• BMB Reports
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• 제53권4호
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• pp.191-205
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• 2020

The unexpected pandemic set off by the novel coronavirus 2019 (COVID-19) has caused severe panic among people worldwide. COVID-19 has created havoc, and scientists and physicians are urged to test the efficiency and safety of drugs used to treat this disease. In such a pandemic situation, various steps have been taken by the government to control and prevent the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). This pandemic situation has forced scientists to rework strategies to combat infectious diseases through drugs, treatment, and control measures. COVID-19 treatment requires both limiting viral multiplication and neutralizing tissue damage induced by an inappropriate immune reaction. Currently, various diagnostic kits to test for COVID-19 are available, and repurposing therapeutics for COVID-19 has shown to be clinically effective. As the global demand for diagnostics and therapeutics continues to rise, it is essential to rapidly develop various algorithms to successfully identify and contain the virus. This review discusses the updates on specimens/samples, recent efficient diagnostics, and therapeutic approaches to control the disease and repurposed drugs mainly focusing on chloroquine/hydroxychloroquine and convalescent plasma (CP). More research is required for further understanding of the influence of diagnostics and therapeutic approaches to develop vaccines and drugs for COVID-19.

• 한국치위생학회지
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• 제9권3호
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• pp.229-247
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• 2009

The purpose of this study is to provide the improvement basis for Dental Hygiene education program by analyzing the current implement status of Dental Hygiene curriculum in Korea and comparing the status with the US ADA standard. The researcher analyzed the Dental Hygiene syllabus limiting "Dental prophxis", "Comprehensive dental hygiene" subjects only from 31 universities which offer 3 years program. The main interest was to figure the implementing status of the curriculum and to compare the actual teaching content with the CODA 2-17 standard. The results show that there are a number of problems in implementing the Dental Hygiene courses among different universities. First, there is a significant inconsistence among schools in terms of course title, total credit, hours, the ratio for theory and practice, etc. In addition, there is a big gap between the actual content of Dental Hygiene courses and the essential/required content of CODA 2-17 standard. For instance, most of the Dental Hygiene programs in Korea cover the overall assessment stage content and some of implementation stage content. However, very few programs deal with the planning and evaluation stage content. To improve these problematic circumstance a number of suggestions were made. Developing the standardized curriculum for the Dental Hygiene program might be one of the major solutions. Next, the regular accreditation and/or assessment system for the Dental Hygiene program should be developed. This research can provide the basis for the need to assess and improve the Dental Hygiene curriculum.

• 상하수도학회지
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• 제30권4호
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• pp.449-457
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• 2016

In this study, the effectiveness of electrodialysis in removing inorganic arsenic from groundwater was investigated. To evaluate the feasibility of the electrodialysis, operating parameters such as treatment time, feed concentration, applied voltage and superficial velocity were experimentally investigated on arsenic removal. The higher conductivity removal and arsenic removal efficiency were obtained by increasing applied voltages and operation time. An increase of salinity concentrations in arsenic polluted groundwater exerted no effects on the arsenic separation ratios. Arsenic polluted waters were successfully treated with stack voltages of 1.8 ~ 2.4 V/cell-pair to approximately 93.4% of arsenic removal. Increase flow rate in diluate cell gave positive effect to removal rate. However, increase of superficial velocity in the concentrated cell exerted no effects on either the conductivity reduction or on the separation efficiency. Hopefully, this paper will provide direction in selecting appropriate operating conditions of electrodialysis for arsenic removal.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2011년도 제40회 동계학술대회 초록집
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• pp.335-335
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• 2011

Instability of a thin film attached to a compliant substrate often leads to emergence of exquisite wrinkle patterns with length scales that depend on the system geometry and applied stresses. However, the patterns that are created using the current techniques in polymer surface engineering, generally have low aspect ratio of undulation amplitude to wavelength, thus, limiting their application. Here, we present a novel and effective method that enables us to create wrinkles with a desired wavelength and high aspect ratio of amplitude over wavelength as large as to 2.5:1. First, we create buckle patterns with high aspect ratio of amplitude to wavelength by deposition of an amorphous carbon film on a surface of a soft polymer poly(dimethylsiloxane) (PDMS). Amorphous carbon films are used as a protective layer in structural systems and biomedical components, due to their low friction coefficient, strong wear resistance against, and high elastic modulus and hardness. The deposited carbon layer is generally under high residual compressive stresses (~1 GPa), making it susceptible to buckle delamination on a hard substrate (e.g. silicon or glass) and to wrinkle on a flexible or soft substrate. Then, we employ glancing angle deposition (GLAD) for deposition of a high aspect ratio patterns with amorphous carbon coating on a PDMS surface. Using this method, pattern amplitudes of several nm to submicron size can be achieved by varying the carbon deposition time, allowing us to harness patterned polymers substrates for variety of application. Specifically, we demonstrate a potential application of the high aspect wrinkles for changing the surface structures with low surface energy materials of amorphous carbon coatings, increasing the water wettability.

