• 대한두경부종양학회지
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• 제28권2호
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• pp.118-121
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• 2012

Backgrounds : To evaluated the use of FDG PET/CT for the identification of extracapsular spread(ECS) with histologic correlation in laryngeal cancer. Methods : We reviewed 79 medical records of patients who underwent of FDG PET/CT for laryngeal cancer before surgery. Results : ECS was present in 41.9%(18/43) dissected necks and in 34.5%(20/58) dissected cervical levels. There was a significant difference in the SUVmax between cervical lymph nodes with ECS and without ECS($6.39{\pm}4.53$ vs. $1.19{\pm}1.64$, p<0.001). The cut-off value for the SUVmax for differentiating with ECS from without ECS was 2.8 with the sensitivity of 85.7% and the specificity of 85.6%. Conclusion : The median SUVmax cut-off values of FDG PET/CT higher than 2.8 was associated with greater risk cervical lymph node metastasis with ECS in patients with laryngeal cancer.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제21권1호
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• pp.59-67
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• 2018

Purpose: to compare cut off points corrected for age and gender (COOP) with fixed cut off points (FCOP) for fasting plasma insulin and Homeostatic model assessment-insulin resistance (HOMA-IR) for the diagnosis of IR in obese children and adolescents and their correlation with dyslipidemia. Methods: A multicenter, cross-sectional study including 383 subjects aged 7 to 18 years, evaluating fasting blood glucose, plasma insulin, and lipid profile. Subjects with high insulin levels and/or HOMA-IR were considered as having IR, based on two defining criteria: FCOP or CCOP. The frequency of metabolic abnormalities, the presence of IR, and the presence of dyslipidemia in relation to FCOP or CCOP were analyzed using Fisher and Mann-Whitney exact tests. Results: Using HOMA-IR, IR was diagnosed in 155 (40.5%) and 215 (56.1%) patients and, using fasting insulin, 150 (39.2%) and 221 (57.7%), respectively applying FCOP and CCOP. The use of CCOP resulted in lower insulin and HOMA-IR values than FCOP. Dyslipidemia was not related to FCOP or CCOP. Blood glucose remained within normal limits in all patients with IR. There was no difference in the frequency of IR identified by plasma insulin or HOMA-IR, both for FCOP and CCOP. Conclusion: The CCOP of plasma insulin or of HOMA-IR detected more cases of IR as compared to the FCOP, but were not associated with the frequency of dyslipidemia. As blood glucose has almost no fluctuation in this age group, even in the presence of IR, fasting plasma insulin detected the same cases of IR that would be detected by HOMA-IR.

• Journal of Yeungnam Medical Science
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• 제30권2호
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• pp.90-94
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• 2013

Background: This study was conducted to examine if basal luteinizing hormone (LH) levels could be useful for screening central precocious puberty (CPP) in girls. Methods: A total of 90 girls under the age of 8 years were included in this study. They underwent the gonadotropin-releasing hormone (GnRH) stimulation test at Good Gang-An Hospital from March 2008 to December 2012 for evaluation of premature sexual development. Patients were classified into two groups: the pubertal response group of patients who had 5 IU/L peak LH levels in the GnRH stimulation test, and the prepubertal response group of patients who had LH levels <5 IU/L. Chronological and bone ages, height, weight, body mass index, gonadotropin response to GnRH stimulation, and basal levels of LH, follicle-stimulating hormone, and estradiol were studied in both groups. The relationship between basal LH and peak-stimulated LH was evaluated using Spearman's correlation. To determine the optimal cut-off values of basal LH levels for differentiating between two groups, the receiver operating characteristic (ROC) curves were analyzed. Results: When the correlation between basal LH levels and peak LH after GnRH stimulation was analyzed in all subjects (N=90), basal LH levels had a statistically significant positive correlation with peak stimulated LH levels (rs=0.493, p<0.001). The cut-off level of optimal basal LH was 0.1 IU/L, according to the ROC curves. Its sensitivity was 73.3%, and its specificity was 77.8%. Conclusion: The study results showed that serum basal LH levels are useful for screening CPP in girls.

• 대한기계학회논문집
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• 제13권1호
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• pp.67-76
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• 1989

본 논문에서는 표면거칠기 측정에 있어 70% 이상을 차지하는 촉침식을 이용하여 필터의 cut-off치와 위상특성에 따른 표면거칠기 값의 변화와 필터의 선택에 따른 장점 및 문제점에 대하여 알아보고자 한다.

