• 한국수의병리학회지
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• 제1권2호
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• pp.149-152
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• 1997

A 13-years and 8-months old Jindo dog showed vomiting and pale red vulvular discharge. At necropsy, the uterus was swollen and endometrium was diffusely thickened by numerous protruding cysts which measured approximately from 0.5 to 1 cm in diameter. On sectioning the cysts exuded pale red watery fluid. histologically the endometrium was thickened and characterized by mild to moderate edema congestion and hemorrhagic foci. The cystic endometrial glands were lined by a single layer of flattened cuboidal or vacuolated columnar epithelium. Occasional dilated glands had traversed through the submucosa into the myometrial region. Afew mixed inflammatory cells infiltrated in the lamina propria. Bacteriologically Escherichia coli was isolated from the uterine contents. Gross and microscopic finding were consistent with cystic endometrial hyperplasia.

• 대한수의학회지
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• 제57권4호
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• pp.245-248
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• 2017

At the time of visiting, the cat was 6-year-old female Siamese cat. The mammary mass was solid and firm and measured $2{\times}5cm^2$ in greatest diameter. The uterus revealed thick uterine horn and cross sectioned wall. Histopathologically, the mammary mass revealed feline mammary carcinoma. In the uterus, cystic endometrial hyperplasia was observed. Feline leukemia virus positive reaction was detected by polymerase chain reaction. As far as we know, this is the first report of the simultaneous feline mammary carcinoma and uterine endometrial cystic hyperplasia with Feline leukemia virus infection in a cat.

• 한국동물위생학회지
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• 제36권2호
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• pp.127-132
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• 2013

An 11-year-old poodle bitch was presented for investigation of multicentric mammary masses. Abdominal sonography and radiography demonstrated abnormal enlargement of uterus and ovaries. Blood analysis revealed high progesterone concentration. The ovariohysterectomy and mastectomy were performed. Histopathologically, the mammary masses revealed complex carcinoma-tubulopapillary carcinoma with papillary pattern and tubule pattern. In the uterus, cystic endometrial hyperplasia was observed. Scattered inflammatory cells were observed in the endometrial stroma and mucinous material was protruded from endometrial surface. Also, in the ovaries, bilateral ovary granulosa cell tumor was detected. The bitch made a complete recovery following the ovariohysterectomy and mastectomy. This case was a very rare multiple tumor occurrence with bilateral ovary granulosa cell tumor and mammary complex carcinoma. High progesterone concentration was characterized clinically in the bitch.

• 한국임상수의학회지
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• 제12권1호
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• pp.819-827
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• 1995

An attempt to reproduce pyometra by means of experimental uterine infection was conducted with the 10 mongrel hitches of the anestrus, proestrus, metestrus, and postpartum uterine involution stages. Organism used was hemoltic E. coli. origially isolated from uterine pus of a bitch that had the canine pyometra. One ml of broth culture containing $2{\times}10^6$ CFU was inoculated into the uterine horn with the uterine cervix ligated. Aか bitches were ovariohysterectomized at the 7th or 14th day after inoculation and the uterus was provided for macroscopic and microscopic observations. An experimental production of pyometra was successful in 7(70%) of 10 mongrel bitches, and the incidence of pyometra was seen 100% in the stage of anestrus, 100% in the stage of metestrus, 50.0% in the stage of pyomestrus, and 33.359 in the stage of uterine involution. Histologically, these uteri were characterized by the presence of cystic. endomeetrial hyperplasia(CEH) and acute endometritis superimposed on the cystic hyperplasia. And the pyometra with CEH could be seen 66.7% in metestrus 50% in anestrus, 33.3% in involution and in 0% in proestrus stage. Blood progesterone concentrations were showed as a normal range of the each stage of sexual cycle and any relationships between the progesterone concentrations and the incidence of pyometra were not observed.

• 한국임상수의학회지
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• 제28권6호
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• pp.610-612
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• 2011

9 년령 암컷 콜리견이 복부 팽만, 식욕 부진 및 변비를 주증으로 본원에 내원하였다. X-ray, 초음파 및 CT 검사를 통하여 복강내 연부조직종괴를 확인하였으나 세포학적 검사에서 종양 세포는 관찰 할 수 없었다. 탐색적 개복술을 계획하였다. 크고 둥근 모양의 종괴가 우측 자궁각에 위치하는 것을 확인하고 난소자궁적출술을 실시하였다. 종괴의 크기는 $40{\times}25{\times}18$ cm 였으며 무게는 9.5 kg 이었다. 조직학적 검사를 통해 낭상자궁내막증식증(CEH)으로 진단하였다. CEH는 자궁 내용물이 감염되거나 자궁 축농증으로 이어짐에도 불구하고 임상 증상이 없는 경우가 많으므로 정확한 진단이 어렵다. 본 증례는 자궁 축농증을 동반하지 않은 매우 큰 크기의 국소성 낭상자궁내막증식증의 드문 예이다.

