• Resources Recycling
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• v.27 no.1
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• pp.84-91
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• 2018

In this study, a novel soft information based most probable classification scheme is proposed for sorting recyclable metal alloys with laser induced breakdown spectroscopy (LIBS). Regression analysis with LIBS captured spectrums for estimating concentrations of common elements can be efficient for classifying unknown arbitrary metal alloys, even when that particular alloy is not included for training. Therefore, partial least square regression (PLSR) is employed in the proposed scheme, where spectrums of the certified reference materials (CRMs) are used for training. With the PLSR model, the concentrations of the test spectrum are estimated independently and are compared to those of CRMs for finding out the most probable class. Then, joint soft information can be obtained by assuming multi-variate normal (MVN) distribution, which enables to account the probability measure or a prior information and improves classification performance. For evaluating the proposed schemes, MVN soft information is evaluated based on PLSR of LIBS captured spectrums of 9 metal CRMs, and tested for classifying unknown metal alloys. Furthermore, the likelihood is evaluated with the radar chart to effectively visualize and search the most probable class among the candidates. By the leave-one-out cross validation tests, the proposed scheme is not only showing improved classification accuracies but also helpful for adaptive post-processing to correct the mis-classifications.

• Conservation Science in Museum
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• v.17
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• pp.69-84
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• 2016

Yuso is the term for decorative tassels of a braided string which hangs a scroll painting. This study, drawing on extant research concerning the yuso made for Joseon period portrait scrolls of kings and meritorious retainers, focuses on the yuso created to hang literati portraits. Concretely, It examines yuso of seven portraits in the collection of the National Museum of Korea in order to characterize their appearance and determine their material composition. The study found that most of the yuso are sixteen-strand strings braided into a rounded cross-section(dongdahoe). The seven yuso, of which six are red and one indigo-blue, reflect the popular style associated with Joseon period literati portraits. The yuso for the portrait of Yun Geup(duksu 3503) is made from gilded paper. Analysis showed Fe particles present in a red pigment underlying the gold layer, suggesting the presence of red ochre(seokganju), an iron oxide mineral. The yuso of the portrait of Shin Im(duksu 4846) is used a paper which contains gold as well as traces of Pb, Hg and Ag. The paper in the yuso for the portrait of Yi Seongwon(bongwan 10122) mainly consisted of Ag, indicating silver paper having been used in its fabrication. The inner paper in the yuso of the portrait of Yi Seogu(sinsu 1065) is a leather combined with Ag, Fe, and Br, according to chemical analysis. The FTIR of the leather sample reveals that the spectrum in the fingerprint region is nearly identical to that of sheepskin, indicating the yuso was made from gold-coated sheepskin.

• Korean Journal of Clinical Pharmacy
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• v.20 no.3
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• pp.255-261
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• 2010

Cefprozil is a broad-spectrum oral beta-lactam cephalosporin consisting of cis- and trans-isomeric mixture whose ratio is approximately 90:10. Cefprozil is used to treat certain infections caused by bacteria such as bronchitis and ear, skin, and throat infections. The purpose of the present study was to evaluate the bioequivalence of two cefprozil tablets, $Cefzil^{(R)}$ tablet 250 mg (BMS Pharmaceutical Korea., Ltd.) and Procezil tablet 250 mg (Hanmi Pharm. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The in vitro release of cefprozil from the two cefprozil formulations were tested using KP VIII Apparatus I method with water dissolution media. Thirty five healthy male subjects, $24.00{\pm}1.53$ years in age and $69.77{\pm}9.99$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After four tablets containing 1000 mg as cefprozil were orally administered, blood samples were taken at predetermined time intervals and the concentrations of cefprozil in serum were determined using HPLC/UV detector. The dissolution profiles of two formulations were similar in water tested dissolution media. The pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ on the basis of total-cefprozil were calculated, and computer program (K-BE Test 2002) was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, $Cefzil^{(R)}$ tablets, were -0.81%, -3.00% and -6.83% for $AUC_t$, $C_{max}$ and $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log 0.9515~log 1.0454 and log 0.9613~log 1.0465 for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Procezil tablet was bioequivalent to $Cefzil^{(R)}$ tablet.

