• 제목/요약/키워드: Cross-Modulation

검색결과 161건 처리시간 0.023초

Inhibition of Major Histocompatibility Complex (MHC)-Restricted Presentation of Exogenous Antigen in Dendritic Cells by Korean Propolis Components

  • Han, Shin-Ha;Cho, Kyung-Hae;Lee, Seung-Jeong;Lee, Chong-Kil;Song, Young-Cheon;Ha, Nam-Joo;Kim, Kyung-Jae
    • IMMUNE NETWORK
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    • 제5권3호
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    • pp.150-156
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    • 2005
  • Background: Dendritic cells (DCs) playa critical role not only in the initiation of immune responses, but also in the induction of immune tolerance. In an effort to regulate immune responses through the modulation of antigen presenting cell (APC) function of DCs, we searched for and characterized APC function modulators from natural products. Methods: DCs were cultured in the presence of propolis components, WP and CP, and then examined for their ability to present exogenous antigen in association with major histocompatibility complexes (MHC). Results: WP and CP inhibited class I MHC-restricted presentation of exogenous antigen (cross-presentation) in a DC cell line, DC2.4 cells, and DCs generated from bone marrow cells with GM-CSF and IL-4. The inhibitory activity of WP and CP appeared to be due not only to inhibition of phagocytic activity of DCs, but also to suppression of expression of MHC molecules on DCs. We also examined the effects of WP and CP on T cells. Interestingly, WP and CP increased IL-2 production from T cells. Conclusion: These results demonstrate that WP and CP inhibit MHC-restricted presentation of exogenous antigen through down-regulation of phagocytic activity and suppression of expression of MHC molecules on DCs.

5'' True Color FED 구동시스템 설계 (Design of 5'' True Color FED Driving System)

  • 신홍재;권오경;곽계달
    • 전자공학회논문지SC
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    • 제38권5호
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    • pp.70-78
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    • 2001
  • 본 연구에서는 전류제어 효과를 갖는 전압제어 펄스폭 변조 방식의 5' true color FED 구동시스템을 설계하였다. 제안한 구동방식은 전압제어 펄스폭 변조방식과 전류제어 방식의 장점을 가지고 있다. 또한, FED 구동회로의 시뮬레이션을 위하여 FED 서브 픽셀에 대한 새로운 회로 모델을 제안한다. 제안된 모델은 FED 서브 픽셀의 특성과 FED 패널의 기생 효과인 게이트 라인간 커플링 현상과 인접한 캐소드 라인을 통하여 흐르는 누설 전류 등을 고려하고 있다. FED 구동회로의 출력단은 제안된 모델을 사용하여 최적화되었다. R.G.B 입력데이터 신호 처리를 병렬처리 방식으로 하여 기존의 직렬처리 방식에 비해서 화면에 영상을 디스플레이하는 duty ratio를 최대로 하여 휘도를 높일 수 있도록 하였다. 이러한 연구 결과를 바탕으로 $300{\times}224$의 해상도를 가지는 5' true color FED를 성공적으로 디스플레이 하였다.

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RGS Protein Specificity Towards Gq- and Gi/o-Mediated ERK 1/2 and Akt Activation, in vitro

