• The Korean Journal of Physiology and Pharmacology
• /
• v.13 no.3
• /
• pp.195-200
• /
• 2009

Zinc released from excited glutamatergic neurons accelerates amyloid ${\beta}$ (A ${\beta}$) aggregation, underscoring the therapeutic potential of zinc chelation for the treatment of Alzheimer's disease (AD). Zinc can also alter A ${\beta}$ concentration by affecting its degradation. In order to elucidate the possible role of zinc influx in secretase-processed A ${\beta}$ production, SH-SY5Y cells stably expressing amyloid precursor protein (APP) were treated with pyrrolidine dithiocarbamate (PDTC), a zinc ionophore, and the resultant changes in APP processing were examined. PDTC decreased A ${\beta}$ 40 and A ${\beta}$ 42 concentrations in culture media bathing APP-expressing SH-SY5Y cells. Measuring the levels of a series of C-terminal APP fragments generated by enzymatic cutting at different APP-cleavage sites showed that both ${\beta}$-and ${\alpha}$-cleavage of APP were inhibited by zinc influx. PDTC also interfered with the maturation of APP. PDTC, however, paradoxically increased the intracellular levels of A ${\beta}$ 40. These results indicate that inhibition of secretase-mediated APP cleavage accounts -at least in part- for zinc inhibition of A ${\beta}$ secretion.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.15 no.9
• /
• pp.5419-5424
• /
• 2014

A weld scallop is a small quadrant or half circle type hole installed in the weld line cross area for easy welding operation. Many types of T-bars with a scallop can be welded in a block assembly stage in shipbuilding. The difficulties arise from the fact that scallops are to be filled by build-up welding after welding of the cross line is complete. In this study, a non-scallop block joint welding method was developed using special type CBM (ceramic backing material). The wedge shaped CBM was devised to insert a CBM into just the V groove of weld line cross area without weld scallop. A saw-toothed shape was adopted for easy cutting of the unnecessary part in the CBM fitting process. The applicability of the developed method was verified through welding experiments based on the yard welding conditions.

• The KIPS Transactions:PartD
• /
• v.11D no.7 s.96
• /
• pp.1507-1516
• /
• 2004

Recently, the most remarkable word is 'ubiuuitous' in field of information and communication. Ubiquitous has a meaning 'exist everywhere' that means our daily life is connect as network. It means we can get the information which in need whenever and wherever with safety. We predict this word will be symbolical keyword which lead an information-oriented society including the internet a quite long it. It's already per-meate to us the Ubiquitous. It's taken by CCTV when we visit bank. It's made to us can know the fastest way the GPS system to be connected by an artificial satcllite on mobile, and many people use mobile and PDA for investment in stocks. Among them, it has begun to spread many mobile services to us. In this paper, it's the aim a creation of value added through an efficient mobile services to use wireless internet different with previous way, cutting down on expenses and business modeling.

• Hwankyungkyoyuk
• /
• v.18 no.2 s.27
• /
• pp.113-125
• /
• 2005

Korea, China and Japan show distinct features in their school environmental education, which are derived from their own spreading processes. Japanese school environmental education has developed as a result of assimilating of anti-pollution education and nature education, and has a feature that makes much of nature experiences. The introduction of 'Period for Integrated Study' in 2002 seems to begin activating Japanese school environmental education. Chinese school environmental education started in higher education institutions around the middle of 1970's, and has a feature that makes a point of scientific approach, even in primary education schools. The two government ordinances,'National Action Program for Environmental General Knowledge ($1996{\sim}2010$)' and 'Educational Scheme of Environmental Theme Study for Elementary and Secondary School Students' issued in 2003, gradually promote school environmental education in China. It is remarkable that Science and Technology Centers for Youth and also increasing environmental NPOs often support environmental activities in elementary or secondary schools. The most notable feature of Korean school environmental education is that 'Environment' has already offered as a regular elective subject in junior high school, and official 'Environment' textbook has published since early 1990's. Though, the adoption rate of 'Environment' is not yet so high. Each country's peculiar issues are as follows. Japan: (1) Students often lack basic knowledge about environmental important problems. (2) 'Period for Integrated Study' is now threatened with cutting hours by the idea of increasing periods for basic subjects to keep high achievement. China: (1) There are large regional differences and school distinctions in operation of environmental education. (2) Adult environmental education needs to be expanded, because the most part of Chinese have no experience of school environmental education. Korea: (1) The relationship between the administrative division which plans school environmental education and teachers group is not quite well. The adoption rate of 'Environment' in junior high school needs to be improved. The training of many teachers for environmental education instructors may be the most important and effective cooperative action among Korea, China and Japan, and for that purpose we ought to work on making a better handbook for instructors, at first.

