• Journal of Gastric Cancer
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• v.17 no.2
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• pp.132-144
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• 2017

Purpose: To identify baseline prognostic factors for survival in patients with disease progression, during or after chemotherapy for the treatment of advanced gastric or gastroesophageal junction (GEJ) cancer. Materials and Methods: We pooled data from patients randomized between 2009 and 2012 in 2 phase III, global double-blind studies of ramucirumab for the treatment of advanced gastric or GEJ adenocarcinoma following disease progression on first-line platinum- and/or fluoropyrimidine-containing therapy (REGARD and RAINBOW). Forty-one key baseline clinical and laboratory factors common in both studies were examined. Model building started with covariate screening using univariate Cox models (significance level=0.05). A stepwise multivariable Cox model identified the final prognostic factors (entry+exit significance level=0.01). Cox models were stratified by treatment and geographic region. The process was repeated to identify baseline prognostic quality of life (QoL) parameters. Results: Of 1,020 randomized patients, 953 (93%) patients without any missing covariates were included in the analysis. We identified 12 independent prognostic factors of poor survival: 1) peritoneal metastases; 2) Eastern Cooperative Oncology Group (ECOG) performance score 1; 3) the presence of a primary tumor; 4) time to progression since prior therapy <6 months; 5) poor/unknown tumor differentiation; abnormally low blood levels of 6) albumin, 7) sodium, and/or 8) lymphocytes; and abnormally high blood levels of 9) neutrophils, 10) aspartate aminotransferase (AST), 11) alkaline phosphatase (ALP), and/or 12) lactate dehydrogenase (LDH). Factors were used to devise a 4-tier prognostic index (median overall survival [OS] by risk [months]: high=3.4, moderate=6.4, medium=9.9, and low=14.5; Harrell's C-index=0.66; 95% confidence interval [CI], 0.64-0.68). Addition of QoL to the model identified patient-reported appetite loss as an independent prognostic factor. Conclusions: The identified prognostic factors and the reported prognostic index may help clinical decision-making, patient stratification, and planning of future clinical studies.

• The Journal of Traditional Korean Medicine
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• v.15 no.1
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• pp.113-127
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• 2006

Objectives: This study was produced to examine the effects of moxibustion that had been played important role to traditional oriental medical treatment on disease. Recently, it was reported that moxi-tar which is generated in the process of moxibustion as burning combustibles decreased nitric oxide(NO) and inducible NO synthase (iNOS) generation in cellular experiments. Methods: Carrageenan-induced arthritis rat model was used to test the effect of moxi-tar as a chronic pain model. Diluted moxi-tar was single injected in several acupoints or combined with electroacupuncture (l ms, 2 Hz, and 2 mA) into contralateral ST36 acupoint for 30 min to assess the synergic effects. After the treatment, behavioral tests measuring stepping force were periodically conducted during the next 12 hours. Endogenous NO and iNOS, cyclooxygenase-2 (COX-2), and c-Fos protein expression in the spinal cord were examined on a rat model of carrageenan-induced arthritis. Results : After the induction of arthritis, rats subsequently showed a reduced stepping force of the affected limb for at least the next 4 days. The reduced stepping force of the limb was presumably due to a painful knee, since oral injection of indomethacin produced temporary improvement of weight bearing. Maxi-tar produced significant improvement of stepping force of the hindlimb affected by the arthritis lasting at least 9 hours. The magnitude of this improvement was equivalent to that obtained after an oral injection of 3 mg/kg of indomethacin and this improvement of stepping force was interpreted as an analgesic effect. Maxi-tar produced the improvement of stepping force of the affected hindlimb in a dose-dependent manner. Both NO production and iNOS, COX-2 protein expression increased by arthritis were suppressed by maxi-tar. Moxi-tar on combination with electroacupuncture (EA) produced more powerful and longer lasting improvement of stepping force of the hindlimb affected by the arthritis than either moxi-tar or EA did. Conclusion : The present study suggest that maxi-tar produces a potent analgesic effect on the chronic knee arthritis pain model in the rat and that moxi-tar-induced analgesia modulate endogenous NO through the suppression of iNOS/COX-2 protein expression.

• Journal of Fashion Business
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• v.23 no.2
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• pp.48-61
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• 2019

The objective of this study was to derive a list of creative thinking techniques applied with the requirements of the appropriate technique for the task of fashion design development among the process of fashion product planning. This was done through the analysis of thinking techniques by the type of thinking and idea method. Also, the study presented how each creative thinking technique derived is applied to the task of developing fashion design. The scope of the study was 'Fashion Design Development Task', which corresponds to the design sketch of a fashion item based on the seasonal design concept derived through the fashion design planning stage. Research on the thinking techniques consisted largely of the process of idea thinking, the elements of creative thinking, the patterns and types of thinking. Four studies by Makoto, Michalko, De Bono, and Cox suggesting that the patterns and types of thinking techniques were analyzed for the purpose of this study as empirical studies through FGI of a group of five fashion experts. The analysis results showed that the thinking techniques suitable for the development of fashion design were derived from the technique of fractionation, attributive listing, scamper, morphological analysis, mind mapping, lotus blossom, pattern language, provocative operation, and forced connection. In particular, it can be confirmed that the scamper was treated as an efficient and practical technique in the many studies.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.5
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• pp.1048-1054
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• 2002

