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MediScore: MEDLINE-based Interactive Scoring of Gene and Disease Associations

  • Cho, Hye-Young;Oh, Bermseok;Lee, Jong-Keuk;Kim, Kuchan;Koh, InSong
    • Genomics & Informatics
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    • v.2 no.3
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    • pp.131-133
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    • 2004
  • MediScore is an information retrieval system, which helps to search for the set of genes associated with a specific disease or the set of diseases associated with a specific gene. Despite recent improvement of natural language processing (NLP) and other text mining approaches to search for disease associated genes, many false positive results come out due to diversity of exceptional cases as well as ambiguities in gene names. In order to overcome the weak points of current text mining approaches, MediScore introduces statistical normalization based on binomial to normal distribution approximation which corrects inaccurate scores caused by common words not representing genes and interactive rescoring by the user to remove the false positive results. Interactive rescoring includes individual alias scoring for each gene to remove false gene synonyms, referring MEDLINE abstracts, and cross referencing between OMIM and other related information.

Optimal Hyper Analytic Wavelet Transform for Glaucoma Detection in Fundal Retinal Images

  • Raja, C.;Gangatharan, N.
    • Journal of Electrical Engineering and Technology
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    • v.10 no.4
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    • pp.1899-1909
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    • 2015
  • Glaucoma is one of the most common causes of blindness which is caused by increase of fluid pressure in the eye which damages the optic nerve and eventually causing vision loss. An automated technique to diagnose glaucoma disease can reduce the physicians’ effort in screening of Glaucoma in a person through the fundal retinal images. In this paper, optimal hyper analytic wavelet transform for Glaucoma detection technique from fundal retinal images is proposed. The optimal coefficients for transformation process are found out using the hybrid GSO-Cuckoo search algorithm. This technique consists of pre-processing module, optimal transformation module, feature extraction module and classification module. The implementation is carried out with MATLAB and the evaluation metrics employed are accuracy, sensitivity and specificity. Comparative analysis is carried out by comparing the hybrid GSO with the conventional GSO. The results reported in our paper show that the proposed technique has performed well and has achieved good evaluation metric values. Two 10- fold cross validated test runs are performed, yielding an average fitness of 91.13% and 96.2% accuracy with CGD-BPN (Conjugate Gradient Descent- Back Propagation Network) and Support Vector Machines (SVM) respectively. The techniques also gives high sensitivity and specificity values. The attained high evaluation metric values show the efficiency of detecting Glaucoma by the proposed technique.

A study on the optimal sizing and topology design for Truss/Beam structures using a genetic algorithm (유전자 알고리듬을 이용한 트러스/보 구조물의 기하학적 치수 및 토폴로지 최적설계에 관한 연구)

  • 박종권;성활경
    • Journal of the Korean Society for Precision Engineering
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    • v.14 no.3
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    • pp.89-97
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    • 1997
  • A genetic algorithm (GA) is a stochastic direct search strategy that mimics the process of genetic evolution. The GA applied herein works on a population of structural designs at any one time, and uses a structured information exchange based on the principles of natural selection and wurvival of the fittest to recombine the most desirable features of the designs over a sequence of generations until the process converges to a "maximum fitness" design. Principles of genetics are adapted into a search procedure for structural optimization. The methods consist of three genetics operations mainly named selection, cross- over and mutation. In this study, a method of finding the optimum topology of truss/beam structure is pro- posed by using the GA. In order to use GA in the optimum topology problem, chromosomes to FEM elements are assigned, and a penalty function is used to include constraints into fitness function. The results show that the GA has the potential to be an effective tool for the optimal design of structures accounting for sizing, geometrical and topological variables.variables.

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Quantitative Review of Oral Cancer Research Output from Pakistan

  • Khan, Zohaib;Muller, Steffen;Ahmed, Shahzad;Tonnies, Justus;Nadir, Faryal;Samkange-Zeeb, Florence
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.11
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    • pp.4733-4739
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    • 2015
  • Background: Oral cancer is the most common cancer among men and second only to breast cancer among women in Pakistan. For the effective control and prevention of oral cancer, Pakistan needs to recognize the importance of research and generation of the evidence-base which can inform policy making and planning and implementation of intervention programs. The objective of this review was to quantify oral cancer research output in Pakistan. Materials and Methods: A systematic electronic search in "Medline", "ISI-Web of Science" and "Pakmedinet", supplemented by a Google search, was carried out in January and February, 2014, to identify literature from Pakistan relevant to oral cancer. The selection of publications for the review was carried out according to preset criteria. Data were recorded and analyzed using Microsoft Excel. Results: A total of 166 publications comprising 62 case series, 36 cross sectional, 31 case control, 10 basic laboratory research, eleven reviews and two trials, were included in this review. Some 35 % of the publications focused on risk factors for oral cancer. COMSATS Institute of Information Technology was the institution with the highest contribution. Conclusions: There is a lack of research in the field of oral cancer research in Pakistan. Focused efforts should be put in place to improve both quality and quantity of oral cancer research in the country.

