• Biomolecules & Therapeutics
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• v.1 no.1
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• pp.31-36
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• 1993

To evaluate the feasibility of transmucosal delivery of methionine enkephalin analog, [$D-Ala^2$]-me-thionine enkephalinamide (YAGFM), the influence of pH, temperature, ionic strength and initial peptide concentration on the physicochemical stability of YAGFM in aqueous buffered solutions were investigated using a stability-indicating HPLC method. The degradation of YAGFM followed the pseudo-first-order kinetics. From the pH-rate profile, the maximum stability of YAGFM was shown to be at the pH of about 5.0. The halflife for the degradation of YAGFM was found to be 181.3 days at pH 5.0 and $37^{\circ}C.$ Arrhenius plots of the data obtained at 25~$45^{\circ}C$ were reasonably linear with a correlation coefficient greater than 0.99, and the activation energy was calculated to be 8.9 kcal/mole. A higher ionic strength and/or a higher peptide concentration in buffered solutions retarded the degradation of YAGFM.

• Proceedings of the KIEE Conference
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• 1998.07b
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• pp.795-797
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• 1998

This paper suggests a design method of the optimal PD control system having robust performance. This PD control system is designed by applying genetic algorithm(GA) with reference model to the optimal determination of proportional(P) gain and derivative(D) gain that are given by PD servo controller. These proportional and derivative gains are simultaneously optimized in the search domain guaranteeing the robust performance of closed-loop system. This PD control system is applied to the fuel-injection control system of diesel engine and compared with ${\mu}$ -synthesis control system for robust performance. The effectiveness of this PD control system is verified by computer simulation.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2010.11a
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• pp.1057-1058
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• 2010

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.11C
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• pp.1077-1084
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• 2006

This paper proposed a fast algorithm to reduce the amount of calculation for inter prediction which takes a great deal of the operational time in H.264/AVC. This algorithm decides a search range according to the direction of predicted motion vector, and then performs an adaptive spiral search for the candidates with JM(Joint Model) FME(Fast Motion Estimation) which employs the rate-distortion optimization(RDO) method. Simultaneously, it decides a threshold cost value for each of the variable block sizes and performs the motion estimation for the variable search ranges with the threshold. These activities reduce the great amount of the complexity in inter prediction encoding. Experimental results by applying the proposed method .to various video sequences showed that the process time was decreased up to 80% comparing to the previous prediction methods. The degradation of video quality was only from 0.05dB to 0.19dB and the compression ratio decreased as small as 0.58% in average. Therefore, we are sure that the proposed method is an efficient method for the fast inter prediction.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.5C
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• pp.503-511
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• 2006

H.264 adopts new coding tools such as intra-prediction, loop filter, etc. The adoption of these tools enables an H.264-coded bitstream to have more information compared with previous standards. In this paper we proposed an effective spatial error concealment method for H.264. Among the information included in an H.264-coded bitstream, we use intra-mode for recovering a damaged block. This is because prediction direction in intra-mode is highly correlated to the edge direction of a lost macroblock. We first estimate the edge direction using intra-modes of blocks adjacent to a lost macroblock, and classify the area in a damaged macroblock into the edge and the flat area. And then our method recovers pixel values in the edge area using edge-directed interpolation, and recovers pixel values in the flat area using weighted interpolation. Simulation results show the proposed method yields better video quality than conventional approaches by 0.35 to 5.48 dB.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2009.06a
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• pp.969-970
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• 2009

• Journal of the Korean Magnetics Society
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• v.5 no.3
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• pp.216-221
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• 1995

Both manufacturing parameters and particles' chemical composition controll coercivity and its distribution of magnetic particles. The coercivity and its distribution are important properties for high density magnetic recording, so these are used as tool for evaluation of reproducibility of magnetic particles. We report in this paper the applications of dM/dH versus H curve, which is derived from magnetic hysteresis loop, to the evaluation of coercivity distribution of magnetic particles and oxidation studies of recording metal particles. The coercivity distri-bution can be estimated from the full width half rnaximun (FWHM) and the peak shape of the dM/dH versus H curve. The peak shape of the curve depends upon distribution of particles' coercivity. The peak of dM/dH versus H curve becomes broad and lor is splitted into two or rmre peaks. It depends on uniformity of particles' coercivity. When the coercivity difference between Ba-Ferrite and ${\gamma}-Fe_{2}O_{3}$ is larger than 600 Oe, the peak becomes broad and is consequently splitted into two peaks. Ununiformly substituted Ba-Ferrite particles show broad peak. It is apparent that the analysis of the curve is one of sensitive measuring techniques for determination of coercivity distri-bution and studies on magnetic properties of substituted Ba-Ferrite and oxidation of magnetic recording metal particles.

