• The Korean Journal of Physiology and Pharmacology
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• 제25권3호
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• pp.217-225
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• 2021

Neuropathic pain (NP) that contributes to the comorbidity between pain and depression is a clinical dilemma. Neuroinflammatory responses are known to have potentially important roles in the initiation of NP and depressive mood. In this study, we aimed to investigate the effects of paeoniflorin (PF) on NP-induced depression-like behaviors by targeting the hippocampal neuroinflammation through the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) signaling pathway. We used a murine model of NP caused by unilateral sciatic nerve cuffing (Cuff). PF was injected intraperitoneally once a day for a total of 14 days. Pain and depression-like behavior changes were evaluated via behavioral tests. Pathological changes in the hippocampus of mice were observed by H&E staining. The levels of proinflammatory cytokines in the hippocampus were detected using ELISA. Activated microglia were measured by immunohistochemical staining. The TLR4/NF-κB signaling pathway-associated protein expression in the hippocampus was detected by western blotting. We found that the PF could significantly alleviate Cuff-induced hyperalgesia and depressive behaviors, lessen the pathological damage to the hippocampal cell, reduce proinflammatory cytokines levels, and inhibit microglial over-activation. Furthermore, PF downregulated the expression levels of TLR4/NF-κB signaling pathway-related proteins in the hippocampus. These results indicate that PF is an effective drug for improving the comorbidity between NP and depression.

• 대한물리의학회지
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• 제13권4호
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• pp.149-162
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• 2018

PURPOSE: The aim of this study was to investigate the effect of scapular dynamic taping on pain, disability, upper body posture, and range of motion (ROM) in the postoperative shoulder. METHODS: Twenty-two patients who underwent acromioplasty and rotator cuff repair surgery volunteered for this study. The subjects were randomly divided into an experimental group (EG, n=11) and a control group (CG, n=11). For the EG, exercise therapy, manual therapy, and scapular dynamic taping were applied for 6 weeks; for the CG, only exercise therapy and manual therapy were applied for 6 weeks. Shoulder pain, disability, upper body posture, and ROM were evaluated at baseline, after 3 weeks of intervention, and after 6 weeks of intervention. Assessment tools included quadruple visual analog scale (QVAS) for level of pain; shoulder pain and disability index (SPADI) for functional disability level; forward head angle (FHA), forward shoulder angle (FSA), and pectoralis minor index (PMI) for upper body posture; and ROM testing. RESULTS: Significant differences were observed between the EG and CG in SPADI total scores; internal rotation and external rotation ROM of the glenohumeral joint ; FSA ; and PMI. All groups showed statistically significant improvement in QVAS; SPADI; flexion; abduction; external rotation and internal rotation ROM of the glenohumeral joint; FSA; and PMI. CONCLUSION: These results suggest that, for patients who have undergone acromioplasty and rotator cuff repair surgery, the addition of scapular dynamic taping during therapy is effective for improvement of shoulder disability level, ROM, and upper body posture.

• Clinics in Shoulder and Elbow
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• 제21권4호
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• pp.186-191
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• 2018

Background: To determine the normal range of humeral head positioning on magnetic resonance imaging (MRI). Methods: We selected normal subjects (64 patients; group A) to study the normal range of humeral head positioning on the glenoid by MRI measurements. To compare the MRI measurement method with the computed tomography (CT), we selected group B (70 patients) who underwent both MRI and CT. We measured the humeral-scapular alignment (HSA) and the humeral-glenoid alignment (HGA). Results: The HSA in the control group was $1.47{\pm}1.05mm$, and the HGA with and without reconstruction were $1.15{\pm}0.65mm$ and $1.03{\pm}0.59mm$, respectively, on MRI. In the test group, HSA was $2.67{\pm}1.47mm$ and HGA with and without reconstruction was $1.58{\pm}1.16mm$ and $1.49{\pm}1.08mm$, on MRI. On CT, the HSA was $1.72{\pm}1.01mm$, and HGA with and without reconstruction were $1.54{\pm}0.96mm$ and $1.59{\pm}0.93mm$, respectively. HSA was significantly different according to image modality (p=0.0006), but HGA was not significantly different regardless of reconstruction (p=0.8836 and 0.9234). Conclusions: Although additional CT scans can be taken to measure decentering in patients with rotator cuff tears, reliable measurements can be obtained with MRI alone. When using MRI, it is better to use HGA, which is a more reliable measurement value based on the comparison with CT measurement (study design: Study of Diagnostic Test; Level of evidence II).

