• Proceedings of the Korean Society of Toxicology Conference
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• 2003.05a
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• pp.75-75
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• 2003

Silica has been known to be a factor in acute cell injury and chronic pulmonary fibrosis. In Rat2 fibroblasts, silica induced the activation of NFkB, which plays a crucial role in regulating the expression of many genes involved in the subsequent inflammatory response. In addition, we observed that TAK1 and NIK were involved in silica-mediated NF-kB activation in Rat2 cells. (omitted)

• Neonatal Medicine
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• v.18 no.1
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• pp.1-5
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• 2011

Coagulation involves the regulated sequence of proteolytic activation of a series of proteins to achieve appropriate and timely hemostasis in an injured vessel. In the non-pathological state, the inciting event involves exposure of circulating factor VIIa to extravascularly expressed tissue factor, which brings into motion the series of steps which results in cell based model of coagulation. In the new concepts of coagulation system, initiation, amplification and propagation steps are involved to converse of fibrinogen to fibrin. The precisely synchronized cascade of events is counter-balanced by a system of anticoagulant mechanisms. Developmental hemostasis refers to the age-related changes in the coagulation system that are most marked during neonate and childhood. An understanding of these changes in crucial to the accurate diagnosis of hemostatic abnormalities in neonate and children. This review aims to elucidate the main events within the coagulation cascade as it is currently understood to operate in vivo, and also a short review of the anticoagulants as they relate to this model. Also this paper describes the common pitfalls observed in the clinical data related to the coagulation system in neonate to children.

• CELLMED
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• v.3 no.1
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• pp.3.1-3.3
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• 2013

The receptor activator of NF-${\kappa}B$ ligand (RANKL), a member of the tumor necrosis factor ligand family, has extensive functions beyond osteoclast development. RANKL is expressed in many immune cells such as osteoblasts, osteocytes, marrow stromal cells, activated T cells, synovial cells, keratinocytes, and mammary gland epithelial cells as well as in various tissues. The ligation of RANK by RANKL promotes dendritic cells (DCs) survival through prosurvival signals and the up-regulation of the anti-apoptotic proteins Bcl-2 and Bcl-$x_L$ and plays a crucial role in DCs-mediated Th1 differentiation. Therefore, RANKL plays an important role in the regulation of DCs/T cells-mediated specific immunity. This review will briefly inform our current understanding of the role of RANKL signaling in T cells-DCs communication in the immune system.

• Journal of the Korea Institute of Military Science and Technology
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• v.14 no.2
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• pp.246-263
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• 2011

Mankind has just begun to recognize that the most crucial factor to achieve the sustainable society in the future is green technology. Most countries support the development of green technology to prevent catastrophes from global warming, mainly in the areas of reducing carbon dioxide from the atmosphere. However, most products we consume in everyday life are produced through chemical processes, and we often oversee the fact that the huge amount of waste and energy during these chemical processes will seriously influence our goal to achieve our future society sustainable. Thus the technologies to minimize the amount of disposed waste and energy consumption during chemical processes may be more important than to reduce the greenhouse gases. In this regard this review introduces the recent status of green chemistry and future prospects in order to help our chemists and engineers establish research projects based on the green chemistry principles.

• Childhood Kidney Diseases
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• v.11 no.2
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• pp.145-151
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• 2007

Hypertonicity (hypernatremia) of extracellular fluid causes water movement out of cells, while hypotonicity(hyponatremia) causes water movement into cells, resulting in cellular shrinkage or cellular swelling, respectively. In most part of the body, the osmolality of extracellular fluid is maintained within narrow range($285-295 mOsm/kgH_2O$) and some deviations from this range are not problematic in most tissue of the body except brain. On the other hand, the osmolality in the human renal medulla fluctuates between 50 and $1,200 mOsm/kgH_2O$ in the process of urine dilution and concentration. The adaptation of renal medullary cells to the wide fluctuations in extracellular tonicity is crucial for the cell survival. This review will summarize the mechanisms of urine concentration and the adaptation of renal medullary cells to the hyper tonicity, which is mediated by TonEBP transcription factor and its target gene products(UT-A1 urea transporter etc.).

