• Journal of Korean Neurosurgical Society
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• v.62 no.1
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• pp.10-26
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• 2019

Magnetic resonance-guided focused ultrasound (MRgFUS) is an emerging new technology with considerable potential to treat various neurological diseases. With refinement of ultrasound transducer technology and integration with magnetic resonance imaging guidance, transcranial sonication of precise cerebral targets has become a therapeutic option. Intensity is a key determinant of ultrasound effects. High-intensity focused ultrasound can produce targeted lesions via thermal ablation of tissue. MRgFUS-mediated stereotactic ablation is non-invasive, incision-free, and confers immediate therapeutic effects. Since the US Food and Drug Administration approval of MRgFUS in 2016 for unilateral thalamotomy in medication-refractory essential tremor, studies on novel indications such as Parkinson's disease, psychiatric disease, and brain tumors are underway. MRgFUS is also used in the context of blood-brain barrier (BBB) opening at low intensities, in combination with intravenously-administered microbubbles. Preclinical studies show that MRgFUS-mediated BBB opening safely enhances the delivery of targeted chemotherapeutic agents to the brain and improves tumor control as well as survival. In addition, BBB opening has been shown to activate the innate immune system in animal models of Alzheimer's disease. Amyloid plaque clearance and promotion of neurogenesis in these studies suggest that MRgFUS-mediated BBB opening may be a new paradigm for neurodegenerative disease treatment in the future. Here, we review the current status of preclinical and clinical trials of MRgFUS-mediated thermal ablation and BBB opening, described their mechanisms of action, and discuss future prospects.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2007.11a
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• pp.578-582
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• 2007

In this paper, vibration modes and frequencies of a ring-type stacked piezoelectric actuator for a wire bonding transducer system are analyzed using FEM simulations. We implement experiments using a commercial product model of the actuator PZT module which consists of 6 layer ring-type PZT and 7 electrodes, combined bolts, nut and tinut. There are two main results: One is that FEM analysis should consider the effect the harmonic voltage input in order to meet the experimental results. The other is that the current wire bonder using exciting frequency of 136 kHz should be modified in order to improve the actuator and bonding performance because the actuator module has the main longitudinal mode of 145 kHz.

• Proceedings of the KIEE Conference
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• 2011.07a
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• pp.2083-2084
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• 2011

본 논문에서는 유입식변압기에 대한 부분방전진단방법에 있어 초음파센서 및 HFCT(High Frequency Current Transducer)센서의 동시측정방법 이용하여 유입식변압기 내부에서 발생한 부분방전신호의 위치추적 및 현장잡음에서의 유효한 부분방전 위치추적을 위한 하이브리드 센서적용방법을 제안하고 국내외 부분방전진단시험을 통하여 제안한 진단방법을 이용한 부분방전위치추적에 대한 고장진단사례를 소개하고자 한다.

• Journal of Electrical Engineering and Technology
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• v.13 no.6
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• pp.2268-2275
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• 2018

This paper presents a high-efficiency low-power permanent magnet (PM) generator for the power supply of the generator exciter. In the conventional generator system, the power for the exciter is fed by the generator output power or an emergency battery for the starting. The proposed low-power PM generator can generate the proper power and voltage to excite the exciter field winding. According to the starting of the generator, the designed PM generator can supply the constant voltage to the Automatic Voltage Regulator (AVR), then it can be used to control of exciter field current for the generator. Because of the designed PM generator which is placed inside the conventional generator system, the emergency battery and Potential Transducer(PT) for AVR can be removed. Thus, the total efficiency can be improved. The proposed generator system is tested in the practical system. And the efficiency characteristic is analyzed.

• 제어로봇시스템학회:학술대회논문집
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• 1993.10a
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• pp.125-132
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• 1993

When a mobile robot moves around autonomously without man-made landmarks, it is essential to recognize the placement of surrounding objects especially for current position estimation, obstacle avoidance, or homing into the work station. In this paper, we propose a novel approach to recognize the floor paln for indoor mobile robot navigation using ultrasonic time-of-flight method. We model the floor plan as a collection of polygonal plane objects and recognize the floor plan by locating edges and vertices of the objects. The direction is estimated by the patterns of transmission beam and reception sensitivity of the ultrasonic transducer, and the distance is estimated by the correlation detection method. We show the validity of the proposed approach through experimental results and discuss the resolution and the accuracy of the estimation of direction and distance.