• Journal of Korean Society of Forest Science
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• v.5 no.1
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• pp.27-32
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• 1966

Taking an opportunity of the application of clearcutting method, 140 red pine (Pinus densiflora Sieb. et Zucc.) trees grown at Chon-nam province, the southern part of South Korea, were fellen and the tree height, clear-bole length, D.B.H. diameter at base(0.2m above from the ground line) and the length of the longest branch were measured. The correlation between factors mentioned were analysed. The results are summarized as follows: 1. The correlation between crown length and tree height (r=0.821) was sinificant. 2. The correlation between the diameter at base and D.B.H. was highly significant (r=0.961). D.B.H. can be calculated from multiplying the diameter at base by 0.88. 3. A weak relation between D.B.H and tree height was abserved. 4. The positive correlation between tree height and clear-bole-length was calculated, but it was not sharp between D.B.H. and the length of the longest branch. 5. The height, basal area, D.B.H. and volume increment by tree class calculated from the data of the stem analysis are presented (Tab. 3~10).

• Journal of Animal Reproduction and Biotechnology
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• v.37 no.4
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• pp.246-254
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• 2022

Current studies have revealed the capacity of mesenchymal stem cells (MSCs) in term of immunomodulatory properties, and this distinct potential is downgraded according to the disease duration of patients-derived MSCs. In order to enhance the immunomodulatory and anti-tumorigenic properties of the rheumatoid arthritis (RA) joints-derived MSCs, we aggregate synovial fluid-derived MSCs from RA joints (RA-hMSCs) into 3D-spheroids by the use of hanging drop culture method. Cells were isolated from synovial fluids of RA joints with longstanding active status over 13 years. For aggregation of RA-hMSCs into 3D-spheroids, cells were plated in hanging drops in 30 μL of advanced DMEM (ADMEM) containing 25,000-30,000 cells/drop and cultured for 48 h. To analyze the comparative immunomodulatory effects of 3D-spheroid and 2D monolayer cultured RA-hMSCs and then cells were cultured in ADMEM supplemented with 20% of synovial fluids of RA patients for 48 h and were evaluated by qRT-PCR for their expression of mRNA levels of inflammatory and anti-inflammatory markers. Cellular aggregation of RA-hMSCs was observed and cells were aggregate into a single sphere. Following treatment of RA patient's synovial fluids into the RA-hMSCs, spheroids formed RA-hMSCs showed significantly (p < 0.05) higher expression of TNFα stimulated gene/protein 6 (TSG-6) than the monolayer cultured RA-hMSCs. Therefore, the 3D-spheroid culture methods of RA-hMSCs were more effective than 2D monolayer cultures in suppressing inflammatory response treated with 20% of RA-synovial fluids by expression of TNFα (TSG-6) according to the immune response and enhanced secretion of inflammatory factors.

• Journal of the Korean Geotechnical Society
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• v.23 no.5
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• pp.153-162
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• 2007

For the reinforced earth wall constructed on a soft ground in parallel with replacing soft soils, the behavior of the wall according to variations of thickness and stiffness of soft layer, replacement depth, and wall height is investigated using a finite element method, in which incremental construction steps including consolidation of soft soil layer are considered. The behavior of wall is characterized by investigating displacements and settlements developing at the wall, and shear strains developing in a soil deposit. The stability of wall is, then, evaluated by comparing these values with the safety criteria determined on the basis of the literature. Based on the investigation, it is shown that the behavior of wall is influenced naturally from soft soil thickness(t), replacement depth(d) and wall height(h), but more significantly from d and h. In addition, it is also shown that the normalized replacement depth, d/h, required for the safety of wall is not influenced significantly by the variations of t and h. Consequently, it can be concluded that the proper replacement depth can be suggested in an equivalent value in terms of d/h, even for the cases where the wall height is varying with stations, but the variation is not significant.