• 제목/요약/키워드: Cross-tolerance

검색결과 189건 처리시간 0.028초

Subtle inflammation: a possible mechanism of future cardiovascular risk in obese children

  • Sontichai, Watchareewan;Dejkhamron, Prapai;Pothacharoen, Peraphan;Kongtaweelert, Prachya;Unachak, Kevalee;Ukarapol, Nuthapong
    • Clinical and Experimental Pediatrics
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    • 제60권11호
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    • pp.359-364
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    • 2017
  • Purpose: The risk of cardiovascular disease (CVD) has been shown to be associated with systemic inflammation in obese adults with metabolic syndrome (MetS). The aims of this study were to evaluate the prevalence of MetS and its relation to inflammatory markers in obese Thai children. Methods: A cross-sectional study was conducted. Children with history of endogenous obesity, chronic diseases, drug ingestion, and any acute illness within 2 weeks prior to enrollment were excluded. Their fasting blood glucose (FBG) levels, oral glucose tolerance tests, insulin, lipid profiles, and selected inflammatory markers, including interleukin-6, tumor necrosis factor-alpha, and high-sensitivity C-reactive protein (hs-CRP) levels, were tested. Results: In this study, 58 obese Thai children (female, 20; male, 38) with a mean body mass index z score of $5.1{\pm}2.2$ were enrolled. The prevalence of MetS and prediabetes was 31% and 17.2%, respectively. None of the children had diabetes. FBG levels, 2-hour glucose levels, and lipid profiles were not statistically different between those with and without MetS. However, obese children with MetS had higher insulin levels and homeostasis model assessment of insulin resistance values. Elevated hs-CRP levels were found in 69% of the cases, although it was not statistically different between the 2 groups. Conclusion: We described a substantial prevalence of MetS in Thai obese children. Regardless of MetS status, two-thirds of the obese children had elevated hs-CRP level, indicating subtle ongoing inflammatory process. This chronic inflammation feasibly predisposes them to CVD in the future, even in children without MetS.

삼차원정상지하수모형에 의한 홍적대지의 지하수류동해석 (Groundwater Flow Analysis Using a Steady State Three-dimensional Model in an Upland Area)

  • 배상근
    • 물과 미래
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    • 제22권1호
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    • pp.81-90
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    • 1989
  • 호수와 접하고 있는 홍적대지의 지하수류동계를 알기 위하여 삼차유한차분모형을 개발하여 삼차원정상모의 발생을 행하였다. 대표지층속에 점토층이 렌즈상으로 포함되어 있어 세가지 경우의 이방성을 고려하였다. 모의 발생에는 60$\times$50$\times$30=90,000의 격자점을 설정하였으며 수속판정체계는 0.001m로 하였다. 세가지 경우의 이방성에 대하여, 삼차원정상모의 발생을 행하여 얻어진 결과로부터 해석된 지하수류동계와 추적자 및 수질에 의한 해석(배.비근, 1987)의 결과를 비교하였다. 삼차원해석에서 얻어진 네 개의 대표적인 연직2차원 등 포텐샬단면으로부터 연구지역의 지하수류동계를 추정하였으며 그 결과는 유역산출율과 지하수의 함량-유출량 분포로부터 추정되는 결과와 다름이 없었다.

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영양생장기 습해 처리에 따른 콩 품종의 해부형태학적 특성 비교 (Comparisons in Anatomical Morphology Between Soybean Cultivars of Different Flooding Tolerance under Early Vegetative Flooding Conditions)

  • 이충열;조진웅
    • 한국작물학회지
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    • 제52권3호
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    • pp.320-324
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    • 2007
  • 본 실험은 내습성 품종과 감수성 품종을 5엽기에 9일간 침수 처리한 후 잎과 배축을 대상으로 횡단면을 해부학적 특성을 광학현미경으로 관찰하여 그 결과 다음과 같다. 1. 엽록소함량, 광합성, 책상조직 수, 엽두께 및 잎 건물중은 습해에 의해 급격히 감소되었으며 풍산나물콩보다 소백나물콩의 감소가 더 많았다. 2. 잎 조직의 책상조직의 치밀함은 습해에 의해 급격히 감소되었고 품종간 차이도 관찰되었으며, 풍산나물콩은 주맥의 통도조직 중 목부의 발달을 볼 수 있었다. 3. 배축의 통기조직 형성은 소백나물콩은 보이지 않았으나 풍산나물콩은 피층에 파생통기조직이 형성되는 것을 볼 수 있었다.