  • Anger, Thomas;Klintworth, Nils;Stumpf, Christian;Daniel, Werner G.;Mende, Ulrike;Garlichs, Christoph D.
    • BMB Reports
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    • 제40권6호
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    • pp.899-910
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    • 2007
  • Extracellular Regulated Kinases (ERK) and Protein Kinase B (Akt) are intermediaries in relaying extracellular growth signals to intracellular targets. Each pathway can become activated upon stimulation of G protein-coupled receptors mediated by $G_q$ and $G_{i/o}$ proteins subjected to regulation by RGS proteins. The goal of the study was to delineate the specificity in which cardiac RGS proteins modulate $G_{q^-}$ and $G_{i/o}$-induced ERK and Akt phosphorylation. To isolate $G_{q^-}$ and $G_{i/o}$-mediated effects, we exclusively expressed muscarinic $M_2$ or $M_3$ receptors in COS-7 cells. Western blot analyses demonstrated increase of phosphorylation of ERK 1.7-/3.3-fold and Akt 2.4-/6-fold in $M_{2^-}/M_{3^-}$ expressing cells through carbachol stimulation. In co-expressions, $M_3/G_q$-induced activation of Akt was exclusively blunted through RGS3s/RGS3, whereas activation of ERK was inhibited additionally through RGS2/RGS5. $M_2/G_{i/o}$ induced Akt activation was inhibited by all RGS proteins tested. RGS2 had no effect on $M_2/G_{i/o}$-induced ERK activation. The high degree of specificity in RGS proteins-depending modulation of $G_{q^-}$ and $G_{i/o}$-mediated ERK and Akt activation in the muscarinic network cannot merely be attributed exclusively to RGS protein selectivity towards $G_q$ or $G_{i/o}$ proteins. Counter-regulatory mechanisms and inter-signaling cross-talk may alter the sensitivity of GPCR-induced ERK and Akt activation to RGS protein regulation.

The Flow Instability Over the Infinite Rotating Disk

  • Lee, Yun-Yong;Hwang, Young-Kyu;Lee, Kwang-Won
    • Journal of Mechanical Science and Technology
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    • 제17권9호
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    • pp.1388-1396
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    • 2003
  • The hydrodynamic instability of the three-dimensional boundary layer on a rotating disk introduces a periodic modulation of the mean flow in the form of stationary cross flow vortices. The instability labeled Type II by Faller occurs first at lower Reynolds number than that of well known Type I instability. Detailed numerical values of the amplification rates, neutral curves and other characteristics of the two instabilities have been calculated over a wide range of parameters. Presented are the neutral stability results concerning the two instability modes by solving the appropriate linear stability equations reformulated not only by considering whole convective terms but also by correcting some errors in the previous stability equations. The present stability results agree with the previously known ones within reasonable limit. Consequently, the flow is found to be always stable for a disturbance whose dimensionless wave number is greater than 0.75. Some spatial amplification contours have been computed for the stationary disturbance wave, whose azimuth angle $\varepsilon$= 11.29$^{\circ}$ to 15$^{\circ}$ and for the moving disturbance wave, whose azimuth angle $\varepsilon$ = 12.5$^{\circ}$ to 15$^{\circ}$. Also, some temporal amplification contours have been computed for the stationary disturbance wave, whose azimuth angle $\varepsilon$= 11.29$^{\circ}$ to 15$^{\circ}$ and for the moving disturbance wave, whose azimuth angle $\varepsilon$= 12$^{\circ}$ to 15$^{\circ}$. The flow instability was observed by using a white titanium tetrachloride gas over rotating disk system. When the numerical results are compared to the present experimental data, the numerical results agree quantitatively, indicating the existence of the selective frequency mechanism.

Effects of 8 weeks administration of Korean Panax ginseng extract on the mood and cognitive performance of healthy individuals

