• Title/Summary/Keyword: Crucial Factor

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Effects of Circular Type TGF-$\beta$1 Antisense Oligonucleotides on Anti-Thy-1 Glomerulonephritis

  • Han, Sang-Mi;Lee, Kwang-Gill;Yeo, Joo-Hong;Kweon, Hae-Yong;Woo, Soon-Ok;Park, Kwan-Kyu
    • Proceedings of the Korean Society of Sericultural Science Conference
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    • 2003.10a
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    • pp.145-146
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    • 2003
  • Overproduction of transforming growth factor (TGF)-$\beta$l has been implicated in the pathogenesis of fibrotic diseases. TGF-$\beta$l plays a crucial role in the accumulation of extracellular matrix (ECM) in human and experimental glomerular diseases. However, it remains unclear whether inhibition of TGF- $\beta$l overproduction would suppress TGF- $\beta$l induced ECM accumulation. To inhibit the overproduction of TGF- $\beta$l in experimental glomerulonephritis induced by anti-Thy 1.1 antibody, we introduced antisense oligodeoxynucleotides (ODN) fur TGF- $\beta$l into the nephritic kidney by the HVJ-liposome-mediated gene transfer method. (omitted)

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Effect of Desiccant and Channel Geometries on the Performance of Desiccant Rotor (제습제와 채널이 제습로터 성능에 미치는 영향)

  • Chung, Jae-Dong;Lee, Dae-Young;Yoon, Seok-Mann
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.19 no.8
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    • pp.569-576
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    • 2007
  • The desiccant rotor is the most essential component of desiccant cooling system, but one of its drawbacks to spread out is rotor size. To reduce the size of rotor the analysis of rotor performance is crucial. Systematic examination on the effect of desiccant and channel geometries has been conducted based on the numerical program previously developed. Considered parameters related to channel geometries are channel shape and cross section area of channel, and parameters related to desiccant are mass fraction, heat capacity, density, maximum water uptake and separation factor of isotherm. Considerable reduction of rotor size is expected by adjusting the parameters.

A Study of Efficient Access Method based upon the Spatial Locality of Multi-Dimensional Data

  • Yoon, Seong-young;Joo, In-hak;Choy, Yoon-chul
    • Proceedings of the Korea Database Society Conference
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    • 1997.10a
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    • pp.472-482
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    • 1997
  • Multi-dimensional data play a crucial role in various fields, as like computer graphics, geographical information system, and multimedia applications. Indexing method fur multi-dimensional data Is a very Important factor in overall system performance. What is proposed in this paper is a new dynamic access method for spatial objects called HL-CIF(Hierarchically Layered Caltech Intermediate Form) tree which requires small amount of storage space and facilitates efficient query processing. HL-CIF tree is a combination of hierarchical management of spatial objects and CIF tree in which spatial objects and sub-regions are associated with representative points. HL-CIF tree adopts "centroid" of spatial objects as the representative point. By reflecting objects′sizes and positions in its structure, HL-CIF tree guarantees the high spatial locality of objects grouped in a sub-region rendering query processing more efficient.

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Application of Virtual SEA for the Prediction of Acoustic Performance of Cockpit (칵핏 흡차음 성능 예측을 위한 Virtual SEA 의 활용)

  • Jeong, Won-Tae;Ko, Chang-Sung;Park, Hyung-Hwan
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2007.11a
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    • pp.903-912
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    • 2007
  • One of the crucial factors which determine the quality and the accuracy of SEA model is how subsystems are defined. Experimental SEA technique had been a unique way to divide entire systems accurately for mid-frequency range, until FEA based virtual FRF response technique, virtual SEA method presented. Virtaul SEA has been developed for predictive SEA tool in early design process. In this study, Modal analysis results from modified crash FE model is used for Statistical transfer matrix. Observation nodes on the cockpit are grouped by attractive substructuring method based on point to point transfer and correlation matrix. Complex cockpit structure is divided into subsystems by automatic substructuring. Comparison with experimental SEA results validates the application of Virtual SEA to cockpit.

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A Study on the Creep Characteristics of Solder of 63 Sn-37Pb (63Sn-37Pb 땜납의 크리프 특성에 관한 연구)

  • 이억섭;김의상
    • Journal of the Korean Society for Precision Engineering
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    • v.21 no.2
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    • pp.138-144
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    • 2004
  • The initiation and the propagation of solder joint crack depend on its environmental conditions, such as high temperature creep and thermal fatigue. Creep is known to be the most important factor for the mechanical failure of solder joints in micro-electronic components and micro-systems. This is mainly caused by the different thermal expansion coefficients of the materials used in the micro-electronic packages. To determine the reliability of solder joints and consequently the electronic components, the characterization of the creep behavior of this group of materials is crucial. This paper is to apply the theory of creep into solder joints and to provide related technical information needed for evaluation of reliability of solder joint to failure. 63Sn-37Pb solder was used in this study. This paper experimentally shows a way to enhance the reliability of solder joints.

