• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3495-3501
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• 2014

Melanoma-associated antigen (MAGE) family genes have been considered as potentially promising targets for anticancer immunotherapy. MAGED4 was originally identified as a glioma-specific antigen. Current knowledge about MAGED4 expression in glioma is only based on mRNA analysis and MAGED4 protein expression has not been elucidated. In the present study, we investigated this point and found that MAGED4 mRNA and protein were absent or very lowly expressed in various normal tissues and glioma cell line SHG44, but overexpressed in glioma cell lines A172,U251,U87-MG as well as glioma tissues, with significant heterogeneity. Furthermore, MAGED4 protein expression was positively correlated with the glioma type and grade. We also found that the expression of MAGED4 inversely correlated with the overall methylation status of the MAGED4 promoter CpG island. Furthermore, when SHG44 and A172 with higher methylation were treated with the DNA demethylating agent 5-aza-2'-deoxycytidine (5-AZA-CdR) reactivation of MAGED4 mRNA was mediated by significant demethylation in SHG44 instead of A172. However, 5-AZA-CdR treatment had no effect on MAGED4 protein in both SHG44 and A172 cells. In conclusion, MAGED4 is frequently and highly expressed in glioma and is partly regulated by DNA methylation. The results suggest that MAGED4 might be a promising target for glioma immunotherapy combined with 5-AZA-CdR to enhance its expression and eliminate intratumor heterogeneity.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.11 no.6
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• pp.131-142
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• 2016

Since global circumstances have become competitive, entrepreneurship has been regarded as the most important factors in economic revitalization not only in korea but also internationally. According to these changes, public entrepreneurship education has been started from the year of 2004 establishing Entrepreneurial Graduate School as a part of governmental plan. Although entrepreneurship education history is not long enough in korea, but the need for entrepreneurship education in social is now going ahead of the public education systems such as universities and graduate schools. Therefore, this study is conducted for the purpose of drawing the subject frame for systematized integration curriculum of entrepreneurship education through evaluating the importance of the subjects by Analytic Hierarchy Process analysis after being composed of 6 modularity in the Entrepreneurship subjects. This was structured based on studying the current status for entrepreneurship education in domestic universities and graduate schools. The research findings under the condition of Judgement consistency ratio 0.1 are as follows. The most important factors are in order as following; "Entrepreneurial Issues for Fund"(.242), "Entrepreneurship Plan"(.195), "Entrepreneurship & Entrepreneurship mindset"(.161), "Entrepreneurial Issues for Growth & Development"(.160), "Management Skill & Strategy"(.150), and "Special Entrepreneurship"(.093). Then, these findings also represent subfactors as well. The results of this study provide the practical guidelines where the curriculums needed for the entrepreneurship education at graduate schools by suggesting consistency for the systematic and comprehensive curriculum design. It was reflected the survey result from the graduate students taking the entrepreneurship subjects. Therefore, it will contribute the foundation of the present curriculum of Entrepreneurial Graduate School.

• The Journal of the Korea Contents Association
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• v.16 no.1
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• pp.382-390
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• 2016

This study has investigated the status and overview of design characteristics of customized shoes, which receives much recognition at domestic and overseas markets. Based on the market research on current consumer lifestyle and needs of the custom-shoes(which is an abbreviation of customized shoes), this study has provided its development directions, views and demands. The design types of custom-shoes have been broadly divide into two: firstly 'style centered custom-shoes'; secondly 'function centered custom-shoes'. Style centered custom-shoes are specifically divided into 3 types; first, formal custom-shoes; second, sports and casual custom-shoes; and lastly, bespoke shoes. Function centered custom-shoes design refers to enhancing the function of personal soleprint which has to be designed by delicately detailed insole and outsole, rather than alignment of exterior parts of the shoes. These are used in professional sports shoes and also include orthopedics footwear and grafted footwear for people who have disabled on foot. Custom footwear market has been highly expanded and has entered value-added market according to increasing interest in foot health and shopping trends on shoes buying like taking shoes as personal expression in accordance with a variety of places and situations. In the near future, custom-shoes can be produced in a couple of days due to the technological advance of 3D scanners and 3D printers. This phenomenon will wants more demands of specific shoes experts such as custom-design consultants or shoes fitting experts, who can overcome limitations of online custom-shoes stores.

