• Korean Journal of Environmental Biology
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• v.28 no.4
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• pp.196-201
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• 2010

The phenethyl ester of caffeic acid (CAPE), an active component of honeybee propolis extract, is shown to inhibit cancer growth previously. However, studies on human ovarian cancer are largely obscure. This study evaluated the effects of CAPE as a potential anti-proliferative and pro-apoptotic agent in the human ovarian cancer line, OVCAR-3. CAPE treated OVCAR-3 cells showed inhibition of cell viability and proliferation in a dose-dependent manner by WST-1 assay, LDH assay and bromodeoxyuridine (BrdU) incorporation assay. Furthermore, CAPE-mediated OVCAR-3 cell growth inhibition was associated with apoptotic changes as evident by cell cycle arrest and accumulation of cells in the apoptotic phase and DNA fragmentation. Taken together, CAPE inhibits cell proliferation via DNA synthesis reduction and induces apoptotic cell death via DNA damage, thus elucidating a novel, plausible mechanism of CAPE anti-tumorigenic property in OVCAR-3 cells.

• Journal of the Korean Society for Precision Engineering
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• v.21 no.12
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• pp.167-173
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• 2004

Recently, it has been reported that frictional behavior at nanometer scale can be different from that at macro scale. In this article, friction and wear tests were conducted using an AFM to investigate the effect of real contact area on the coefficient of friction and wear property. SiO$_2$, Hica, and SiGe were used in friction test and the AFM tip was Si$_3$N$_4$. The real contact area between an AFM tip and flat surface was calculated by the Johnson-Kendall-Roberts (JKR) theory. Wear specimen was Mica, and the diamond tip was used. We found that the coefficient of friction is constant below a critical area, but it is degraded over the area. Moreover, it is found that wear depth increased rapidly from a certain load and was degraded as a function of the number of the scanning cycles. Also, the range of scanning velocity used in this study had little effect on the wear depth.

• Journal of the Korean Society for Precision Engineering
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• v.23 no.6 s.183
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• pp.104-110
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• 2006

A design and control of electrostatic suspension system for flexible objects is presented. A number of electrode pairs of which the number depends on the object flexibility are positioned above the object and the voltages applied to each electrode pair are controlled, independently on the others, on the basis of the gap length. To implement the system with low cost and compactness, switched-voltage control scheme that is based on the relay feedback control is utilized. Relay feedback control method deploys only a single high-voltage power supply that can deliver a DC voltage of positive and/or negative polarity and thus high voltage amplifiers that are costly and bulky are not needed any more. It is shown that despite the inherent limit cycle property of the relay feedback based control, an excellent performance in vibration suppression is attained due to the presence of a relatively large squeeze film damping originating from the electrodes and levitated object. Employing fourteen electrode pairs, a thin aluminum plate with a thickness of 0.1 mm has been suspended at a gap length of 0.75mm.

• Nuclear Engineering and Technology
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• v.28 no.4
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• pp.366-372
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• 1996

The simulated spent PWR fuel pellet which is corresponding to the turnup of 33,000 MWD/MTU is prepared by adding 11 fission-product elements to UO$_2$. The simulated spent fuel pellet is treated at 40$0^{\circ}C$ in air (oxidation), at 110$0^{\circ}C$ in air (high-temperature treatment), and at $600^{\circ}C$ in hydrogen (reduction). The product is treated through additional addition and reduction up to 3 cycles. Pellets are completely pulverized by the first oxidation, and the high-temperature treatment causes particle and crystallite to grow and surface to be smooth, and thus particle size significantly increases and surface area decreases. The reduction following the high-temperature treatment decreases much the particle size by means of the formation of intercrystalline cracks. The particle size decreases a little during the second oxidation and reduction cycle and then remains nearly constant during the third and fourth cycles. Surface area of pounder increases progressively with the repetition of oxidation and reduction cycles, mainly due to the formation of Surface cracks. The degradation of surface area resulting from high-temperature treatment is restored by too subsequent resulting oxidation and reduction cycles.

• Tunnel and Underground Space
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• v.7 no.3
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• pp.238-245
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• 1997

A transient pulse methos has been used to measure the permeability of Pocheon granite pre-heated from $25^{\circ}C$ to $600^{\circ}C$ at effective pressure up to 32MPa. The permeability of whole rock ranged from 0.72 $\mu$d at 10MPa to 0.20 $\mu$d at 32MPa. The permeability of rock heated to $600^{\circ}C$ ranged from 18.07$\mu$d at 10MPa to 6.39$\mu$d at 32MPa. Confining pressure has greater effects on the rocks thermally treated to lower thermal-cycle temperatures than on the higher thermally treated rocks. The increase of permeability is most pronounced between 40$0^{\circ}C$ and $600^{\circ}C$. Below 40$0^{\circ}C$, permeability increase is expected to be associated with the formation of new cracks and widening of preexisting cracks, whereas above 40$0^{\circ}C$, permeability increase is expected to reflect widening of cracks. Using the equivalent channel model, author shows that the exponent n in the relationship relating the permebility(k) to porosity($\phi$) by k∝$$\phi$^n$ falls in the range 2.7$\leq$n$\leq$3.0.