Silsosangami(SSG) is a formula of oriental medicines as an effective biological response modifier for augmenting host homeostasis of body circulation. Also SSG has been known to have an anti-diabetic activity and anti-platelet aggregation activity. The present study was undertaken to examine the effects of a new SSG on murine macrophage and human neutrophil functions as well as on several enzymes relevant to the inflammatory process. The results of the present study indicate that SSG exerts anti-inflammatory effects related to the inhibition of neutrophil functions and of PGE2 production, which could be due to a decreased expression of and COX-2.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.1171-1174
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• 2005

Manufacturing capability at the micro or nano scale production field is requested strongly in view of parts and product miniaturization. Miniaturized parts and products will introduce lots of benefits in terms of high precision functionality and low energy consumption. This paper presents the results of micro milling machine tool development for micro machining process. Finite element analysis has been performed to know the relationship between design dimensional variables and structural stiffness in terms of static, dynamic, thermal aspects. Performance evaluation through machining has been tested and discussed for achievable machining characteristics.

• Journal of Haehwa Medicine
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• v.22 no.1
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• pp.37-48
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• 2013

This study aims to summarize and makes a reference of anti-inflammatory activities of herbal medicines. In this process, this review collated papers of anti-inflammation-focused studies using herbal medicines in Oriental medical journals since 2003. Finally 221 papers were included and the type of materials, the type and effective classification of herbal medicines, the type of cells used in the experiments and the action and mechanisms of herbal medicine were analysed. The herbal medicines having the effects of decreasing fire and tonifying and nourishment were used the most. Most herbal medicines in this study can decrease proinflammatory cytokines, NO and prostaglandin 2 (PGE 2) production, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by regulating of nuclear factor kappa B (NF-${\kappa}B$) and/or mitogen activated protein kinases (MAPKs).

• Journal of the Korean Statistical Society
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• v.36 no.1
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• pp.57-76
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• 2007

Kriging is a nonparametric regression method used in geostatistics for estimating curves and surfaces for spatial data. It may come as a surprise that the Kriging estimator, normally derived as the best linear unbiased estimator, is also the solution of a particular variational problem. Thus, Kriging estimators can also be interpreted as generalized smoothing splines where the roughness penalty is determined by the covariance function of a spatial process. We build off the early work by Silverman (1982, 1984) and the analysis by Cox (1983, 1984), Messer (1991), Messer and Goldstein (1993) and others and develop an equivalent kernel interpretation of geostatistical estimators. Given this connection we show how a given covariance function influences the bias and variance of the Kriging estimate as well as the mean squared prediction error. Some specific asymptotic results are given in one dimension for Matern covariances that have as their limit cubic smoothing splines.

• Journal of the Korean Data and Information Science Society
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• v.12 no.2
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• pp.125-143
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• 2001

We, in this paper, propose a kernel estimator of hazard ratio with censored survival data. The uniform consistency and asymptotic normality of the proposed estimator are proved by using counting process approach. In order to assess the performance of the proposed estimator, we compare the kernel estimator with Cox estimator and the generalized rank estimators of hazard ratio in terms of MSE by Monte Carlo simulation. Two examples are illustrated for our results.

• Bulletin of the Korean Chemical Society
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• v.29 no.2
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• pp.389-392
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• 2008

High purity carbon nano fibers/tubes (CNF/Ts) which contain 97% pure graphitic carbon are prepared by a new catalytic method. These carbon nano fibers/tubes are ready to use without any further purification. The striking feature of this method is the production of carbon nano fibers/tubes of narrow distribution range. The developed catalytic method also produces pure hydrogen. An additional advantage of this catalytic method is that catalyst can be reused without reactivation. Ni:Cu catalyst system is embodied into SCHOTT-DURAN filter disc of large pore size (40-100 mm). Due to the production of hydrogen in the reaction catalyst stability is enhanced and deactivation process is considerably slowed down.

• Honam Mathematical Journal
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• v.9 no.1
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• pp.113-119
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• 1987

Random variables $X_1$, $X_1$, ..., $X_m$ are said to be weakly associated if whenever $\pi$ is a permutation of {1, 2,..., m}, $1{\leq}k<m$, and f: $R^{k}{\rightarrow}R$, g: $R^{m-k}{\rightarrow}R$ are coordinatewise nondecreasing functions then Cov $[f(X_{x(1)},...,\;X_{\pi(k)},\;g(X_{x(k+1)},...,\;X_{x(m)})]{\geq}0$, whenever the covariance is defined. An infinite collection of random variables is weakly associated if every finite subcollection is weakly associated. The basic properties of weak association and central limit theorem for weakly associated random variables are derived. We also extend this idea to point random fields and prove that a Cox process with a stationary weakly associated intensity rardom measure is weakly associated. Another inequalities and the fact that positive correlated normal random variables are weakly associated are also proved.