• The Journal of the Acoustical Society of Korea
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• v.16 no.5
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• pp.76-82
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• 1997

The paper describes simulations and experimental results using a measuring system which utilizes the acoustic holographic method in order to exactly estimate an absolute position of a sound source. The measuring surface is installed to satisfy with a far field to the sound source and is composed of linear arrayed seven microphones. A measurement is simultaneously recorded by a reference microphone setting up a neighbour sound source and the linear arrayed seven microphones which are moved to the same interval. An absolute position of sound source is estimated by the cross-spectrum method to the received sounds between a reference and the measuring microphones. Phase differences of each microphone and time delays during scanning are compensated to the reference microphone and the measuring time of the first column. An optimal interval for each microphone in the measuring surface is decided by a numerical simulation. A source signal makes use of a sinusoid, and S/N ratio is 30dB in the experiment. The optimal microphone's interval in the simulation and the experiment is decided in order to satisfy with the Nyquist space sampling condition related to the wave length of 2kHz sinusoid. Mainlobe width of a estimated 3D hologram in the case of 2kHz source signal is decreased to 87% and 30% in comparison to 500Hz and 1kHz, and then a valid of simulation results is confirmed. Therefore, we verified a utilization of the study for a sound source estimation using 3ㅇ acoustic holographic method.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.47 no.1
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• pp.103-119
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• 2010

In this paper, we propose a subpixel shift estimation method using phase correlation with a local region for the registration of noisy images. Phase correlation is commonly used to estimate the subpixel shift between images, which is derived from analyzing shifted and downsampled images. However, when the images are affected by additive white Gaussian noise and aliasing artifacts, the estimation error is increased. Thus, instead of using the whole image, the proposed method uses a specific local region that is less affect by noises. In addition, to improve the estimation accuracy, iterative phase correlation is applied between selected local regions rather than using a fitting function. the restricted range is determined by analyzing the maximum peak and the two adjacent values of the inverse Fourier transform of the normalized cross power spectrum. In the experiments, the proposed method shows higher accuracy in registering noisy images than the other methods. Thus, the edge-sharpness and clearness in the super-resolved image is also improved.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.5B
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• pp.321-329
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• 2012

Two regular progressive wave trains, the directions of which are slightly different from each other, develop a honeycomb pattern of wave crests due to their nonlinear interaction. In the honeycomb pattern of wave crest, the nodal line area, which has very low wave energy, is formed. When the honeycomb pattern is developed near the beach area, rip current evolves through the nodal line area formed in the cross shore direction. In this study, to confirm that the formation of honeycomb pattern of waves near the beach area is a dominant mechanism of rip current occurred at Haeundae beach, we performed a numerical simulation of nearshore circulation at Haeundae beach under an unidirectional and monochromatic wave condition by using a nonlinear Boussinesq equation model. As a result, wave refraction due to topographical characteristics (i.e., submerged shoal) of Haeundae gave rise to several wave trains propagating with slightly different directions toward the beach, and consequently rip currents well developed through the nodal line area of honeycomb patterns of wave crest. In addition, we found that a narrow-banded spectral wave condition (i.e., a swell spectrum) increases more likelihood of rip current than a broad-banded spectral wave condtion based on the simulations employing various wave spectra with an equivalent wave height and period.

• Journal of the Korean Society for Nondestructive Testing
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• v.36 no.6
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• pp.443-450
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• 2016

In this study, we propose a novel fiber optic sensor to show the measurement feasibility of distributed temperature and strains in a single sensing fiber line. Distributed temperature can be measured using optical time domain reflectometry (OTDR) with a Raman anti-Stokes light in the sensing fiber line. Moreover, the strain can be measured by fiber Bragg gratings (FBGs) in the same sensing fiber line. The anti-Stokes Raman back-scattering lights from both ends of the sensing fiber, which consists of a 4 km single mode optical fiber, are acquired and inserted into a newly formulated equation to calculate the temperature. Furthermore, the center wavelengths from the FBGs in the sensing fiber are detected by an optical spectrum analyzer; these are converted to strain values. The initial wavelengths of the FBGs are selected to avoid a cross-talk with the wavelength of the Raman pulsed pump light. Wavelength shifts from a tension test were found to be 0.1 nm, 0.17 nm, 0.29 nm, and 0.00 nm, with corresponding strain values of $85.76{\mu}{\epsilon}$, $145.55{\mu}{\epsilon}$, $247.86{\mu}{\epsilon}$, and $0.00{\mu}{\epsilon}$, respectively. In addition, a 50 m portion of the sensing fiber from $30^{\circ}C$ to $70^{\circ}C$ at $10^{\circ}C$ intervals was used to measure the distributed temperature. In all tests, the temperature measurement accuracy of the proposed sensor was less than $0.50^{\circ}C$.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.13 no.1
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• pp.37-42
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• 2013

