• Journal of Life Science
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• v.28 no.11
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• pp.1268-1276
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• 2018

The cytidine analog decitabine (DEC) acts as a nucleic acid synthesis inhibitor, whereas ammonium pyrrolidine dithiocarbamate (PDTC) is an inhibitor of nuclear factor-${\kappa}B$. The aim of this study was to investigate the possible synergistic inhibitory effect of these two inhibitors on proliferation of human gastric cancer AGS cells. The inhibitory effect of PDTC on AGS cell proliferation was significantly increased by DEC in a concentration-dependent manner, and this inhibition was associated with cell cycle arrest at the G2/M phase and the induction of apoptosis. This induction of apoptosis by the co-treatment with PDTC and DEC was related to the induction of DNA damage, as assessed by H2AX phosphorylation. Further studies demonstrated that co-treatment with PDTC and DEC induced the disruption of mitochondrial membrane potential, increased the generation of intracellular reactive oxygen species (ROS) and the expression of pro-apoptotic Bax, and down-regulated the expression of anti-apoptotic Bcl-2, ultimately resulting in the release of cytochrome c from the mitochondria into the cytoplasm. Co-treatment with PDTC and DEC also activated caspase-8 and caspase-9, which are representative caspases of the extrinsic and intrinsic apoptosis pathways. Co-treatment also activated caspase-3, which was accompanied by proteolytic degradation of poly (ADP-ribose) polymerase. Taken together, these data clearly indicated that co-treatment with PDTC and DEC suppressed the proliferation of AGS cells by increasing DNA damage and activating the ROS-mediated extrinsic and intrinsic apoptosis pathways.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.16 no.4
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• pp.411-420
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• 2018

This study presents a revised crackling core model for the description of $UO_2$ sphere oxidation in air atmosphere. For close reproduction of the sigmoid behavior exhibited in $UO_2$ to $U_3O_8$ conversion, the fragmentation effect contributing to the increased reactive surface area and the concept of variable grain conversion time were considered in the model development. Under the assumptions of two-step successive reaction of $UO_2{\rightarrow}U_3O_7{\rightarrow}U_3O_8$ and final grain conversion time equivalent to ten times the initial grain conversion time, the revised model showed good agreement with the experimental data measured at 599 - 674 K and a lowest deviation when compared with Nucleation and Growth model and AutoCatalytic Reaction model. The evaluated activation energy at 100% conversion to $U_3O_8$, $57.6kJ{\cdot}mol^{-1}$, was found to be closer to the experimentally extrapolated value than to the value determined in AutoCatalytic Reaction model, $48.6kJ{\cdot}mol^{-1}$.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.2
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• pp.434-442
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• 2019

Low Impact Development(LID) techniques has been attracting attention as a countermeasure to solve frequent flood damage in urban areas. LID is a techniques for returning to the natural hydrological cycle system by infiltrating the runoff from the impervious surface into the soil. The Bio-retention, one of the LID element technology has outflow reduction effect by reserving and infiltrating storm water runoff from watersheds. Recently, a number of studies have been carried out as interest in the reduction of storm water runoff and non-point pollutants in Bio-retention has increased. However, quantitative analysis on the outflow reduction of Bio-retention applied to small watershed is insufficient. In this study, Bio-retention model was constructed in a small watershed using K-LIDM which is capable of hydrologic analysis. When the storage capacity was increased or dividing the Bio-retention and watershed, the outflow reduction effect was 20% according to the storage capacity increase and 5~15% in the distributed Bio-retention system. The results of this analysis will be used as the basic data of future Bio-retention research related to watershed characteristics, vegetation type and soil condition.