The influence of breakfast on the academic performance of school-age adolescents: systematic review

  • Jeong, Eun-Young
    • Journal of Nutrition and Health
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    • v.52 no.2
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    • pp.119-128
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    • 2019
  • Purpose: This review article provides an overview of the importance of breakfast by examining the relationship between breakfast and academic achievement including the papers published in Korean. Methods: This study searched a total of six domestic and international databases. The main search words for searching the database were 'breakfast,' 'morning meal,' 'adolescent,' 'teen or teenage,' 'children' and 'academic performance,' and used search operators when available such as 'breakfast AND adolescent AND academic performance'. Results: We searched a total of 274 studies through six databases and included a total of 15 primary studies in which 12 studies were cross-sectional and three were cohort studies. Since a quantitative integration of the primary studies was difficult to achieve such as performing a meta-analysis, this study performed a descriptive analysis of all the 15 studies and the results have shown that eating breakfast has a significant effect on academic achievement. In other words, students who regularly had breakfast showed more than twice the academic performance compared to those who did not have breakfast, and even though the math scores of students who had breakfast were statistically significantly higher, none of the study results inferred the reason. Conclusion: This study showed the importance of eating breakfast during adolescence by presenting that academic achievement increases with regular or more frequent habits of eating breakfast.

Hardware Accelerated Design on Bag of Words Classification Algorithm

  • Lee, Chang-yong;Lee, Ji-yong;Lee, Yong-hwan
    • Journal of Platform Technology
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    • v.6 no.4
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    • pp.26-33
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    • 2018
  • In this paper, we propose an image retrieval algorithm for real-time processing and design it as hardware. The proposed method is based on the classification of BoWs(Bag of Words) algorithm and proposes an image search algorithm using bit stream. K-fold cross validation is used for the verification of the algorithm. Data is classified into seven classes, each class has seven images and a total of 49 images are tested. The test has two kinds of accuracy measurement and speed measurement. The accuracy of the image classification was 86.2% for the BoWs algorithm and 83.7% the proposed hardware-accelerated software implementation algorithm, and the BoWs algorithm was 2.5% higher. The image retrieval processing speed of BoWs is 7.89s and our algorithm is 1.55s. Our algorithm is 5.09 times faster than BoWs algorithm. The algorithm is largely divided into software and hardware parts. In the software structure, C-language is used. The Scale Invariant Feature Transform algorithm is used to extract feature points that are invariant to size and rotation from the image. Bit streams are generated from the extracted feature point. In the hardware architecture, the proposed image retrieval algorithm is written in Verilog HDL and designed and verified by FPGA and Design Compiler. The generated bit streams are stored, the clustering step is performed, and a searcher image databases or an input image databases are generated and matched. Using the proposed algorithm, we can improve convenience and satisfaction of the user in terms of speed if we search using database matching method which represents each object.

Search for Dark Photon in e+e- → A'A' Using Future Collider Experiments

  • Kihong Park;Kyungho Kim;Alexei Sytov;Kihyeon Cho
    • Journal of Astronomy and Space Sciences
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    • v.40 no.4
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    • pp.259-266
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    • 2023
  • The Standard Model (SM) does not provide an information for 26% of dark matter of the universe. In the dark sector, dark matter is supposed to be linked with the hypothetical particles called dark photons that have similar role to photons in electromagnetic interaction in the SM. Besides astronomical observation, there are studies to find dark matter candidates using accelerators. In this paper, we searched for dark photons using future electron-positron colliders, including Circular Electron Positron Collider (CEPC)/CEPC, Future Circular Collider (FCC-ee)/Innovative Detector for Electron-positron Accelerator (IDEA), and International Linear Collider (ILC)/International Large Detector (ILD). Using the parameterized response of the detector simulation of Delphes, we studied the sensitivity of a double dark photon mode at each accelerator/detector. The signal mode is double dark photon decay channel, e+e- → A'A', where A' (dark photon with spin 1) decaying into a muon pair. We used MadGraph5 to generate Monte Carlo (MC) events by means of a Simplified Model. We found the dark photon mass at which the cross-sections were the highest for each accelerator to obtain the maximum number of events. In this paper we show the expected number of dark photon signal events and the detector efficiency of each accelerator. The results of this study can facilitate in the dark photon search by future electron-positron accelerators.

