• The Korean Journal of Pain
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• v.30 no.3
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• pp.183-191
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• 2017

Background: Current therapy for the treatment of neuropathic pain is often unsatisfactory. Considerable variation in treatment pattern still exists in spite of availability of sufficient literature from various guidelines. Recent Indian market data suggested that the utilization (sale) of drugs such as amitriptyline, pregabalin, and gabapentin was more for low-dose unit packs than that of the high-dose unit packs, raising the belief that these drugs are prescribed at a lower dose than is actually recommended in the guidelines. To test this hypothesis, a survey was conducted across speciality throughout the country to observe the prescription pattern of these drugs amongst the health care providers in India. Methods: Three hundred fifty survey forms were distributed of which 281 forms were included for analysis. Results: It was observed that the commonly used initiation and maintenance dose for amitriptyline, pregabalin, and gabapentin was 5-10 mg/day, 50-75 mg/day, and 100-300 mg/day, respectively. The reason to select the lower dosages was to have a balancing effect to achieve good efficacy with minimum side effects. Care-givers reported no side effects/not many side effects as a reason in 22.2%, 16.88%, and 23.86% patients with amitriptyline, pregabalin, and gabapentin, respectively. Sedation and giddiness were commonly reported with all three drugs. Conclusions: Commonly prescribed drugs for management of neuropathic pain, such as amitriptyline, pregabalin, and gabapentin are preferred at lower doses in Indian clinical settings. Acceptable efficacy and low tolerance to the standard dosage is believed to be the reason behind the prescribed dose.

• The Transactions of the Korea Information Processing Society
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• v.5 no.6
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• pp.1620-1632
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• 1998

This paper presents a fast parallel algorithm for volume rendering and its implementation using C language and MPI MasPar Programming Language) on the 4,096 processor MasPar MP-2 machine. This parallel algorithm is a parallelization hased on the Lacroute' s sequential shear - warp algorithm currently acknowledged to be the fastest sequential volume rendering algorithm. This algorithm reduces communication overheads by using the sheared space partition scheme and the load balancing technique using load estimates from the previous iteration, and the number of voxels to be processed by using the run-length encoded volume data structure.Actual performance is 3 to 4 frames/second on the human hrain scan dataset of $128\times128\times128$ voxels. Because of the scalability of this algorithm, performance of ]2-16 frames/sc.'cond is expected on the 16,384 processor MasPar MP-2 machine. It is expected that implementation on more current SIMD or MIMD architectures would provide 3O~60 frames/second on large volumes.

• Korean Journal of Optics and Photonics
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• v.11 no.4
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• pp.239-245
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• 2000

In this paper, the fundamental properties of diffractive optical element were investigated. Also, this work deals with theoretical approaches for achromatization in DOE's optical system based on thin lens theory. It is found that achromatization could be satisfied by one hybrid lens only, which is composed of a diffractive and a refractive element. In order to have compact optical system, we used the tele-photo type lens composed of a positive and a negative power elements instead of retro-focus lens. From the Gaussian brackets and Seidel aberration theory, the initial design was numerically obtained. The aberration properties of an initial design was aplanat and flat field. In order to correct the chromatic aberrations, refractive and diffractive elements were used on front element. This hybrid lens is also useful for correction of higher order aberrations. Compared to conventional design composed of refractive lenses only, this approach dramatically improved the compactness of the optical system. Finally, residual aberration balancing results in a lens with focal length of 3.89 mm and overall length of 5.19 mm, which has enough performance over an f-number of 4.0. Also, it is expected to fulfill all the requirements of a digital still camera lens. This optical system is superior to the current refractive lens system in the number of elements, weight, and aberration properties. rties.

