• BMB Reports
• /
• 제49권11호
• /
• pp.587-589
• /
• 2016

The circadian clock system enables organisms to anticipate the rhythmic environmental changes and to manifest behavior and physiology at advantageous times of the day. Transcriptional/translational feedback loop (TTFL) is the basic feature of the eukaryotic circadian clock and is based on the rhythmic association of circadian transcriptional activator and repressor. In Drosophila, repression of dCLOCK/CYCLE (dCLK/CYC) mediated transcription by PERIOD (PER) is critical for inducing circadian rhythms of gene expression. Pacemaker neurons in the brain control specific circadian behaviors upon environmental timing cues such as light and temperature cycle. We show that amino acids 657-707 of dCLK are important for the transcriptional activation and the association with PER both in vitro and in vivo. Flies expressing dCLK lacking AA657-707 in $Clk^{out}$ genetic background, homologous to the mouse Clock allele where exon 19 region is deleted, display pacemaker-neuron-dependent perturbation of the molecular clockwork. The molecular rhythms in light-cycle-sensitive pacemaker neurons such as ventral lateral neurons ($LN_vs$) were significantly disrupted, but those in temperature-cycle-sensitive pacemaker neurons such as dorsal neurons (DNs) were robust. Our results suggest that the dCLK-controlled TTFL diversify in a pacemaker-neuron-dependent manner which may contribute to specific functions such as different sensitivities to entraining cues.

• 한국신뢰성학회지:신뢰성응용연구
• /
• 제16권3호
• /
• pp.224-230
• /
• 2016

Purpose: Military maintenance involves corrective and preventive actions carried out to keep a system in or restore it to a predetermined condition. This research develops an optimal maintenance cycle for aviation oil testing equipment with acceptable reliability level and minimum maintenance cost. Methods: The optimal maintenance policy in this research aims to satisfy the desired reliability level at the lowest cost. We assume that the failure process of equipment follows the power law non-homogeneous Poisson process model and the maintenance system is a minimal repair policy. Estimation and other statistical procedures (trend test and goodness of fit test) are given for this model. Results: With time varying failure rate, we developed reliability-based maintenance cost optimization model. This model will reduce the ownership cost through adopting a proactive reliability focused maintenance system. Conclusion: Based on the analysis, it is recommended to increase the current maintenance cycle by three times which is 0.5 year to 1.5 years. Because of the system's built-in self-checking features, it is not expected to have any problems of preventative maintenance cycle.

• 대한기계학회논문집A
• /
• 제21권2호
• /
• pp.199-208
• /
• 1997

A local strain approach was applied to an external single and double grooved C-shaped specimen in order to evaluate and predict the fatigue crack initiation life by using low cycle fatigue properties. The low cycle fatigue properties were determined from the strain-controlled fatigue tests using smooth cylindrical axial specimens. Fatigue crack initiation life was evaluated by a life prediction software, FALIPS, based on the local strain approach. The fatigue life was significantly influenced by the mean stress, and SWT parameter represented the fatigue life effectively. The predicted fatigue crack initiation life was then compared to the experimental fatigue life evaluated from the C-shaped fatigue test specimens. A good correlation was found between the experimental and predicted fatigue lives within factors of 2 and 4 for the single and double grooved C-shaped specimens respectively. Also, experimental fatigue life of the double grooved specimen was 10-12 times longer than that of the single grooved specimen.

• 품질경영학회지
• /
• 제38권3호
• /
• pp.439-448
• /
• 2010

Since the six sigma strategy was first introduced to Motorola in 1987, it has been taken as an important business strategy to strengthen the competitiveness of leading companies in the global competitiveness environm ent. This paper presents a six sigma project to reduce the cycle time of assembly line in a medium size automotive part company. The project follows a structured methodology of DMAIC cycle which consists of Define, Measure, Analyze, Improve, and Control. A CTQ is determined based on COPQ analysis, and a process map is utilized for identifying process input variables. As a result of the project, two assembly lines are converted to cell line production lines. The cycle times become 55 sec./unit and 64 sec./unit from 64 sec./unit and 83 sec./unit at the beginning of the project, respectively.

• 대한산업공학회지
• /
• 제28권4호
• /
• pp.415-424
• /
• 2002

Semiconductor manufacturing has been emerged as a highly competitive but profitable business. Accordingly it becomes very important for semiconductor manufacturing companies to meet customer demands at the right time, in order to keep the leading edge in the world market. However, due-date oriented production is very difficult task because of the complex job flows with highly resource conflicts in fabrication shop called FAB. Due to its cyclic manufacturing feature of products, to be completed, a semiconductor product is processed repeatedly as many times as the number of the product manufacturing cycles in FAB, and FAB processes of individual manufacturing cycles are composed with similar but not identical unit processes. In this paper, we propose a production scheduling and control scheme that is designed specifically for semiconductor scheduling environment (FAB). The proposed scheme consists of three modules: simulation module, cycle due-date estimation module, and dispatching module. The fundamental idea of the scheduler is to introduce the due-date for each cycle of job, with which the complex job flows in FAB can be controlled through a simple scheduling rule such as the minimum slack rule, such that the customer due-dates are maximally satisfied. Through detailed simulation, the performance of a cycle due-date based scheduler has been verified.