Design of the Web based Mini-PACS (웹(Web)을 기반으로 한 Mini-PACS의 설계)

  • 안종철;신현진;안면환;박복환;김성규;안현수
    • Progress in Medical Physics
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    • v.14 no.1
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    • pp.43-50
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    • 2003
  • PACS mostly has been used in large scaled hospital due to expensive initial cost to set up the system. The network of PACS is independent of the others: network. The user's PC has to be connected physically to the network of PACS as well as the image viewer has to be installed. The web based mini-PACS can store, manage and search inexpensively a large quantity of radiologic image acquired in a hospital. The certificated user can search and diagnose the radiologic image using web browser anywhere Internet connected. The implemented Image viewer is a viewer to diagnose the radiologic image. Which support the DICOM standard and was implemented to use JAVA programming technology. The JAVA program language is cross-platform which makes easier upgrade the system than others. The image filter was added to the viewer so as to diagnose the radiologic image in detail. In order to access to the database, the user activates his web browser to specify the URL of the web based PACS. Thus, The invoked PERL script generates an HTML file, which displays a query form with two fields: Patient name and Patient ID. The user fills out the form and submits his request via the PERL script that enters the search into the relational database to determine the patient who is corresponding to the input criteria. The user selects a patient and obtains a display list of the patient's personal study and images.

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Influence of picture presence in reviews on online seller product rating: Moderation role approach

  • Hossin, Md Altab;Mu, Yinping;Fang, Jiaming;Frimpong, Adasa Nkrumah Kofi
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.13 no.12
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    • pp.6097-6120
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    • 2019
  • Online consumer reviews (OCRs) provide product information and recommendations especially pictures in reviews depict the true information about the product. This study investigates the influence of pictured reviews on online seller (for a particular product of a seller) rating with moderating effect of price, brand type (foreign vs local), goods type (experience vs search), and brand familiarity. Multiple robust linear regression analysis with moderation interaction and quadratic effect used to explain the relationship of the explanatory variables with the criterion variable. We collected cross-sectional data from the two most renowned Chinese online shopping platforms (B2C) of total 15,621 product links. Results show that higher number of reviews with a low ratio of picture reviews response negative effect on rating, whereas the lower number of reviews with a high ratio of picture reviews response positive effect on the rating. In overall picture in the reviews improve the online seller product rating. For the moderation effect, results show that price and brand familiarity have a positive interaction effect on the relation of pictured reviews and rating whereas experience goods have less negative effect comparing search goods. Finally, local brand has less negative interaction effect comparing foreign brand to pictured reviews and rating.

Trends in Nursing Research on Life-Sustaining Treatment in South Korea after the Enforcement of the Act on Decisions on Life-Sustaining Treatment

  • Choi, Jun-Hwa;Choi, Eun-Suk
    • Journal of Hospice and Palliative Care
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    • v.25 no.1
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    • pp.25-41
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    • 2022
  • Purpose: This study investigated trends of nursing research on life-sustaining treatment in South Korea. Methods: The period for data search was set from January 2018 to December 2020. The major search terms used were advance directives and life-sustaining treatment. Of the 492 records identified in the initial search, 461 articles were excluded for various reasons. A total of 31 records were included in the final qualitative analysis. Results: Sixteen studies had nursing students as study subjects, while nine studies had nurses as study subjects. The majority of the studies employed cross-sectional descriptive surveys as their research design. The major themes that emerged from the studies were as follows: attitudes toward withdrawal of life-sustaining treatment, knowledge of and attitudes toward advance directives, perceptions of a good death, and nurses' attitude toward life support care. Most of the studies reviewed concluded that attitudes toward withdrawal of life-sustaining treatment significantly impacted both knowledge of and attitudes toward advance directives and perceptions of a good death. Conclusion: To date, Korea still lacks extensive nursing research concerning life support care. Further research is needed to provide systematic education for nursing ethics and life support care, as well as the introduction of a specialist course. Furthermore, a multidisciplinary approach is necessary to provide diverse support systems and policy measures. In particular, since nurses are directly responsible for providing life support care, nurses' roles should be expanded in accordance with the Act on Decisions on Life-Sustaining Treatment.