  • L., Reay J.;B., Scholey A.;O., Kennedy D.
    • Journal of Ginseng Research
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    • 제31권1호
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    • pp.34-43
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    • 2007
  • Background: Previous research has suggested that single doses of a standardised Panax ginseng extract can decrease fasted blood-glucose levels and modulate cognitive performance in healthy young volunteers. The latter has generally been seen in terms of improved secondary memory performance. However, both the cognitive effects of chronic administration of ginseng and the potential modulation of working memory have received comparatively little research attention. Aims: The current double-blind, placebo-controlled, balanced cross-over study investigated the effects of 8-weeks administration of Korean ginseng extract (200 mg) on cognitive performance, gluco-regulatory parameters and ratings of subjective mood and 'quality of life'. Methods: 'Eighteen healthy young participants were assessed pre-dose and 3 hours post-dose on the mornings of Day 1, Day 29 and Day 57 of 8 week treatment regimens of both placebo and ginseng. A four-week placebo wash-out separated the treatment phases. Each assessment included the Cognitive Drug Research battery, computerised working memory tasks, and Bond-Lader mood scales. The WHO Quality of Life scale (WHOQOL-BREF) was completed once per visit. Gluco-regulatory parameters were assessed with assays of blood glucose, insulin and HbA1c. Results: Data from the 16 participants that completed the study showed that there were no significant, acute treatment related differences on Day 1 of treatment, or in gluco-regulatory parameters throughout the study. However, time related performance improvements were evident following chronic administration of ginseng on the '3-Back' and 'Corsi-block' computerised working memory tasks. Ginseng was also associated with an improved score on the 'social relations' subscale of the WHOQOL-100, and a significant shift on the 'calm' factor of the Bond-Lader mood scales (from calm/relaxed towards excited/tense). Conclusion: The results of the current study suggest that Korean ginseng extract can modulate working memory performance and subjective ratings of 'quality of life' and mood. Replication with a larger sample size may further elucidate the actions of this product.

미세가공 정전용량형 초음파 탐촉자 개발(III) - 탐촉자 성능평가 (Development of capacitive Micromachined Ultrasonic Transducer (III) - Performance Test)

  • 김기복;안봉영;박해원;김영주;이승석
    • 비파괴검사학회지
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    • 제24권6호
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    • pp.581-589
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    • 2004
  • 본 연구는 선행연구의 결과를 바탕으로 cMUT를 개발하여 그 특성을 분석하기 위하여 수행되었다. 미세 반도체 제작공정을 적용하여 cMUT를 제작하여 단면특성을 측정하여 분석하였다. 제작된 cMUT의 미소 진동 막의 변위를 측정할 수 있는 마이켈슨 위상변조 간섭계를 구성하여 측정결과와 이론적인 해석결과와 비교하였다. cMUT의 초음파 특성을 분석하기 위하여 송수신 시스템을 구성하였다 비접촉 방법으로 cMUT에 의해 발생되는 초음파 신호를 수신하여 수신파형의 특성을 분석한 결과 양호한 주파수 특성을 나타내었다. 본 연구에서 개발된 cMUT는 향후 비접촉식 초음파 응용분야에 다양하게 활용될 것으로 판단된다.

RETRIEVAL OF LOCAL INTERPLANETARY DUST EMISSIVITY BY ASTRO-F

  • HONG S. S.;KWON S. M.;PYO J.;UENO M.;ISHIGURO M.;USUI F.;WEINBERG J. L.
    • 천문학회지
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    • 제37권4호
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    • pp.159-169
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    • 2004
  • This is a proposal to probe local part of the interplanetary dust (IPD) cloud complex and retrieve mean volume emissivity of the local IPDs at mid-infrared wavelengths. This will be done by monitoring, with Infrared Camera (IRC) aboard the ASTRO-F, the annual modulation of the zodiacal emission. In pointing mode of the ASTRO-F mission the spacecraft can make attitude maneuvering over approximately ${\pm}1^{\circ}$ range centered at solar elongation $90^{\circ}$ in the ecliptic plane. The attitude maneuvering combined with high sensitivity of the IRC will provide us with a unique opportunity observationally to take derivatives of the zodiacal emission brightness with respect to the solar elongation. From the resulting differential of the brightness over the ${\pm}1^{\circ}$ range, one can directly determine the mean volume emissivity of the local IPDs with a sufficient accuracy to de-modulate the annual emissivity variations due to the Earth's elliptical motion and the dis-alignment of the maximum IPD density plane with respect to the ecliptic. The non-zero eccentricity ($e_{\oplus}$= 0.0167) of the Earth's orbit combined with the sensitive temperature dependence of the Planck function would bring modulations of amplitude at least $3.34\%$ to the zodiacal emission brightness at mid-infrared wavelengths, with which one may determine the IPD temperature T(r) and mean number density n(r) as functions of heliocentric distance r. This will in turn fix the power-law exponent $\delta$ in the relation $T(r) = T_o(r/r_o)^{-\delta}$ for the dust temperature and v in $n(r) = n_o(r/r_o)^-v$ for the density. We discuss how one may de-couple the notorious degeneracy of cross-section, density, reference temperature $T_o$ and exponent $\delta$.