• The Journal of Korean Physical Therapy
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• 제23권2호
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• pp.69-76
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• 2011

Purpose: The aim of this study was to investigate the prevalence of depressive symptoms in stroke patients and to compare characteristics of different rating scales - Hamilton Depression Rating Scale (HDRS), Beck Depression Inventory (BDI) and Hospital Anxiety and Depression Scale-Depression (HAD.D)- with regard to diagnosis and severity assessment for post-stroke depression. Methods: Participants included 44 stroke patients who could communicate. At admission, all study participants received a semi-structured interview using the HDRS and a self-completed questionnaire using the BDI and the HAD-D. Pearson's correlation method was used to examine associations among the three depression scales. The BDI and HAD-D were compared based on HDRS criteria, and the sensitivity and specificity using cut-off values were analyzed. Results: The HDRS showed that 52.30% of stroke patients had depressive symptoms on the BDI and HAD-D it was 59.10%. The HDRS correlated significantly with the BDI (r=0.81, p<0.01) and HAD-D (r=0.55, p<0.01). The BDI correlated significantly with HADS (r=0.50, p<0.01). After calculating the area under the ROC curve to decide on HDRS criteria, the BDI (AUC=0.91, 95% CI: 0.83.0.99) showed a significantly larger area compared to the HAD.D (AUC=0.82, 95% CI: 0.69-0.94). The cut-off value of the BDI was 12.50 points with a sensitivity of 81.00% and a specificity of 76.20%. Conclusion: These findings show that the BDI is a useful screening test for depression that most closely predicts the HRDS score.

• 대한치과교정학회지
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• 제46권5호
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• pp.323-330
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• 2016

Objective: The purpose of this study was to determine whether the results of fractal analysis can be used as criteria for midpalatal suture maturation evaluation. Methods: The study included 131 subjects aged over 18 years of age (range 18.1-53.4 years) who underwent cone-beam computed tomography. Skeletonized images of the midpalatal suture were obtained via image processing software and used to calculate fractal dimensions. Correlations between maturation stage and fractal dimensions were calculated using Spearman's correlation coefficient. Optimal fractal dimension cut-off values were determined using a receiver operating characteristic curve. Results: The distribution of maturation stages of the midpalatal suture according to the cervical vertebrae maturation index was highly variable, and there was a strong negative correlation between maturation stage and fractal dimension (-0.623, p < 0.001). Fractal dimension was a statistically significant indicator of dichotomous results with regard to maturation stage (area under curve = 0.794, p < 0.001). A test in which fractal dimension was used to predict the resulting variable that splits maturation stages into ABC and D or E yielded an optimal fractal dimension cut-off value of 1.0235. Conclusions: There was a strong negative correlation between fractal dimension and midpalatal suture maturation. Fractal analysis is an objective quantitative method, and therefore we suggest that it may be useful for the evaluation of midpalatal suture maturation.

• Journal of the Optical Society of Korea
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• 제18권3호
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• pp.207-216
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• 2014

In this work, we report detailed numerical analysis of the near-elliptic core index-guiding triangular-lattice and square-lattice photonic crystal fiber (PCFs); where we numerically characterize the birefringence, single mode, cut-off behavior and group velocity dispersion and effective area properties. By varying geometry and examining the modal field profile we find that for the same relative values of $d/{\Lambda}$, triangular-lattice PCFs show higher birefringence whereas the square-lattice PCFs show a wider range of single-mode operation. Square-lattice PCF was found to be endlessly single-mode for higher air-filling fraction ($d/{\Lambda}$). Dispersion comparison between the two structures reveal that we need smaller lengths of triangular-lattice PCF for dispersion compensation whereas PCFs with square-lattice with nearer relative dispersion slope (RDS) can better compensate the broadband dispersion. Square-lattice PCFs show zero dispersion wavelength (ZDW) red-shifted, making it preferable for mid-IR supercontinuum generation (SCG) with highly non-linear chalcogenide material. Square-lattice PCFs show higher dispersion slope that leads to compression of the broadband, thus accumulating more power in the pulse. On the other hand, triangular-lattice PCF with flat dispersion profile can generate broader SCG. Square-lattice PCF with low Group Velocity Dispersion (GVD) at the anomalous dispersion corresponds to higher dispersion length ($L_D$) and higher degree of solitonic interaction. The effective area of square-lattice PCF is always greater than its triangular-lattice counterpart making it better suited for high power applications. We have also performed a comparison of the dispersion properties of between the symmetric-core and asymmetric-core triangular-lattice PCF. While we need smaller length of symmetric-core PCF for dispersion compensation, broadband dispersion compensation can be performed with asymmetric-core PCF. Mid-Infrared (IR) SCG can be better performed with asymmetric core PCF with compressed and high power pulse, while wider range of SCG can be performed with symmetric core PCF. Thus, this study will be extremely useful for designing/realizing fiber towards a custom application around these characteristics.