• Proceedings of the Korean Society of Agricultural Engineers Conference
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• 2005.10a
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• pp.626-631
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• 2005

Monitoring data from agricultural reservoirs throughout the country were analyzed to evaluate the limiting factor for algal growth and correlationship between Chl-a, total phosphorus (TP), total nitrogen (TN), and chemical oxygen demand (COD). It was used for the analysis to monitored data of 394 reservoirs such as TP, TN, Chl-a, and COD from 1999 to 2003. This study analyzed water quality items in terms of areas, seasons. It turned out that phosphorus in agricultural reservoirs (about 80%) was dominant limiting factor for algal growth. Therefor, it appears that the appropriate managements of phosphorus in the agricultural watershed are crucial to prevent excessive on algal growth. Generally, there is correlation between Chl-a and TP while Chl-a do not have effect on TN. Also, Chl-a have influence on COD. This study could be used beneficially for water quality management of agricultural reservoirs and related water quality modeling.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.02a
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• pp.457-457
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• 2013

Current-voltage (I-V) measurements of crystalline silicon solar cells was conducted under dark conditions with the temperature range of 260 K~350 K. Using the calculation method, we extracted the crucial factors of ideality factor (n) and activation energy (Ea) to investigate the carrier conducting path in the space charge region (SCR) and the quasi-neutral region (QNR). Values of n were decreased with increasing temperature in both SCR and QNR. We also conformed that the value of Ea of SCR was larger than that of QNR about 0.4 eV. The temperature dependence of n indicates that the carrier conducting path is dominated by carrier recombination-generation in the SCR region than in the QNR region.

• Steel and Composite Structures
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• v.5 no.5
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• pp.407-420
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• 2005

This study presents the strength of braced and unbraced cold-formed steel wall frames consisting of several wall studs acting as columns, top and bottom tracks, and bracing members. The strength and the buckling mode of steel wall frames were found to be different due to the change of bracing type. In addition, the spacing of wall studs is a crucial factor to the strength of steel wall frames. The comparisons were made between the test results and the predictions computed based on AISI Code. The related specifications do not clearly provides the effective length factors for the member of cold-formed steel frame under compression. This paper proposes effective length factors for the steel wall frames based on the test results. A theoretical model is also derived to obtain the modulus of elastic support provided by the bracing at mid-height of steel wall frames in this research.

• Journal of Families and Better Life
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• v.15 no.4
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• pp.65-80
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• 1997

Korean-American and American adolescents' attitudes toward the elderly(OP Scale) and their perception on the generational difference(GN GAP) were compared to find whether there is a difference according to the race. Adolescents' perceived generational gap was considered to be one of the most influential factor affecting their attitudinal differences. Adolescents regardless of face showed a somewhat positive attitudes toward the elderly and they perceived generational gap a little positively. Adolescents' age and sex were found not to be related with their attitude toward the elderly and generational gap. For the Korean-Americans birth-order was negatively related to the generational gap perception. the quality of relationship with grandparents was the crucial factor influencing adolescents' perceptions on generational gap and their attitudes toward the elderly indirectly. Grandparents' health and age affected on the quality of relationship. Additionally adolescents' favorite g andparent was found to be maternal grandmother and their relation style and conflict areas were different according to the race.

• East Asian Economic Review
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• v.23 no.3
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• pp.261-284
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• 2019

This paper explores the ramifications of international outsourcing on unemployment, income distribution and welfare, which is an important but yet unresolved issue. Using the well-known Harris-Todaro (1970) model of sector-specific unemployment, it shows that the effects of outsourcing on employment, income-distribution and welfare depend on the sector in which the outsourcing occurs, whereby sectoral factor intensities, unemployment-outsourcing response and the dynamic stability condition play crucial roles. In particular, outsourcing in the manufacturing (primary) sector widens (narrows) income inequality by increasing (decreasing) the sectoral wage gap and raising (not affecting) the rental income of the capital owners in the economy. Moreover, outsourcing in the manufacturing (primary) sector can be welfare-decreasing (is always welfare-increasing) due to its negative (positive) employment effect mitigating (reinforcing) the primary gains from the outsourcing.