• 설비공학논문집
• /
• 제29권4호
• /
• pp.167-174
• /
• 2017

This study attempted to investigate the value of photoelectric sensors in terms of a defrost-control method. Tests were conducted in a calorimeter room under the heating with the defrost-performance test conditions described in KS C 9306. Accordingly, the photoelectric technology is a competitive defrost-control method that can precisely control the operational defrost cycle using the output voltages that are proportional to the frost height. The heating period is gradually reduced because the complex defrost-control method, for which the sensors initiate the defrosting process and the defrosting process is terminated by the time parameter, could not adjust the net defrosting time by itself. Therefore, a complex defrost-control method, for which the photoelectric sensors start the defrosting process and it is terminated by the temperature parameter, is preferred because of the adjustment of the net defrosting time. Regardless of the defrost-control method, the first defrosting cycle is activated earlier than the times that are determined in the second and third cycles and so on, because the first operation cycle can decide the characteristics of the subsequent cycle.

• 산업공학
• /
• 제14권1호
• /
• pp.95-105
• /
• 2001

Previous work measurement methods need much time and effort of time study analysts because they have to measure required time through direct observations. In this study, we propose a method which efficiently measures standard times without involvement of human analysts using digital image processing techniques. This method consists of two main steps: motion representation step and cycle segmentation step. In motion representation step, we first detect the motion of any object distinct from its background by differencing two consecutive images separated by a constant time interval. The images thus obtained then pass through an edge detector filter. Finally, the mean values of coordinates of significant pixels of the edge image are obtained. Through these processes, the motions of the observed worker are represented by two time series data of worker location in horizontal and vertical axes. In the second step, called the cycle segmentation step, we extract the frames which have maximum or minimum coordinates in one cycle and store them in a stack, and calculate each cycle time using these frames. In this step we also consider methods on how to detect work delays due to unexpected events such as operator's escapement from the work area, or interruptions. To condude, the experimental results show that the proposed method is very cost-effective and useful for measuring time standards for various work environment.

• 한국전기전자재료학회:학술대회논문집
• /
• 한국전기전자재료학회 2007년도 추계학술대회 논문집
• /
• pp.242-242
• /
• 2007

To verify the applicability of High Temperature Superconducting (HTS) cable system into the real grid, the HTS cable system with the specification of 22.9 kV, 1250 A, 100 m long was installed in the second quarter of 2006, and the long term field test has been in progress at the KEPCO's Gochang power testing yard. Apart from the conventional power cable, HTS cable system requires sufficient thermo-mechanical strength to endure a large temperature difference. To date, the KEPCO HTS cable system was cooled down and warmed to the room temperature several times to investigate the influence of thermal cycles experimentally. Dielectric properties, critical current dependance and heat losses were evaluated at each step of thermal cycle. The test results showed that thermal cycle did not induce the degradation of dielectric properties, and the critical current decreased to 5 % of the initial value.

• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 2005년도 추계학술대회 논문집
• /
• pp.627-631
• /
• 2005

In this study, low fatigue behavior of laser welded sheet metal were investigated. Before welding, the cross section of butt joint was prepared only by fine shearing without milling process. Specimens were same sheet metal and welding condition that using automobile manufacturing company at present. Butt joint of cold rolled sheet metal was welded by $CO_2$ laser. It is used that welding condition such as laser welding speed was 5.5m/sec and laser output power was 5kW for 0.8mm and 1.2mm sheet metal. The laser weldments were machined same or different thickness and same or different material. In order to mechanical properties of around welding zone, hardness test was performed. Hardness of welding bead is about 2 times greater than base material. We performed the low cycle fatigue tests for obtaining fatigue properties about thickness and the weld line direction of specimen. The results of strain controlled low cycle fatigue test indicate that all specimens occur cyclic softening, as indicated by the decrease in stress to reach a prescribed strain.

• Computers and Concrete
• /
• 제25권2호
• /
• pp.167-179
• /
• 2020

Optimal design of structures against earthquake loads is often limited to reduce initial construction costs, while the cost induced to structures during their useful life may be several times greater than the initial costs. Therefore, it is necessary to consider the indirect costs due to earthquakes in the design process. In this research, an integrated methodology for calculating life cycle cost (LCC) of moment-resisting concrete frames is presented. Increasing seismic safety of structures and reducing human casualties can play an important role in determining the optimal design. Costs incurred for structures are added to the costs of construction, including the costs of reconstruction, financial losses due to the time spent on reconstruction, interruption in building functionality, the value of people's life or disability, and content loss are a major part of the future costs. In this research, fifty years of useful life of structures from the beginning of the construction is considered as the life cycle. These costs should be considered as factors of calculating indirect costs of a structure. The results of this work represent the life cycle cost of a 4 story, 7 story, and 10 story moment-resisting concrete frame by details. This methodology is developed based on the economic conditions of Iran in 2016 and for the case of Tehran city.