한국 농촌 성인의 당뇨 신환군과 비당뇨군의 식품섭취빈도 조사법에 의한 식품섭취 비교 연구 (Comparison of Food Intakes between Newly Diagnosed Diabetics and Nondiabetics by Food Frequency Questionnaire in Adults Living in Rural Area of Korea)

  • 백희영;안윤진;이홍규;박용수
    • 한국식품영양과학회지
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    • 제27권1호
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    • pp.182-190
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    • 1998
  • This study was conducted to compare food intakes between newly diagnosed diabetics and non-diabetics by food frequency questionnarie in adults in rural area. Food frequency questionnaire containing 65 food items was executed to 2,406 subjects over 30 years of age living inYeonchon-gun, Kyungki province. Frequency of consumption of each food items were divided into 9 categories ranging from 'over 3 tiemes a day' to 'never'. Fasting blood glucose levels were measured and 2-hour glucose tolerance test was administered for each subject. Newly diagnosed diabetics were identified as those with fasting blood glucose level ≥ 140mg/dl or 2-hour postprandial glucose level ≥200mg/dl and without previous diagnosis of diabetes. Intake frequencies of food items were compared between newly diagnosed diabetics and nondiabetics. For each food item examined, odds ratios for developing diabetes were calculated for people consuming more frequently, after adjusting for age, BMI and sex. Food intake frequencies were compared according to the occurrence of diabetes. Twenty four items were more frequently consumed by nonidabetics and 12 items were more frequently consumed by newly diagnosed diabetics. Odds ratios for diabetes were significantly lower for breads, biscuit, beef loin, beef tender loin, pork belly, fish paste, coffee, cola/cider, candy, beer, chongak kimchi, carrot, mushrooms and other white vegetables, banana, melon and juice. On the other hand, odds ratios for diabetes were higher for zucchini and garlic. Although this was a cross over prevalence study, the results indicate that consumption frequencies of several food items were related with the occurrence of diabetes in the study subjects.

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A WUSCHEL Homeobox Transcription Factor, OsWOX13, Enhances Drought Tolerance and Triggers Early Flowering in Rice

  • Minh-Thu, Pham-Thi;Kim, Joung Sug;Chae, Songhwa;Jun, Kyong Mi;Lee, Gang-Seob;Kim, Dong-Eun;Cheong, Jong-Joo;Song, Sang Ik;Nahm, Baek Hie;Kim, Yeon-Ki
    • Molecules and Cells
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    • 제41권8호
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    • pp.781-798
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    • 2018
  • Plants have evolved strategies to cope with drought stress by maximizing physiological capacity and adjusting developmental processes such as flowering time. The WOX13 orthologous group is the most conserved among the clade of WOX homeodomain-containing proteins and is found to function in both drought stress and flower development. In this study, we isolated and characterized OsWOX13 from rice. OsWOX13 was regulated spatially in vegetative organs but temporally in flowers and seeds. Overexpression of OsWOX13 (OsWOX13-ov) in rice under the rab21 promoter resulted in drought resistance and early flowering by 7-10 days. Screening of gene expression profiles in mature leaf and panicles of OsWOX13-ov showed a broad spectrum of effects on biological processes, such as abiotic and biotic stresses, exerting a cross-talk between responses. Protein binding microarray and electrophoretic mobility shift assay analyses supported ATTGATTG as the putative cis-element binding of OsWOX13. OsDREB1A and OsDREB1F, drought stress response transcription factors, contain ATTGATTG motif(s) in their promoters and are preferentially expressed in OsWOX13-ov. In addition, Heading date 3a and OsMADS14, regulators in the flowering pathway and development, were enhanced in OsWOX13-ov. These results suggest that OsWOX13 mediates the stress response and early flowering and, thus, may be a regulator of genes involved in drought escape.