• Journal of Microbiology and Biotechnology
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• 제33권8호
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• pp.1084-1090
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• 2023

The strain KIST612, initially identified as E. limosum, was a suspected member of E. callanderi due to differences in phenotype, genotype, and average nucleotide identity (ANI). Here, we found that E. limosum ATCC 8486^T and KIST612 are genetically different in their central metabolic pathways, such as that of carbon metabolism. Although 16S rDNA sequencing of KIST612 revealed high identity with E. limosum ATCC 8486^T (99.2%) and E. callanderi DSM 3662^T (99.8%), phylogenetic analysis of housekeeping genes and genome metrics clearly indicated that KIST612 belongs to E. callanderi. The phylogenies showed that KIST612 is closer to E. callanderi DSM 3662^T than to E. limosum ATCC 8486^T. The ANI between KIST612 and E. callanderi DSM 3662^T was 99.8%, which was above the species cut-off of 96%, Meanwhile, the ANI value with E. limosum ATCC 8486^T was not significant, showing only 94.6%. The digital DNA-DNA hybridization (dDDH) results also supported the ANI values. The dDDH between KIST612 and E. callanderi DSM 3662^T was 98.4%, whereas between KIST612 and E. limosum ATCC 8486^T , it was 57.8%, which is lower than the species cut-off of 70%. Based on these findings, we propose the reclassification of E. limosum KIST612 as E. callanderi KIST612.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10363-10366
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• 2015

Background: The aim of this study was to determine diagnostic and prognostic roles of the neutrophil to lymphocyte ratio (NLR) in breast cancer patients. To date, data are limited on associations of primary breast carcinoma (PBC) and benign proliferative breast disease (BPBD) with preoperative NLR values. Materials and Methods: Our study covered of 120 female patients with PBC and 50 with BPBD. Diagnostic values of NLR were estimated using sensitivity, specificity and areas under receiver operating characteristic curves (AUC). Results: NLR values were significantly higher in the PBC patients than in those with BPBD, with an AUC of 0.668 in the PBC case. The optimal cut-off for NLR was 2.96 and this was validated in the testing set, giving a sensitivity and a specificity of 79.7% and 76.2%, respectively, in PBC patients. Conclusions: Preoperative high NLR is a significant diagnostic predictor of distinction of breast cancer from BPBD and elevated NLR is also an important prognostic marker for primary invasive breast cancer.

• Journal of Gastric Cancer
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• 제9권4호
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• pp.246-255
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• 2009

목적: 위암의 근치 절제술에서 광범위 림프절 절제는 중요한 의미를 가지며 전이 림프절의 수가 종양의 침윤 정도와 함께 병기 결정의 기준이 되고 있다. 이에 저자들은 근치 절제술을 시행 받은 위암 환자에서 절제 림프절 수가 생존율에 미치는 영향을 분석하고 종양의 각 병기에 따라서 생존율 및 병기결정에 영향을 미치는 절제 림프절수의 최소 기준값을 구하고자 하였다. 대상 및 방법: 1992년부터 2002년까지 고려대학교병원에서 근치적 위절제술을 시행 받고 5년 이상 추적 관찰이 가능하였던 949명의 환자들을 대상으로 하였다. 조직검사결과에 따른 종양 침윤 정도에 따라 환자군을 분류하여 절제 림프절의 수를 조사하였다. 절제 림프절 수의 최소 기준값은 생존율에 유의한 차이를 보이는 최소값으로 정하였다. 결과: 종양의 크기, 위치, 림프절 병기, 전이 림프절의 수 및 절제 림프절의 수는 종양의 병기에 따라 유의한 차이를 보였다. Cox 비례위험모형을 통한 분석 결과 절제 림프절 수의 최소 기준값은 전체 환자에서는 14개였으며 각 병기별로 pT1군에서 15개, pT2군에서 28개, pT3군에서 37개의 값을 보였고 기준값 이상으로 절제된 경우 생존율이 유의하게 높았다. 결론: 근치적 위절제술을 받은 환자에서 기준값 이상의 림프절 절제가 생존을 향상시킬 수 있으며 이를 위해 외과의가 근치적 위절제술 시 기준값 이상의 림프절 절제술을 위해 노력해야 하며 병리의는 절제된 조직의 림프절 개수의 정확한 결과를 보고 하기 위해 더욱 노력해야 할 것이다.