• Journal of the Korean Operations Research and Management Science Society
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• v.17 no.1
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• pp.117-117
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• 1992

Pubilc utility industries including the electric utility industry are facing a new stream of privatization com-petition with the private sector and deregulation. The necewssity to solve now and in the future power supply and demand problems has been increasing through the sophisticated generation expansion plan(GEP) approach con-sidering not only KEPCo's supply-side resources but also outside resources such as non-utility generation(NUG) demand-side management (DSM). Under the environmental situation in the current electric utility industry a new approach is needed to acquire multiple resources competitively. This study presents the development of a modified electric generation expansion analysis system(EGEAS) model with avoided cost based on the existing EGEAS model which is a dynamic program to develope an optimal generation expansion plan for the electric utility. We are trying to find optimal GEP in Korea's case using our modified model and observe the difference for the level of reliabilities such as the reserve margin(RM) loss of load probability(LOLP) and expected unserved energy percent(EUEP) between the existing EGEAS model and our model. In addition we are trying to calculate avoided cost for NUG resources which is a criterion to evaluate herem and test possibility of connection calculation of avoided cost with GEP implementation using our modified model. The results of our case study are as follows. First we were able to find that the generation expansion plan and reliability measures were largely influenced by capacity size and loading status of NUG resources, Second we were able to find that avoided cost which are criteria to evaluate NUG resources could be calculated by using our modified EGEAS model with avoided cost. We also note that avoided costs were calculated by our model in connection with generation expansion plans.

• Journal of the Korean Institute of Landscape Architecture
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• v.41 no.2
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• pp.27-37
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• 2013

The purpose of this research is to identify the selection status of the evaluation index in Korea and suggest improvements. In order to do so, comparison and analysis are conducted of terms, items and measures for biotope evaluation indexes attested in related documents published in domestic and foreign areas. The findings of this research are listed in the following. First, terms about biotope evaluation indexes are used and integrated with each other. Second, items used to denote biotope evaluation indexes are largely different in each region since comprehensive concepts have not been established for selecting the items. Third, there are poor grounds for items denoting biotope evaluation indexes to the species of creatures. Fourth, the items cannot provide satisfying explanations for the relative values of the current condition in the urban ecosystem of a specific region. The results of this research may be applied to provide basic materials about what is to be improved for selecting biotope evaluation indexes in Korea. In order to systematically preserve an urban ecosystem environment in Korea for the future, it is necessary for the state to develop and set up such evaluation indexes and guidelines that reflect the relative values of biotopes in each level of urban areas in Korea.

• Atmosphere
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• v.20 no.3
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• pp.247-260
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• 2010

A recent dramatic increase of natural hazards in the Korean peninsular (KP) due to typhoons have raised necessities for the accurate typhoon prediction. Ieodo ocean research station (IORS) has been constructed in June 2003 at the open ocean where typhoons pass frequently, aiming to observe typhoons before the landfall to the KP and hence to improve the prediction skill. This paper investigates the importance of measurements at the IORS in the typhoon research and forecast. Analysis of the best track data in the N. W. Pacific shows that about one typhoon passes over the IORS per year on the average and 54% of the KP-landfall typhoons during 59 years (1950-2008) passed by the IORS within the range of the 150-km radius. The data observed during the event of typhoons reveals that the IORS can provide useful information for the typhoon prediction prior to the landfall (mainland: before 8-10 hrs, Jeju Island: before 4-6 hrs), which may contribute to improving the typhoon prediction skill and conducting the disaster prevention during the landfall. Since 2003, nine typhoons have influenced the IORS by strong winds above 17m/s. Among them, the typhoon Maemi (0314) was the strongest and brought the largest damages in Korea. The various oceanic and atmospheric observation data at the IORS suggest that the Maemi (0314) has kept the strong intensity until the landfall as passing over warm ocean currents, while the Ewiniar (0603) has weakened rapidly as passing over the Yellow Sea Bottom Cold Water (YSBCW), mainly due to the storm's self-induced surface cooling. It is revealed that the IORS is located in the best place for monitering the patterns of the warm currents and the YSBCW which varies in time and space.

• Journal of Distribution Science
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• v.13 no.7
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• pp.41-51
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• 2015