• Journal of the Korea Computer Graphics Society
• /
• v.25 no.5
• /
• pp.11-20
• /
• 2019

With the development of deep learning technology, research is being actively carried out on user-friendly interfaces that are suitable for use in virtual reality or augmented reality applications. To support the interface using the user's hands, this paper proposes a deep learning-based fingertip detection method to enable the tracking of fingertip coordinates to select virtual objects, or to write or draw in the air. After cutting the approximate part of the corresponding fingertip object from the input image with the Grad-CAM, and perform the convolution neural network with Atrous Convolution for the cut image to detect fingertip location. This method is simpler and easier to implement than existing object detection algorithms without requiring a pre-processing for annotating objects. To verify this method we implemented an air writing application and showed that the recognition rate of 81% and the speed of 76 ms were able to write smoothly without delay in the air, making it possible to utilize the application in real time.

• Journal of Drive and Control
• /
• v.16 no.4
• /
• pp.74-79
• /
• 2019

In this study, an edible fresh corn harvest testing machine was designed and manufactured. And harvesting performance was analyzed through the field test. The testing machine is of the tractor attached type. It is connected to the tractor PTO shaft to transfer power to the each part of the harvesting machine. And it harvests fresh corn by one row through the processes of cutting, stem crushing, detaching, and collecting. The performance test was performed at PTO speed (540, 750, 1050 rpm, respectively), working speed (0.1, 0.15, 0.2 m/s, respectively), and cropping cultivation (row spacing·hill spacing 70·25 cm, 70·40 cm, 90·30 cm, respectively). The performance test was repeated three times in the 15 m section. The detachment loss ratio, uncollected crop ratio, damage ratio, and harvest ratio were analyzed. As a result of the performance test, it was analyzed that the PTO speed 540 rpm, running speed of 0.1 m/s, and row spacing·hill spacing 70·40 cm were the optimal condition.

• Journal of the Korean Society of Costume
• /
• v.38
• /
• pp.51-72
• /
• 1998

Futurists objected the existent style, that is the conventional fashion, and took part in these disciplines of fashion to make clothes the instruments being able to represent the individuality. Giacomo Balla and fortunato Depero, pain-ters who in 1915 were to work with Diaghilev's company, were the first to see clothing as a dynamic interfaced between th body and the atmosphere, between physical gestures and the urban context, which could be translated into encounters between forms and colours, volumes and architecture. For them, clothing began to exist as an object and an event, something to be removed from a mainly static conception and made mobile, active. The interaction between movement and clothing was based on the relativity of perception : the appearance and disappearance of the body produced points without dimension or duration which served, as Balla wrote in the Futurist Mnaifesto of Men's Clothing to“renew incessantly the enjoyment and impetuous movement of the body”. The historical achievement in the effort for the reformation of Futurist, Art to Wear. First, for Futurist, clothing is removed from a static conception and focused on dynamics. Second, Balla used asymmetry in men's clothing. Moreover he supposed dynamic men's clothes by using optical intersection. Third, the after image of Chronophotograph represented rapidity. This rhythmic expression is the fore-runner in Optical and Kinetic Art of Visual Art. Fourth, Futurist emphasized flexibility in fashion. They aimed to create‘Clothing Machines’whose parts would interact to aceelerate the real and virtual, inner and outer movement of the human being. Fifth, the variety and short life of cutting skills and colors are focused and‘Fast Substance’in fashion is admitted by Futurists. Futurist concern with clothing was not lim-ited its appearance in terms of cut and colour. What important was also the way it appeared and disappeared according to fashion. It was a“fast substance”, able to reflect rapid, sudden changes of social and aesthetic taste. To reach to the aim of internationalization, Gesamtkunstwerk in our Art to Wear, it is extremely meaningful to examine art fashion which is created under the conception of Gesamtkunstwerk production of avang garde artist in the early 20th century and look at formative conscious of truth, goodess and beauty synthetically which they faced on their works of art.