• Journal of Internet Computing and Services
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• v.8 no.3
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• pp.131-143
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• 2007

The current trends in information technology and intelligent systems use data mining techniques to discover patterns and extract rules from distributed databases. In distributed environment, the extracted rules from data mining techniques can be used in dynamic replications, adaptive load balancing and other schemes. However, transmission of large data through the system can cause errors and unreliable results. This paper proposes the intelligent distributed platform based on dynamic group binding using mobile agents which addresses the use of intelligence in distributed environment. The proposed grouping service implements classification scheme of objects. Data compressor agent and data miner agent extracts rules and compresses data, respectively, from the service node databases. The proposed algorithm performs preprocessing where it merges the less frequent dataset using neuro-fuzzy classifier before sending the data. Object group classification, data mining the service node database, data compression method, and rule extraction were simulated. Result of experiments in efficient data compression and reliable rule extraction shows that the proposed algorithm has better performance compared to other methods.

• Journal of The Korean Association For Science Education
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• v.13 no.1
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• pp.66-79
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• 1993

The purposes of this study are to analyse trend of STS movement in Korea and to collect basic data on application of STS to school science education. It investigated, from 1990 to March 1993, journals of 6 associations, a monthly magazine of science education, and printed materials of seminars or workshops about science education. It also surveied a question to 47 science teachers and 26 researchers who had experienced STS workshop. The results of the study are as follows: (1) The studies of STS increased since 1990, but they are made at a introduction or background of STS. (2) The 98.7% of the respondents want to apply STS in school science education. (3) They responded that a device for the application of STS which is added last part of each chapter or last chapter, will use the STS program that made by subject, still maintain current science curriculum. (4) They responded that the knowledge & compreshion domain and inquiry process domain contain more high than others. 5) The STS subjects for application to the school science education are as follows; Environment pollution, science for living, ethics of science, human health and disease, information communication, an ecosystem destruction, development and storage of natural resources. This study suggested that establishment of a research institute for systematic research of STS, in-service training, a new evaluation process, a balancing of other subjects and increasing learning hour and changing objectives.

• Journal of Korean Society of Transportation
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• v.27 no.6
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• pp.147-156
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• 2009

We present a methodology for modeling and solving the transit frequency design problem with variable demand. The problem is described as a bi-level model based on a non-cooperative Stackelberg game. The upper-level operator problem is formulated as a non-linear optimization model to minimize net cost, which includes operating cost, travel cost and revenue, with fleet size and frequency constraints. The lower-level user problem is formulated as a capacity-constrained stochastic user equilibrium assignment model with variable demand, considering transfer delay between transit lines. An efficient algorithm is also presented for solving the proposed model. The upper-level model is solved by a gradient projection method, and the lower-level model is solved by an existing iterative balancing method. An application of the proposed model and algorithm is presented using a small test network. The results of this application show that the proposed algorithm converges well to an optimal point. The methodology of this study is expected to contribute to form a theoretical basis for diagnosing the problems of current transit systems and for improving its operational efficiency to increase the demand as well as the level of service.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.4 no.6
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• pp.1311-1326
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• 2010

Peer-to-peer (P2P) networks consume the most bandwidth in the current Internet and file sharing accounts for the majority of the P2P traffic. Thus it is important for a P2P file sharing application to be efficient in bandwidth consumption. Bandwidth consumption as much as downloaded file sizes is inevitable, but those in file search and bad downloads, e.g. wrong, corrupted, or malicious file downloads, are overheads. In this paper, we target to reduce these overheads even in the presence of high volume of malicious users and their bad files. Sybil attacks are the example of such hostile environment. Sybil attacker creates a large number of identities (Sybil nodes) and unfairly influences the system. When a large portion of the system is subverted, either in terms of the number of users or the number of files shared in the system, the overheads due to the bad downloads rapidly increase. We propose ELiSyR, a file search protocol that can tolerate such a hostile environment. ELiSyR uses social networks for P2P file search and finds benign files in 71% of searches even when more than half of the users are malicious. Furthermore, ELiSyR provides similar success with less bandwidth than other general efforts against Sybil attacks. We compare our algorithm to SybilGuard, SybilLimit and EigenTrust in terms of bandwidth consumption and the likelihood of bad downloads. Our algorithm shows lower bandwidth consumption, similar chances of bad downloads and fairer distribution of computation loads than these general efforts. In return, our algorithm takes more rounds of search than them. However the time required for search is usually much less than the time required for downloads, so the delay in search is justifiable compared to the cost of bad downloads and subsequent re-search and downloads.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.9
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• pp.4398-4417
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• 2017