Evaluation of the Effect on the Valve Flow Coefficient by Attached Fitting (밸브 후단 피팅에 따른 밸브 용량계수의 영향 평가)

  • Kang, Seung-Kyu;Lee, Won-Sik;Yoon, Joon-Yong;Min, Kyung-Wha
    • The KSFM Journal of Fluid Machinery
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    • v.6 no.4 s.21
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    • pp.29-37
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    • 2003
  • This study was undertaken to verify the effect of flow coefficient when a globe control valve was attached by different type of fitting. The valve flow coefficient is usually determined by measuring the flow rate and the pressure drop with the connection of straight pipe through the valve. The effect of different fitting that is mounted on the downstream of the valve is studied. Four types of fittings and three distances between the valve and a downstream fitting are compared parametrically to investigate the effect on the flow coefficient of it. Measured flow coefficient and numerically predicted value by using computational fluid dynamics were compared in detail. It is concluded that the flow coefficient is reduced if the fitting is attached after a valve, but the effect of different type of fitting is not crucial.

Experimental Study on Thermal Conductivity and Viscosity of Grouts for Backfilling Ground Heat Exchanger (수직 밀폐형 자중 열교환기용 뒤채움재의 열전도 및 점도특성 연구)

  • Choi, Hang-Seok;Lee, Chul-Ho;Gil, Hu-Jeong;Choi, Hyo-Pum;Woo, Sang-Baik
    • New & Renewable Energy
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    • v.3 no.4
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    • pp.38-46
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    • 2007
  • In order to characterize the thermal conductivity and viscosity of grout materials used for backfilling ground heat exchangers, nine bentonite grouts and cement grouts being adapted in the United State have been considered in this study. The bentonite grouts indicate that the thermal conductivity and viscosity increase with the content of bentonite or filler (silica sand). In addition, material segregation can be observed when the viscosity of grout is relatively low. The saturated cement grouts appear to possess much higher thermal conductivity than the saturated bentonite grouts, and the reduction of thermal conductivity in the cement grouts after drying specimens is less than the case of the bentonite grouts. Maintaining the moisture content of grouts is a crucial factor in enhancing the efficiency of ground heat exchangers.

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A Study on Estimation of Induction Motor Parameter (유도전동기의 파라메터 추정에 관한 연구)

  • Lee, Jeong-Min;Joe, Jee-Won;Kang, Woong-Suk;Choe, Gyu-Ha;Kim, Han-Sung
    • Proceedings of the KIEE Conference
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    • 1991.07a
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    • pp.623-626
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    • 1991
  • Crucial to the success of the vector control scheme without speed sensor is up to computing instantaneous position of the rotor flux. In tracing this flux depending on the machine parameter, variations of those factor lead to the non-linear charlcteristic between I/O value and decrease overall efficiency of the vector control scheme. This paper, using recursive least square method estimating instantaneous value of the machine speed and parameter from the shift of current and voltage, proposes an algorithm for compensating the I/O error of the scheme.

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Experimental and Analytical Study on the Surface Strain and Internal Pressure Due to Corrosion of Reinforcement (철근부식에 의한 콘크리트의 표면변형률과 내부팽창압에 대한 실험 및 해석연구)

  • 오병환;김기현;강의영;장승엽;김지상;서정문
    • Proceedings of the Korea Concrete Institute Conference
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    • 2001.11a
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    • pp.777-780
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    • 2001
  • Corrosion products of reinforcement in the concrete exerts pressure to the adjacent concrete that the concrete is subject to tensile stress. If the tensile strength exceeds the tensile strength, cracks are initiated around steel and propagates through concrete cover. Cracking of the cover means that the lifetime of the structure is ended. So the amount of corrosion which introduces crack in the concrete cover is a crucial factor in the reinforcement corrosion problem. In this study, relation between internal pressure and amount of corrosion are pursued by way of corrosion experiment and finite element analysis.

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A PC-Based System for Gear Pitch Analysis and Monitoring in Gear Manufacturing Process (기어피치분석 및 공정관측을 위한 PC기반시스템 구축)

  • 김성준;지용수
    • Journal of Korean Society for Quality Management
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    • v.30 no.3
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    • pp.111-119
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    • 2002
  • Gears are essential elements for mechanical power transmission. Geometric precision is the main factor for characterizing gear grade and qualify. Gear pitch is one of the crucial measurements, which is defined as a distance between two adjacent gear teeth. It is well-known that variability in gear pitches may causes wear-out and vibration noise. Therefore maintaining pitch errors at a low level plays a key role in assuring the gear quality to customers. This paper is concerned with a case study, which presents a computerized system for Inspecting pitch errors in a gear machining process. This system consists of a PC and window-based programs. Although the start and stop is manually accomplished, the process of measuring and analyzing pitch data is automatically conducted in this system. Our purpose lies in reducing inspection cost and time as well as Increasing test reliability. Its operation is briefly illustrated by example. Sometimes a strong autocorrelation is observed from pitch data. We also discuss a process monitoring scheme taking account of autocorrelations.