• 한국통신학회논문지
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• 제23권6호
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• pp.1602-1609
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• 1998

본 논문은 CDMA 방식의 PCS 전화기용 고주파 전위회로에 관한 것으로 전력증폭기와 듀플렉서를 결합하여 하나의 모듈로 구성하였다. 기존의 듀플렉서를 구성하고 있는 유전체 여파기들이 서로 분리되어 전력증폭기내에서 재배치되며 특히 송신용 대역저지여파기가 전력증폭기의 구동증폭기 이후에 위치된다. 결합모듈은 크기가 1.5CC에 불과하여 전화기 소형화에 크게 기여할 것으로 기대된다. 출력 24dBm에서 IS-95에 준하는 CDMA 선형특성을 만족하였으며 PCS 송수신 주파수대역에서 필요한 감쇠특성을 나타내어 듀플렉서로서 역할도 수행하였다. 결합모듈의 출력단자가 곧바로 안테나에 연결되므로 결합전보다 출력이 줄어들게 되어 이에 상응하는 동작전류가 줄어들었으며, CDMA 전화기가 실제 환경에서 동작시 출력크기의 대부분이 선형영역에 있는 점을 감안하여 전력증폭기의 동작점을 B급으로 제한하여 전류소모를 줄였다. 이 결과 약 95mA 의 드레인 전류를 절약할 수 있었다.

• ALGAE
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• 제23권4호
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• pp.277-288
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• 2008

The relationship between nutrients and phytoplankton dynamics was investigated daily from 12 April to 22 July 2003 in Sagami Bay, Japan. According to multidimensional scaling (MDS) and cluster analysis, phytoplankton community was divided into four distinct groups. The first group was consisted of centric diatom species, such as Guinardia spp., Detonula spp., Letocylindrus danicus, Skeletonema costatum, Eucampia zodiacus and Chaetoceros spp.. The second and third clusters comprised mainly diatoms and dinoflagellates, respectively. The other cluster was restricted to the samples collected during the last sampling period when the rainfall and river discharge was frequently recorded. Canonical correspondence analysis (CCA) was applied to analyze four groups respectively, which focused on the effects of nutrients concentration and ratio on phytoplankton variations. Based on CCA analysis, most species of centric diatom were negatively correlated with DSi concentrations and Si/N ratio. Nutrients were strongly limited phytoplankton growth during the summer when the rainfall was not observed, whereas river discharge by rainfall and counterclockwise coastal currents (although the surface circulation pattern is often altered by Kuroshio Current, the counterclockwise coastal currents are generally dominant) has brought phytoplankton population accumulation and triggered the micoalgae growth in western part of the bay. Phosphorous (P) was strongly limited after significantly increases in the phytoplankton abundances. However, silicate (Si) was not a major limiting factor for phytoplankton production, since Si/DIN and Si/P ratio did not create any potential stoichiometric limitation. This indicates that high Si availability contributes favorably to the maintenance of diatom ecosystems in Sagami Bay.

• Nuclear Engineering and Technology
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• 제47권3호
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• pp.380-387
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• 2015

A lead slowing-down spectrometer (LSDS) system is a promising nondestructive assay technique that enables a quantitative measurement of the isotopic contents of major fissile isotopes in spent nuclear fuel and its pyroprocessing counterparts, such as $^{235}U$, $^{239}Pu$, $^{241}Pu$, and, potentially, minor actinides. The LSDS system currently under development at the Korea Atomic Energy Research Institute (Daejeon, Korea) is planned to utilize a high-flux ($>10^{12}n/cm^2{\cdot}s$) neutron source comprised of a high-energy (30 MeV)/high-current (~2 A) electron beam and a heavy metal target, which results in a very intense and complex radiation field for the facility, thus demanding structural shielding to guarantee the safety. Optimization of the structural shielding design was conducted using MCNPX for neutron dose rate evaluation of several representative hypothetical designs. In order to satisfy the construction cost and neutron attenuation capability of the facility, while simultaneously achieving the aimed dose rate limit (< $0.06{\mu}Sv/h$), a few shielding materials [high-density polyethylene (HDPE)eBorax, $B_4C$, and $Li_2CO_3$] were considered for the main neutron absorber layer, which is encapsulated within the double-sided concrete wall. The MCNP simulation indicated that HDPE-Borax is the most efficient among the aforementioned candidate materials, and the combined thickness of the shielding layers should exceed 100 cm to satisfy the dose limit on the outside surface of the shielding wall of the facility when limiting the thickness of the HDPE-Borax intermediate layer to below 5 cm. However, the shielding wall must include the instrumentation and installation holes for the LSDS system. The radiation leakage through the holes was substantially mitigated by adopting a zigzag-shape with concrete covers on both sides. The suggested optimized design of the shielding structure satisfies the dose rate limit and can be used for the construction of a facility in the near future.