• Journal of Climate Change Research
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• v.3 no.2
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• pp.129-142
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• 2012

This study was carried out to evaluate carbon footprint during unhulled rice production and to compare mitigation technologies of methane, main carbon source during rice production, Carbon footprint of unhulled rice was a sum of $CO_2$ emission of agri-materials manufacture, rice cultivation and waste treatment. It was emitted 1.40 kg $CO_2$ during unhulled rice production, its distribution was 71.1% by $CH_4$ emission of rice cultivation, 11.8% of $N_2O$ emission by nitrogen application and 7.6% of complex fertilizer manufacture. $CH_4$ emission could be mitigated by some technologies; cultivation of the early maturing rice variety emitted lower by 44.4% than the mid maturing variety, intermittent drainage of submerged water by 43.8% than the continuous flooding condition, direct seeding by 32.0% than transplanting cultivation, no-ploughing by 20.9% than ploughing cultivation. It means that LCA on Global Warming Potential and the statistical data on innovated technical practice are key tools to systemize Measurable-Reportable-Verifiable (MRV) system for carbon footprint and carbon emission trade in the farm base.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.17 no.6
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• pp.25-39
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• 2018

The purpose of this study is to develop an efficient incident detection algorithm by applying machine learning, which is being widely used in the transport sector. As a first step, network of the target site was constructed with micro-simulation model. Secondly, data has been collected under various incident scenarios produced with combination of variables that are expected to affect the incident situation. And, detection results from both McMaster algorithm, a well known incident detection algorithm, and the Naive Bayes algorithm, developed in this study, were compared. As a result of comparison, Naive Bayes algorithm showed less negative effect and better detect rate (DR) than the McMaster algorithm. However, as DR increases, so did false alarm rate (FAR). Also, while McMaster algorithm detected in four cycles, Naive Bayes algorithm determine the situation with just one cycle, which increases DR but also seems to have increased FAR. Consequently it has been identified that the Naive Bayes algorithm has a great potential in traffic incident detection.

• International Area Studies Review
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• v.22 no.1
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• pp.123-140
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• 2018

This paper analyzes herd behavior observed in the loan market from 2001 to 2014 using a panel data on commercial banks including state-owned banks, domestic private banks, foreign banks, and Islamic banks. The paper finds evidence that herd behaviors of domestic private and foreign banks have been pronounced and long-lasting around the 2008 global financial crisis when state-owned banks did not show such a behavior. This result shows that since private banks tend to be keen on maximizing profits and avoid financial risks exposed by lending during a financial crisis, their lending decisions are not independent but dependent on whether other banks increase loans or not. On the other hand, Islamic banks do not show herd behavior during the financial crisis. This finding is consistent with earlier studies that Islamic banks have different characteristics, such as profit and operation mechanisms, from other private banks. Another interesting finding is that when it comes to rural loans, all the banks' herd behavior is short-lived and the herding indexes are quite volatile. This finding is attributable to distinct features of rural loans. Usually maturities of rural loans are shorter than city loans and related to the cycle of farming. Agricultural production is heavily dependent on unpredicted factors, such as floods and droughts, not previous year's production. Lastly, the paper finds a herding across bank type that state-owned, foreign, and Islamic banks follow domestic private banks'lending decisions.

• Journal of Digital Convergence
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• v.16 no.12
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• pp.359-371
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• 2018

The aim of this study was to investigate experience and education needs on medication and emergency situations for young children of child caregivers. The data from 190 caregivers were collected using open-ended questionnaires composed of four items and analysed by content analysis. The categories derived for each theme were as follows: experience of medication of six categories(no referral for medication, young children refused medication, inaccurate referral, a variety of medication, sick children but not having medication), education need of four categories(for child caregivers, for parents, for children, guideline required), experience of emergency situation of six categories(skin damage or bleeding, decreased consciousness due to seizures, high fever persisted, asphyxiation due to foreign body, dislocation or fracture, emergency not knowing how to cope), education need of emergency situation of five categories(contents, methods, cycle, necessity, institutionalization). It is required to improve more practically the education contents and methods related to medication and emergency situation of child caregivers.