조생 순백색 자주 화심 글라디올러스 '아리랑' ('Arirang', Early-flowering Pure White Gladiolus with Purple Core)

  • 조해룡;이혜경;임진희
    • 화훼연구
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    • 제18권2호
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    • pp.142-146
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    • 2010
  • 순백색 바탕에 자주색 화심이 있는 조생종 글라디올러스 '아리랑'이 1998년 국립원예특작과학원(구 원예연구소)에 의해 개발되었다. '아리랑'은 어두운 오렌지색 조생종 '아리안느'에 밝은 홍적색 대형종 국산품종인 '홍광'을 교배한 조합에서 선발되었다. 1993년에 교배하여 얻은 실생 종자를 파종, 1994년에 처음 선발하였으며 1998년까지 5년에 걸쳐 생육특성검정을 하였다. 아리랑은 밝은 백색바탕에 자주색 화심이 있는 절화용 품종으로 조생종이면서 꽃대가 휘지 않는 강한 초세를 갖고 있다. 따라서 여름철 노지 재배용으로 이용이 가능하다. 또한 장마철 습해에도 강하고 구근부패병에 강해 장마철 절화가 가능한 품종이다. 생육속도는 매우 빠르며 구근 번식력도 좋다. 아리랑의 여름철 개화소요일수는 75일 정도이며 구근 생산재배 시 품질 좋은 구근생산을 위해 생육 기간 중 추비를 1-2회 뿌려 주는 것이 좋다.

Protection of Metal Stress in Saccharomyces cerevisiae: Cadmium Tolerance Requies the Presence if Two ATP-Binding Domains of Hsp 104 Protein

  • 이경희;엄정훈
    • Bulletin of the Korean Chemical Society
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    • 제22권5호
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    • pp.514-518
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    • 2001
  • We have explored the importance of two ATP binding domains of Hsp104 protein in protection of yeast cells from cadmium exposure. In the previous study we have discovered that the presence of two ATP binding sites was essential in providing heat sh ock protection as well as rescuing cells from oxidative stress. In this paper we first report wild type cell with functional hsp104 gene is more resistant to cadmium stress than hsp104-deleted mutant cell, judging from decrease in survival rates as a result of cadmium exposure. In order to demonstrate functional role of two ATP binding sites in cadmium defense, we have transformed both wild type (SP1) and hyperactivated ras mutant (IR2.5) strains with several plasmids differing in the presence of ATP binding sites. When an extra copy of functional hsp104 gene with both ATP binding sites was overexpressed with GPD-promoter, cells showed increased survival rate against cadmium stress than mutants with ATP binding sites changed. The degree of protection in the presence of two ATP binding sites was similarly observed in ira2-deleted hyperactivated ras mutant, which was more sensitive to oxidative stress than wild type cell. We have concluded that the greater sensitivity to cadmium stress in the absence of two ATP binding sites is attributed to the higher concentration of reactive oxygen species (ROS) produced by cadmium exposure based on the fluorescence tests. These findings, taken all together, imply that the mechanism by which cadmium put forth toxic effects may be closely associated with the oxidative stress, which is regulated independently of the Ras-cAMP pathway. Our study provides a better understanding of cadmium defense itself and cross-talks between oxidative stress and metal stress, which can be applied to control human diseases due to similar toxic environments.