Purpose - This study analyzes loading efficiency by loading pattern for package standardization and reduction of logistics costs, along with the creation of revenue for the revenue review panel (RRP) of Membership Wholesale Clubs (MWC). The study aims to identify standard dimensions that can help improve the compatibility of the pallets related to display patterns preferred by the MWC and thereby explore ways to enhance logistics efficiency between manufacturers and retailers through standardization. Research design, data, and methodology - The study investigates and analyzes the current status based on actual case examples, i.e., manufacturer A and Korea's MWC (A company, B company, and C company), and thus devises improvement measures. To achieve this, the case of manufacturer A delivering to MWC was examined, and the actual pallet display patterns for each MWC were investigated by visiting each distribution site. In this study, TOPS (Total Optimization Packaging Software, USA) was used as the tool for pallet loading efficiency simulations the maximum allowable dimension was set to 0.0mm to prevent the pallet from falling outside the parameters, and the loading efficiency was analyzed with the pallet area. In other words, the study focused on dimensions (length x width x height) according to the research purpose and thereby deduced results. Results - The analysis of pallet loading patterns showed that the most preferred loading patterns for loading efficiency according to product specification, such as pinwheel, brick, and block patterns, were used in the case of the general distribution products, but the products were configured with block patterns in most cases when delivered to MWCs. The loading efficiency by loading pattern was analyzed with respect to 104 nationally listed standard dimensions. Meanwhile, No.51 (330 × 220mm) of KS T 1002 (1,100 × 1,100mm) was found to be the dimension that could bring about an improved loading efficiency, over 90.0% simultaneously in both the T-11 and T-12 pallet systems in a loading pattern configuration with the block pattern only, and the loading efficiency simulation results also confirmed this as the standard dimension that can be commonly applied to both the T-11 pallet (90.0%) and the T-12 pallet (90.7%) systems. Conclusions - The loading efficiency simulation results by loading pattern were analyzed: For the T-11 pallet system, 17 standard dimension sizes displayed the loading efficiency of 90.0% or more as block patterns, and the loading capacity was an average of 99.0%. For the T-12 pallet system, 35 standard dimension sizes displayed the loading efficiency of more than 90% as block patterns (the average loading efficiency of 98.6%). Accordingly, this study proposes that the standard dimensions of 17 sizes with the average loading efficiency of 99.0% should be applied in the use of the T-11 pallet system, and those of 35 sizes with the average loading efficiency of 98.6% should be reviewed and applied in the use of the T-12 pallet system.

• The Journal of the Korea Contents Association
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• v.19 no.11
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• pp.46-56
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• 2019

This study aimed to understand the value pursued when consuming performances for classical music performance audiences, to identify the difference in influence by type, and to expand into the base of academic research focusing on audiences who are consumers in classical music performances, which was the existing supplier-centered. Also, this study tried to verify the effect of consumption value on flow and satisfaction. and we aimed to prove whether consumption value leads to re-spectating intention through structural relationship. For this purpose, a survey was conducted on the audience who watched classical music performances within one year by applying consumption value theory, and the analysis was conducted using smartPLS 3.0. As a result, functional value and emotional value had an effect on flow. The second one is that functional value had a positive effect on satisfaction. The third fact is that social value had a negative effect. Overall, the structural relationship between flow, satisfaction, and re-spectating intention had a strong effect on each other. Implications of this study are that the market characteristics and current status of classical music performances were examined, and that an effective marketing strategy to increase the re-spectator rate was sought by finding out the factors of audience's consumption value that affect viewing satisfaction.

• Tunnel and Underground Space
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• v.24 no.1
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• pp.67-80
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• 2014

Long-term stability and delayed failure of granite were evaluated through the laboratory test based on Wilkins method and Brazilian disc test (BDT) which yields tensile strength, mode I fracture toughness and subcritical crack growth parameters. Then, the long-term strength of granite was estimated by using analytical models and long-term stability of compressed air-energy storage (CAES) pilot cavern pressurized up to 5 ~ 6 MPa was evaluated using numerical code, FRACOD with the determined subcritical crack growth parameters. The results of test and analyses showed that the subcritical crack growth index, n was determined as 29.39 and the inner pressure of 5 ~ 6 MPa had an insignificant effect on the long-term stability of pilot cavern. It was also found that the measurement and analysis of acoustic emission events can describe the accumulation of damage due to subcritical crack growth quantitatively. That is, AE monitoring can provide the current status of rock under loading if we make an identical installation condition in the field with that of the laboratory test.

• Journal of Korean Society of Transportation
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• v.25 no.4
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• pp.79-87
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• 2007

The interchanges of urban freeways have many problems with traffic operation due to high off-ramp flows and frequent congestion at adjacent intersections. The flow exiting from off-ramps is affected by the operational status and traffic volume conditions of the nearest signalized intersection. As a result, off-ramp flow cannot exit and the queue backs up the freeway mainline when queues from the signalized intersection form up to the junction of the off-ramp and street. The spacing between an off-ramp and an adjacent intersection is likely to determine the traffic conditions at the adjacent intersection. However, the current design guidelines do not consider such a factor. This study is to develop a model calculating the spacing between off-ramps and adjacent intersections considering the signal, traffic, and road conditions. The variables affecting the model in this study are effective green time (g/C), volume-capacity ratio (v/c), the number of lanes, and off-ramp volume. Various scenarios are designed to represent the effects of the variables and the road networks are constructed using VISSIM, which is a common traffic micro-simulation software package. The queue length is derived from VISSIM and this length is considered as the recommended spacing between the off-ramp and the adjacent intersection. Through the simulation analysis, regression models are developed to calculate the queue length reflecting the various conditions such as signals, traffic, and road configurations. The developed model can be used to create road design guidelines to determine the location of off-ramps in the planning stage.