• Clinics in Shoulder and Elbow
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• 제25권3호
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• pp.210-216
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• 2022

Background: Reverse shoulder arthroplasty (RSA), first introduced as a management option for cuff tear arthropathy, is now an accepted treatment for complex proximal humeral fractures. Few studies have identified whether the outcomes of RSA for shoulder trauma are comparable to those of RSA for shoulder arthritis. Methods: This is a retrospective, single-institution cohort study of all patients who underwent RSA at our institution between January 2013 and December 2019. In total, 49 patients met the inclusion criteria. As outcomes, we evaluated the 1-year American Shoulder and Elbow Surgeons (ASES) and Constant shoulder scores, postoperative shoulder range of motion, intra- and postoperative complications, and cumulative revision rate. The patients were grouped based on preoperative diagnosis to compare postoperative outcomes across two broad groups. Results: The median follow-up period was 32.8 months (interquartile range, 12.6-66.6 months). The 1-year visual analog scale, range of motion, and Constant and ASES functional scores were comparable between RSAs performed to treat shoulder trauma and that performed for arthritis. The overall complication rate was 20.4%, with patients with a preoperative diagnosis of arthritis having significantly more complications than those with a preoperative diagnosis of trauma (34.8% vs. 7.7%). Conclusions: Patients who underwent RSA due to a proximal humeral fracture or dislocation did not fare worse than those who underwent RSA for arthritis at 1 year, in terms of both functional and radiological outcomes.

• Clinics in Shoulder and Elbow
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• 제26권1호
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• pp.32-40
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• 2023

Background: The purpose of this study was to identify predictors of the time from initial presentation to total shoulder arthroplasty (TSA) in patients with primary glenohumeral osteoarthritis (OA) and rotator cuff (RTC) arthropathy who were conservatively managed with corticosteroid injections. Methods: We conducted a retrospective cohort study of patients who underwent TSA from 2010 to 2021. Kaplan-Meier survival analysis was used to estimate median time to TSA for primary OA and RTC arthropathy patients. The Cox proportional hazards model was used to identify significant predictors of time to TSA and to calculate hazard ratios (HRs) with 95% confidence intervals (CIs). Statistical significance was set at P<0.05. Results: The cohort included 160 patients with primary OA and 92 with RTC arthropathy. In the primary OA group, median time to TSA was 15 months. Significant predictors of shorter time to TSA were older age at presentation (HR, 1.02; 95% CI, 1.00-1.04; P=0.03) and presence of moderate or severe acromioclavicular joint arthritis (HR, 1.45; 95% CI, 1.05-2.01; P=0.03). In the RTC arthropathy group, median time to TSA was 14 months, and increased number of corticosteroid injections was associated with longer time to TSA (HR, 0.87; 95% CI, 0.80-0.95; P=0.003). Conclusions: There are distinct prognostic factors for progression to TSA between primary OA patients and RTC arthropathy patients managed with corticosteroid injections. Multiple corticosteroid injections are associated with delayed time to TSA in RTC arthropathy patients.

• Clinics in Shoulder and Elbow
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• 제25권4호
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• pp.257-264
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• 2022