• 한국콘텐츠학회논문지
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• 제10권12호
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• pp.1-9
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• 2010

당뇨병은 대사질환의 일종으로 고혈당을 특징으로 하며, 고혈당으로 인하여 여러 증상 및 징후와 합병증을 유발하여 삶의 질을 급격히 저하시킨다. 당뇨병의 예방 및 치료를 위해서는 식이, 운동, 약물 처방 등이 있지만 무엇보다도 체계적인 식단 관리가 필수적이다. 본 논문에서는 체계적인 당뇨병 관리를 위해서 스마트폰 기반의 개인 맞춤형 식단 관리 시스템을 제안한다. 현재 대부분의 당뇨병 환자의 식단 서비스는 영양사나 의사의 주관적인 판단으로 식단을 처방하며 상황 및 개인의 선호도는 반영 되지 않는다. 제안하는 시스템은 당뇨식단을 계절, 날씨, 시간, 선호도에 맞추어 제공한다. 특히, 스마트 폰 서비스로 구현하여 언제 어디서나 장소에 제한받지 않고 사용자에게 레시피 및 개인화된 식단을 제공하며, 사용자의 간단한 조작만으로도 손쉽게 식단 변경이 가능하다.

• 한국구조물진단유지관리공학회 논문집
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• 제19권6호
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• pp.72-79
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• 2015

이 논문에서는 해안구조물에 대한 실질적이고 효율적인 구조신뢰성평가 기법을 제시하였다. 제안기법은 파랑, 조류 등의 하중관련 변수 그리고 콘크리트의 탄성계수와 압축강도, 지반정수 및 경계조건 등과 같은 저항관련 설계변수의 불확실성을 명확히 고려한 복잡한 해안구조물의 신뢰성을 평가할 수 있다. 라틴 하이퍼큐브 샘플링(LHS), 몬테카를로 시뮬레이션(MCS) 및 유한요소법을 합리적으로 결합한 제안기법에서 LHS기반 MCS는 신뢰성평가에 필요한 샘플링 수를 대폭 줄여주므로 계산노력이 획기적으로 감소된다. 검증예제를 통하여 제안기법이 상대적인 정확도를 보장하며 계산상의 효율성이 우수한 것으로 확인되었다. 또한 실제의 케이슨형식 방파제 구조물을 대상으로 한 수치예제를 통하여 그 적용성과 효율성을 입증하였다. 특히 유한요소법 또는 유한차분법과 같은 알고리즘 형태의 암시적 한계상태함수를 갖는 경우와 비선형해석, 복합재료, 다양한 기하형상 등을 복잡한 구조거동을 고려해야 하는 실제적인 구조물의 신뢰성평가에 적합한 것으로 판단된다.

• 대한화학회지
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• 제9권2호
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• pp.67-70
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• 1965

水銀滴下電極에 있어서 Ni(II)-CN complex의 還元反應은 두가지 經路를 밟고 있는데, 一電子還元일때는 Ni(CN)42- + e [1]↔[2] Ni(CN)43- =(eq) Ni(CN)2- + 2CN- 그리고 二電子還元일 때는 Ni(CN)42- + 2e [3]--> 1/2[Ni(CN)33-]2 + CN- 이다. 反應 [1]이 反應[3]에 比하여 빠르게 일어나고 있다. $CN^-$濃度가 묽을 때 (0.004∼0.01M)의 還元波는 反應[1]에 依해 나타나며 이때 $CN^-$ 두個가 關與하게 된다. $CN^-$ 濃度가 增加하면 反應[2]는 빨라져서 反應[1]과 [2]는 平衡狀態에 到達하게 된다. $CN^-$濃度 0.2M 以上에서는 反應[3]에 依한 二電子還元으로 電極反應을 하게 되는데 이 反應機構는 $CN^-$濃度 0.004M일 때보다 8M때의 限界電流値가 約 2倍가 되는 現象도 說明할 수 있게 된다.