• Journal of the Korean Association of Geographic Information Studies
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• v.22 no.3
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• pp.65-81
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• 2019

The twenty-four Solar Terms are Chinese traditional astronomical divisions that describe seasonal cycles of the year. Based on the analyses of meteorological data during 1979~2018, study results showed that the temperatures of the Solar Terms had increased in general in the Korean Peninsula. In North Korea, temperature increases were observed on 21 Solar Terms, and their seasonal mean temperatures were increased by $0.87^{\circ}C$, $1.19^{\circ}C$, $1.45^{\circ}C$, and $0.64^{\circ}C$ on average in spring, summer, fall, and winter, respectively. The duration of summer has lengthened due to the temperature rise in fall, and the magnitude of temperature change was greater in summer compared to winter. As for South Korea, increases in temperature were observed on 18 Solar Terms, and the temperature changes were more pronounced in fall and winter than spring and summer. The Great Snow temperature decreased more than any other Solar Terms during the study period, and this temperature change was observed both in North and South Koreas. The Great Cold, which represents the coldest day of the year, showed a significant temperature increase of $3.08^{\circ}C$, while the Slight Heat had a marginal temperature increase of $0.29^{\circ}C$. The hottest day and the first day of frost tended to come later than the Great Heat and the Frost's Decent. By contrast, the coldest day tended to occur later than the Great Cold in the study area. On average over the entire study period, the climatic fitness of the Great Heat and the Frost's Decent was higher in North Korea, and that of the Great Cold was higher in South Korea, respectively.

• The Korean Journal of Archival Studies
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• no.32
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• pp.177-217
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• 2012

The National Archives of Korea(NAK) has a mission to ingest large-scaled digital records and information from a number of different government agencies annually from 2015. There are important issues related to the digital records and information transfer between NAK and agencies, and one of them is how to configure deployment of digital repositories for the archives management systems. The purpose of this paper is to offer the way to design it by examining the checkpoints through the whole life cycle of digital records and information in the archives management systems and calculating the amount of ingested digital records and information to the systems in 2015 and deploying the digital repositories configured according to the amount the records and information. Firstly, this paper suggests that the archives management systems in NAK should be considered and examined into at least three different parts called Ingest tier, Preservation tier and Access tier in aspects to the characteristics of the flow and process of the digital records and information. Secondly, as a results of the calculation the amount of the digital records and information ingested to the archives management systems in 2015 is sum up to around 2.5 Tera bytes. This research draws several requirements related to the large-scaled data and bulk operations which should be satisfied by the database or database management system implemented on to the archives management systems. Thirdly, this paper configures digital repositories deployment according to the characteristics of the three tiers respectively. This research triggers discussion in depth and gives specific clues about how to design the digital repositories in the archives management systems for preparing the year of 2015.

• Animal Bioscience
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• v.34 no.6
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• pp.993-1005
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• 2021

Objective: Zearalenone (ZEA) has estrogen-like effects. Our previous study has shown that ZEA (0.5 to 1.5 mg/kg) could induce abnormal uterine proliferation through transforming growth factor signaling pathway. To further study the other regulatory networks of uterine hypertrophy caused by ZEA, the potential mechanism of ZEA on porcine endometrial epithelial cells (PECs) was explored by the Illumina Hiseq 2000 sequencing system. Methods: The PECs were treated with ZEA at 0 (ZEA0), 5 (ZEA5), 20 (ZEA20), and 80 (ZEA80) µmol/L for 24 h. The collected cells were subjected to cell cycle, RNA-seq, real-time quantitative polymerase chain reaction, immunofluorescence, and western blot analysis. Results: The proportion of cells in the S and G2 phases decreased (p<0.05), but the proportion of cells in the G1 phase increased (p<0.05) in the ZEA80 treatment. Data analysis revealed that the expression of Wnt pathway-related genes, estrogen-related genes, and mitogen-activated protein kinase pathway-related genes increased (p<0.05), but the expression of genetic stability genes decreased (p<0.05) with increasing ZEA concentrations. The relative mRNA and protein expression of WNT1, β-catenin, glycogen synthase kinase 3β (GSK-3β) were increased (p<0.05) with ZEA increasing, while the relative mRNA and protein expression of cyclin D1 (CCND1) was decreased (p<0.05). Moreover, our immunofluorescence results indicate that β-catenin accumulated around the nucleus from the cell membrane and cytoplasm with increasing ZEA concentrations. Conclusion: In summary, ZEA can activate the Wnt/β-catenin signaling pathway by up-regulating WNT1 and β-catenin expression, to promote the proliferation and development of PECs. At the same time, the up-regulation of GSK-3β and down-regulation of CCND1, as well as the mRNA expression of other pathway related genes indicated that other potential effects of ZEA on the uterine development need further study.