• Journal of the Korean Society of Manufacturing Process Engineers
• /
• v.13 no.1
• /
• pp.92-99
• /
• 2014

An aspherical lens, which resolves several problems with a spherical lens,typically serves asa key part of an optical system. Generally, an aspherical lens is fabricated using a diamond turning machine or by mean of injection molding. However, residual stress and/or tool marks can arise when using a commercial fabricating method such as DTM or injection molding. A polishing process, thus, is commonly used to obtain a high-precision aspherical lens. In this study, a polishing method using MR fluid was applied to minimize several problems, in this case residual stress and the creation of tool marks, during the cutting process. The MR polishing system was developed to polish aspherical lenses. A series of experiments were performed to obtain a very fine surface roughness. PMMA (the lens material for molding) was used as a workpiece, and the gap size, magnetic field intensity, wheel speed and feed rate were selected as the parameters in this study. Finally, a very fine surface roughness of Ra=2.12nm was obtained after MR polishing.

• Steel and Composite Structures
• /
• v.27 no.3
• /
• pp.337-353
• /
• 2018

In previous weak-axis moment connection tests, brittle fracture always initiated near the edge of the beam flange groove weld due to force flow towards the stiffer column flanges, which is the opposite pattern as strong-axis moment connections. As part of the China NSFC (51278061) study, this paper tested two full-scale novel weak-axis reduced beam section moment connections, including one exterior frame connection specimen SJ-1 under beam end monotonic loading and one interior frame joint specimen SJ-2 under column top cyclic loading. Test results showed that these two specimens were able to satisfy the demands of FEMA-267 (1995) or ANSI/AISC 341-10 (2010) without experiencing brittle fracture. A parametric analysis using the finite element software ABAQUS was carried out to better understand the cyclic performance of the novel weak-axis reduced beam section moment connections, and the influence of the distance between skin plate and reduced beam section, a, the length of the reduced beam section, b, and the cutting depth of the reduced beam section, c, on the cyclic performance was analyzed. It was found that increasing three parametric values reasonably is beneficial to forming beam plastic hinges, and increasing the parameter a is conducive to reducing stress concentration of beam flange groove welds while increasing the parameters b and c can only reduce the peak stress of beam flange groove welds. The rules recommended by FEMA350 (2000) are suitable for designing the proposed weak-axis RBS moment connection, and a proven calculation formulation is given to determine the thickness of skin plate, the key components in the proposed weak-axis connections. Based on the experimental and numerical results, a design procedure for the proposed weak-axis RBS moment connections was developed.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.35 no.8
• /
• pp.991-1005
• /
• 2011

This study researches the historical production, process, and design method for 3 pairs of corsets in $18^{th}$ century France. In the analytical stage of historical materials, it grasped the kind, form, origin, and change in style through a lexical definition of relevant terms. Through a precedent study on Garsault's 'L'art du tailleur', preservation costume, and historical reconstruction of pattern in preservation costume, it confirmed corps size, silhouette, pattern form, and material for historical production. The sewing method and the producing sequence were analyzed. In the production stage, 3 selective models in corps plein baleine, corps demi-baleine, and corset were historically produced. With neckline of forming broad Letter U, the bust part is covered roundly. The bodice was composed of 10 panels based on the corps form in the mid-$18^{th}$ century of following a curve of a human body. A shoulder strap was allowed to make the arm movement comfortable by producing and attaching it separately. The cutting line except the center in the front and the back of vertical line was distributed according to the natural flow of a form and movement of the human body. The curve-based pattern line was confirmed.