Background: Chronic subscapularis tendon tear (SBT) is a degenerative disease and a common pathologic cause of shoulder pain. Several potential risk factors for chronic SBT have been reported. Although metabolic abnormalities are common risk factors for degenerative disease, their potential etiological roles in chronic SBT remains unclear. The purpose of this study was to investigate potential risk factors for chronic SBT, with particular attention to metabolic factors. Methods: This study evaluated single shoulders of 939 rural residents. Each subject undertook a questionnaire, physical examinations, blood tests, and simple radiographs and magnetic resonance imaging (MRI) evaluations of bilateral shoulders. Subscapularis tendon integrity was determined by MRI findings based on the thickness of the involved tendons. The association strengths of demographic, physical, social, and radiologic factors, comorbidities, severity of rotator cuff tear (RCT), and serologic parameters for SBT were evaluated using logistic regression analyses. The significance of those analyses was set at p<0.05. Results: The prevalence of SBT was 32.2% (302/939). The prevalence of partial- and full-thickness tears was 23.5% (221/939) and 8.6% (81/939), respectively. The prevalence of isolated SBT was 20.2% (190/939), SBT combined with supraspinatus or infraspinatus tendon tear was 11.9% (112/939). In multivariable logistic regression analysis, dominant side involvement (p<0.001), manual labor (p=0.002), diabetes (p<0.001), metabolic syndrome (p<0.001), retraction degree of Patte tendon (p<0.001), posterosuperior RCT (p=0.010), and biceps tendon injury (p<0.001) were significantly associated with SBT. Conclusions: Metabolic syndrome is a potential risk factor for SBT, as are these factors: overuse activity, diabetes, posterosuperior RCT, increased retraction of posterosuperior rotator cuff tendon, and biceps tendon injury.

• 한국전문물리치료학회지
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• 제30권1호
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• pp.41-49
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• 2023

Background: Scapular dyskinesis may cause not only rotator cuff (RC) tear but also weakness of the upper extremity, studies on scapular dyskinesis that may occur after RC repair is still lacking. Objects: To determine whether scapular dsykinesis was present in patients after arthroscopic RC repair and to investigate the influence of passive scapular stabilization on upper extremity strength. Methods: A total of 30 patients after RC repair participated in this study. To compare the scapula of the arthroscopic RC repair shoulder and the contralateral shoulder, the winged scapula (WS) was measured using a scapulometer and scapular dyskinesis was also classified by type. Fixed instruments for muscle strength measurements were used to measure upper extremity muscle strength differences depending on passive scapular stabilization position or natural scapular position. A chi-square test, an independent t-test and a 2-way mixed measures analysis of variance (ANOVA) was used as statistical analysis. In analyses, p < 0.05 was deemed to be statistically significant. Results: Postoperative shoulder had a significant association with scapular dyskinesis and the WS compared to the contralateral shoulder (F = 0.052, p < 0.01). Postoperative shoulder, muscle strength in the shoulder abduction (p < 0.01), elbow flexion (p < 0.01) and forearm supination (p < 0.05) were significantly greater in the scapular stabilization position than in the scapular natural position. Conclusion: Patients underwent arthroscopic RC repair had a significant association with scapular dyskinesis and muscle strength was improved by a passive scapular stabilization position, therefore scapular stabilization is important in rehabilitation program.

• 대한정형외과학회지
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• 제54권2호
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• pp.100-109
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• 2019

견관절 인공관절 성형술의 빈도가 빠른 속도로 증가함에 따라 일차적 인공관절 성형술과 관련된 다양한 형태의 합병증이 발생하고, 이로 인해 재치환술 역시 증가하고 있는 추세이다. 견관절 인공관절 재치환술은 여러 원인에 의해 발생되는 것으로 알려져 있는데 일차적 인공관절 성형술 후 나타난 회전근 개 파열, 관절와 상완 관절의 불안정성, 관절와 또는 상완골 치완물의 해리, 인공 치환물의 실패, 치환물 주위 골절, 감염 등이 있다. 재치환술은 술기적으로 어려운 과제이다. 실패한 견관절 인공관절 성형술은 해결할 수 있는 외과적 선택이 많지 않다. 특히 관절와 골 결손 또는 봉합 불가능한 회전근 개 파열이 있는 경우에는 더욱 어렵다. 또한 재치환술의 결과는 일차적 성형술의 결과에 비해 항상 좋지 않다. 결국 외과의는 수술을 결정하기 전에 일차적 인공관절 성형술이 실패한 원인을 잘 파악하여야 한다. 따라서 본 논문에서는 실패한 일차적 인공관절 성형술 후 재치환술의 적응증에 대해 살펴보고 실패의 원인에 따른 재치환술의 술기에 대해 논의하고자 한다.