전광 그레이코드 이진코드 변환기 (All-Optical Gray Code to Binary Coded Decimal Converter)

  • 정영진;박남규;전영민;우덕하;이석
    • 한국광학회지
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    • 제19권1호
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    • pp.60-67
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    • 2008
  • 전광 그레이코드(gray code) 이진코드(binary code) 변환기를 상용화 전산모사 프로그램(VPI)을 이용하여 처음으로 구현하였다. 전자회로 디자인 방법을 상호 이득변조를 이용한 전광 논리회로에 적합하도록 변형하여, 이상적이지 않은 전광 논리게이트에 의한 신호 왜곡이 최소화 되도록 하였다. 2.5 Gbps의 20 dB 소광비를 가지는 입력 신호에 대해, 신호재생기 없이 가장 많이 왜곡된 출력 신호에 (최하위 비트-LSB) 대해 약 4 이상의 Q값을 얻을 수 있었다. 또한 그레이 코드 이진코드 변환기를 디자인하면서, 이단 단순화 방법을 (two-level simplification method) 변형하여, 그레이코드 이진코드 변환기뿐 아니라 일반적인 전광 회로에 적용할 할 수 있는 일반적 방법을(일단 단순화 방법: one-level simplification method) 얻을 수 있었다.

반도체 광증폭기를 이용한 다기능 전광 논리 소자의 설계 및 측정 (Design and Demonstration of All-Optical XOR, AND, OR Gate in Single Format by Using Semiconductor Optical Amplifiers)

  • 손창완;윤태훈;김상헌;전영민;변영태;이석;우덕하;김선호
    • 한국광학회지
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    • 제17권6호
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    • pp.564-568
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    • 2006
  • 반도체 광증폭기에 기반을 둔 이득포화특성을 이용하여 XOR, AND, OR 논리 게이트를 동시에 구현하는 다기능 전광 논리소자를 설계하고 구현하였다. 상용화된 프로그램인 VPI Component $Maker^{TM}$을 사용하여 시뮬레이션을 수행하였고 10 Gbit/s의 입력 신호를 사용하여 XOR, AND, OR 논리동작을 동시에 구현하는 다기능 전광 논리소자를 구현하였다.

넓은 입력 다이너믹 영역을 가지는 상호이득변조 방식의 전광 파장전환기 (All Optical Wavelength Converters Based on XGM for Wide Input Power Dynamic Range)

  • 방준학;이상록;이성은;이종현
    • 전자공학회논문지D
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    • 제36D권8호
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    • pp.62-67
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    • 1999
  • 본 논문에서는 반도체 광 증폭기내에서 상호 이득변조 방식을 이용한 파장변환기의 입력 다이너믹 영역을 넓히기 위한 구조를 제안하였다. 파장변환기에서의 성능의 척도가 되는 파워 패널티에 대한 입력 펌프 및 프로우브 광 세기의 영향을 조사하였으며, 그 결과 프로우브광의 세기가 펌프광의 세기보다 약 3 dB, 낮은 경우에 최적의 BER 성능을 보였다. 이러한 특성을 이용하여 입력 펌프광의 세기를 감지하고 그에 따라 프로우브 광원에 가해지는 바이어스 전류로 프로우브 광의 세기를 제어하는 파장변환기 구조를 제안하였다. 따라서 넓은 입력 다이너믹 영역을 가지는 파장변환기를 구현할 수 있으며, 2.5 Gb/s 광신호에 대해 20 dB 이상의 입력 다이너믹 영역을 얻었다.

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