Multi-user Multiple-Input and Multiple-Output (MU-MIMO) has potential for prominently enhancing the capacity of wireless network by simultaneously transmitting to multiple users. User selection is an unavoidable problem which bottlenecks the gain of MU-MIMO to a great extent. Major state-of-the-art works are focusing on improving network throughput by using Channel State Information (CSI), however, the overhead of CSI feedback becomes unacceptable when the number of users is large. Some work does well in balancing tradeoff between complexity and achievable throughput but is lack of consideration of fairness. Current works universally ignore the rational utilizing of time resources, which may lead the improvements of network throughput to a standstill. In this paper, we propose TOUSE, a scalable and fair user selection scheme for MU-MIMO. The core design is dynamic-time-warping-based user selection mechanism for downlink MU-MIMO, which could make full use of concurrent transmitting time. TOUSE also presents a novel data-rate estimation method without any CSI feedback, providing supports for user selections. Simulation result shows that TOUSE significantly outperforms traditional contention-based user selection schemes in both throughput and fairness in an indoor condition.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.3
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• pp.567-575
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• 2011

The two most popular virtual machine allocation schemes, both match making and round robin, do consider hardware specifications such as CPU, RAM, and HDD, but not CPU usage, which results in balanced resource distribution, but not in balanced resource usage. Thus, in this paper a new virtual machine allocation scheme considering current CPU usage rate is proposed while retaining even distribution of node resources. In order to evaluate the performance of the proposed scheme, a cloud computing platform composed of three cloud nodes and one front end is implemented. The proposed allocation scheme was compared with both match making and round robin schemes. Experimental results show that the proposed scheme performs better in even distribution of overall CPU usage, which results in efficient load balancing.

• 대한생식의학회:학술대회논문집
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• 2000.06a
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• pp.13-28
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• 2000

Human spermatozoa exhibit a capacity to generate ROS and initiate peroxidation of the unsaturated fatty acids in the sperm plasma membrane, which plays a key role in the etiology of male infertility. The short half-life and limited diffusion of these molecules is consistent with their physiologic role in key biological events such as acrosome reaction and hyperactivation. The intrinsic reactivity of these metabolites in peroxidative damage induced by ROS, particularly $H_2O_2$ and the superoxide anion, has been proposed as a major cause of defective sperm function in cases of male infertility. The number of antioxidants known to attack different stages of peroxidative damage is growing, and it will be of interest to compare alpha-tocopherol and ascorbic acid with these for their therapeutic potential in vitro and in vivo. Both spermatozoa and leukocytes generate ROS, although leukocytes produce much higher levels. The clinical significance of leukocyte presence in semen is controversial. Seminal plasma confers some protection against ROS damage because it contains enzymes that scavenge ROS, such as catalase and superoxide dismutase. A variety of defense mechanisms comprising a number of antioxidants can be employed to reduce or overcome oxidative stress caused by excessive ROS. Determination of male infertility etiology is important, as it will help us develop effective therapies to overcome excessive ROS generation. ROS can have both beneficial and detrimental effects on the spermatozoa and the balancing between the amounts of ROS produced and the amounts scavenged at any moment will determine whether a given sperm function will be promoted or jeopardized. Accurate assessment of ROS levels and, subsequently, OS is Vital, as this will help clinicians both elucidate the fertility status and identify the subgroups of patients that respond or do not respond to these therapeutic strategies. The overt commercial claims of antioxidant benefits and supplements for fertility purposes must be cautiously looked into, until proper multicentered clinical trials are studied. From the current data it appears that no Single adjuvant will be able to enhance the fertilizing capacity of sperm in infertile men, and a combination of the possible strategies that are not toxic at the dosage used would be a feasible approach.