• Food Science and Biotechnology
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• v.18 no.4
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• pp.991-995
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• 2009

As a principle ingredient in omija-eui, the physicochemical properties of mung bean starch (MBS) paste were investigated and compared to those of rice and corn starch. The amylose and the protein content of MBS were higher than those of rice or corn starch while the total sugar content and the swelling power of MBS were lower. In addition, the clarity of MBS paste was higher than either rice or corn starch paste. Regarding pasting properties, the peak viscosity and cool paste viscosity of MBS were higher than those of either rice or corn starch. During the freeze-thaw cycle, MBS exhibited higher degree of syneresis than corn and rice starch, which decreased with high starch concentration and heating temperature. The paste properties and freeze-thaw stability of MBS showed a potential for improving the quality of omija-eui.

• Earthquakes and Structures
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• v.14 no.5
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• pp.437-447
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• 2018

Computational cost is one of the major obstacles for detailed risk analysis of structures. This paper puts forward a methodology for efficient probabilistic seismic loss assessment of structures using the Endurance Time (ET) analysis and the first-order reliability method (FORM). The ET analysis efficiently yields the structural responses for a continuous range of intensities through a single response-history analysis. Taking advantage of this property of ET, FORM is employed to estimate the annual rate of exceedance for the loss components. The proposed approach is an amalgamation of two analysis approaches, ET and FORM, that significantly lower the computational costs. This makes it possible to evaluate the seismic risk of complex systems. The probability distribution of losses due to the structural and non-structural damage as well as injuries and fatalities of a prototype structure are estimated using the proposed methodology. This methodology is an alternative to the prevalent risk analysis framework of the total probability theorem. Hence, the risk estimates of the proposed approach are compared with those from the total probability theorem as a benchmark. The results indicate a satisfactory agreement between the two methods while a significantly lower computational demand for the proposed approach.

• The Journal of Pediatrics of Korean Medicine
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• v.17 no.1
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• pp.1-16
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• 2003

Background: Delayed mucociliary clearance develops the pooling of nasal secretion in the nasal cavity and is a common cause of vicious cycle of symptoms in chronic sinusitis. mucociliary clearance depends on the ciliary activity, the rheological property of the secretion and on the interaction between cilia and the mucous blanket. Objective: To demonstrate the therapeutic effect of herbal medicine (Hyunggyeyungotang) on the mucociliary transport in the chronic sinusitis using saccharine Materials and methods: Forty patients treated in our hospital between september 2000 and september 2001 were studied. Before and after therapy group are composed of twenty patients. Kamihyunggyeyungyotang was administered mainly. We analyzed the saccharine mucociliary transport time of patients. Results: 1) In the control group, the transport time is about 13.4 minutes. 2) In chronic sinusitis before Kamihyunggyeyungotang therapy, the transport time is about 27.7 minutes. 3) In chronic sinusitis after Kamihyunggyeyungotang therapy, the transport time is about 13.8 minutes. Conclusion: Delayed mucociliary transport time in chronic sinusitis is earlier after Kamihyunggyeyungotang therapy.

• Journal of Korea Foundry Society
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• v.9 no.1
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• pp.58-66
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• 1989

The effect of heat treating temperature and ${\alpha}$ phase In the ${\beta}$ phase matrix were investigated for ${\beta}-CuZnAl$ shape memory alloys by tension test, fatigue test, and shape memory effect test. After heat treatment at $677^{\circ}C$, $750^{\circ}C$, $800^{\circ}C$ and $850^{\circ}C$ for 10 min. respectively, static fracture stress(${\sigma}_f$), fatigue fracture stress(${\tau}_{max}$) at $10^6$ cycle, and elongation(${\epsilon}_f$) was $24.2kg/mm^2$, $17.21kg/mm^2$ and 11.8%, respectively. As heat treating temperature decreased, fracture surfaces of the specimens were changed from the intergranular to the transgranular fracture mode. Especially, the a phase precipitated in the ${\beta}$ phase matrix had an effect on crack propagation and the fracture surface was characterized by dimple-like pattern when crack propagated in transgranular cracking mode. Precipitation of the ${\alpha}$ phase in the ${\beta}$ phase matrix lowered the transformation temperature by $10^{\circ}C$, and about 2.5 vol.% ${\alpha}$ phase did not affect the shape memory effect examined by the bending test.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2000.10a
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• pp.412-418
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• 2000

In this paper, we will propose that HCN(n,n) gets Hamiltonian Cycles and analyze embedding among HCN(n,n) and UFN(n,n), and HFN(n,n) and In-hypercube. Further, we will prove that HCN(n,n) can be embedded into HFN(n,n) with dilation 3 and the cost for HFN(n,n) to be embedded into HCN(n,n) will be O(n), and HW(n,n) can be embedded into 2n-hypercube with dilation 3 and the cost for In-hypercube to be embedded into HFN(n,n) will be O(n).