^{2b+3}\sum\limits_{k=0}^\infty\;{\frac{(-1)^k}{(2k+1)^{2b+3}$ if and only if EX=0 and $EX^2={\sigma}^2<{\infty}$.

• 전자공학회논문지B
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• 제33B권3호
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• pp.133-141
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• 1996

As the recording density of digital magnetic recording channels increased, the nonlinear distortion caused by inadequate rise-times, demagnetizing field, and overwrite effect during the recording process becomes significant, resulting in limitation on the recording rate. In this paper, a new method for identifying the nonlinear distortion in hihg-density magnetic recording channel using and i.i.d. (independent, identically distributed) inut is described. The proposed method does not require the operatin of large-size matrix inversion which are necessary for the conventional method, and it enables us to estimate nonlinear parameters transition shifts, which can be used to compensate the nonlinear distortion, is demonstrated by computer simulations.

• Communications for Statistical Applications and Methods
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• 제13권2호
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• pp.243-254
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• 2006

The relative frequency of order statistics is investigated for independent and identically distributed (i.i.d.) random variables. Specifically, it is shown that the probability $Pr\{X_{[s]}=x\}$ is no less than the probability $Pr\{X_{[r]}=x\}$ at any point $x{\geqq}x_0$ when r$X_{[r]}$ denotes the r-th order statistic of an i.i.d. discrete random vector and $x_0$ depends on the population probability distribution. A similar result for i.i.d. continuous random vectors is also presented.