기름함량이 높은 종실용 들깨 신품종 '다유' (A New Perilla Cultivar for Edible Seed 'Dayu' with High Oil Content)

  • 이명희;정찬식;오기원;박충범;김대균;최재근;남상영
    • 한국육종학회지
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    • 제43권6호
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    • pp.616-619
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    • 2011
  • '다유'는 종실수확을 목적으로 하는 품종육성을 위하여 대엽 들깨를 모본으로 하고, YCPL1846을 부본으로 인공교배하여 계통육종법으로 선발한 SF94007-2B-13-2-1 계통으로 계통명은 '밀양30호'이며 주요특성을 요약하면 다음과 같다. 1. '다유'는 화색은 흰색, 잎색은 녹색이며, 종자는 진한갈색의 구형이다. 2. 노지재배시 경장이 127 cm로 경장이 낮아 도복에 유리하며 화방군당 삭수가 많고 화방군장이 길다. 3. 기름함량이 48.5%로 표준품종인 새엽실들깨에 비하여 높고 리놀렌산은 59.8% 함량을 가지고 있다. 4. '다유'는 2000년부터 2001년까지 2년간 하계에 생산력 검정시험을 실시한 결과 1 ha당 평균 수량이 1.34 MT으로 표준품종에 비해 12% 증수하였으며, 5개 지역에서 실시한 지역적응시험 결과에서는 1 ha당 1.44 MT으로 표준품종보다 4% 증수하였다.

Half-cell 기반 multi-wires 접합 공정에서 접합 특성에 영향을 주는 요인과 효율의 상관관계 연구 (A Study on the Relationship between Factors Affecting Soldering Characteristics and Efficiency of Half-cell Soldering Process with Multi-wires)

  • 김재훈;손형진;김성현
    • Current Photovoltaic Research
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    • 제7권3호
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    • pp.65-70
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    • 2019
  • As a demand of higher power photovoltaic modules, shingled, multi-busbar, half-cell, and bifacial techniques are developed. Multi-busbar module has advantage for large amount of light havesting. And, half-cell is high power module for reducing resistive losses and higher shade tolerance. Recently, researches on multi-busbar is focused on reliability according to adhesion and intermetallic compound between Sn-Pb solder and Ag electrode. And half-cell module is researched to comparing with full-sized cell module for structure difference. In this study, we investigated the factors affecting to efficiency and adhesion of multi-wires half-cell module according to wire thickness, solder thickness, and flux. The results of solar simulator and peel test was that peel strength and efficiency of soldered cell is not related. But samples with flux including high solid material showed high efficiency. The results of FE-SEM and EDX line scan on cross-section between wire and Ag electrode for different flux showed thickness of solder joint between wire and Ag electrode is increasing through solid material increasing. Flux including high solid material would affect to solder behavior on Ag electrode. Higher solid material occurred lower growth of IMC layer because solder permeate to sider of wire ribbon than Ag electrode. And it increased fill factor for high efficiency. In soldering process, amount of solid material in flux and solder thickness are the factor related with characteristic of soldered photovoltaic cell.

BO-105 헬리콥터 복합재 로터 블레이드 역설계 (Reverse Design for Composite Rotor Blade of BO-105 Helicopter)

  • 이창배;장기주;임병욱;신상준
    • 한국항공우주학회지
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    • 제49권7호
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    • pp.539-547
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    • 2021
  • 회전익 항공기의 로터 블레이드는 공기역학, 구조적 유연성, 제어 가능성 등의 상호작용 효과를 고려한 설계가 필요하다. 역설계는 형상정보 및 실험결과를 통해 공통된 특성을 갖는 구성품을 설계할 때 유용하게 사용될 수 있다. 본 논문에서는 BO-105 헬리콥터의 복합재 로터 블레이드를 선정하여 공통된 특성을 갖도록 역설계하고자 하였다. 이를 위해 로터 블레이드를 여러 구간으로 나누어 복합재료가 단면에 따라 연속적으로 적층될 수 있도록 역설계를 수행하였다. 각 구간에 대해서는 variational asymptotic beam sectional analysis (VABS) 단면해석 프로그램을 사용하여 설계안의 플랩 방향, 래그 방향 및 비틀림 강성값이 실험 결과와 일정 수준 이하의 차이를 갖도록 하였다. 최종으로 CAMRAD II를 통해 특정 비행 조건에서 로터 블레이드에 작용하는 하중을 예측한 후 설계된 블레이드가 구조적으로 유효한지 확인하였다.