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2007년도 추계국제학술대회 및 컨퍼런스
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• pp.565-565
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• 2007

• KSBB Journal
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• 제17권4호
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• pp.409-415
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• 2002

폐경기 여성들에게 있어서 에스트로겐의 결핍현상은 골다공증, 동맥경화, 심장질환과 같은 치명적인 질병을 유발하고, 혈관 운동 불안정으로 인하여 일과성 열감과 같은 증상이 일어나며, 치매의 위험이 있다. 또한, 안면홍조, 우울증, 무력감 등의 증상을 경험하는데, 식물성 에스트로겐 대체요법으로서 위와 같은 폐경기 증후군을 치유 예방 관리가 가능함과 동시에 동물성 혹은 화학적 에스트로겐 요법에서 우려되는 유방암 및 자궁암 등의 부작용에 대한 우려를 씻어낼 수 있다. 본 연구에서는 이와 같이 안전하면서 각종 폐경기 증후군에 대처할 수 있는 식물성 에스트로겐 대체제 (Phytoesoogen)의 효과를 확인하였다. 가장 고전적인 효과인 생식기 조직의 재생효과를 확인하였고, 혈중 에스트로겐 농도의 증가도 관찰되었다. 따라서 본 실험을 통해 확인된 여성호르몬 대체효과를 가지는 식물 추출물 FGF271이 추가의 연구를 통해 여성들이 인생의 1/3에 해당되는 폐경기를 즐겁고 안정된 삶으로 보낼 수 있도록 되기를 바란다.

• 한국임상수의학회지
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• 제34권6호
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• pp.420-424
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• 2017

Cystic endometrial hyperplasia (CEH) and uterine dilation (hydro-, muco-, hemato- and pyometra) are common uterine diseases in intact female dogs. The aim of the present study was to assess the usefulness of digital abdominal radiography in diagnosing uterine disease in intact female dogs. Two hundred and thirteen intact female dogs were included, and were classified into four groups on the basis of radiographic uterine visibility (visible/invisible) and ultrasonographic findings (normal uterus/abnormal uterine condition including CEH and uterine dilation). For each dog, the ratio of the maximum uterine diameter to the height of the fifth lumbar vertebral body (U/L5 ratio) was calculated on radiographs. There were 78 and 135 dogs in the normal and abnormal groups, respectively; 34.6% normal and 53.5% abnormal uteri were visible on abdominal radiographs. Our results suggested that a mean U/L5 ratio of $1.18{\pm}0.53$ ($mean{\pm}2SD$) indicated a normal radiographic uterus diameter, and that a value of > 1.60 should be used as an indicator of uterine disease in clinical practice. However, because false negative results were noted, radiography cannot replace ultrasonography for assessment of the uterus.

• 한국임상수의학회지
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• 제24권4호
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• pp.542-549
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• 2007

During a designated period(Jan. 2003$\sim$Jun. 2006), a total of 2,051 biopsy and necropsy cases submitted to Veterinary Medical Teaching Hospital of Seoul National University and local practitioners were diagnosed as canine tumors based on microscopic evaluation in the Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University. Four hundred and twenty of 2,051 tumor specimens excluding mammary(883, 43.1%) and cutaneous(748, 36.5%) tumors were included in this retrospective study. They were composed of genital tumors(189, 45.0%) followed by alimentary(113, 26.9%), hematopoietic(52, 12.4%), urinary(20, 4.8%), bone & joint(15, 3.6%), ocular & otic(9, 2.1%), respiratory(6, 1.4%), endocrine(6, 1.4%), and miscellaneous(10, 2.4%). Particular top ten tumor most frequently diagnosed were seminoma(48, 11.4%) followed by fibrous epulis(38, 9.0%), lymphoma(38, 9.0%), leiomyoma(33, 7.9%), fibroma(26, 6.2%), ovarian cyst(19, 4.5%), melanoma(15, 3.6%), papilloma(14, 3.3%), cystic endometrial hyperplasia(13, 3.1%), granulosa cell tumor(13, 3.1%) in descending order comprising 257(61.2%). The affected age of the animals with ten frequent tumors ranged from 3 months to 17 years old with a mean of 9.2 years old(n=218). There were no significant sex prevalence except female leiomyoma. The top seven anatomical sites of tumors inclusive were gingiva(62, 14.8%), testis(61, 14.5%), ovary(48, 11.4%), vagina(40, 9.5%), uterus(36, 8.6%), lymph node(30, 7.1%), and spleen(21, 5.0%).