• Wind and Structures
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• v.8 no.3
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• pp.179-196
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• 2005

This paper describes the application of a wireless data acquisition system to monitor wind pressures and velocities with absolute pressure sensors and an anemometer. The system was developed for future deployment, as part of a research effort currently underway to instrument coastal homes in Florida to monitor roof wind pressures during hurricanes. The proposed wireless system will replace the current system that involves a large amount of hardwired connections from the sensors to the data processing unit that requires labor intensive wiring and preparation of the home. The paper describes comparison studies and field tests to assess the performance of the system. The new system offers the advantages of light hardware, ease of installation, capacity for 48 hours of continuous data acquisition, good frequency and amplitude responses, and a relatively simple maintenance. However, the tests also show that the shape of the shell that has been previously used to protect the sensors might interfere with the proper measurement of the pressures.

• Proceedings of the KIEE Conference
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• 1989.07a
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• pp.75-78
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• 1989

In this paper, A last time delay damper is presented for HB ( HyBrid ) step motor, which has large oscillation characteristics.The design objective is to develop a cost-effective and good-performance damper that would be applyed to HB step motor / driver system without the addition of transducer that would add a weight, size and cost to the system. The Back EMF signal which is recovered from current and voltage signal is used for the measuring the rotor position. It would be possible to get more accurate delay time for the motor driver system. It is proved that the maximum overshoot can be reduced to 13% at stopping through experiment.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.32B no.3
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• pp.38-47
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• 1995

A new automatic cardiac output control algorithm for the motor-driven electromechanical total artificial heart(TAH) was developed based on the motor current waveform analysis without using any extra transducer. The basic control requirements of artificial heart can be described in terms of three features : preload sensitivity, afterload insensitivity, and balanced ventricular outputs. In the previous studies, many transducers were utilized to obtain informations of hemodynamic states for the automatic cardiac output control, But such automatic control systems with sensors have had reliability problems. We proposed a new sensorless automatic cardiac output control algorithm providing adequate cardiac output to the time-varying physiological demand without causing right atrial collapse, which is one of the critical problem in an active-filling type device. In-vitro tests were performed on a mock circulation system to evaluate the performance of the developed algorithm and the results show that the new algorithm satisfied the basic control requirements on the cardiac output response and the possibility of application of the developed algorithm to in vivo experiments.

• Journal of Microbiology and Biotechnology
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• v.14 no.4
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• pp.698-706
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• 2004

$\beta$-Lactam antibiotics such as penicillin G, amoxicillin, and ampicillin were determined by a potentiometric biosensor system which exploited penicillinase immobilized on Immobilon cellulose nitrate membrane and a flat-bottomed pH electrode-as the biological component and transducer. The optimum reaction buffer for maximum sensitivity was found as 2 mM of sodium phosphate buffer (pH 7.2). The detection limit of the biosensor could be extended to 1 $\mu{M}$ of the analytes by increasing the enzyme loading for immobilization to 100 units/$m\ell$. The model samples spiked with each of the standard penicillins were measured for their biosensor responses and HPLC peak area, resulting in the relative responses of 82.1-103.5% and 79.5-106.1% for the biosensor method along with HPLC analysis, respectively. This result showed a good precision of the current biosensor method for screening the penicillin compounds.

• Journal of Biomedical Engineering Research
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• v.39 no.4
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• pp.153-160
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• 2018

3D ultrasound bladder scanners are getting popular in hospitals for the patients with bladder dysfunction. A current bladder scanner adopts a mechanical scan to acquire 3D images and requires two motors and complicated mechanical devices. In this paper, we propose a new ultrasound bladder scanner using hand-motion scan. Instead of two motors and mechanical devices, it has a motion sensor to record transducer positions during hand-motion scan. The experiments with a bladder phantom and volunteers showed similar measurement accuracy to a conventional 3D ultrasound bladder scanner. We expect that the proposed method will reduce the cost and size of the bladder scanner.