• 대한의용생체공학회:의공학회지
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• 제45권1호
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• pp.49-55
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• 2024

Accurate measurement of blood pressure is essential for classifying an individual's disease, identifying blood pressure-related risks, and managing health. Due to the environmental and health hazards of mercury sphygmomanometers, automatic sphygmomanometers using the oscillometric method are widely used in hospitals as well as in general homes, and have established themselves as a practical standard sphygmomanometer. In this study, we developed a blood pressure simulator using an actuator that provides simulated pressure to an automatic blood pressure cuff. The developed blood pressure simulator adopts an arm-shaped cylindrical shape similar to the situation in which a person measures blood pressure with an automatic blood pressure monitor, and implements a method of transmitting pressure to the cuff using a pressure plate. Accuracy was evaluated through the mean and standard deviation of the difference with the commercialized blood pressure simulator BP PUMP 2, and reproducibility was confirmed using two automatic blood pressure monitors. The developed blood pressure simulator enables automatic blood pressure monitoring in a simple manner and also meets the evaluation standards for accuracy and reproducibility. In the future, as a standardized blood pressure simulator, it is expected to be of great help in evaluating and verifying the performance of automatic blood pressure monitors by supplementing precise hardware and software and building a blood pressure database.

• 대한정형외과스포츠의학회지
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• 제5권1호
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• pp.50-57
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• 2006

목적: 견관절 회전근 개 전층 파열시 관절경적 복원술 후 대결절에 부착되어진 회전근 개의 건이 상완골에 어느 정도의 비율로 건-골(tendon to bone)에 치유되는지에 대하여 알아보고자 하였다. 또한 저자들은 극상건 전층 파열된 례에서 관절경적 복원술 후의 기능적 평가를 시행하였다. 대상 및 방법: 연속적 인 30례의 극상건 전층 파열을 19례에서 one row of anchor를, 11례에서는 two rows of anchor를 사용해 관절경적 복원술을 시행하였다. 환자들의 연령은 51세부터 79세로 평균 63세였으며, 평균 추시 기간은 술후 12개월부터 28개월로 평균 16개월이었다. 술전과 마지막 추시에 주관적 및 객관적인 기능적인 평가를 위해 Constant, ASES와 HCLA score를 측정하였다. 해부학적인 건 치유를 확인하기 위해 30례 전례에서 술후 6개월에서 20개월, 평균 10개월째 자기 공명 관절 조영술(25례)이나 자기 공명 술(5례)을 시행하였다. 결과: 관절경적 복원술후 회전근 개의 대결절에 대한 완전 치유는 30례중 21례(70.0%)였고, 부분적인 파열은 3례(10%)였으며, 극상건이 전혀 치유되지 않아 대결절에 부착되지 못한 경우는 6례 (20%)였으나, 그 중 5례에서는 술후 남아있는 결손의 크기가 처음 술전 보다는 작았다. 객관적인 평가로 Constant score는 술전에 평균 $55.7{\pm}7.1$점에서 술후 마지막 추시 관찰시에 $77.7{\pm}9.7$점으로 향상되었고(p<0.001), ASES xcore는 술전 $39.2{\pm}7.4$점에서 $72.4{\pm}12.6$점으로 향상되었고(p<0.001), UCLA score는 술전 $17.9{\pm}2.2$점에서 $26.5{\pm}5.0$점으로 향상되었다(p<0.001). 견관절의 전방 거상시 근력 이 대결절에 치유된 례 $(7.1kgs{\pm}2.4)$에서 전혀 치유되지 않아 완전히 재 파열되었거나, 부분 파열을 보인 례 $(4.5kgs{\pm}1.0)$에서 보다 통계학적으로 의미 있는 향상을 보였다(p<0.05). 건 치유에 결정적인 영향을 미치는 인자는 환자의 나이였다. 65세 이상의 환자에서는 단지 41.7%만이 대결절에 극상건의 완전한 치유율을 보였다(p<0.05). 결론: 회전근 개 중 극상건 전층 파열된 례에서 관절경적 복원술 후 약 70%에서 완전한 치 유를 보였다. 술후 극상건의 부분 파열 및 재파열은 근력 저하와 직접적인 연관을 가졌다. 특히, 노령 환자에서의 회전근 개 상태가 술후 재파열과 밀접한 관련이 있다.