Gaucher disease is a lysosomal storage disease caused by deficiency of glucocerebrosidase (GBA). This condition is characterized by accumulation of glucocerebrosidase in liver, spleen, lung, skeletal system, and central nervous system. Gaucher disease is the prototype of disease in which efficacy of enzyme replacement therapy has been established. However, because recombinant enzyme is not able to enter the central nervous system, its efficacy is limited to the non-neurological manifestations of Gaucher disease. Importantly, approximately a half of Korean patients with Gaucher disease suffer from neurological manifestations. In addition, Korean Gaucher disease patients exhibit distinct mutation spectrum from those in other populations. Common mutations in Korean patients with Gaucher disease are also associated with neurological phenotype. Therefore, therapeutic strategies tailored to Korean patients were necessary. Interestingly, a chemical chaperone, ambroxol, has been known to increase residual enzymatic activities of the select mutant GBAs encoded by mutations prevalent in Korean patients. One promising aspect of this drug is that it can cross blood-brain barrier, and enhance the enzyme activity in the brain. In vitro study suggested this chemical chaperone as one of new therapeutic agents in Gaucher disease, and a well-designed human trial is required to confirm its efficacy.

• Economic and Environmental Geology
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• v.49 no.4
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• pp.269-280
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• 2016

I presented three vector crustal magnetic anomaly components and six gradients by using spherical Slepian functions over the cap area of $20^{\circ}$ of radius centered on the South Pole. The Swarm mission, launched by European Space Agency(ESA) in November of 2013, was planned to put three satellites into the low-Earth orbits, two in parallel in East-West direction and one in cross-over of the higher altitude. This orbit configuration will make the gradient measurements possible in North-South direction, vertical direction, as well as E-W direction. The gravity satellites, such as GRACE and GOCE, have already implemented their gradient measurements for recovering the accurate gravity of the Earth and its temporal variation due to mass changes on the subsurface. However, the magnetic gradients have little been applied since Swarm launched. A localized magnetic modeling method is useful in taking an account for a region where data availability was limited or of interest was special. In particular, computation to get the localized solutions is much more efficient and it has an advantage of presenting high frequency anomaly features with numbers of solutions fewer than the global ones. Besides, these localized basis functions that were done by a linear transformation of the spherical harmonic functions, are orthogonal so that they can be used for power spectrum analysis by transforming the global spherical harmonic coefficients. I anticipate in scientific and technical progress in the localized modeling with the gradient measurements from Swarm and here will do discussion on the results of the localized solution to represent the three vector and six gradient anomalies over the Antarctic area from the synthetic data derived from a global solution of the spherical harmonics for the crustal magnetic anomalies of Swarm measurements.

• Polymer(Korea)
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• v.29 no.5
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• pp.457-462
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• 2005

Polyurethane foams (PUFs) were prepared from polymeric 4,4'-diphenylmethane diisocyanate (PMDI), mixed polyol with OH value of 480, silicone surfactant, three catalysts, and hydrofluorocarbon(HFC) as blowing agent. Balance (PC-8), gelling (33LV), and trimerization (TMR-2) catalysts were used. The effect of the catalysts on the physical properties of PUF with increase of isocyanate (NCO) index and aging time was investigated. The cell size of the PUF with PC-8 and 33LV slightly increased with an increase in NCO index from 100 to 170 but compressive strength did not change significantly. In case of trimerization catalyst, the compressive strength of PUF increased from 8.75 to 1$10.5 kg_f/cm^2$ and the cell size decreased with an increase in NCO index. The compressive strength of the PUF with 33LV increased from 9.21 to $10.15 kg_f/cm^2$ with an increase in aging time. However, there was no detectable change in the compressive strength of PUF with TMR-2. A possible interpretation of the results includes an additional cross-link reaction of non-reacted MDI and FTIR spectrum illustrated the change of NCO peak.